Aliases for LAYN Gene

Aliases for LAYN Gene

  • Layilin 2 3 4 5
  • FLJ30977 2
  • FLJ31092 2
  • LAYN 5

External Ids for LAYN Gene

Previous GeneCards Identifiers for LAYN Gene

  • GC11P110917
  • GC11P111411
  • GC11P107335
  • GC11P111541
  • GC11P111562
  • GC11P111567
  • GC11P111573
  • GC11P111581
  • GC11P111542
  • GC11P111547
  • GC11P111554
  • GC11P111586

Summaries for LAYN Gene

GeneCards Summary for LAYN Gene

LAYN (Layilin) is a Protein Coding gene. Diseases associated with LAYN include Cerebral Convexity Meningioma. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is CHODL.

UniProtKB/Swiss-Prot Summary for LAYN Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LAYN Gene

Genomics for LAYN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LAYN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LAYN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LAYN

Top Transcription factor binding sites by QIAGEN in the LAYN gene promoter:
  • FOXL1
  • GATA-1
  • IRF-7A
  • Lhx3a
  • LHX3b
  • MZF-1
  • NF-kappaB
  • NF-kappaB1
  • SRY
  • STAT3

Genomic Locations for LAYN Gene

Latest Assembly
chr11:111,540,280-111,561,745
(GRCh38/hg38)
Size:
21,466 bases
Orientation:
Plus strand

Previous Assembly
chr11:111,411,005-111,432,470
(GRCh37/hg19 by Entrez Gene)
Size:
21,466 bases
Orientation:
Plus strand

chr11:111,411,005-111,432,264
(GRCh37/hg19 by Ensembl)
Size:
21,260 bases
Orientation:
Plus strand

Genomic View for LAYN Gene

Genes around LAYN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAYN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAYN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAYN Gene

Proteins for LAYN Gene

  • Protein details for LAYN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX15-LAYN_HUMAN
    Recommended name:
    Layilin
    Protein Accession:
    Q6UX15
    Secondary Accessions:
    • A6NJB0
    • B4DJU0
    • Q8TAY8
    • Q96NC5
    • Q96NF3

    Protein attributes for LAYN Gene

    Size:
    382 amino acids
    Molecular mass:
    43108 Da
    Quaternary structure:
    • Interacts with NF2, RDX and TLN1.

    Alternative splice isoforms for LAYN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAYN Gene

Post-translational modifications for LAYN Gene

  • Glycosylation at Asn117 and Ser195
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for LAYN
  • Santa Cruz Biotechnology (SCBT) Antibodies for LAYN

No data available for DME Specific Peptides for LAYN Gene

Domains & Families for LAYN Gene

Gene Families for LAYN Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LAYN Gene

Suggested Antigen Peptide Sequences for LAYN Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50977, highly similar to Homo sapiens layilin, mRNA (B4DJU0_HUMAN)
  • cDNA FLJ51015, highly similar to Homo sapiens layilin, mRNA (B4DP26_HUMAN)
  • Layilin (LAYN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UX15

UniProtKB/Swiss-Prot:

LAYN_HUMAN :
  • The C-terminal domain interacts with the N-terminal domain of RDX.
Domain:
  • The C-terminal domain interacts with the N-terminal domain of RDX.
genes like me logo Genes that share domains with LAYN: view

Function for LAYN Gene

Molecular function for LAYN Gene

UniProtKB/Swiss-Prot Function:
Receptor for hyaluronate.

Phenotypes From GWAS Catalog for LAYN Gene

Gene Ontology (GO) - Molecular Function for LAYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0005540 hyaluronic acid binding IDA 11294894
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LAYN: view
genes like me logo Genes that share phenotypes with LAYN: view

Animal Models for research

  • Taconic Biosciences Mouse Models for LAYN

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LAYN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LAYN Gene

Localization for LAYN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAYN Gene

Membrane. Single-pass type I membrane protein. Note=Colocalizes with TLN1 at the membrane ruffles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAYN gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 2
cytosol 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LAYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0005925 NOT focal adhesion HDA,ISS --
GO:0009986 cell surface ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LAYN: view

Pathways & Interactions for LAYN Gene

PathCards logo

SuperPathways for LAYN Gene

No Data Available

Gene Ontology (GO) - Biological Process for LAYN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LAYN Gene

Drugs & Compounds for LAYN Gene

(1) Drugs for LAYN Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target, binder 827
genes like me logo Genes that share compounds with LAYN: view

Transcripts for LAYN Gene

mRNA/cDNA for LAYN Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LAYN

Alternative Splicing Database (ASD) splice patterns (SP) for LAYN Gene

No ASD Table

Relevant External Links for LAYN Gene

GeneLoc Exon Structure for
LAYN

Expression for LAYN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LAYN Gene

Protein differential expression in normal tissues from HIPED for LAYN Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LAYN Gene



Protein tissue co-expression partners for LAYN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LAYN

SOURCE GeneReport for Unigene cluster for LAYN Gene:

Hs.503831

Evidence on tissue expression from TISSUES for LAYN Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with LAYN: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LAYN Gene

Orthologs for LAYN Gene

This gene was present in the common ancestor of chordates.

Orthologs for LAYN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LAYN 29 30
  • 99.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LAYN 29 30
  • 89.04 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Layn 29 16 30
  • 86.02 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LAYN 29 30
  • 85.52 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Layn 29
  • 83.24 (n)
Oppossum
(Monodelphis domestica)
Mammalia LAYN 30
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LAYN 30
  • 48 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LAYN 30
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia layn 29
  • 62.57 (n)
Zebrafish
(Danio rerio)
Actinopterygii layna 29 30
  • 59.57 (n)
OneToMany
laynb 30
  • 35 (a)
OneToMany
Species where no ortholog for LAYN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LAYN Gene

ENSEMBL:
Gene Tree for LAYN (if available)
TreeFam:
Gene Tree for LAYN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LAYN: view image
Alliance of Genome Resources:
Additional Orthologs for LAYN

Paralogs for LAYN Gene

Paralogs for LAYN Gene

(1) SIMAP similar genes for LAYN Gene using alignment to 8 proteins:

  • LAYN_HUMAN
  • B4DJU0_HUMAN
  • E9PI98_HUMAN
  • E9PK64_HUMAN
  • E9PMI0_HUMAN
  • E9PQU7_HUMAN
  • E9PQY8_HUMAN
  • E9PR90_HUMAN
genes like me logo Genes that share paralogs with LAYN: view

Variants for LAYN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LAYN Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11213935 Benign: not provided 111,540,883(+) G/A
NM_001258390.1(LAYN):c.40G>A (p.Val14Met)
MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON
rs114394665 Benign: not provided 111,560,325(+) C/T
NM_001258390.1(LAYN):c.1016C>T (p.Ser339Leu)
MISSENSE
rs11827718 Benign: not provided 111,544,009(+) G/Ap.Glu66Lys
NM_001258390.1(LAYN):c.196G>A (p.Glu66Lys)
MISSENSE_VARIANT,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LAYN Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LAYN Gene

Variant ID Type Subtype PubMed ID
nsv472629 CNV novel sequence insertion 20440878

Variation tolerance for LAYN Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 60.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LAYN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LAYN
Leiden Open Variation Database (LOVD)
LAYN

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAYN Gene

Disorders for LAYN Gene

MalaCards: The human disease database

(1) MalaCards diseases for LAYN Gene - From: COP

Disorder Aliases PubMed IDs
cerebral convexity meningioma
  • cerebral hemispheric convexity meningioma
- elite association - COSMIC cancer census association via MalaCards
Search LAYN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LAYN

genes like me logo Genes that share disorders with LAYN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LAYN Gene

Publications for LAYN Gene

  1. Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. (PMID: 15913605) Bono P … Hynes RO (Experimental cell research 2005) 2 3 22
  2. Layilin, a novel integral membrane protein, is a hyaluronan receptor. (PMID: 11294894) Bono P … Hynes RO (Molecular biology of the cell 2001) 3 4 22
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for LAYN Gene

Sources for LAYN Gene