Aliases for LAT Gene
External Ids for LAT Gene
Previous GeneCards Identifiers for LAT Gene
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for LAT Gene
LAT (Linker For Activation Of T Cells) is a Protein Coding gene. Diseases associated with LAT include Immunodeficiency 52 and Cranial Nerve Palsy. Among its related pathways are RET signaling and G beta-gamma signalling through PI3Kgamma. Gene Ontology (GO) annotations related to this gene include protein kinase binding and SH3/SH2 adaptor activity.
UniProtKB/Swiss-Prot for LAT Gene
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.