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LBP Gene(Protein Coding)

Lipopolysaccharide Binding Protein

GCID:
GC20P038346
GIFtS:
51
Genes Participants
UDN Logo

Aliases for LBP Gene

Aliases for LBP Gene

  • Lipopolysaccharide Binding Protein 2 3 5
  • BPI Fold Containing Family D, Member 2 2 3
  • Lipopolysaccharide-Binding Protein 2 3
  • LPS-Binding Protein 3
  • BPIFD2 3

External Ids for LBP Gene

Previous GeneCards Identifiers for LBP Gene

  • GC20P036703
  • GC20P037613
  • GC20P037660
  • GC20P036408
  • GC20P036974
  • GC20P033709

Summaries for LBP Gene

Entrez Gene Summary for LBP Gene

  • The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]

GeneCards Summary for LBP Gene

LBP (Lipopolysaccharide Binding Protein) is a Protein Coding gene. Diseases associated with LBP include Toxic Pneumonitis and Infective Endocarditis. Among its related pathways are Bacterial infections in CF airways and NF-kappa B signaling pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and lipopolysaccharide binding. An important paralog of this gene is BPI.

UniProtKB/Swiss-Prot for LBP Gene

  • Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).

Gene Wiki entry for LBP Gene

Additional gene information for LBP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LBP Gene

Genomics for LBP Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for LBP Gene

Promoters and enhancers for LBP Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH20J038346 Promoter 0.9 EPDnew 655.8 +0.1 107 0.1 TAF1 RXRA NR2F1 CEBPB MAX CEBPG REST NR2F2 YY1 SP1 LBP GC20P038348
GH20J038341 Enhancer 1.1 Ensembl ENCODE 7.6 -3.4 -3393 2.7 ATF1 PKNOX1 FOXA2 ARID4B DMAP1 ZNF48 SLC30A9 TCF12 GATA2 ATF7 PIR48740 GC20P038343 GC20P038342 BPI ENSG00000224635 SNORA71A SNORA71B LBP
GH20J038245 Enhancer 1 FANTOM5 ENCODE dbSUPER 6.9 -99.3 -99291 2.5 RXRA ZNF189 MAX MNT REST ZNF623 ZNF121 SP1 ZFHX2 POLR2A KIAA1755 TGM2 LBP ENSG00000285144 ENSG00000277829
GH20J038230 Enhancer 0.3 dbSUPER 11.9 -114.6 -114605 1.7 CEBPG LBP ENSG00000206249 KIAA1755 ENSG00000277829 TGM2
GH20J037362 Enhancer 0.4 dbSUPER 4.5 -983.2 -983164 1.7 ZFP36 EGR2 GHRH LBP SRC GC20M037240 RPL7AP14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LBP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LBP gene promoter:
  • HNF-4alpha2
  • HNF-4alpha1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • TGIF
  • CREB
  • deltaCREB

Genomic Locations for LBP Gene

Genomic Locations for LBP Gene
chr20:38,346,356-38,377,023
(GRCh38/hg38)
Size:
30,668 bases
Orientation:
Plus strand
chr20:36,974,759-37,005,665
(GRCh37/hg19)
Size:
30,907 bases
Orientation:
Plus strand

Genomic View for LBP Gene

Genes around LBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LBP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LBP Gene

Proteins for LBP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for LBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18428-LBP_HUMAN
    Recommended name:
    Lipopolysaccharide-binding protein
    Protein Accession:
    P18428
    Secondary Accessions:
    • B2R938
    • O43438
    • Q92672
    • Q9H403
    • Q9UD66

    Protein attributes for LBP Gene

    Size:
    481 amino acids
    Molecular mass:
    53384 Da
    Quaternary structure:
    • When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

neXtProt entry for LBP Gene

Protein Expression for LBP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LBP Gene

  • Glycosylation at isoforms=394, isoforms=386, posLast=355355, and posLast=300300
  • Modification sites at PhosphoSitePlus

Other Protein References for LBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LBP Gene

Domains & Families for LBP Gene

Gene Families for LBP Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for LBP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18428

UniProtKB/Swiss-Prot:

LBP_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with LBP: view

Function for LBP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for LBP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).
GENATLAS Biochemistry:
lipopolysaccharide,acute-phase protein specifically binding to the lipid A moiety of liposaceharide (LPS,endotoxin) from the cell wall of Gram- bacteria binding protein,and directing it to the CD14 receptor mainly expressed by phagocytes

Phenotypes From GWAS Catalog for LBP Gene

Gene Ontology (GO) - Molecular Function for LBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding ISS 2477488
GO:0005102 signaling receptor binding ISS,IEA 2477488
GO:0005515 protein binding IPI 15294986
GO:0008289 lipid binding IEA --
GO:0070891 lipoteichoic acid binding IDA 12594207
genes like me logo Genes that share ontologies with LBP: view
genes like me logo Genes that share phenotypes with LBP: view

Animal Models for LBP Gene

MGI Knock Outs for LBP:
  • Lbp Lbp<tm1Buru>
  • Lbp Lbp<tm1b(EUCOMM)Hmgu>
  • Lbp Lbp<tm1Jack>

Animal Model Products

  • Taconic Biosciences Mouse Models for LBP

miRNA for LBP Gene

miRTarBase miRNAs that target LBP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LBP Gene

Localization for LBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LBP Gene

Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000250 UniProtKB:P17213}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LBP gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS 2477488
GO:0009986 cell surface IEA,IDA 11528597
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with LBP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LBP Gene

Pathways & Interactions for LBP Gene

genes like me logo Genes that share pathways with LBP: view

Gene Ontology (GO) - Biological Process for LBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002232 leukocyte chemotaxis involved in inflammatory response IEA --
GO:0002281 macrophage activation involved in immune response IMP,ISS 2402637
GO:0002376 immune system process IEA --
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with LBP: view

No data available for SIGNOR curated interactions for LBP Gene

Drugs & Compounds for LBP Gene

Products:

  1. Drug

(26) Drugs for LBP Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menthol Approved Pharma Partial agonist, Activator 3047
Sphingosine Experimental Pharma 0
Eleuthero Nutra 11
Goji Nutra 12
Lycium Nutra 12

(534) Additional Compounds for LBP Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • 3-dehydro-D-Sphinganine
  • 3-Ketodihydrosphingosine
  • 3-Ketosphinganine
  • (2S)-2-amino-1-Hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
 16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
 852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
 862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
 244215-65-4
genes like me logo Genes that share compounds with LBP: view

Transcripts for LBP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for LBP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LBP Gene

Lipopolysaccharide binding protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LBP Gene

No ASD Table

Relevant External Links for LBP Gene

GeneLoc Exon Structure for
LBP
ECgene alternative splicing isoforms for
LBP

Expression for LBP Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LBP Gene

mRNA expression in normal human tissues for LBP Gene
mRNA expression by BioGPS for LBP GenemRNA expression by GTEx for LBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LBP Gene

This gene is overexpressed in Liver (x49.2).

Protein differential expression in normal tissues from HIPED for LBP Gene

This gene is overexpressed in Serum (17.8), Synovial fluid (8.5), and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LBP Gene



Protein tissue co-expression partners for LBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LBP Gene:

LBP

SOURCE GeneReport for Unigene cluster for LBP Gene:

Hs.154078

mRNA Expression by UniProt/SwissProt for LBP Gene:

P18428-LBP_HUMAN
Tissue specificity: Detected in blood serum (at protein level).

Evidence on tissue expression from TISSUES for LBP Gene

  • Liver(4.7)
  • Blood(2.7)
  • Intestine(2.3)
  • Lung(2)
genes like me logo Genes that share expression patterns with LBP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LBP Gene

Orthologs for LBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for LBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LBP 34
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia LBP 34 33
  • 83.99 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia LBP 34 33
  • 80.68 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Lbp 16 34 33
  • 76.66 (n)
rat
(Rattus norvegicus)
 Mammalia Lbp 33
  • 76.17 (n)
oppossum
(Monodelphis domestica)
 Mammalia LBP 34
  • 54 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves -- 34
  • 45 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 38 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 22 (a)
 OneToMany
Species where no ortholog for LBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LBP Gene

ENSEMBL:
Gene Tree for LBP (if available)
TreeFam:
Gene Tree for LBP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LBP: view image

Paralogs for LBP Gene

Paralogs for LBP Gene

(1) SIMAP similar genes for LBP Gene using alignment to 2 proteins:

  • LBP_HUMAN
  • Q8TCF0_HUMAN
genes like me logo Genes that share paralogs with LBP: view

Variants for LBP Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for LBP Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs2232613 uncertain-significance, not provided 38,369,011(+) C/G/T coding_sequence_variant, missense_variant
rs1000008739 -- 38,374,621(+) AAAGAAAGAAA/AAAGAAA intron_variant
rs1000124144 -- 38,362,977(+) G/A intron_variant
rs1000255860 -- 38,351,784(+) G/A intron_variant
rs1000286293 -- 38,365,884(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LBP Gene

Variant ID Type Subtype PubMed ID
esv2666106 CNV deletion 23128226
esv2758794 CNV gain 17122850
esv3429648 CNV duplication 20981092
esv35121 CNV gain 17911159
esv3645775 CNV loss 21293372
nsv1058457 CNV loss 25217958
nsv1063495 CNV gain 25217958
nsv817893 CNV gain 17921354

Variation tolerance for LBP Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.80; 89.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LBP Gene

Human Gene Mutation Database (HGMD)
LBP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LBP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LBP Gene

Disorders for LBP Gene

MalaCards: The human disease database

(9) MalaCards diseases for LBP Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
toxic pneumonitis
  • acute chemical fume pulmonary edema
infective endocarditis
  • endocarditis, infective
mesenteric lymphadenitis
  • mesenteric adenitis
mastitis
  • breast inflammation
alcoholic hepatitis
  • acute alcoholic hepatitis
- elite association - COSMIC cancer census association via MalaCards
Search LBP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LBP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LBP Gene

Publications for LBP Gene

  1. Lipopolysaccharide-binding protein (LBP) gene polymorphisms: rapid genotyping by real-time PCR and association with infective endocarditis. (PMID: 19560454) Vollmer T … Dreier J (Clinical biochemistry 2009) 3 22 44 58
  2. A common haplotype of the LBP gene predisposes to severe sepsis. (PMID: 19707138) Flores C … GRECIA and Gen-SEP groups (Critical care medicine 2009) 3 22 44 58
  3. Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation. (PMID: 18056482) Chien JW … Clark JG (Blood 2008) 3 22 44 58
  4. Polymorphisms in the lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in patients with myocardial infarction. (PMID: 12521224) Hubacek JA … Poledne R (Clinical chemistry and laboratory medicine 2002) 3 22 44 58
  5. Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis. (PMID: 11373419) Hubacek JA … Schmitz G (Critical care medicine 2001) 3 22 44 58

Products for LBP Gene

Sources for LBP Gene

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