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This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastat... See more...
Aliases for LASP1 Gene
Aliases for LASP1 Gene
External Ids for LASP1 Gene
- HGNC: 6513
- Entrez Gene: 3927
- Ensembl: ENSG00000002834
- OMIM: 602920
- UniProtKB: Q14847
Previous GeneCards Identifiers for LASP1 Gene
- GC17P036529
- GC17P039024
- GC17P036936
- GC17P037401
- GC17P034280
- GC17P037026
- GC17P032821
Summaries for LASP1 Gene
-
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
GeneCards Summary for LASP1 Gene
LASP1 (LIM And SH3 Protein 1) is a Protein Coding gene. Diseases associated with LASP1 include Breast Cancer and Colorectal Cancer. Among its related pathways are Cytoskeletal Signaling and Aquaporin-mediated transport. Gene Ontology (GO) annotations related to this gene include actin filament binding and ion transmembrane transporter activity. An important paralog of this gene is NEBL.
UniProtKB/Swiss-Prot Summary for LASP1 Gene
-
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
Additional gene information for LASP1 Gene
- HGNC(6513)
- Entrez Gene(3927)
- Ensembl(ENSG00000002834)
- OMIM(602920)
- UniProtKB(Q14847)
- Open Targets Platform(ENSG00000002834)
- Monarch Initiative
- Search for LASP1 at DataMed
- Search for LASP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LASP1 Gene
Genomics for LASP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LASP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LASP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LASP1
- Top Transcription factor binding sites by QIAGEN in the LASP1 gene promoter:
-
- AREB6
- CREB
- deltaCREB
- MAZR
- RFX1
- STAT5A
Genomic Locations for LASP1 Gene
Genomic Locations for LASP1 Gene
- chr17:38,869,859-38,921,770
- (GRCh38/hg38)
- Size:
- 51,912 bases
- Orientation:
- Plus strand
- chr17:37,026,112-37,078,023
- (GRCh37/hg19)
- Size:
- 51,912 bases
- Orientation:
- Plus strand
Genomic View for LASP1 Gene
Genes around LASP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by HGNC
- 17q12 by Entrez Gene
- 17q12 by Ensembl
LASP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LASP1 Gene
Proteins for LASP1 Gene
-
Protein details for LASP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14847-LASP1_HUMAN
- Recommended name:
- LIM and SH3 domain protein 1
- Protein Accession:
- Q14847
- B4DGQ0
- Q96ED2
- Q96IG0
Protein attributes for LASP1 Gene
- Size:
- 261 amino acids
- Molecular mass:
- 29717 Da
- Quaternary structure:
-
- Interacts with F-actin (By similarity). Interacts with ANKRD54 (By similarity). Interacts with KBTBD10.
Protein Expression for LASP1 Gene
Post-translational modifications for LASP1 Gene
Other Protein References for LASP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences LASP1 Antibody
- NSJ Bioreagents LASP1 Antibody
- BioLegend Purified anti-LASP1
-
Custom Antibody ServicesOriGene Antibodies for LASP1
- Novus Biologicals Antibodies for LASP1
-
Abcam antibodies for LASP1
- Invitrogen Antibodies for LASP1 (AFLGC-Lasp1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for LASP1
- Sino Biological Antibodies for LASP1
Protein Products
-
OriGene Purified Proteins for LASP1
- Search Origene for MassSpec and Protein Over-expression Lysates for LASP1
- Origene Custom Protein Services for LASP1
- ProSpec Recombinant Proteins for LASP1
-
Abcam proteins for LASP1
Assay Products
- antibodies-online: Show 14 available LASP1 Elisa Kits ranked by validation data
- Compare Top LASP1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for LASP1 Gene
Domains & Families for LASP1 Gene
Gene Families for LASP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for LASP1 Gene
- InterPro:
- Blocks:
-
- SH3 domain signature
- Zn-binding protein, LIM
- ProtoNet:
Suggested Antigen Peptide Sequences for LASP1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ51834, highly similar to LIM and SH3 domain protein 1 (B4DGQ0_HUMAN)
- cDNA FLJ52195, highly similar to LIM and SH3 domain protein 1 (B4DIC4_HUMAN)
- Metastatic lymph node gene 50 protein (LASP1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LASP1 Gene
Function for LASP1 Gene
Molecular function for LASP1 Gene
- UniProtKB/Swiss-Prot Function:
- Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
- GENATLAS Biochemistry:
- LIM and SH3 protein 1,actin binding protein,amplified in breast cancer,metastatic axillary lymph nodes,cDNA50,potentially involved in a signaling pathway for the organization of the cytoskeleton
Phenotypes From GWAS Catalog for LASP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005070 | SH3/SH2 adaptor activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0015075 | ion transmembrane transporter activity | ISS | -- |
| GO:0045296 | cadherin binding | HDA | 25468996 |
Phenotypes for LASP1 Gene
- MGI mutant phenotypes for LASP1:
-
inferred from 2 alleles
- nervous system phenotype
- cardiovascular system phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for LASP1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Increased epidermal growth factor (EGF) endocytosis
- Decreased shRNA abundance
- Increased ionizing radiation sensitivity
- Weakly decreased NFAT1-GFP nuclear translocation
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased ionizing radiation sensitivity
Animal Models for LASP1 Gene
- MGI Knock Outs for LASP1:
-
- Lasp1 Lasp1<tm1Chew>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LASP1 - Select products 50% OFF >
- * LASP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LASP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LASP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for LASP1
miRNA for LASP1 Gene
- miRTarBase miRNAs that target LASP1
-
- hsa-miR-1-3p (MIRT002808)
- hsa-miR-218-5p (MIRT003708)
- hsa-miR-133a-3p (MIRT005813)
- mmu-miR-425-5p (MIRT008538)
- mmu-miR-181a-5p (MIRT014185)
- hsa-miR-193b-3p (MIRT016319)
- hsa-miR-505-5p (MIRT037933)
- hsa-miR-23b-3p (MIRT046268)
- hsa-miR-203a-3p (MIRT053001)
- hsa-miR-17-5p (MIRT145596)
- hsa-miR-20a-5p (MIRT145597)
- hsa-miR-93-5p (MIRT145598)
- hsa-miR-106a-5p (MIRT145599)
- hsa-miR-106b-5p (MIRT145601)
- hsa-miR-20b-5p (MIRT145604)
- hsa-miR-519c-3p (MIRT145605)
- hsa-miR-526b-3p (MIRT145606)
- hsa-miR-519b-3p (MIRT145607)
- hsa-miR-519d-3p (MIRT145608)
- hsa-miR-519a-3p (MIRT145609)
- hsa-miR-625-5p (MIRT145610)
- hsa-miR-1910-3p (MIRT145613)
- hsa-miR-3136-3p (MIRT145614)
- hsa-miR-548t-5p (MIRT145615)
- hsa-miR-3153 (MIRT145616)
- hsa-miR-3714 (MIRT145620)
- hsa-miR-548an (MIRT145623)
- hsa-miR-4666b (MIRT145627)
- hsa-miR-548az-5p (MIRT145628)
- hsa-miR-6511a-5p (MIRT145629)
- hsa-miR-6733-5p (MIRT145630)
- hsa-miR-6734-5p (MIRT145631)
- hsa-miR-6739-5p (MIRT145632)
- hsa-miR-6768-3p (MIRT145633)
- hsa-miR-6795-5p (MIRT145634)
- hsa-miR-6818-5p (MIRT145635)
- hsa-miR-6887-5p (MIRT145636)
- hsa-miR-7155-3p (MIRT145637)
- hsa-miR-423-5p (MIRT474273)
- hsa-miR-3184-5p (MIRT474274)
- hsa-miR-1294 (MIRT485425)
- hsa-miR-4316 (MIRT485426)
- hsa-miR-6738-5p (MIRT485427)
- hsa-miR-5194 (MIRT485428)
- hsa-miR-1914-3p (MIRT485429)
- hsa-miR-29b-3p (MIRT733068)
- hsa-miR-92a-3p (MIRT733594)
- hsa-miR-1-5p (MIRT734174)
- hsa-miR-103a-3p (MIRT735808)
- hsa-miR-107 (MIRT735844)
- hsa-miR-1184 (MIRT735893)
- hsa-miR-1197 (MIRT735931)
- hsa-miR-125a-3p (MIRT736629)
- hsa-miR-1265 (MIRT736690)
- hsa-miR-1285-3p (MIRT737025)
- hsa-miR-1321 (MIRT737337)
- hsa-miR-149-3p (MIRT737745)
- hsa-miR-185-5p (MIRT738249)
- hsa-miR-2861 (MIRT739497)
- hsa-miR-3117-3p (MIRT739938)
- hsa-miR-3175 (MIRT740666)
- hsa-miR-3187-5p (MIRT740920)
- hsa-miR-3605-5p (MIRT741513)
- hsa-miR-3665 (MIRT742053)
- hsa-miR-3925-5p (MIRT743003)
- hsa-miR-4306 (MIRT743904)
- hsa-miR-4419a (MIRT744185)
- hsa-miR-4459 (MIRT744812)
- hsa-miR-4510 (MIRT745624)
- hsa-miR-4512 (MIRT745677)
- hsa-miR-451b (MIRT745804)
- hsa-miR-4644 (MIRT746376)
- hsa-miR-4688 (MIRT747010)
- hsa-miR-4710 (MIRT747402)
- hsa-miR-4722-5p (MIRT747605)
- hsa-miR-4728-5p (MIRT747841)
- hsa-miR-4736 (MIRT748002)
- hsa-miR-4739 (MIRT748055)
- hsa-miR-4756-5p (MIRT748427)
- hsa-miR-4764-5p (MIRT748587)
- hsa-miR-4773 (MIRT748697)
- hsa-miR-486-3p (MIRT749110)
- hsa-miR-5008-5p (MIRT749445)
- hsa-miR-5189-5p (MIRT749880)
- hsa-miR-6077 (MIRT751707)
- hsa-miR-6089 (MIRT751955)
- hsa-miR-6127 (MIRT752099)
- hsa-miR-6129 (MIRT752171)
- hsa-miR-612 (MIRT752223)
- hsa-miR-6130 (MIRT752260)
- hsa-miR-6133 (MIRT752364)
- hsa-miR-6721-5p (MIRT753804)
- hsa-miR-6731-5p (MIRT754011)
- hsa-miR-6743-5p (MIRT754410)
- hsa-miR-6774-5p (MIRT755344)
- hsa-miR-6785-5p (MIRT755836)
- hsa-miR-6860 (MIRT757853)
- hsa-miR-6873-5p (MIRT758070)
- hsa-miR-6883-5p (MIRT758421)
- hsa-miR-6894-5p (MIRT758776)
- hsa-miR-8085 (MIRT760214)
- hsa-miR-936 (MIRT760696)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LASP1
- Browse OriGene Inhibitory RNA Products For LASP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LASP1
Clone Products
- Applied Biological Materials (abm): Clones for LASP1 - Select products 50% OFF >
- * LASP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LASP1
- Addgene plasmids for LASP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LASP1
Cell Line Products
-
Horizon Cell Lines for LASP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LASP1 Gene
Localization for LASP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LASP1 Gene
- Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Associated with the F-actin rich cortical cytoskeleton. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 4 |
| nucleus | 4 |
| cytosol | 4 |
| plasma membrane | 3 |
| extracellular | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Plasma membrane (3)
- Focal adhesion sites (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 25468996 |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005925 | focal adhesion | IBA | 21873635 |
| GO:0005938 | cell cortex | IEA | -- |
| GO:0030864 | cortical actin cytoskeleton | ISS | -- |
Pathways & Interactions for LASP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytoskeletal Signaling | ||
| 2 | Aquaporin-mediated transport |
Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
.40
|
|
Pathways by source for LASP1 Gene
1 GeneGo (Thomson Reuters) pathway for LASP1 Gene
- Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
1 Cell Signaling Technology pathway for LASP1 Gene
Interacting Proteins for LASP1 Gene
Selected Interacting proteins:
Q14847-LASP1_HUMAN
ENSP00000325240
for LASP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for LASP1
SIGNOR curated interactions for LASP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | ISS | -- |
| GO:0009967 | positive regulation of signal transduction | IEA | -- |
| GO:0034220 | ion transmembrane transport | IEA | -- |
Transcripts for LASP1 Gene
mRNA/cDNA for LASP1 Gene
- 2 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000318008 3910 nts (view in UCSC)
- ENST00000419929 762 nts (view in UCSC)
- ENST00000433206 4023 nts (view in UCSC)
- ENST00000435347 3492 nts (view in UCSC)
- ENST00000443937 1482 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LASP1 - Select products 50% OFF >
- * LASP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LASP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LASP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for LASP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LASP1
- Browse OriGene Inhibitory RNA Products For LASP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LASP1
Clone Products
- Applied Biological Materials (abm): Clones for LASP1 - Select products 50% OFF >
- * LASP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LASP1
- Addgene plasmids for LASP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LASP1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||
| SP8: |
Relevant External Links for LASP1 Gene
- GeneLoc Exon Structure for
- LASP1
Expression for LASP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Blood (Hematopoietic System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Stomach (Gastrointestinal Tract)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for LASP1 Gene
This gene is overexpressed in Whole Blood (x5.9).
This gene is overexpressed in Bone marrow stromal cell (9.3) and Lymph node (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LASP1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LASP1
SOURCE GeneReport for Unigene cluster for LASP1 Gene:
Hs.741156Evidence on tissue expression from TISSUES for LASP1 Gene
- Nervous system(5)
- Skin(4.8)
- Liver(4.7)
- Blood(4.6)
- Intestine(4.2)
- Lung(3.9)
- Pancreas(3.7)
- Kidney(3.7)
- Stomach(3.1)
- Lymph node(2.8)
- Muscle(2.5)
- Heart(2.4)
- Spleen(2.3)
- Bone marrow(2.2)
- Gall bladder(2.1)
- Eye(2.1)
Primer Products
-
OriGene qPCR primer pairs for LASP1
-
OriGene qPCR primer pairs and template standards for LASP1
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LASP1 Gene
Orthologs for LASP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LASP1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LASP1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LASP1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | LASP1 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Lasp1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Lasp1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | LASP1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LASP1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | LASP1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lasp1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | lasp1 30 31 |
|
OneToOne | |
| Dr.3684 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006526 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | F42H10.3 30 31 |
|
OneToMany | |
| F42H10.4 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for LASP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for LASP1 Gene
- ENSEMBL:
- Gene Tree for LASP1 (if available)
- TreeFam:
- Gene Tree for LASP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LASP1: view image
Paralogs for LASP1 Gene
(10) SIMAP similar genes for LASP1 Gene using alignment to 6 proteins:
- LASP1_HUMAN
- B4DGQ0_HUMAN
- C9J9W2_HUMAN
- F6S2S5_HUMAN
- J3KSN1_HUMAN
- K7ESD6_HUMAN
Variants for LASP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LASP1 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 728929 | Benign: not provided | 38,878,112(+) | C/T | NONSENSE,NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 745719 | Likely Benign: not provided | 38,914,462(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 778689 | Benign: not provided | 38,918,616(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.47;
10.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LASP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LASP1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LASP1 Gene
Disorders for LASP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
|
| colorectal cancer |
|
|
| medulloblastoma |
|
|
Search LASP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LASP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for LASP1 Gene
Publications for LASP1 Gene
- Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PMID: 7490069) Tomasetto C … Rio MC (Genomics 1995) 2 3 4
- Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains. (PMID: 7589475) Tomasetto C … Rio MC (FEBS letters 1995) 3 4 23
- An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein. (PMID: 25622104) Orth MF … Grunewald TG (Oncotarget 2015) 2 3
- LIM and SH3 protein-1 modulates CXCR2-mediated cell migration. (PMID: 20419088) Raman D … Richmond A (PloS one 2010) 3 23
- Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer. (PMID: 20461080) Frietsch JJ … Butt E (British journal of cancer 2010) 3 23
ExternalLinks
Products for LASP1 Gene
- Custom Antibody ServicesOriGene Antibodies for LASP1
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for LASP1
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- OriGene qPCR primer pairs for LASP1
- OriGene qPCR primer pairs and template standards for LASP1
- OriGene CRISPR knockouts for LASP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LASP1
- Sino Biological Human cDNA Clone for LASP1
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins and lysates for LASP1
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- VectorBuilder Custom and pre-made DNA vectors for LASP1 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder CRISPR vectors for LASP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for LASP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for LASP1
- Addgene plasmids for LASP1
- antibodies-online: Show 29 available LASP1 Antibodies ranked by validation data
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- antibodies-online: Show 14 available LASP1 Elisa Kits ranked by validation data
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- antibodies-online: Show 13 available LASP1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for LASP1
- Search Santa Cruz Biotechnology (SCBT) for LASP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LASP1
- Horizon Cell Lines for LASP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LASP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LASP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for LASP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LASP1
Sources for LASP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
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- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (38) dbSNP
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- (44) Atlas
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
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- (83) Illumina
- (84) COMPARTMENTS
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- (89) antibodies-online
- (90) CYP
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- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
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- (98) ProteomicsDB
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- (100) DGIdb
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- (104) diseasecard
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- (110) Genetics Home Reference
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- (115) NCBI Bookshelf
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