This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RN... See more...

Aliases for LARP4B Gene

Aliases for LARP4B Gene

  • La Ribonucleoprotein 4B 2 3
  • La Ribonucleoprotein Domain Family Member 4B 2 3 4 5
  • KIAA0217 2 3 4
  • La Ribonucleoprotein Domain Family, Member 5 2 3
  • La-Related Protein 4B 3 4
  • La-Related Protein 5 3 4
  • LARP5 3 4
  • La Ribonucleoprotein Domain Family, Member 4B 2
  • La Ribonucleoprotein Domain Family Member 5 4

External Ids for LARP4B Gene

Previous HGNC Symbols for LARP4B Gene

  • KIAA0217
  • LARP5

Previous GeneCards Identifiers for LARP4B Gene

  • GC10M000851

Summaries for LARP4B Gene

Entrez Gene Summary for LARP4B Gene

  • This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012]

GeneCards Summary for LARP4B Gene

LARP4B (La Ribonucleoprotein 4B) is a Protein Coding gene. An important paralog of this gene is LARP4.

UniProtKB/Swiss-Prot Summary for LARP4B Gene

Additional gene information for LARP4B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LARP4B Gene

Genomics for LARP4B Gene

GeneHancer (GH) Regulatory Elements for LARP4B Gene

Promoters and enhancers for LARP4B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LARP4B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LARP4B

Genomic Locations for LARP4B Gene

Genomic Locations for LARP4B Gene
chr10:806,914-988,323
(GRCh38/hg38)
Size:
181,410 bases
Orientation:
Minus strand
chr10:855,484-977,564
(GRCh37/hg19)
Size:
122,081 bases
Orientation:
Minus strand

Genomic View for LARP4B Gene

Genes around LARP4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LARP4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LARP4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LARP4B Gene

Proteins for LARP4B Gene

  • Protein details for LARP4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92615-LAR4B_HUMAN
    Recommended name:
    La-related protein 4B
    Protein Accession:
    Q92615
    Secondary Accessions:
    • A7MD20
    • Q5T3R3
    • Q5T3R4
    • Q5T3R5
    • Q68CY4

    Protein attributes for LARP4B Gene

    Size:
    738 amino acids
    Molecular mass:
    80552 Da
    Quaternary structure:
    • Interacts with PABPC1 (PubMed:20573744, Ref.23). Interacts with RACK1 (PubMed:20573744). Associates with polysomes via the 40S ribosomal subunit (PubMed:20573744).
    SequenceCaution:
    • Sequence=BAA13207.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LARP4B Gene

neXtProt entry for LARP4B Gene

Post-translational modifications for LARP4B Gene

  • Ubiquitination at Lys311 and Lys321
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LARP4B Gene

Domains & Families for LARP4B Gene

Gene Families for LARP4B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LARP4B Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LARP4B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75864, highly similar to Homo sapiens La ribonucleoprotein domain family, member 5 (LARP5), mRNA (A7MD20_HUMAN)
  • La-related protein 5 (LAR4B_HUMAN)
  • La ribonucleoprotein domain family, member 5 (Q5JUS6_HUMAN)
  • La ribonucleoprotein domain family, member 5 (Q5T3R6_HUMAN)
  • LARP5 protein (Q9BTS9_HUMAN)
genes like me logo Genes that share domains with LARP4B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LARP4B Gene

Function for LARP4B Gene

Molecular function for LARP4B Gene

UniProtKB/Swiss-Prot Function:
Stimulates mRNA translation.

Phenotypes From GWAS Catalog for LARP4B Gene

Gene Ontology (GO) - Molecular Function for LARP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with LARP4B: view
genes like me logo Genes that share phenotypes with LARP4B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LARP4B Gene

Localization for LARP4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for LARP4B Gene

Cytoplasm, cytosol. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs in response to arsenite treatment. {ECO:0000269 PubMed:20573744}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LARP4B gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LARP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IDA 20573744
GO:0010494 cytoplasmic stress granule IDA 20573744
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with LARP4B: view

Pathways & Interactions for LARP4B Gene

PathCards logo

SuperPathways for LARP4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for LARP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0045727 positive regulation of translation IMP 20573744
genes like me logo Genes that share ontologies with LARP4B: view

No data available for Pathways by source and SIGNOR curated interactions for LARP4B Gene

Drugs & Compounds for LARP4B Gene

No Compound Related Data Available

Transcripts for LARP4B Gene

mRNA/cDNA for LARP4B Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LARP4B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:

Relevant External Links for LARP4B Gene

GeneLoc Exon Structure for
LARP4B

Expression for LARP4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LARP4B Gene

Protein differential expression in normal tissues from HIPED for LARP4B Gene

This gene is overexpressed in Lung (49.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LARP4B Gene



Protein tissue co-expression partners for LARP4B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LARP4B

SOURCE GeneReport for Unigene cluster for LARP4B Gene:

Hs.159069

Evidence on tissue expression from TISSUES for LARP4B Gene

  • Nervous system(4.7)
  • Liver(4.2)
  • Blood(4.1)
  • Lung(2.7)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with LARP4B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LARP4B Gene

Orthologs for LARP4B Gene

This gene was present in the common ancestor of animals.

Orthologs for LARP4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LARP4B 31 30
  • 99.5 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Larp4b 17 31 30
  • 86.99 (n)
rat
(Rattus norvegicus)
Mammalia Larp4b 30
  • 86.93 (n)
dog
(Canis familiaris)
Mammalia LARP4B 30
  • 83.63 (n)
cow
(Bos Taurus)
Mammalia LARP4B 31 30
  • 82.3 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LARP4B 31
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LARP4B 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves LARP4B 31 30
  • 74.59 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LARP4B 31
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia larp4b 30
  • 71.72 (n)
Str.3957 30
zebrafish
(Danio rerio)
Actinopterygii larp4b 31 30
  • 59.93 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11505 31
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea larp-5 31
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10553 31
  • 17 (a)
OneToMany
Species where no ortholog for LARP4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LARP4B Gene

ENSEMBL:
Gene Tree for LARP4B (if available)
TreeFam:
Gene Tree for LARP4B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LARP4B: view image

Paralogs for LARP4B Gene

Paralogs for LARP4B Gene

(1) SIMAP similar genes for LARP4B Gene using alignment to 5 proteins:

  • LAR4B_HUMAN
  • B5MCU2_HUMAN
  • H0Y4V9_HUMAN
  • H0Y641_HUMAN
  • V9GYI5_HUMAN
genes like me logo Genes that share paralogs with LARP4B: view

Variants for LARP4B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LARP4B Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
747170 Benign: not provided 815,050(-) G/A SYNONYMOUS_VARIANT
752716 Benign: not provided 813,136(-) T/C SYNONYMOUS_VARIANT
778457 Benign: not provided 825,876(-) T/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for LARP4B Gene

Structural Variations from Database of Genomic Variants (DGV) for LARP4B Gene

Variant ID Type Subtype PubMed ID
dgv119n67 CNV gain 20364138
dgv170e212 CNV loss 25503493
dgv334n106 CNV deletion 24896259
dgv654n100 CNV gain 25217958
esv2638233 CNV deletion 19546169
esv2660097 CNV deletion 23128226
esv2664004 CNV deletion 23128226
esv3578580 CNV loss 25503493
esv3622084 CNV loss 21293372
esv3622085 CNV loss 21293372
esv3622086 CNV loss 21293372
esv3622087 CNV loss 21293372
esv3622088 CNV loss 21293372
esv3622089 CNV gain 21293372
nsv1048707 CNV gain 25217958
nsv1069003 CNV deletion 25765185
nsv1161921 CNV duplication 26073780
nsv466698 CNV loss 19166990
nsv510208 OTHER sequence alteration 20534489
nsv549753 CNV gain 21841781
nsv549765 CNV gain 21841781
nsv549766 CNV loss 21841781
nsv5498 CNV deletion 18451855
nsv5509 CNV insertion 18451855
nsv819263 CNV loss 19587683
nsv820121 CNV gain 19587683
nsv951230 CNV deletion 24416366

Variation tolerance for LARP4B Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LARP4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LARP4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARP4B Gene

Disorders for LARP4B Gene

Additional Disease Information for LARP4B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LARP4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LARP4B Gene

Publications for LARP4B Gene

  1. A stimulatory role for the La-related protein 4B in translation. (PMID: 20573744) Schäffler K … Fischer U (RNA (New York, N.Y.) 2010) 2 3 4 54
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for LARP4B Gene

Sources for LARP4B Gene