Aliases for LARP4 Gene

Aliases for LARP4 Gene

  • La Ribonucleoprotein 4 2 3
  • La Ribonucleoprotein Domain Family Member 4 2 3 4 5
  • La-Related Protein 4 2 3 4
  • La Ribonucleoprotein Domain Family, Member 4 2
  • C-Mpl Binding Protein 3
  • PP13296 3

External Ids for LARP4 Gene

Previous GeneCards Identifiers for LARP4 Gene

  • GC12P049082
  • GC12P050794
  • GC12P047827

Summaries for LARP4 Gene

GeneCards Summary for LARP4 Gene

LARP4 (La Ribonucleoprotein 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is LARP4B.

UniProtKB/Swiss-Prot Summary for LARP4 Gene

  • RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744).

Gene Wiki entry for LARP4 Gene

Additional gene information for LARP4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LARP4 Gene

Genomics for LARP4 Gene

GeneHancer (GH) Regulatory Elements for LARP4 Gene

Promoters and enhancers for LARP4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LARP4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LARP4

Top Transcription factor binding sites by QIAGEN in the LARP4 gene promoter:
  • AP-4
  • AREB6
  • Arnt
  • c-Ets-1
  • C/EBPbeta
  • COMP1
  • E47
  • HEN1
  • HNF-3beta

Genomic Locations for LARP4 Gene

Genomic Locations for LARP4 Gene
chr12:50,392,383-50,480,005
(GRCh38/hg38)
Size:
87,623 bases
Orientation:
Plus strand
chr12:50,786,166-50,873,788
(GRCh37/hg19)
Size:
87,623 bases
Orientation:
Plus strand

Genomic View for LARP4 Gene

Genes around LARP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LARP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LARP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LARP4 Gene

Proteins for LARP4 Gene

  • Protein details for LARP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71RC2-LARP4_HUMAN
    Recommended name:
    La-related protein 4
    Protein Accession:
    Q71RC2
    Secondary Accessions:
    • A8K6T1
    • E9PDG5
    • G3XAA8
    • G5E976
    • Q5CZ97
    • Q6ZV14
    • Q96NF9

    Protein attributes for LARP4 Gene

    Size:
    724 amino acids
    Molecular mass:
    80596 Da
    Quaternary structure:
    • Interacts (via N-terminal region) with PABPC1 (PubMed:27615744, PubMed:21098120). Interacts with RACK1 (PubMed:21098120).
    Miscellaneous:
    • [Isoform 3]: May be due to competing acceptor splice site.
    SequenceCaution:
    • Sequence=BAC86052.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LARP4 Gene

    Alternative splice isoforms for LARP4 Gene

neXtProt entry for LARP4 Gene

Post-translational modifications for LARP4 Gene

  • Ubiquitination at Lys280 and Lys372
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LARP4 Gene

Domains & Families for LARP4 Gene

Gene Families for LARP4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LARP4 Gene

Suggested Antigen Peptide Sequences for LARP4 Gene

GenScript: Design optimal peptide antigens:
  • La ribonucleoprotein domain family member 4 (LARP4_HUMAN)
  • LARP4 protein (Q8WVX5_HUMAN)
genes like me logo Genes that share domains with LARP4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LARP4 Gene

Function for LARP4 Gene

Molecular function for LARP4 Gene

UniProtKB/Swiss-Prot Function:
RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744).

Phenotypes From GWAS Catalog for LARP4 Gene

Gene Ontology (GO) - Molecular Function for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IEA 22658674
GO:0005515 protein binding IPI 21098120
GO:0008143 poly(A) binding IDA 21098120
genes like me logo Genes that share ontologies with LARP4: view
genes like me logo Genes that share phenotypes with LARP4: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LARP4 Gene

Localization for LARP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LARP4 Gene

Cytoplasm, Stress granule. Cytoplasm, cytosol. Note=Localized throughout the cytosol. Partially localized in stress granules in response to arsenite treatment. {ECO:0000269 PubMed:21098120}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LARP4 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,IEA 21098120
GO:0005844 colocalizes_with polysome IDA 21098120
GO:0010494 colocalizes_with cytoplasmic stress granule IEA,IDA 21098120
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with LARP4: view

Pathways & Interactions for LARP4 Gene

PathCards logo

SuperPathways for LARP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0022604 regulation of cell morphogenesis IMP 21834987
GO:0045727 positive regulation of translation IMP 21098120
genes like me logo Genes that share ontologies with LARP4: view

No data available for Pathways by source and SIGNOR curated interactions for LARP4 Gene

Drugs & Compounds for LARP4 Gene

No Compound Related Data Available

Transcripts for LARP4 Gene

mRNA/cDNA for LARP4 Gene

30 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LARP4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for LARP4 Gene

GeneLoc Exon Structure for
LARP4

Expression for LARP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LARP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LARP4 Gene

This gene is overexpressed in Lung (30.0), Heart (22.3), and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LARP4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LARP4

SOURCE GeneReport for Unigene cluster for LARP4 Gene:

Hs.26613

Evidence on tissue expression from TISSUES for LARP4 Gene

  • Bone marrow(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with LARP4: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LARP4 Gene

Orthologs for LARP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LARP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LARP4 31 30
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LARP4 31 30
  • 92.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LARP4 31 30
  • 91.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Larp4 17 31 30
  • 86.65 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910299 30
  • 84.75 (n)
oppossum
(Monodelphis domestica)
Mammalia LARP4 31
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LARP4 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves LARP4 31 30
  • 72.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LARP4 31
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia larp4 30
  • 66.43 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC797570 30
  • 57.29 (n)
larp4ab 31
  • 47 (a)
OneToMany
larp4aa 31
  • 45 (a)
OneToMany
Dr.25940 30
fruit fly
(Drosophila melanogaster)
Insecta CG11505 31
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea larp-5 31
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10553 31
  • 18 (a)
OneToMany
Species where no ortholog for LARP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LARP4 Gene

ENSEMBL:
Gene Tree for LARP4 (if available)
TreeFam:
Gene Tree for LARP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LARP4: view image

Paralogs for LARP4 Gene

Paralogs for LARP4 Gene

(4) SIMAP similar genes for LARP4 Gene using alignment to 14 proteins:

  • LARP4_HUMAN
  • E5RHZ8_HUMAN
  • E5RJH8_HUMAN
  • F8VNV1_HUMAN
  • F8VSA9_HUMAN
  • F8VXL0_HUMAN
  • F8VY40_HUMAN
  • F8VZ60_HUMAN
  • F8W1I4_HUMAN
  • F8W1Z5_HUMAN
  • Q6P4E2_HUMAN
  • Q8TBL5_HUMAN
  • Q8WVX5_HUMAN
  • Q96J85_HUMAN

Pseudogenes.org Pseudogenes for LARP4 Gene

genes like me logo Genes that share paralogs with LARP4: view

Variants for LARP4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LARP4 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs17124706 - p.Phe351Leu
rs17124715 - p.Asn502Thr

Additional dbSNP identifiers (rs#s) for LARP4 Gene

Structural Variations from Database of Genomic Variants (DGV) for LARP4 Gene

Variant ID Type Subtype PubMed ID
dgv1498n100 CNV gain 25217958
dgv1499n100 CNV gain 25217958
esv2745871 CNV deletion 23290073
esv2761738 CNV gain 21179565
esv3629481 CNV loss 21293372
nsv1122732 CNV deletion 24896259
nsv1134229 CNV deletion 24896259
nsv1144624 CNV deletion 24896259
nsv469376 CNV loss 19166990
nsv470291 CNV gain 18288195
nsv558841 CNV loss 21841781
nsv973063 CNV duplication 23825009
nsv973064 CNV duplication 23825009

Variation tolerance for LARP4 Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LARP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LARP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARP4 Gene

Disorders for LARP4 Gene

Additional Disease Information for LARP4

No disorders were found for LARP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LARP4 Gene

Publications for LARP4 Gene

  1. La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability. (PMID: 21098120) Yang R … Maraia RJ (Molecular and cellular biology 2011) 2 3 4 54
  2. LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection. (PMID: 28895529) Mattijssen S … Maraia RJ (eLife 2017) 2 3 54
  3. The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives. (PMID: 28782243) Maraia RJ … Conte MR (Wiley interdisciplinary reviews. RNA 2017) 2 3 54
  4. The RNA-binding protein LARP4 regulates cancer cell migration and invasion. (PMID: 27615744) Seetharaman S … Ridley AJ (Cytoskeleton (Hoboken, N.J.) 2016) 3 4 54
  5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. (PMID: 21834987) Bai SW … Ridley AJ (BMC biology 2011) 3 4 54

Products for LARP4 Gene

Sources for LARP4 Gene