The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex show... See more...

Aliases for LATS1 Gene

Aliases for LATS1 Gene

  • Large Tumor Suppressor Kinase 1 2 3 5
  • WARTS 2 3 4
  • LATS (Large Tumor Suppressor, Drosophila) Homolog 1 2 3
  • Serine/Threonine-Protein Kinase LATS1 3 4
  • Large Tumor Suppressor Homolog 1 3 4
  • WARTS Protein Kinase 3 4
  • EC 2.7.11.1 4 50
  • H-Warts 3 4
  • LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) 2
  • LATS, Large Tumor Suppressor, Homolog 1 3
  • EC 2.7.11 50
  • LATS1 5
  • Wts 3

External Ids for LATS1 Gene

Previous GeneCards Identifiers for LATS1 Gene

  • GC06M149558
  • GC06M149892
  • GC06M9Q0072
  • GC06M150023
  • GC06M147548

Summaries for LATS1 Gene

Entrez Gene Summary for LATS1 Gene

  • The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]

GeneCards Summary for LATS1 Gene

LATS1 (Large Tumor Suppressor Kinase 1) is a Protein Coding gene. Diseases associated with LATS1 include Peritoneal Mesothelioma and Tetraploidy. Among its related pathways are Signaling by GPCR and Hippo signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LATS2.

UniProtKB/Swiss-Prot Summary for LATS1 Gene

  • Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668).

Gene Wiki entry for LATS1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LATS1 Gene

Genomics for LATS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LATS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LATS1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LATS1

Top Transcription factor binding sites by QIAGEN in the LATS1 gene promoter:
  • NF-1
  • NF-1/L
  • p53

Genomic Locations for LATS1 Gene

Latest Assembly
chr6:149,658,153-149,718,105
(GRCh38/hg38)
Size:
59,953 bases
Orientation:
Minus strand

Previous Assembly
chr6:149,979,289-150,039,237
(GRCh37/hg19 by Entrez Gene)
Size:
59,949 bases
Orientation:
Minus strand

chr6:149,979,289-150,039,392
(GRCh37/hg19 by Ensembl)
Size:
60,104 bases
Orientation:
Minus strand

Genomic View for LATS1 Gene

Genes around LATS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LATS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LATS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LATS1 Gene

Proteins for LATS1 Gene

  • Protein details for LATS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95835-LATS1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LATS1
    Protein Accession:
    O95835
    Secondary Accessions:
    • Q6PKD0

    Protein attributes for LATS1 Gene

    Size:
    1130 amino acids
    Molecular mass:
    126870 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Complexes with CDK1 in early mitosis (PubMed:9988268). LATS1-associated CDK1 has no mitotic cyclin partner and no apparent kinase activity (PubMed:9988268). Binds phosphorylated ZYX, locating this protein to the mitotic spindle and suggesting a role for actin regulatory proteins during mitosis (PubMed:10831611). Binds to and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis (PubMed:15220930). Interacts (via PPxY motif 2) with YAP1 (via WW domains) (PubMed:18158288). Interacts with MOB1A and MOB1B (PubMed:19739119). Interacts with LIMD1, WTIP and AJUBA (PubMed:20303269). Interacts with ESR1, DCAF1 and DCAF13; probably recruits DCAF1 and DCAF13 to ESR1 to promote ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation (PubMed:28068668). Interacts with STK3/MST2; this interaction is inhibited in the presence of DLG5 (PubMed:28087714). Interacts with SCRIB in the presence of DLG5 (PubMed:28169360). Interacts with WWTR1/TAZ (By similarity).

    Three dimensional structures from OCA and Proteopedia for LATS1 Gene

    Alternative splice isoforms for LATS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LATS1 Gene

Selected DME Specific Peptides for LATS1 Gene

O95835:
  • DIKPDNI
  • AHVKAERD
  • HRDIKPDN
  • KLTDFGL
  • YIAPEVL
  • GHIKLTD
  • WSVGVIL
  • IKLTDFG
  • DRDGHIK

Post-translational modifications for LATS1 Gene

  • Autophosphorylated and phosphorylated during M-phase of the cell cycle (PubMed:9988268, PubMed:10518011, PubMed:15122335). Phosphorylated by STK3/MST2 at Ser-909 and Thr-1079, which results in its activation (PubMed:15688006). Phosphorylation at Ser-464 by NUAK1 and NUAK2 leads to decreased protein level and is required to regulate cellular senescence and cellular ploidy (PubMed:19927127).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for LATS1
  • Santa Cruz Biotechnology (SCBT) Antibodies for LATS1

Domains & Families for LATS1 Gene

Gene Families for LATS1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for LATS1 Gene

Suggested Antigen Peptide Sequences for LATS1 Gene

GenScript: Design optimal peptide antigens:
  • WARTS protein kinase (LATS1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95835

UniProtKB/Swiss-Prot:

LATS1_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with LATS1: view

Function for LATS1 Gene

Molecular function for LATS1 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:15122335};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:15122335};.

Enzyme Numbers (IUBMB) for LATS1 Gene

Phenotypes From GWAS Catalog for LATS1 Gene

Gene Ontology (GO) - Molecular Function for LATS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 10518011
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0005515 protein binding IPI 9988268
genes like me logo Genes that share ontologies with LATS1: view
genes like me logo Genes that share phenotypes with LATS1: view

Animal Models for LATS1 Gene

MGI Knock Outs for LATS1:

Animal Models for research

  • Taconic Biosciences Mouse Models for LATS1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LATS1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LATS1 Gene

Localization for LATS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LATS1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. {ECO:0000269 PubMed:10518011}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LATS1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LATS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IBA,IDA 10518011
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with LATS1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LATS1 Gene

Pathways & Interactions for LATS1 Gene

genes like me logo Genes that share pathways with LATS1: view

Pathways by source for LATS1 Gene

1 BioSystems pathway for LATS1 Gene
2 Reactome pathways for LATS1 Gene
2 Cell Signaling Technology pathways for LATS1 Gene

SIGNOR curated interactions for LATS1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LATS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IBA 21873635
GO:0000086 G2/M transition of mitotic cell cycle IDA 15122335
GO:0000278 mitotic cell cycle IEA --
GO:0000819 sister chromatid segregation IDA 15122335
GO:0001827 inner cell mass cell fate commitment IEA --
genes like me logo Genes that share ontologies with LATS1: view

Drugs & Compounds for LATS1 Gene

(5) Drugs for LATS1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for LATS1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with LATS1: view

Transcripts for LATS1 Gene

mRNA/cDNA for LATS1 Gene

5 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LATS1

Alternative Splicing Database (ASD) splice patterns (SP) for LATS1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -
SP4: - - - -
SP5:

Relevant External Links for LATS1 Gene

GeneLoc Exon Structure for
LATS1

Expression for LATS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LATS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for LATS1 Gene

This gene is overexpressed in Adipocyte (24.2), Synovial fluid (16.8), Plasma (13.4), and Pancreas (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LATS1 Gene



Protein tissue co-expression partners for LATS1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LATS1

SOURCE GeneReport for Unigene cluster for LATS1 Gene:

Hs.549084

mRNA Expression by UniProt/SwissProt for LATS1 Gene:

O95835-LATS1_HUMAN
Tissue specificity: Expressed in all adult tissues examined except for lung and kidney.

Evidence on tissue expression from TISSUES for LATS1 Gene

  • Liver(4.5)
  • Nervous system(2.7)
  • Kidney(2.6)
  • Intestine(2.5)
  • Heart(2.5)
  • Muscle(2.4)
  • Skin(2.3)
  • Lung(2.3)
  • Blood(2.2)
  • Stomach(2.1)
  • Lymph node(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with LATS1: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LATS1 Gene

Orthologs for LATS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LATS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LATS1 29 30
  • 99.53 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LATS1 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LATS1 29 30
  • 92.94 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lats1 29 16 30
  • 88.04 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LATS1 30
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lats1 29
  • 87.82 (n)
Oppossum
(Monodelphis domestica)
Mammalia LATS1 30
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LATS1 29 30
  • 80.04 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LATS1 30
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lats1 29
  • 70.51 (n)
Zebrafish
(Danio rerio)
Actinopterygii lats1 29 30
  • 63.23 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta wts 30 31
  • 41 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T20F10.1 31
  • 50 (a)
wts-1 30
  • 35 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 68 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4187 29
Species where no ortholog for LATS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LATS1 Gene

ENSEMBL:
Gene Tree for LATS1 (if available)
TreeFam:
Gene Tree for LATS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LATS1: view image
Alliance of Genome Resources:
Additional Orthologs for LATS1

Paralogs for LATS1 Gene

(7) SIMAP similar genes for LATS1 Gene using alignment to 3 proteins:

  • LATS1_HUMAN
  • H0YG09_HUMAN
  • Q6PJG3_HUMAN
genes like me logo Genes that share paralogs with LATS1: view

Variants for LATS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LATS1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs139055895 A lung adenocarcinoma sample p.Met669Ile
rs1408705745 Likely Pathogenic: Peritoneal mesothelioma 149,676,695(-) C/T
NM_004690.4(LATS1):c.2636G>A (p.Trp879Ter)
NONSENSE,NON_CODING_TRANSCRIPT
rs1582867955 Likely Pathogenic: Multiple myeloma 149,680,019(-) C/T
NM_004690.4(LATS1):c.2449G>A (p.Glu817Lys)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs34793526 Benign: not provided 149,684,479(-) T/Cp.Ser204Gly
NM_004690.4(LATS1):c.610A>G (p.Ser204Gly)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs55874734 Likely Benign: not provided 149,683,498(-) G/Ap.Pro531Ser
NM_004690.4(LATS1):c.1591C>T (p.Pro531Ser)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LATS1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LATS1 Gene

Variant ID Type Subtype PubMed ID
esv2671976 CNV deletion 23128226
esv2732861 CNV deletion 23290073
esv3363174 CNV duplication 20981092
esv3611212 CNV loss 21293372
nsv1140711 CNV deletion 24896259

Variation tolerance for LATS1 Gene

Residual Variation Intolerance Score: 6.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LATS1 Gene

Human Gene Mutation Database (HGMD)
LATS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LATS1
Leiden Open Variation Database (LOVD)
LATS1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LATS1 Gene

Disorders for LATS1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for LATS1 Gene - From: CVR, COP, and GCD

Disorder Aliases PubMed IDs
peritoneal mesothelioma
  • advanced malignant mesothelioma of peritoneum
tetraploidy
  • tetraploidy syndrome
wilson-turner x-linked mental retardation syndrome
  • wts
plasma cell neoplasm
  • plasma cell dyscrasia
myeloma, multiple
  • multiple myeloma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search LATS1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LATS1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LATS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LATS1 Gene

Publications for LATS1 Gene

  1. Molecular characterization of human homologs of yeast MOB1. (PMID: 19739119) Chow A … Yang X (International journal of cancer 2010) 3 4 22
  2. Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. (PMID: 15122335) Iida S … Saya H (Oncogene 2004) 2 3 4
  3. LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. (PMID: 15220930) Yang X … Xu T (Nature cell biology 2004) 3 4 22
  4. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. (PMID: 9988268) Tao W … Xu T (Nature genetics 1999) 2 3 4
  5. The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. (PMID: 28068668) Britschgi A … Bentires-Alj M (Nature 2017) 3 4

Products for LATS1 Gene

Sources for LATS1 Gene