Aliases for LBP Gene
External Ids for LBP Gene
Previous GeneCards Identifiers for LBP Gene
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
GeneCards Summary for LBP Gene
LBP (Lipopolysaccharide Binding Protein) is a Protein Coding gene. Diseases associated with LBP include Toxic Pneumonitis and Blind Loop Syndrome. Among its related pathways are Bacterial infections in CF airways and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and lipopolysaccharide binding. An important paralog of this gene is BPI.
UniProtKB/Swiss-Prot Summary for LBP Gene
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).