Aliases for LBP Gene
External Ids for LBP Gene
Previous GeneCards Identifiers for LBP Gene
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
GeneCards Summary for LBP Gene
LBP (Lipopolysaccharide Binding Protein) is a Protein Coding gene. Diseases associated with LBP include Alcoholic Hepatitis and Toxic Pneumonitis. Among its related pathways are Toll-like Receptor Signaling Pathway and Transcription_NF-kB signaling pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and lipopolysaccharide binding. An important paralog of this gene is BPI.
UniProtKB/Swiss-Prot Summary for LBP Gene
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).