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Aliases for LAYN Gene

Aliases for LAYN Gene

External Ids for LAYN Gene

Previous GeneCards Identifiers for LAYN Gene

  • GC11P110917
  • GC11P111411
  • GC11P107335
  • GC11P111541
  • GC11P111542

Summaries for LAYN Gene

GeneCards Summary for LAYN Gene

LAYN (Layilin) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is CHODL.

UniProtKB/Swiss-Prot for LAYN Gene

  • Receptor for hyaluronate.

Additional gene information for LAYN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAYN Gene

Genomics for LAYN Gene

GeneHancer (GH) Regulatory Elements for LAYN Gene

Promoters and enhancers for LAYN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J111539 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.0 2012 3.1 CTCF ZIC2 ZNF335 ZFHX2 GLIS2 POLR2A PATZ1 SCRT2 PRDM10 EZH2 LAYN PPP2R1B SIK2
GH11J111559 Enhancer 1.1 Ensembl ENCODE dbSUPER 19 +22.6 22567 3.9 SOX13 IRF2 SAP130 ERF RARA TEAD3 FOSL2 NR2F6 GATAD2A SOX5 SIK2 LAYN ENSG00000254980 BTG4 C11orf88 MIR34C MIR34B POU2AF1 LOC644277 PPP2R1B
GH11J111764 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 9.7 +227.0 227031 3.3 ZNF493 ARID4B SIN3A ZNF48 YY1 ZNF121 POLR2B GLIS2 RUNX3 ZNF202 PPP2R1B ALG9 SIK2 PIH1D2 NKAPD1 LAYN C11orf88 MIR34B MIR34C BTG4
GH11J111357 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 9.6 -174.1 -174081 15.7 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B DMAP1 YBX1 IRF4 COLCA2 COLCA1 LAYN BTG4 MIR34B MIR34C C11orf88 POU2AF1 MIR4491 RNU2-60P
GH11J111793 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10.3 +256.2 256177 3.7 ATF1 INSM2 FEZF1 YY1 CTBP1 LCORL ZNF316 ZNF366 POLR2A RCOR1 PPP2R1B ALG9 LAYN BCO2 SIK2 ENSG00000254990 ALG9-IT1 ENSG00000258529
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LAYN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LAYN gene promoter:
  • FOXL1
  • SRY
  • STAT3
  • NF-kappaB1
  • NF-kappaB
  • GATA-1
  • MZF-1
  • IRF-7A
  • LHX3b
  • Lhx3a

Genomic Locations for LAYN Gene

Genomic Locations for LAYN Gene
chr11:111,538,985-111,561,745
(GRCh38/hg38)
Size:
22,761 bases
Orientation:
Plus strand
chr11:111,411,005-111,432,264
(GRCh37/hg19)
Size:
21,260 bases
Orientation:
Plus strand

Genomic View for LAYN Gene

Genes around LAYN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAYN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAYN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAYN Gene

Proteins for LAYN Gene

  • Protein details for LAYN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX15-LAYN_HUMAN
    Recommended name:
    Layilin
    Protein Accession:
    Q6UX15
    Secondary Accessions:
    • A6NJB0
    • B4DJU0
    • Q8TAY8
    • Q96NC5
    • Q96NF3

    Protein attributes for LAYN Gene

    Size:
    382 amino acids
    Molecular mass:
    43108 Da
    Quaternary structure:
    • Interacts with NF2, RDX and TLN1.

    Alternative splice isoforms for LAYN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAYN Gene

Post-translational modifications for LAYN Gene

  • Glycosylation at isoforms=2195 and posLast=117117
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LAYN Gene

Domains & Families for LAYN Gene

Gene Families for LAYN Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LAYN Gene

Graphical View of Domain Structure for InterPro Entry

Q6UX15

UniProtKB/Swiss-Prot:

LAYN_HUMAN :
  • The C-terminal domain interacts with the N-terminal domain of RDX.
Domain:
  • The C-terminal domain interacts with the N-terminal domain of RDX.
genes like me logo Genes that share domains with LAYN: view

Function for LAYN Gene

Molecular function for LAYN Gene

UniProtKB/Swiss-Prot Function:
Receptor for hyaluronate.

Phenotypes From GWAS Catalog for LAYN Gene

Gene Ontology (GO) - Molecular Function for LAYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005540 hyaluronic acid binding IDA 11294894
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LAYN: view
genes like me logo Genes that share phenotypes with LAYN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LAYN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LAYN Gene

Localization for LAYN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAYN Gene

Membrane; Single-pass type I membrane protein. Note=Colocalizes with TLN1 at the membrane ruffles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAYN gene
Compartment Confidence
extracellular 3
cytosol 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LAYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0005925 NOT focal adhesion HDA,ISS --
GO:0009986 cell surface ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LAYN: view

Pathways & Interactions for LAYN Gene

No Data Available

Interacting Proteins for LAYN Gene

Gene Ontology (GO) - Biological Process for LAYN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LAYN Gene

Drugs & Compounds for LAYN Gene

(1) Drugs for LAYN Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target, binder 535
genes like me logo Genes that share compounds with LAYN: view

Transcripts for LAYN Gene

Unigene Clusters for LAYN Gene

Layilin:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAYN Gene

No ASD Table

Relevant External Links for LAYN Gene

GeneLoc Exon Structure for
LAYN
ECgene alternative splicing isoforms for
LAYN

Expression for LAYN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LAYN Gene

Protein differential expression in normal tissues from HIPED for LAYN Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LAYN Gene



Protein tissue co-expression partners for LAYN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LAYN Gene:

LAYN

SOURCE GeneReport for Unigene cluster for LAYN Gene:

Hs.503831

Evidence on tissue expression from TISSUES for LAYN Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with LAYN: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LAYN Gene

Orthologs for LAYN Gene

This gene was present in the common ancestor of chordates.

Orthologs for LAYN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAYN 34 33
  • 99.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LAYN 34 33
  • 89.04 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Layn 16 34 33
  • 86.02 (n)
cow
(Bos Taurus)
Mammalia LAYN 34 33
  • 85.52 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Layn 33
  • 83.24 (n)
oppossum
(Monodelphis domestica)
Mammalia LAYN 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAYN 34
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LAYN 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia layn 33
  • 62.57 (n)
zebrafish
(Danio rerio)
Actinopterygii layna 34 33
  • 59.57 (n)
OneToMany
laynb 34
  • 35 (a)
OneToMany
Species where no ortholog for LAYN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAYN Gene

ENSEMBL:
Gene Tree for LAYN (if available)
TreeFam:
Gene Tree for LAYN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LAYN: view image

Paralogs for LAYN Gene

Paralogs for LAYN Gene

(1) SIMAP similar genes for LAYN Gene using alignment to 8 proteins:

  • LAYN_HUMAN
  • B4DJU0_HUMAN
  • E9PI98_HUMAN
  • E9PK64_HUMAN
  • E9PMI0_HUMAN
  • E9PQU7_HUMAN
  • E9PQY8_HUMAN
  • E9PR90_HUMAN
genes like me logo Genes that share paralogs with LAYN: view

Variants for LAYN Gene

Sequence variations from dbSNP and Humsavar for LAYN Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000114802 -- 111,551,774(+) G/C intron_variant
rs1000154255 -- 111,543,899(+) T/C intron_variant
rs1000166849 -- 111,551,470(+) G/T intron_variant
rs1000230443 -- 111,550,471(+) C/T intron_variant
rs1000341042 -- 111,545,083(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LAYN Gene

Variant ID Type Subtype PubMed ID
nsv472629 CNV novel sequence insertion 20440878

Variation tolerance for LAYN Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 60.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LAYN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LAYN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAYN Gene

Disorders for LAYN Gene

Additional Disease Information for LAYN

No disorders were found for LAYN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LAYN Gene

Publications for LAYN Gene

  1. Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. (PMID: 15913605) Bono P … Hynes RO (Experimental cell research 2005) 2 3 22 58
  2. Layilin, a novel integral membrane protein, is a hyaluronan receptor. (PMID: 11294894) Bono P … Hynes RO (Molecular biology of the cell 2001) 3 4 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for LAYN Gene

Sources for LAYN Gene

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