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The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role i... See more...
Aliases for LBP Gene
Aliases for LBP Gene
External Ids for LBP Gene
- HGNC: 6517
- Entrez Gene: 3929
- Ensembl: ENSG00000129988
- OMIM: 151990
- UniProtKB: P18428
Previous GeneCards Identifiers for LBP Gene
- GC20P036703
- GC20P037613
- GC20P037660
- GC20P036408
- GC20P036974
- GC20P033709
Summaries for LBP Gene
-
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
GeneCards Summary for LBP Gene
LBP (Lipopolysaccharide Binding Protein) is a Protein Coding gene. Diseases associated with LBP include Toxic Pneumonitis and Alcoholic Hepatitis. Among its related pathways are Activated TLR4 signalling and Tuberculosis. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and lipopolysaccharide binding. An important paralog of this gene is BPI.
UniProtKB/Swiss-Prot Summary for LBP Gene
-
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).
Additional gene information for LBP Gene
- HGNC(6517)
- Entrez Gene(3929)
- Ensembl(ENSG00000129988)
- OMIM(151990)
- UniProtKB(P18428)
- Open Targets Platform(ENSG00000129988)
- Monarch Initiative
- Search for LBP at DataMed
- Search for LBP at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LBP Gene
Genomics for LBP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LBP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LBP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LBP
- Top Transcription factor binding sites by QIAGEN in the LBP gene promoter:
-
- CREB
- deltaCREB
- HNF-4alpha1
- HNF-4alpha2
- HOXA9
- HOXA9B
- Meis-1
- Meis-1b
- TGIF
Genomic Locations for LBP Gene
Genomic Locations for LBP Gene
- chr20:38,346,482-38,377,013
- (GRCh38/hg38)
- Size:
- 30,532 bases
- Orientation:
- Plus strand
- chr20:36,974,759-37,005,665
- (GRCh37/hg19)
- Size:
- 30,907 bases
- Orientation:
- Plus strand
Genomic View for LBP Gene
Genes around LBP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.23 by HGNC
- 20q11.23 by Entrez Gene
- 20q11.23 by Ensembl
LBP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LBP Gene
Proteins for LBP Gene
-
Protein details for LBP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18428-LBP_HUMAN
- Recommended name:
- Lipopolysaccharide-binding protein
- Protein Accession:
- P18428
- B2R938
- O43438
- Q92672
- Q9H403
- Q9UD66
Protein attributes for LBP Gene
- Size:
- 481 amino acids
- Molecular mass:
- 53384 Da
- Quaternary structure:
-
- When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.
Protein Expression for LBP Gene
Post-translational modifications for LBP Gene
Other Protein References for LBP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ LBP Antibody
- Creative Diagnostics Anti-LBP polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for LBP
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-
Abcam antibodies for LBP
- Invitrogen Antibodies for LBP (AFLGC-LBP)
-
Santa Cruz Biotechnology (SCBT) Antibodies for LBP
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Protein Products
-
OriGene Purified Proteins for LBP
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- ProSpec Recombinant Proteins for LBP
- antibodies-online: Show 37 available LBP Proteins ranked by validation data
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ProSci Proteins for LBP
-
Abcam proteins for LBP
Assay Products
- RayBiotech Human LBP ELISA
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- Novus Biologicals ELISA Kits for LBP
- antibodies-online: Show 94 available LBP Elisa Kits ranked by validation data
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-
Quality Products:
- ABIN414694
- ABIN1115789
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- ABIN367166
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- ABIN4883581
- ABIN455712
- ABIN6720569
- ABIN5664983
- ABIN1889416
- ABIN424317
- ABIN817307
- ABIN5521097
- ABIN4993552
- ABIN2708565
- ABIN2684837
- ABIN2684836
- ABIN6574276
- ABIN1115788
- ABIN431477
- ABIN367550
- ABIN1570986
- ABIN4947823
- ABIN5521098
- ABIN5670506
- ABIN627264
- ABIN5656463
- ABIN1118089
- ABIN2851318
- ABIN1563694
- ABIN779252
- ABIN5656462
- ABIN4970771
- ABIN2536134
- ABIN6205639
-
Abcam assays for LBP
No data available for DME Specific Peptides for LBP Gene
Domains & Families for LBP Gene
Gene Families for LBP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
- Transporters
Protein Domains for LBP Gene
- InterPro:
- Blocks:
-
- Lipid-binding serum glycoprotein
- ProtoNet:
Suggested Antigen Peptide Sequences for LBP Gene
- GenScript: Design optimal peptide antigens:
-
- Lipopolysaccharide-binding protein (LBP_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P18428- Family:
-
- Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Function for LBP Gene
Molecular function for LBP Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).
- GENATLAS Biochemistry:
- lipopolysaccharide,acute-phase protein specifically binding to the lipid A moiety of liposaceharide (LPS,endotoxin) from the cell wall of Gram- bacteria binding protein,and directing it to the CD14 receptor mainly expressed by phagocytes
Phenotypes From GWAS Catalog for LBP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001530 | lipopolysaccharide binding | IDA,ISS | 2477488 |
| GO:0005102 | signaling receptor binding | IEA,ISS | 2477488 |
| GO:0005515 | protein binding | IPI | 15294986 |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0070891 | lipoteichoic acid binding | IDA | 12594207 |
Phenotypes for LBP Gene
- MGI mutant phenotypes for LBP:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for LBP:
Animal Models for LBP Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for LBP
CRISPR Products
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-
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miRNA for LBP Gene
- miRTarBase miRNAs that target LBP
miRNA Products
Inhibitory RNA Products
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for LBP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LBP Gene
Localization for LBP Gene
Subcellular locations from UniProtKB/Swiss-Prot for LBP Gene
- Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000250 UniProtKB:P17213}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| lysosome | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA,ISS | 2477488 |
| GO:0009986 | cell surface | IEA,IDA | 11528597 |
| GO:0016020 | membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for LBP Gene
Pathways & Interactions for LBP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Toll-like Receptor Signaling Pathway | ||
| 3 | Bacterial infections in CF airways |
Bacterial infections in CF airways
.78
Immune response Bacterial infections in normal airways
.78
|
Immune response TLR signaling pathways
.46
|
| 4 | Toll Comparative Pathway |
Immune response MIF in innate immunity response
.46
|
iNOS Signaling
.34
|
| 5 | Cytokine Signaling in Immune system | ||
Pathways by source for LBP Gene
1 Sino Biological pathway for LBP Gene
3 BioSystems pathways for LBP Gene
9 Reactome pathways for LBP Gene
3 KEGG pathways for LBP Gene
7 GeneGo (Thomson Reuters) pathways for LBP Gene
- Bacterial infections in CF airways
- Cytokine production by Th17 cells in CF
- Cytokine production by Th17 cells in CF (Mouse model)
- Immune response Bacterial infections in normal airways
- Immune response MIF in innate immunity response
3 Qiagen pathways for LBP Gene
- iNOS Signaling
- LPS Stimulated MAPK Signaling
- Toll-Like Receptors Pathway
Interacting Proteins for LBP Gene
Selected Interacting proteins:
P18428-LBP_HUMAN
ENSP00000217407
for LBP Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for LBP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
| GO:0002232 | leukocyte chemotaxis involved in inflammatory response | IEA | -- |
| GO:0002281 | macrophage activation involved in immune response | IMP,ISS | 2402637 |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006869 | lipid transport | IEA | -- |
No data available for SIGNOR curated interactions for LBP Gene
Drugs & Compounds for LBP Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 3-Dehydrosphinganine |
|
16105-69-4 |
|
|||
| 3-O-Sulfogalactosylceramide (d18:1/12:0) |
|
852100-88-0 |
|
|||
| 3-O-Sulfogalactosylceramide (d18:1/14:0) |
|
|
||||
| 3-O-Sulfogalactosylceramide (d18:1/16:0) |
|
862509-48-6 |
|
|||
| 3-O-Sulfogalactosylceramide (d18:1/18:0) |
|
244215-65-4 |
|
Drug Products
Transcripts for LBP Gene
mRNA/cDNA for LBP Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000217407 1825 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LBP - Select products 50% OFF >
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-
OriGene CRISPR knockouts for LBP
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-
Santa Cruz Biotechnology (SCBT) CRISPR for LBP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LBP
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Clone Products
- Applied Biological Materials (abm): Clones for LBP - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for LBP
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Relevant External Links for LBP Gene
- GeneLoc Exon Structure for
- LBP
Expression for LBP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Visceral White Adipocytes Visceral White Adipose
- Visceral White Adipose
- Liver (Hepatobiliary System)
- Epithelial Cells (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for LBP Gene
This gene is overexpressed in Liver (x49.2).
This gene is overexpressed in Serum (17.8), Synovial fluid (8.5), and Plasma (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LBP Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LBP
SOURCE GeneReport for Unigene cluster for LBP Gene:
Hs.154078mRNA Expression by UniProt/SwissProt for LBP Gene:
P18428-LBP_HUMAN
Tissue specificity:
Detected in blood serum (at protein level).
Evidence on tissue expression from TISSUES for LBP Gene
- Liver(4.8)
- Blood(3)
- Intestine(2.9)
- Heart(2.4)
- Kidney(2.3)
- Lung(2.3)
- Spleen(2.2)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for LBP
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LBP Gene
Orthologs for LBP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LBP 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LBP 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LBP 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Lbp 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Lbp 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | LBP 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for LBP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for LBP Gene
- ENSEMBL:
- Gene Tree for LBP (if available)
- TreeFam:
- Gene Tree for LBP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LBP: view image
Paralogs for LBP Gene
Variants for LBP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LBP Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 708629 | Likely Benign: not provided | 38,369,028(+) | C/T | MISSENSE_VARIANT | |
| 718787 | Likely Benign: not provided | 38,360,756(+) | A/G | MISSENSE_VARIANT | |
| 735262 | Likely Benign: not provided | 38,350,847(+) | G/A | SYNONYMOUS_VARIANT | |
| 738517 | Benign: not provided | 38,373,947(+) | C/T | SYNONYMOUS_VARIANT | |
| 769090 | Benign: not provided | 38,349,567(+) | A/G | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2666106 | CNV | deletion | 23128226 |
| esv2758794 | CNV | gain | 17122850 |
| esv3429648 | CNV | duplication | 20981092 |
| esv35121 | CNV | gain | 17911159 |
| esv3645775 | CNV | loss | 21293372 |
| nsv1058457 | CNV | loss | 25217958 |
| nsv1063495 | CNV | gain | 25217958 |
| nsv817893 | CNV | gain | 17921354 |
Residual Variation Intolerance Score:
99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.80;
89.53% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LBP Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LBP Gene
Disorders for LBP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| toxic pneumonitis |
|
|
| alcoholic hepatitis |
|
|
| bacterial sepsis |
|
|
| peritonitis |
|
|
| mastitis |
|
|
Search LBP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LBP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for LBP Gene
Publications for LBP Gene
- Lipopolysaccharide-binding protein (LBP) gene polymorphisms: rapid genotyping by real-time PCR and association with infective endocarditis. (PMID: 19560454) Vollmer T … Dreier J (Clinical biochemistry 2009) 3 23 41
- A common haplotype of the LBP gene predisposes to severe sepsis. (PMID: 19707138) Flores C … GRECIA and Gen-SEP groups (Critical care medicine 2009) 3 23 41
- Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae. (PMID: 19200604) Verstraelen H … Temmerman M (Journal of reproductive immunology 2009) 3 23 41
- Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation. (PMID: 18056482) Chien JW … Clark JG (Blood 2008) 3 23 41
- Polymorphisms in the lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in patients with myocardial infarction. (PMID: 12521224) Hubacek JA … Poledne R (Clinical chemistry and laboratory medicine 2002) 3 23 41
ExternalLinks
Products for LBP Gene
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- ABIN4883581
- ABIN455712
- ABIN6720569
- ABIN5664983
- ABIN1889416
- ABIN424317
- ABIN817307
- ABIN5521097
- ABIN4993552
- ABIN2708565
- ABIN2684837
- ABIN2684836
- ABIN6574276
- ABIN1115788
- ABIN431477
- ABIN367550
- ABIN1570986
- ABIN4947823
- ABIN5521098
- ABIN5670506
- ABIN627264
- ABIN5656463
- ABIN1118089
- ABIN2851318
- ABIN1563694
- ABIN779252
- ABIN5656462
- ABIN4970771
- ABIN2536134
- ABIN6205639
- antibodies-online: Show 37 available LBP Proteins ranked by validation data
- Compare Top LBP Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for LBP
- Search Santa Cruz Biotechnology (SCBT) for LBP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LBP
- Horizon Cell Lines for LBP
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LBP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LBP
- Search GeneCopoeia for miRNA 3'UTR Target clone products for LBP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LBP
Sources for LBP Gene
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- (67) Reactome
- (68) GeneGo (Thomson Reuters)
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- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
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- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB