LCE1A belongs to the late cornified envelope (LCE) gene cluster within the epidermal differentiation complex (EDC) on chromosome 1. The LCE cluster contains multiple conserved genes that encode stratum corneum proteins, and these genes are expressed relatively late during fetal assembly of the skin cornified envelope (Jackson et al., 2005 [PubMed 15854049]). For further informa... See more...

Aliases for LCE1A Gene

Aliases for LCE1A Gene

  • Late Cornified Envelope 1A 2 3 5
  • Late Cornified Envelope Protein 1A 3 4
  • Late Envelope Protein 1 3 4
  • LEP1 3 4

External Ids for LCE1A Gene

Previous GeneCards Identifiers for LCE1A Gene

  • GC01P149613
  • GC01P151065
  • GC01P152798
  • GC01P124162

Summaries for LCE1A Gene

Entrez Gene Summary for LCE1A Gene

  • LCE1A belongs to the late cornified envelope (LCE) gene cluster within the epidermal differentiation complex (EDC) on chromosome 1. The LCE cluster contains multiple conserved genes that encode stratum corneum proteins, and these genes are expressed relatively late during fetal assembly of the skin cornified envelope (Jackson et al., 2005 [PubMed 15854049]). For further information on the LCE gene cluster, see GENE FAMILY below.[supplied by OMIM, Feb 2009]

GeneCards Summary for LCE1A Gene

LCE1A (Late Cornified Envelope 1A) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology.

UniProtKB/Swiss-Prot Summary for LCE1A Gene

Additional gene information for LCE1A Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LCE1A Gene

Genomics for LCE1A Gene

GeneHancer (GH) Regulatory Elements for LCE1A Gene

Promoters and enhancers for LCE1A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J152820 Enhancer 0.2 Ensembl 0.4 -6.7 -6672 0.4 LCE6A LCE1F LCE1A LCE1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LCE1A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LCE1A

Top Transcription factor binding sites by QIAGEN in the LCE1A gene promoter:
  • AML1a
  • HOXA5
  • NCX
  • RFX1
  • SEF-1 (1)
  • TBP
  • ZID

Genomic Locations for LCE1A Gene

Genomic Locations for LCE1A Gene
chr1:152,827,473-152,828,097
(GRCh38/hg38)
Size:
625 bases
Orientation:
Plus strand
chr1:152,799,949-152,800,573
(GRCh37/hg19)
Size:
625 bases
Orientation:
Plus strand

Genomic View for LCE1A Gene

Genes around LCE1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCE1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCE1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCE1A Gene

Proteins for LCE1A Gene

  • Protein details for LCE1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7P2-LCE1A_HUMAN
    Recommended name:
    Late cornified envelope protein 1A
    Protein Accession:
    Q5T7P2

    Protein attributes for LCE1A Gene

    Size:
    110 amino acids
    Molecular mass:
    10982 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Belongs to the LCE cluster present on 1q21.

neXtProt entry for LCE1A Gene

Post-translational modifications for LCE1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LCE1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCE1A Gene

Domains & Families for LCE1A Gene

Gene Families for LCE1A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LCE1A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LCE1A Gene

GenScript: Design optimal peptide antigens:
  • Late envelope protein 1 (LCE1A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T7P2

UniProtKB/Swiss-Prot:

LCE1A_HUMAN :
  • Belongs to the LCE family.
Family:
  • Belongs to the LCE family.
genes like me logo Genes that share domains with LCE1A: view

Function for LCE1A Gene

Molecular function for LCE1A Gene

UniProtKB/Swiss-Prot Function:
Precursors of the cornified envelope of the stratum corneum.
UniProtKB/Swiss-Prot Induction:
By UVB.

Phenotypes From GWAS Catalog for LCE1A Gene

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LCE1A Gene

Localization for LCE1A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCE1A gene
Compartment Confidence
cytosol 4
plasma membrane 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LCE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LCE1A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for LCE1A Gene

Pathways & Interactions for LCE1A Gene

PathCards logo

SuperPathways for LCE1A Gene

genes like me logo Genes that share pathways with LCE1A: view

Pathways by source for LCE1A Gene

Gene Ontology (GO) - Biological Process for LCE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development IEA --
GO:0031424 keratinization IEA --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with LCE1A: view

No data available for SIGNOR curated interactions for LCE1A Gene

Drugs & Compounds for LCE1A Gene

No Compound Related Data Available

Transcripts for LCE1A Gene

mRNA/cDNA for LCE1A Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCE1A Gene

No ASD Table

Relevant External Links for LCE1A Gene

GeneLoc Exon Structure for
LCE1A

Expression for LCE1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LCE1A Gene

mRNA differential expression in normal tissues according to GTEx for LCE1A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x33.8) and Skin - Not Sun Exposed (Suprapubic) (x18.7).

Protein differential expression in normal tissues from HIPED for LCE1A Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LCE1A Gene



Protein tissue co-expression partners for LCE1A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LCE1A

SOURCE GeneReport for Unigene cluster for LCE1A Gene:

Hs.534645

mRNA Expression by UniProt/SwissProt for LCE1A Gene:

Q5T7P2-LCE1A_HUMAN
Tissue specificity: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.

Evidence on tissue expression from TISSUES for LCE1A Gene

  • Skin(2.1)
genes like me logo Genes that share expression patterns with LCE1A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCE1A Gene

Orthologs for LCE1A Gene

Evolution for LCE1A Gene

ENSEMBL:
Gene Tree for LCE1A (if available)
TreeFam:
Gene Tree for LCE1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LCE1A: view image

No data available for Orthologs for LCE1A Gene

Paralogs for LCE1A Gene

No data available for Paralogs for LCE1A Gene

Variants for LCE1A Gene

Additional dbSNP identifiers (rs#s) for LCE1A Gene

Structural Variations from Database of Genomic Variants (DGV) for LCE1A Gene

Variant ID Type Subtype PubMed ID
dgv432n100 CNV gain 25217958
esv2758970 CNV gain+loss 17122850
nsv1010576 CNV loss 25217958
nsv547899 CNV gain 21841781

Variation tolerance for LCE1A Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LCE1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LCE1A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LCE1A Gene

Disorders for LCE1A Gene

Additional Disease Information for LCE1A

No disorders were found for LCE1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCE1A Gene

Publications for LCE1A Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  2. Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation. (PMID: 15854049) Jackson B … Byrne C (The Journal of investigative dermatology 2005) 3 4 54
  3. Differentially expressed late constituents of the epidermal cornified envelope. (PMID: 11698679) Marshall D … Byrne C (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for LCE1A Gene

Sources for LCE1A Gene