LARP7 Gene (Protein Coding)

La Ribonucleoprotein 7, Transcriptional Regulator

GC04P112636
GIFtS:
41
This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in mult... See more...

Aliases for LARP7 Gene

Aliases for LARP7 Gene

  • La Ribonucleoprotein 7, Transcriptional Regulator 2 3 5
  • P-TEFb-Interaction Protein For 7SK Stability 2 3 4
  • La Ribonucleoprotein Domain Family Member 7 2 3 4
  • PIP7S 2 3 4
  • La-Related Protein 7 3 4
  • HDCMA18P 2 3
  • HLARP7 3 4
  • La Ribonucleoprotein Domain Family, Member 7 2
  • DKFZP564K112 2
  • ALAZS 3
  • LARP7 5

External Ids for LARP7 Gene

Previous GeneCards Identifiers for LARP7 Gene

  • GC04P113777
  • GC04P113559
  • GC04P109286

Summaries for LARP7 Gene

Entrez Gene Summary for LARP7 Gene

  • This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

GeneCards Summary for LARP7 Gene

LARP7 (La Ribonucleoprotein 7, Transcriptional Regulator) is a Protein Coding gene. Diseases associated with LARP7 include Alazami Syndrome and Autosomal Dominant Non-Syndromic Intellectual Disability 27. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SSB.

UniProtKB/Swiss-Prot Summary for LARP7 Gene

  • RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18483487, PubMed:18281698). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity).

Additional gene information for LARP7 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LARP7 Gene

Genomics for LARP7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for LARP7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LARP7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LARP7

Top Transcription factor binding sites by QIAGEN in the LARP7 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • FOXO4

Genomic Locations for LARP7 Gene

Genomic Locations for LARP7 Gene
chr4:112,636,964-112,657,592
(GRCh38/hg38)
Size:
20,629 bases
Orientation:
Plus strand
chr4:113,558,120-113,578,748
(GRCh37/hg19)
Size:
20,629 bases
Orientation:
Plus strand

Genomic View for LARP7 Gene

Genes around LARP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LARP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LARP7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LARP7 Gene

Proteins for LARP7 Gene

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  • Protein details for LARP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0J3-LARP7_HUMAN
    Recommended name:
    La-related protein 7
    Protein Accession:
    Q4G0J3
    Secondary Accessions:
    • B2ZHN6
    • Q3B7A9
    • Q9P1S7
    • Q9Y3Z8

    Protein attributes for LARP7 Gene

    Size:
    582 amino acids
    Molecular mass:
    66899 Da
    Quaternary structure:
    • Core component of the 7SK RNP complex, at least composed of 7SK RNA, LARP7, MEPCE, HEXIM1 (or HEXIM2) and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) (PubMed:18483487, PubMed:18281698, PubMed:19906723). Interacts with METTL16 (PubMed:29051200). Interacts with RBM7; upon genotoxic stress this interaction is enhanced, triggering the release of inactive P-TEFb complex from the core, yielding to P-TEFb complex activation (PubMed:30824372). Associates with box C/D small nucleolar ribonucleoprotein (snoRNP) complexes (PubMed:32017898).
    SequenceCaution:
    • Sequence=AAH66945.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LARP7 Gene

    Alternative splice isoforms for LARP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LARP7 Gene

Protein Expression for LARP7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LARP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LARP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for LARP7
  • Boster Bio Antibodies for LARP7

No data available for DME Specific Peptides for LARP7 Gene

Domains & Families for LARP7 Gene

Gene Families for LARP7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for LARP7 Gene

InterPro:
Blocks:
  • Lupus La protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for LARP7 Gene

GenScript: Design optimal peptide antigens:
  • P-TEFb-interaction protein for 7SK stability (LARP7_HUMAN)
  • LARP7 protein (Q96IZ8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q4G0J3

UniProtKB/Swiss-Prot:

LARP7_HUMAN :
  • The xRRM domain binds the 3' end of 7SK snRNA (7SK RNA) at the top of stem-loop 4.
  • Belongs to the LARP7 family.
Domain:
  • The xRRM domain binds the 3' end of 7SK snRNA (7SK RNA) at the top of stem-loop 4.
Family:
  • Belongs to the LARP7 family.
genes like me logo Genes that share domains with LARP7: view

Function for LARP7 Gene

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Molecular function for LARP7 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18483487, PubMed:18281698). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity).

Phenotypes From GWAS Catalog for LARP7 Gene

Gene Ontology (GO) - Molecular Function for LARP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 18281698
GO:0017070 U6 snRNA binding IDA 32017898
GO:0097322 7SK snRNA binding IDA 27679474
genes like me logo Genes that share ontologies with LARP7: view
genes like me logo Genes that share phenotypes with LARP7: view

Human Phenotype Ontology for LARP7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LARP7 Gene

MGI Knock Outs for LARP7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LARP7

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for LARP7 Gene

Localization for LARP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LARP7 Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LARP7 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LARP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 28254838
GO:0005654 nucleoplasm IEA,IDA --
GO:0005829 cytosol IDA --
GO:1990904 ribonucleoprotein complex IEA,IDA 19906723
genes like me logo Genes that share ontologies with LARP7: view

Pathways & Interactions for LARP7 Gene

PathCards logo

SuperPathways for LARP7 Gene

No Data Available

SIGNOR curated interactions for LARP7 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for LARP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000494 box C/D snoRNA 3'-end processing IMP 32017898
GO:0006396 RNA processing IEA --
GO:0007283 spermatogenesis ISS --
GO:0048024 regulation of mRNA splicing, via spliceosome IMP 32017898
GO:1904871 positive regulation of protein localization to Cajal body IDA 28254838
genes like me logo Genes that share ontologies with LARP7: view

No data available for Pathways by source for LARP7 Gene

Drugs & Compounds for LARP7 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for LARP7 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for LARP7 Gene

12 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LARP7

Alternative Splicing Database (ASD) splice patterns (SP) for LARP7 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for LARP7 Gene

GeneLoc Exon Structure for
LARP7

Expression for LARP7 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LARP7 Gene

mRNA expression in normal human tissues for LARP7 Gene
mRNA expression by GTEx for LARP7 GenemRNA expression by BioGPS for LARP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LARP7 Gene

This gene is overexpressed in Cerebrospinal fluid (22.3), Lung (14.3), and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LARP7 Gene



Protein tissue co-expression partners for LARP7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LARP7

SOURCE GeneReport for Unigene cluster for LARP7 Gene:

Hs.713663

Evidence on tissue expression from TISSUES for LARP7 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Blood(4.4)
  • Lymph node(4.4)
  • Spleen(4.4)
  • Skin(3.2)
  • Lung(3.1)
  • Kidney(3)
  • Heart(2.2)
  • Muscle(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LARP7 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • face
  • head
  • jaw
  • lip
  • maxilla
  • mouth
  • nose
  • skull
Thorax:
  • lung
  • rib
  • rib cage
Pelvis:
  • pelvis
General:
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with LARP7: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LARP7 Gene

Orthologs for LARP7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LARP7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LARP7 30 31
  • 99.38 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia LARP7 30 31
  • 87.45 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia LARP7 30 31
  • 83.16 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Larp7 30 17 31
  • 81.81 (n)
 OneToMany
Gm12666 31
  • 76 (a)
 OneToMany
Rat
(Rattus norvegicus)
 Mammalia Larp7 30
  • 79.79 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia LARP7 31
  • 76 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia LARP7 31
  • 76 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves LARP7 30 31
  • 73.13 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia LARP7 31
  • 67 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia larp7 30
  • 67.1 (n)
Str.6238 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.13044 30
Zebrafish
(Danio rerio)
 Actinopterygii larp7 30 31
  • 58.59 (n)
 OneToOne
wufa10g04 30
Fruit Fly
(Drosophila melanogaster)
 Insecta CG42569 31
  • 23 (a)
 OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes LHP1 31
  • 25 (a)
 OneToMany
Species where no ortholog for LARP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LARP7 Gene

ENSEMBL:
Gene Tree for LARP7 (if available)
TreeFam:
Gene Tree for LARP7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LARP7: view image

Paralogs for LARP7 Gene

Paralogs for LARP7 Gene

(4) SIMAP similar genes for LARP7 Gene using alignment to 9 proteins:

  • LARP7_HUMAN
  • D6R9Z6_HUMAN
  • D6RAF3_HUMAN
  • D6RBH8_HUMAN
  • D6RF22_HUMAN
  • D6RF49_HUMAN
  • D6RFF0_HUMAN
  • H0YA82_HUMAN
  • Q96IZ8_HUMAN

Pseudogenes.org Pseudogenes for LARP7 Gene

genes like me logo Genes that share paralogs with LARP7: view

Variants for LARP7 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LARP7 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
666361 Likely Pathogenic: Alazami syndrome 112,646,334(+) TTTTTCATTTTCTTTA SPLICE_ACCEPTOR_VARIANT
666362 Likely Pathogenic: Alazami syndrome 112,647,781(+) TAAAG/T FRAMESHIFT_VARIANT
708811 Likely Benign: not provided 112,647,705(+) C/T MISSENSE_VARIANT
711671 Likely Benign: not provided 112,647,693(+) T/C MISSENSE_VARIANT
716109 Benign: not provided 112,647,286(+) A/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for LARP7 Gene

Structural Variations from Database of Genomic Variants (DGV) for LARP7 Gene

Variant ID Type Subtype PubMed ID
nsv1006030 CNV gain 25217958
nsv1014926 CNV gain 25217958
nsv525715 CNV loss 19592680

Variation tolerance for LARP7 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.84; 73.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LARP7 Gene

Human Gene Mutation Database (HGMD)
LARP7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LARP7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARP7 Gene

Disorders for LARP7 Gene

MalaCards: The human disease database

(4) MalaCards diseases for LARP7 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
alazami syndrome
  • alazs
autosomal dominant non-syndromic intellectual disability 27
  • mrd27
med23
  • autosomal recessive nonsyndromic mental retardation-18
isolated growth hormone deficiency, type ia
  • ighd1a
- elite association - COSMIC cancer census association via MalaCards
Search LARP7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LARP7_HUMAN
  • Alazami syndrome (ALAZS) [MIM:615071]: A syndromic form of primordial dwarfism, a condition characterized by severe growth restriction that has its onset in utero, and results in short stature and undersize. ALAZS patients manifest severe intellectual disability and distinct facial features including malar hypoplasia, deep-set eyes, broad nose, short philtrum, and macrostomia. Some patients have non-specific and inconsistent skeletal findings, for example, scoliosis and mild epiphyseal changes in the proximal phalanges, but no frank dysplasia. {ECO:0000269 PubMed:21937992, ECO:0000269 PubMed:22865833, ECO:0000269 PubMed:26374271, ECO:0000269 PubMed:27766953, ECO:0000269 PubMed:29576627, ECO:0000269 PubMed:29619239, ECO:0000269 PubMed:30006060, ECO:0000269 PubMed:32017898}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for LARP7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with LARP7: view

No data available for Genatlas for LARP7 Gene

Publications for LARP7 Gene

  1. Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism. (PMID: 22865833) Alazami AM … Alkuraya FS (Human mutation 2012) 2 3 4
  2. A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis. (PMID: 18249148) He N … Zhou Q (Molecular cell 2008) 2 3 4
  3. LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated. (PMID: 18281698) Krueger BJ … Price DH (Nucleic acids research 2008) 2 3 4
  4. The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness. (PMID: 32017898) Hasler D … Meister G (Molecular cell 2020) 3 4
  5. P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress. (PMID: 30824372) Bugai A … Barborič M (Molecular cell 2019) 3 4

ExternalLinks

View latest publications for LARP7 gene in Mastermind

Products for LARP7 Gene

  • Addgene plasmids for LARP7
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Sources for LARP7 Gene