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The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
LBP (Lipopolysaccharide Binding Protein) is a Protein Coding gene. Diseases associated with LBP include Toxic Pneumonitis and Alcoholic Hepatitis. Among its related pathways are Activated TLR4 signalling and Tuberculosis. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and lipopolysaccharide binding. An important paralog of this gene is BPI.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001530 | lipopolysaccharide binding | IDA,ISS | 2477488 |
GO:0005102 | signaling receptor binding | IEA,ISS | 2477488 |
GO:0005515 | protein binding | IPI | 15294986 |
GO:0008289 | lipid binding | IEA | -- |
GO:0070891 | lipoteichoic acid binding | IDA | 12594207 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA,ISS | 2477488 |
GO:0009986 | cell surface | IEA,IDA | 11528597 |
GO:0016020 | membrane | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Toll-like Receptor Signaling Pathway | ||
3 | Bacterial infections in CF airways |
Bacterial infections in CF airways
.78
Immune response Bacterial infections in normal airways
.78
|
Immune response TLR signaling pathways
.46
|
4 | Toll Comparative Pathway |
Immune response MIF in innate immunity response
.46
|
iNOS Signaling
.34
|
5 | Cytokine Signaling in Immune system |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
GO:0002232 | leukocyte chemotaxis involved in inflammatory response | IEA | -- |
GO:0002281 | macrophage activation involved in immune response | IMP,ISS | 2402637 |
GO:0002376 | immune system process | IEA | -- |
GO:0006869 | lipid transport | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
3-Dehydrosphinganine |
|
16105-69-4 |
|
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3-O-Sulfogalactosylceramide (d18:1/12:0) |
|
852100-88-0 |
|
|||
3-O-Sulfogalactosylceramide (d18:1/14:0) |
|
|
||||
3-O-Sulfogalactosylceramide (d18:1/16:0) |
|
862509-48-6 |
|
|||
3-O-Sulfogalactosylceramide (d18:1/18:0) |
|
244215-65-4 |
|
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LBP 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LBP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LBP 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lbp 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lbp 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | LBP 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708629 | Likely Benign: not provided | 38,369,028(+) | C/T | MISSENSE_VARIANT | |
718787 | Likely Benign: not provided | 38,360,756(+) | A/G | MISSENSE_VARIANT | |
735262 | Likely Benign: not provided | 38,350,847(+) | G/A | SYNONYMOUS_VARIANT | |
738517 | Benign: not provided | 38,373,947(+) | C/T | SYNONYMOUS_VARIANT | |
769090 | Benign: not provided | 38,349,567(+) | A/G | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2666106 | CNV | deletion | 23128226 |
esv2758794 | CNV | gain | 17122850 |
esv3429648 | CNV | duplication | 20981092 |
esv35121 | CNV | gain | 17911159 |
esv3645775 | CNV | loss | 21293372 |
nsv1058457 | CNV | loss | 25217958 |
nsv1063495 | CNV | gain | 25217958 |
nsv817893 | CNV | gain | 17921354 |
Disorder | Aliases | PubMed IDs |
---|---|---|
toxic pneumonitis |
|
|
alcoholic hepatitis |
|
|
bacterial sepsis |
|
|
peritonitis |
|
|
mastitis |
|
|