Aliases for LCE1D Gene

Aliases for LCE1D Gene

  • Late Cornified Envelope 1D 2 3 5
  • LEP4 2 3 4
  • Late Cornified Envelope Protein 1D 3 4
  • Late Envelope Protein 4 3 4
  • LCE1D 5

External Ids for LCE1D Gene

Previous GeneCards Identifiers for LCE1D Gene

  • GC01P149583
  • GC01P151035
  • GC01P152769
  • GC01P152797

Summaries for LCE1D Gene

GeneCards Summary for LCE1D Gene

LCE1D (Late Cornified Envelope 1D) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. An important paralog of this gene is LCE1E.

UniProtKB/Swiss-Prot Summary for LCE1D Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LCE1D Gene

Genomics for LCE1D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LCE1D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J152786 Promoter 0.8 EPDnew Ensembl 49.9 -10.4 -10420 0.2 CTCF PRDM10 LCE1E LCE1D
GH01J152622 Enhancer 0.7 Ensembl ENCODE 13.3 -173.5 -173508 2 GABPA CTCF SPI1 MYC POLR2A NRF1 TCF12 LCE3A LCE1D PGLYRP4 piR-43103-004 LCE2D
GH01J152752 Enhancer 0.6 Ensembl ENCODE 13.6 -44.2 -44221 0.6 FOXA2 FOXA1 MNT FOS CEBPB LCE1D piR-50852-011 KPRP LCEP1 C1orf68
GH01J152626 Enhancer 0.2 Ensembl 13.2 -169.8 -169820 0.6 LCE1D LCE3A piR-43103-004 LCE2D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LCE1D on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LCE1D

Top Transcription factor binding sites by QIAGEN in the LCE1D gene promoter:
  • AML1a
  • ATF6
  • HEN1
  • p53
  • Pax-2a
  • Pax-2b
  • POU3F1
  • ZID

Genomic Locations for LCE1D Gene

Latest Assembly
1,461 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
1,461 bases
Plus strand

(GRCh37/hg19 by Ensembl)
1,431 bases
Plus strand

Genomic View for LCE1D Gene

Genes around LCE1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCE1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCE1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCE1D Gene

Proteins for LCE1D Gene

  • Protein details for LCE1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Late cornified envelope protein 1D
    Protein Accession:

    Protein attributes for LCE1D Gene

    114 amino acids
    Molecular mass:
    11230 Da
    Quaternary structure:
    No Data Available
    • Belongs to the LCE cluster present on 1q21.

neXtProt entry for LCE1D Gene

Post-translational modifications for LCE1D Gene

No Post-translational modifications

Other Protein References for LCE1D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCE1D Gene

Domains & Families for LCE1D Gene

Gene Families for LCE1D Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LCE1D Gene


Suggested Antigen Peptide Sequences for LCE1D Gene

GenScript: Design optimal peptide antigens:
  • Late envelope protein 4 (LCE1D_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LCE family.
  • Belongs to the LCE family.
genes like me logo Genes that share domains with LCE1D: view

Function for LCE1D Gene

Molecular function for LCE1D Gene

UniProtKB/Swiss-Prot Function:
Precursors of the cornified envelope of the stratum corneum.
UniProtKB/Swiss-Prot Induction:

Phenotypes From GWAS Catalog for LCE1D Gene

Gene Ontology (GO) - Molecular Function for LCE1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27107012
GO:0042802 identical protein binding IPI 32296183
genes like me logo Genes that share ontologies with LCE1D: view

Phenotypes for LCE1D Gene

GenomeRNAi human phenotypes for LCE1D:
genes like me logo Genes that share phenotypes with LCE1D: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LCE1D

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LCE1D Gene

Localization for LCE1D Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCE1D gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for LCE1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IDA 11698679
GO:0005737 cytoplasm IDA 11698679
GO:0048471 perinuclear region of cytoplasm IDA 11698679
genes like me logo Genes that share ontologies with LCE1D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for LCE1D Gene

Pathways & Interactions for LCE1D Gene

PathCards logo

SuperPathways for LCE1D Gene

genes like me logo Genes that share pathways with LCE1D: view

Pathways by source for LCE1D Gene

Gene Ontology (GO) - Biological Process for LCE1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development IEA --
GO:0031424 keratinization IEA --
GO:0050890 cognition IMP 23227193
GO:0071277 cellular response to calcium ion IDA 11698679
genes like me logo Genes that share ontologies with LCE1D: view

No data available for SIGNOR curated interactions for LCE1D Gene

Drugs & Compounds for LCE1D Gene

No Compound Related Data Available

Transcripts for LCE1D Gene

mRNA/cDNA for LCE1D Gene

1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LCE1D

Alternative Splicing Database (ASD) splice patterns (SP) for LCE1D Gene

No ASD Table

Relevant External Links for LCE1D Gene

GeneLoc Exon Structure for

Expression for LCE1D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LCE1D Gene

mRNA differential expression in normal tissues according to GTEx for LCE1D Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x34.9) and Skin - Not Sun Exposed (Suprapubic) (x17.8).

Protein differential expression in normal tissues from HIPED for LCE1D Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LCE1D Gene

Protein tissue co-expression partners for LCE1D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LCE1D

SOURCE GeneReport for Unigene cluster for LCE1D Gene:


mRNA Expression by UniProt/SwissProt for LCE1D Gene:

Tissue specificity: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
genes like me logo Genes that share expression patterns with LCE1D: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCE1D Gene

Orthologs for LCE1D Gene

Evolution for LCE1D Gene

Gene Tree for LCE1D (if available)
Gene Tree for LCE1D (if available)
Evolutionary constrained regions (ECRs) for LCE1D: view image
Alliance of Genome Resources:
Additional Orthologs for LCE1D

No data available for Orthologs for LCE1D Gene

Paralogs for LCE1D Gene

genes like me logo Genes that share paralogs with LCE1D: view

Variants for LCE1D Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LCE1D Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs41268490 -- p.Arg78His
rs7527180 -- p.Asn59Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LCE1D Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LCE1D Gene

Variant ID Type Subtype PubMed ID
dgv101e212 CNV gain 25503493
dgv102e212 CNV loss 25503493
dgv104e212 CNV loss 25503493
dgv105e212 CNV gain 25503493
dgv14n17 CNV loss 16327808
dgv429n100 CNV gain 25217958
dgv432n100 CNV gain 25217958
dgv435n100 CNV gain 25217958
dgv436n100 CNV gain+loss 25217958
dgv437n100 CNV gain+loss 25217958
dgv438n100 CNV gain 25217958
dgv439n100 CNV gain 25217958
dgv440n100 CNV gain 25217958
dgv576n54 CNV gain 21841781
dgv577n54 CNV loss 21841781
dgv578n54 CNV gain+loss 21841781
dgv5n50 CNV loss 21212237
dgv72e199 CNV deletion 23128226
dgv77n67 CNV loss 20364138
esv24425 CNV gain+loss 19812545
esv2444007 CNV loss 19546169
esv2535964 CNV deletion 19546169
esv2718228 CNV deletion 23290073
esv2758970 CNV gain+loss 17122850
esv2763813 CNV loss 21179565
esv2764262 CNV gain+loss 21179565
esv2986012 CNV deletion 24192839
esv33483 CNV gain+loss 17666407
esv3587569 CNV loss 21293372
esv992673 CNV deletion 20482838
nsv1004884 CNV gain 25217958
nsv1009758 CNV gain+loss 25217958
nsv1012573 CNV loss 25217958
nsv1143468 CNV deletion 24896259
nsv1161681 CNV deletion 26073780
nsv2910 CNV deletion 18451855
nsv435711 CNV deletion 17901297
nsv438059 CNV loss 16468122
nsv471351 CNV loss 19718026
nsv498690 CNV loss 21111241
nsv508615 CNV deletion 20534489
nsv514009 CNV loss 21397061
nsv547891 CNV loss 21841781
nsv547899 CNV gain 21841781
nsv547919 CNV loss 21841781
nsv79 CNV deletion 15895083
nsv820665 CNV deletion 20802225
nsv8436 CNV gain+loss 18304495
nsv947447 CNV deletion 23825009

Variation tolerance for LCE1D Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.67; 72.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LCE1D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCE1D Gene

Disorders for LCE1D Gene

Additional Disease Information for LCE1D

No disorders were found for LCE1D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCE1D Gene

Publications for LCE1D Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation. (PMID: 15854049) Jackson B … Byrne C (The Journal of investigative dermatology 2005) 3 4
  3. Differentially expressed late constituents of the epidermal cornified envelope. (PMID: 11698679) Marshall D … Byrne C (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3

Products for LCE1D Gene

Sources for LCE1D Gene