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Aliases for LAT Gene

Aliases for LAT Gene

  • Linker For Activation Of T Cells 2 3 5
  • Linker For Activation Of T Cells, Transmembrane Adaptor 2 3
  • Linker For Activation Of T-Cells Family Member 1 3 4
  • 36 KDa Phospho-Tyrosine Adapter Protein 3 4
  • P36-38 3 4
  • Pp36 3 4
  • 36 KDa Phospho-Tyrosine Adaptor Protein 3
  • IMD52 3
  • LAT1 3

External Ids for LAT Gene

Previous GeneCards Identifiers for LAT Gene

  • GC16P079421
  • GC16P029319
  • GC16P028994
  • GC16P029033
  • GC16P029034
  • GC16P028903
  • GC16P026864

Summaries for LAT Gene

Entrez Gene Summary for LAT Gene

  • The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for LAT Gene

LAT (Linker For Activation Of T Cells) is a Protein Coding gene. Diseases associated with LAT include Immunodeficiency 52 and Cranial Nerve Palsy. Among its related pathways are RET signaling and G beta-gamma signalling through PI3Kgamma. Gene Ontology (GO) annotations related to this gene include protein kinase binding and SH3/SH2 adaptor activity.

UniProtKB/Swiss-Prot for LAT Gene

  • Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Gene Wiki entry for LAT Gene

Additional gene information for LAT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAT Gene

Genomics for LAT Gene

GeneHancer (GH) Regulatory Elements for LAT Gene

Promoters and enhancers for LAT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J028983 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 600.7 +2.7 2653 7.2 ZNF24 DPF2 ZNF580 IKZF1 ZFP91 ZNF558 ZNF217 INSM2 ZNF280D LAT TUFM SULT1A2 CDC37P1 KCTD13 ENSG00000261552 ENSG00000261067 SPNS1
GH16J028977 Promoter/Enhancer 1.1 EPDnew ENCODE 600.4 -6.9 -6915 0.2 CTCF ZEB2 ZEB1 RAD21 ZNF654 ZNF143 XRCC5 HLF ENSG00000260367 LAT ENSG00000261067 SPNS1
GH16J028984 Promoter 0.5 EPDnew 600.7 -1.0 -964 0.1 LAT ENSG00000260367 ENSG00000261067 SPNS1
GH16J029011 Enhancer 0.9 ENCODE dbSUPER 13 +28.4 28433 4.2 ZNF121 TRIM24 SP1 IKZF1 PKNOX1 MNT CEBPB ZNF189 BCOR CEBPG LAT SPNS1 CDC37P1 ENSG00000251417 TUFM KIF22 GC16M028992 NPIPB10P
GH16J029172 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.6 +192.2 192200 10 CTCF CBFA2T2 SP1 EGR1 SMARCA4 GMEB1 RXRA ZIC2 ATF1 ZNF143 ENSG00000260908 ENSG00000259807 RRN3P2 ENSG00000260953 LAT PIR44954 PIR51180 ENSG00000260517 ENSG00000284685 ENSG00000284649
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LAT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LAT gene promoter:
  • AP-1
  • ATF-2

Genomic Locations for LAT Gene

Genomic Locations for LAT Gene
chr16:28,984,826-28,990,783
(GRCh38/hg38)
Size:
5,958 bases
Orientation:
Plus strand
chr16:28,996,147-29,002,104
(GRCh37/hg19)
Size:
5,958 bases
Orientation:
Plus strand

Genomic View for LAT Gene

Genes around LAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAT Gene

Proteins for LAT Gene

  • Protein details for LAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43561-LAT_HUMAN
    Recommended name:
    Linker for activation of T-cells family member 1
    Protein Accession:
    O43561
    Secondary Accessions:
    • B7WPI0
    • C7C5T6
    • G5E9K3
    • O43919

    Protein attributes for LAT Gene

    Size:
    262 amino acids
    Molecular mass:
    27930 Da
    Quaternary structure:
    • When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation in thymocytes (By similarity).
    Miscellaneous:
    • Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC, maybe by inducing the dephosphorylation of LAT.

    Alternative splice isoforms for LAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAT Gene

Post-translational modifications for LAT Gene

  • Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes.
  • Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.
  • Ubiquitination at posLast=5252
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LAT Gene

Domains & Families for LAT Gene

Gene Families for LAT Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for LAT Gene

Suggested Antigen Peptide Sequences for LAT Gene

GenScript: Design optimal peptide antigens:
  • Linker for activation of T-cells family member 1 (C7C5T5_HUMAN)
  • Linker for activation of T-cells family member 1 (C7C5T6_HUMAN)
  • Linker for activation of T-cells family member 1 (C7C5T8_HUMAN)
  • p36-38 (LAT_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LAT: view

No data available for UniProtKB/Swiss-Prot for LAT Gene

Function for LAT Gene

Molecular function for LAT Gene

UniProtKB/Swiss-Prot Function:
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Phenotypes From GWAS Catalog for LAT Gene

Gene Ontology (GO) - Molecular Function for LAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IDA 9489702
GO:0005515 protein binding IPI 9489702
GO:0019901 protein kinase binding IBA,IPI 12186560
genes like me logo Genes that share ontologies with LAT: view
genes like me logo Genes that share phenotypes with LAT: view

Human Phenotype Ontology for LAT Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LAT Gene

MGI Knock Outs for LAT:
  • Lat Lat<tm1Les>
  • Lat Lat<tm1Bpay>
  • Lat Lat<tm4Mal>
  • Lat Lat<tm1.2Wz>
  • Lat Lat<tm5Mal>

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for LAT - Now 50% OFF >
  • * LAT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * LAT tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for LAT Gene

Localization for LAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAT Gene

Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAT gene
Compartment Confidence
plasma membrane 5
nucleus 4
golgi apparatus 4
extracellular 3
lysosome 2
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA,IBA 12646565
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
GO:0008180 COP9 signalosome ISS --
genes like me logo Genes that share ontologies with LAT: view

Pathways & Interactions for LAT Gene

PathCards logo

SuperPathways for LAT Gene

SuperPathway Contained pathways
1 RET signaling
2 T cell receptor signaling pathway
3 TCR Signaling (Qiagen)
4 Immune response NFAT in immune response
5 Immune response Fc epsilon RI pathway
genes like me logo Genes that share pathways with LAT: view

SIGNOR curated interactions for LAT Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0002250 adaptive immune response IEA --
GO:0002260 lymphocyte homeostasis IEA --
GO:0002376 immune system process IEA --
GO:0006954 inflammatory response IBA 21873635
genes like me logo Genes that share ontologies with LAT: view

Drugs & Compounds for LAT Gene

(29) Drugs for LAT Gene - From: DrugBank, ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7611
Epinephrine Approved, Vet_approved Pharma 1301
Lidocaine Approved, Vet_approved Pharma Antagonist, Pore Blocker Anasthetic and class Ib antiarrhythmic agent 1820
Racepinephrine Approved Pharma 1301
Tetracaine Approved, Vet_approved Pharma 97

(3) Additional Compounds for LAT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LAT: view

Transcripts for LAT Gene

Unigene Clusters for LAT Gene

Linker for activation of T cells:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for LAT - Now 50% OFF >
  • * LAT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * LAT tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for LAT Gene

No ASD Table

Relevant External Links for LAT Gene

GeneLoc Exon Structure for
LAT
ECgene alternative splicing isoforms for
LAT

Expression for LAT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LAT Gene

mRNA differential expression in normal tissues according to GTEx for LAT Gene

This gene is overexpressed in Whole Blood (x6.2).

Protein differential expression in normal tissues from HIPED for LAT Gene

This gene is overexpressed in Pancreas (51.1) and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LAT Gene



Protein tissue co-expression partners for LAT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LAT Gene:

LAT

SOURCE GeneReport for Unigene cluster for LAT Gene:

Hs.632179

mRNA Expression by UniProt/SwissProt for LAT Gene:

O43561-LAT_HUMAN
Tissue specificity: Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).

Evidence on tissue expression from TISSUES for LAT Gene

  • Blood(4.6)
  • Bone marrow(4.4)
  • Intestine(4.3)
  • Liver(4)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with LAT: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LAT Gene

Orthologs for LAT Gene

This gene was present in the common ancestor of mammals.

Orthologs for LAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAT 35 34
  • 99.25 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LAT 35 34
  • 78.64 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lat 17 35 34
  • 78.15 (n)
rat
(Rattus norvegicus)
Mammalia Lat 34
  • 77.83 (n)
cow
(Bos Taurus)
Mammalia LAT 35 34
  • 77.55 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LAT 35
  • 29 (a)
OneToOne
Species where no ortholog for LAT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LAT Gene

ENSEMBL:
Gene Tree for LAT (if available)
TreeFam:
Gene Tree for LAT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LAT: view image

Paralogs for LAT Gene

No data available for Paralogs for LAT Gene

Variants for LAT Gene

Sequence variations from dbSNP and Humsavar for LAT Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1555524788 pathogenic, Immunodeficiency 52 28,985,461(+) T/TT coding_sequence_variant, frameshift
rs781410769 pathogenic, Immunodeficiency 52 28,986,401(+) GGGGG/GG/GGG coding_sequence_variant, frameshift, inframe_deletion
rs1000209393 -- 28,985,500(+) A/C coding_sequence_variant, missense_variant
rs1000528284 -- 28,986,367(+) A/C intron_variant
rs1001024532 -- 28,991,225(+) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LAT Gene

Variant ID Type Subtype PubMed ID
dgv2830n100 CNV gain 25217958
dgv2831n100 CNV gain 25217958
dgv4987n54 CNV gain 21841781
esv2750677 CNV loss 17666407
esv2758640 CNV gain+loss 17122850
esv3570454 CNV gain 25503493
esv3638351 CNV gain 21293372
esv3892826 CNV gain+loss 25118596
nsv1059555 CNV gain 25217958
nsv457480 CNV gain 19166990
nsv518648 CNV loss 19592680
nsv519100 CNV gain 19592680
nsv571805 CNV loss 21841781
nsv571808 CNV gain 21841781
nsv952964 CNV deletion 24416366

Variation tolerance for LAT Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LAT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LAT
Human Gene Mutation Database (HGMD)
LAT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAT Gene

Disorders for LAT Gene

MalaCards: The human disease database

(3) MalaCards diseases for LAT Gene - From: HGMD, OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 52
  • imd52
cranial nerve palsy
  • cranial nerve paralysis
severe combined immunodeficiency
  • combined t and b cell inborn immunodeficiency
- elite association - COSMIC cancer census association via MalaCards
Search LAT in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LAT_HUMAN
  • Immunodeficiency 52 (IMD52) [MIM:617514]: An autosomal recessive primary immunodeficiency characterized by T-cell abnormalities, resulting in severe combined immunodeficiency, autoimmune disease, progressive lymphopenia and hypogammaglobulinemia, and lymphoproliferation with splenomegaly. Patients develop severe recurrent infections from infancy. {ECO:0000269 PubMed:27242165, ECO:0000269 PubMed:27522155}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for LAT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LAT: view

No data available for Genatlas for LAT Gene

Publications for LAT Gene

  1. Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav. (PMID: 12186560) Perez-Villar JJ … Kanner SB (Biochemistry 2002) 3 4 23 58
  2. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. (PMID: 11259588) Baker JE … Weiss A (Molecular and cellular biology 2001) 3 4 23 58
  3. Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. (PMID: 11368773) Paz PE … Abo A (The Biochemical journal 2001) 3 4 23 58
  4. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. (PMID: 9489702) Zhang W … Samelson LE (Cell 1998) 2 3 4 58
  5. Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency. (PMID: 27522155) Bacchelli C … Gaspar HB (The Journal of allergy and clinical immunology 2017) 3 4 58

Products for LAT Gene

Sources for LAT Gene

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