This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative re... See more...

Aliases for LATS2 Gene

Aliases for LATS2 Gene

  • Large Tumor Suppressor Kinase 2 2 3 5
  • LATS (Large Tumor Suppressor, Drosophila) Homolog 2 2 3
  • Kinase Phosphorylated During Mitosis Protein 3 4
  • Serine/Threonine-Protein Kinase LATS2 3 4
  • Serine/Threonine-Protein Kinase Kpm 3 4
  • Large Tumor Suppressor Homolog 2 3 4
  • Warts-Like Kinase 3 4
  • EC 2.7.11.1 4 50
  • KPM 3 4
  • LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) 2
  • LATS, Large Tumor Suppressor, Homolog 2 3
  • Serine/Threonine Kinase KPM 3
  • EC 2.7.11 50
  • LATS2 5

External Ids for LATS2 Gene

Previous GeneCards Identifiers for LATS2 Gene

  • GC13M019528
  • GC13M015527
  • GC13M020478
  • GC13M019346
  • GC13M020446
  • GC13M021547
  • GC13M002350

Summaries for LATS2 Gene

Entrez Gene Summary for LATS2 Gene

  • This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

GeneCards Summary for LATS2 Gene

LATS2 (Large Tumor Suppressor Kinase 2) is a Protein Coding gene. Diseases associated with LATS2 include Peritoneal Mesothelioma and Myeloproliferative Syndrome, Transient. Among its related pathways are Signaling by GPCR and Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LATS1.

UniProtKB/Swiss-Prot Summary for LATS2 Gene

  • Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.

Gene Wiki entry for LATS2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LATS2 Gene

Genomics for LATS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LATS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J021058 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 273.4 +1.2 1240 4.7 ZNF207 ZNF600 CEBPA BRCA1 POLR2A ZIC2 CTCF CEBPB REST KLF11 LATS2 HSALNG0095573 XPO4
GH13J021076 Promoter 0.3 EPDnew 250.4 -14.9 -14932 0.1 LATS2 HSALNG0095576 RPS12P23 SAP18
GH13J021602 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.4 -542.1 -542139 2.7 SP1 ZNF207 MYC ZNF600 ZNF580 POLR2A ZNF10 BRCA1 NFIC YY1 MICU2 HSALNG0095617 lnc-ZDHHC20-88 RNU2-7P RPS7P10 LATS2 XPO4 ZDHHC20 piR-31534-132
GH13J020901 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 12.5 +159.2 159185 2.8 MYC IKZF1 ZNF592 POLR2A ZIC2 ZBTB10 YY1 MXD4 NONO TARDBP EEF1AKMT1 RF00017-1237 XPO4 lnc-XPO4-1 IFT88 LATS2 IL17D piR-57133-130
GH13J021020 Enhancer 1.1 Ensembl ENCODE dbSUPER 17.7 +39.6 39612 3.9 CHD4 YY1 HOMEZ MAFF RXRA SAP130 RARA RBM22 CREM FOXP1 LATS2 SAP18 ENSG00000252128 HSALNG0095571 LATS2-AS1 XPO4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LATS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LATS2

Top Transcription factor binding sites by QIAGEN in the LATS2 gene promoter:
  • Arnt
  • c-Myb
  • Cdc5
  • E47
  • FOXL1
  • GATA-1
  • p53
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • Tal-1

Genomic Locations for LATS2 Gene

Latest Assembly
chr13:20,973,036-21,061,586
(GRCh38/hg38)
Size:
88,551 bases
Orientation:
Minus strand

Previous Assembly
chr13:21,547,175-21,635,725
(GRCh37/hg19 by Entrez Gene)
Size:
88,551 bases
Orientation:
Minus strand

chr13:21,547,171-21,635,686
(GRCh37/hg19 by Ensembl)
Size:
88,516 bases
Orientation:
Minus strand

Genomic View for LATS2 Gene

Genes around LATS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LATS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LATS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LATS2 Gene

Proteins for LATS2 Gene

  • Protein details for LATS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRM7-LATS2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LATS2
    Protein Accession:
    Q9NRM7
    Secondary Accessions:
    • B1AM47
    • Q9P2X1

    Protein attributes for LATS2 Gene

    Size:
    1088 amino acids
    Molecular mass:
    120136 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with and is phosphorylated by AURKA. Binds to AR. Interacts with AJUBA during mitosis and this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome. Interacts (via PPxY motif) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B. Interacts with LIMD1, WTIP and AJUBA. Interacts with SNAI1.
    SequenceCaution:
    • Sequence=BAA92381.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LATS2 Gene

neXtProt entry for LATS2 Gene

Selected DME Specific Peptides for LATS2 Gene

Q9NRM7:
  • DIKPDNI
  • AHVKAERD
  • HRDIKPDN
  • IKLTDFG
  • KLTDFGL
  • YIAPEVL
  • GHIKLTD
  • WSVGVIL

Post-translational modifications for LATS2 Gene

  • Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle. Phosphorylated and activated by STK3/MST2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LATS2 Gene

Domains & Families for LATS2 Gene

Gene Families for LATS2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for LATS2 Gene

Suggested Antigen Peptide Sequences for LATS2 Gene

GenScript: Design optimal peptide antigens:
  • Warts-like kinase (LATS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NRM7

UniProtKB/Swiss-Prot:

LATS2_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with LATS2: view

Function for LATS2 Gene

Molecular function for LATS2 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:10871863};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:10871863};.
GENATLAS Biochemistry:
LATS Drosophila large tumor suppressor,homolog 2,same as Drosophila loss of the warts

Enzyme Numbers (IUBMB) for LATS2 Gene

Phenotypes From GWAS Catalog for LATS2 Gene

Gene Ontology (GO) - Molecular Function for LATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI 16413547
GO:0005524 ATP binding IDA 10871863
genes like me logo Genes that share ontologies with LATS2: view
genes like me logo Genes that share phenotypes with LATS2: view

Animal Models for LATS2 Gene

MGI Knock Outs for LATS2:

Animal Models for research

  • Taconic Biosciences Mouse Models for LATS2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LATS2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LATS2 Gene

Localization for LATS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LATS2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LATS2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IBA,IDA 12853976
GO:0005634 nucleus IDA,NAS 10673337
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LATS2: view

Pathways & Interactions for LATS2 Gene

genes like me logo Genes that share pathways with LATS2: view

Pathways by source for LATS2 Gene

1 BioSystems pathway for LATS2 Gene
2 Reactome pathways for LATS2 Gene
1 Cell Signaling Technology pathway for LATS2 Gene

SIGNOR curated interactions for LATS2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IBA,IDA 12853976
GO:0006468 protein phosphorylation IDA 10871863
GO:0007049 cell cycle IEA --
GO:0009755 hormone-mediated signaling pathway IDA 15131260
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with LATS2: view

Drugs & Compounds for LATS2 Gene

(4) Drugs for LATS2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for LATS2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with LATS2: view

Transcripts for LATS2 Gene

mRNA/cDNA for LATS2 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LATS2

Alternative Splicing Database (ASD) splice patterns (SP) for LATS2 Gene

No ASD Table

Relevant External Links for LATS2 Gene

GeneLoc Exon Structure for
LATS2

Expression for LATS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LATS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LATS2 Gene

This gene is overexpressed in Heart (48.6) and Monocytes (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LATS2 Gene



Protein tissue co-expression partners for LATS2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LATS2

SOURCE GeneReport for Unigene cluster for LATS2 Gene:

Hs.78960

mRNA Expression by UniProt/SwissProt for LATS2 Gene:

Q9NRM7-LATS2_HUMAN
Tissue specificity: Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined.

Evidence on tissue expression from TISSUES for LATS2 Gene

  • Liver(4.4)
  • Heart(2.3)
  • Lung(2.3)
  • Intestine(2.2)
  • Kidney(2.2)
  • Muscle(2.2)
  • Skin(2.1)
  • Stomach(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with LATS2: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LATS2 Gene

Orthologs for LATS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LATS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LATS2 29 30
  • 99.17 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LATS2 29 30
  • 85.84 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lats2 29 16 30
  • 82.32 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lats2 29
  • 82.19 (n)
Oppossum
(Monodelphis domestica)
Mammalia LATS2 30
  • 76 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LATS2 30
  • 68 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LATS2 30
  • 51 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LATS2 29 30
  • 72.65 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LATS2 30
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lats2 29
  • 69.35 (n)
Zebrafish
(Danio rerio)
Actinopterygii lats2 29 30
  • 64.23 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta wts 30 31
  • 40 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T20F10.1 31
  • 48 (a)
wts-1 30
  • 34 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 66 (a)
OneToMany
Species where no ortholog for LATS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LATS2 Gene

ENSEMBL:
Gene Tree for LATS2 (if available)
TreeFam:
Gene Tree for LATS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LATS2: view image
Alliance of Genome Resources:
Additional Orthologs for LATS2

Paralogs for LATS2 Gene

(2) SIMAP similar genes for LATS2 Gene using alignment to 1 proteins:

  • LATS2_HUMAN
genes like me logo Genes that share paralogs with LATS2: view

Variants for LATS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LATS2 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
932515 Likely Benign: not provided 20,975,032(-) G/A
NM_014572.3(LATS2):c.3105C>T (p.His1035=)
SYNONYMOUS
rs115615162 Benign: not provided 20,988,622(-) C/T
NM_014572.3(LATS2):c.1158G>A (p.Leu386=)
SYNONYMOUS
rs116331282 Benign: not provided 20,988,487(-) G/A
NM_014572.3(LATS2):c.1293C>T (p.Thr431=)
SYNONYMOUS
rs139454181 Benign: not provided 20,983,240(-) G/C
NM_014572.3(LATS2):c.2466C>G (p.Ser822=)
SYNONYMOUS
rs139641767 Benign: not provided 20,988,223(-) C/T
NM_014572.3(LATS2):c.1557G>A (p.Pro519=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LATS2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LATS2 Gene

Variant ID Type Subtype PubMed ID
esv1336723 CNV insertion 17803354
esv3343586 CNV insertion 20981092
nsv1037082 CNV gain 25217958
nsv1078303 OTHER inversion 25765185
nsv1113546 CNV deletion 24896259
nsv1118260 CNV deletion 24896259
nsv1140246 OTHER inversion 24896259
nsv1151909 OTHER inversion 26484159
nsv561243 CNV loss 21841781
nsv64790 CNV deletion 16902084
nsv9059 CNV gain 18304495

Variation tolerance for LATS2 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.27; 90.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LATS2 Gene

Human Gene Mutation Database (HGMD)
LATS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LATS2
Leiden Open Variation Database (LOVD)
LATS2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LATS2 Gene

Disorders for LATS2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for LATS2 Gene - From: CVR, COP, and GCD

Disorder Aliases PubMed IDs
peritoneal mesothelioma
  • advanced malignant mesothelioma of peritoneum
myeloproliferative syndrome, transient
  • mst
wilson-turner x-linked mental retardation syndrome
  • wts
rare tumor
  • rare neoplasm
meningioma, familial
  • meningioma, familial, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search LATS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LATS2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LATS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LATS2 Gene

Publications for LATS2 Gene

  1. Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. (PMID: 10673337) Yabuta N … Nojima H (Genomics 2000) 2 3 4 22
  2. The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. (PMID: 15131260) Powzaniuk M … Bai C (Molecular endocrinology (Baltimore, Md.) 2004) 3 4 22
  3. Lats2, a putative tumor suppressor, inhibits G1/S transition. (PMID: 12853976) Li Y … Tao W (Oncogene 2003) 3 4 22
  4. Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. (PMID: 10871863) Hori T … Uchiyama T (Oncogene 2000) 3 4 22
  5. Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. (PMID: 21952048) Zhang K … Longmore GD (The EMBO journal 2012) 3 4

Products for LATS2 Gene

Sources for LATS2 Gene