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Aliases for LARP4 Gene

Aliases for LARP4 Gene

  • La Ribonucleoprotein Domain Family Member 4 2 3 4 5
  • La Ribonucleoprotein Domain Family, Member 4 2
  • C-Mpl Binding Protein 3
  • La-Related Protein 4 3
  • PP13296 3

External Ids for LARP4 Gene

Previous GeneCards Identifiers for LARP4 Gene

  • GC12P049082
  • GC12P050794
  • GC12P047827

Summaries for LARP4 Gene

GeneCards Summary for LARP4 Gene

LARP4 (La Ribonucleoprotein Domain Family Member 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is LARP4B.

UniProtKB/Swiss-Prot for LARP4 Gene

  • RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744).

Gene Wiki entry for LARP4 Gene

Additional gene information for LARP4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LARP4 Gene

Genomics for LARP4 Gene

GeneHancer (GH) Regulatory Elements for LARP4 Gene

Promoters and enhancers for LARP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J050279 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 659.3 -110.3 -110301 5.3 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF766 ZNF207 ZNF143 LIMA1 LARP4 GC12P050283 CERS5 SMARCD1 ATF1 BCDIN3D FAM186A DIP2B GC12M050258
GH12J050399 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.4 +9.5 9500 4 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 ZNF610 ZNF585B NBN GC12M050402 LARP4 SMARCD1 LIMA1 BCDIN3D PRPF40B ATF1 ENSG00000257298 ENSG00000257964 LOC100422296
GH12J050389 Enhancer 0.9 Ensembl ENCODE 677.9 -1.9 -1866 1.6 PKNOX1 JUN RFX5 CTBP1 GATA3 POLR2A FOS FOSL2 MAFK DEK LARP4 LIMA1 COX14 FAM186A GC12P050366
GH12J050571 Enhancer 1.3 Ensembl ENCODE dbSUPER 24.9 +181.6 181561 5.2 ELF3 CLOCK FOXA2 MLX ARID4B MZF1 RAD21 RFX5 YY1 RCOR1 LARP4 DIP2B CERS5 SLC11A2 GC12P050634
GH12J050762 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.4 +372.4 372414 5.6 CLOCK FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 GLIS1 NBN NR2C1 ATF1 SMARCD1 HNRNPA3P10 BCDIN3D SLC11A2 TFCP2 SMAGP LIMA1 RNU6-1273P RNU6-769P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LARP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LARP4 gene promoter:
  • HNF-3beta
  • AREB6
  • C/EBPbeta
  • c-Ets-1
  • COMP1
  • AP-4
  • Arnt
  • E47
  • HEN1

Genomic Locations for LARP4 Gene

Genomic Locations for LARP4 Gene
chr12:50,392,383-50,480,005
(GRCh38/hg38)
Size:
87,623 bases
Orientation:
Plus strand
chr12:50,786,166-50,873,788
(GRCh37/hg19)
Size:
87,623 bases
Orientation:
Plus strand

Genomic View for LARP4 Gene

Genes around LARP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LARP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LARP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LARP4 Gene

Proteins for LARP4 Gene

  • Protein details for LARP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71RC2-LARP4_HUMAN
    Recommended name:
    La-related protein 4
    Protein Accession:
    Q71RC2
    Secondary Accessions:
    • A8K6T1
    • E9PDG5
    • G3XAA8
    • G5E976
    • Q5CZ97
    • Q6ZV14
    • Q96NF9

    Protein attributes for LARP4 Gene

    Size:
    724 amino acids
    Molecular mass:
    80596 Da
    Quaternary structure:
    • Interacts (via N-terminal region) with PABPC1 (PubMed:27615744, PubMed:21098120). Interacts with RACK1 (PubMed:21098120).
    SequenceCaution:
    • Sequence=BAC86052.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LARP4 Gene

    Alternative splice isoforms for LARP4 Gene

neXtProt entry for LARP4 Gene

Post-translational modifications for LARP4 Gene

  • Ubiquitination at posLast=372372 and posLast=280280
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LARP4 Gene

Domains & Families for LARP4 Gene

Gene Families for LARP4 Gene

Protein Domains for LARP4 Gene

Suggested Antigen Peptide Sequences for LARP4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LARP4: view

No data available for UniProtKB/Swiss-Prot for LARP4 Gene

Function for LARP4 Gene

Molecular function for LARP4 Gene

UniProtKB/Swiss-Prot Function:
RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744).

Phenotypes From GWAS Catalog for LARP4 Gene

Gene Ontology (GO) - Molecular Function for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IEA 22658674
GO:0005515 protein binding IPI 21098120
GO:0008143 poly(A) binding IDA 21098120
genes like me logo Genes that share ontologies with LARP4: view
genes like me logo Genes that share phenotypes with LARP4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LARP4 Gene

Localization for LARP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LARP4 Gene

Cytoplasm, Stress granule. Cytoplasm, cytosol. Note=Localized throughout the cytosol. Partially localized in stress granules in response to arsenite treatment. {ECO:0000269 PubMed:21098120}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LARP4 gene
Compartment Confidence
cytosol 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IDA 21098120
GO:0005844 colocalizes_with polysome IDA 21098120
GO:0010494 colocalizes_with cytoplasmic stress granule IEA,IDA 21098120
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with LARP4: view

Pathways & Interactions for LARP4 Gene

SuperPathways for LARP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LARP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0022604 regulation of cell morphogenesis IMP 21834987
GO:0045727 positive regulation of translation IMP 21098120
genes like me logo Genes that share ontologies with LARP4: view

No data available for Pathways by source and SIGNOR curated interactions for LARP4 Gene

Drugs & Compounds for LARP4 Gene

No Compound Related Data Available

Transcripts for LARP4 Gene

Unigene Clusters for LARP4 Gene

La ribonucleoprotein domain family, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LARP4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for LARP4 Gene

GeneLoc Exon Structure for
LARP4
ECgene alternative splicing isoforms for
LARP4

Expression for LARP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LARP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LARP4 Gene

This gene is overexpressed in Lung (30.0), Heart (22.3), and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LARP4 Gene



NURSA nuclear receptor signaling pathways regulating expression of LARP4 Gene:

LARP4

SOURCE GeneReport for Unigene cluster for LARP4 Gene:

Hs.26613

Evidence on tissue expression from TISSUES for LARP4 Gene

  • Bone marrow(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with LARP4: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LARP4 Gene

Orthologs for LARP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LARP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LARP4 34 33
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LARP4 34 33
  • 92.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LARP4 34 33
  • 91.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Larp4 16 34 33
  • 86.65 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910299 33
  • 84.75 (n)
oppossum
(Monodelphis domestica)
Mammalia LARP4 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LARP4 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves LARP4 34 33
  • 72.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LARP4 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia larp4 33
  • 66.43 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC797570 33
  • 57.29 (n)
larp4ab 34
  • 47 (a)
OneToMany
larp4aa 34
  • 45 (a)
OneToMany
Dr.25940 33
fruit fly
(Drosophila melanogaster)
Insecta CG11505 34
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea larp-5 34
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10553 34
  • 18 (a)
OneToMany
Species where no ortholog for LARP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LARP4 Gene

ENSEMBL:
Gene Tree for LARP4 (if available)
TreeFam:
Gene Tree for LARP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LARP4: view image

Paralogs for LARP4 Gene

Paralogs for LARP4 Gene

(4) SIMAP similar genes for LARP4 Gene using alignment to 14 proteins:

  • LARP4_HUMAN
  • E5RHZ8_HUMAN
  • E5RJH8_HUMAN
  • F8VNV1_HUMAN
  • F8VSA9_HUMAN
  • F8VXL0_HUMAN
  • F8VY40_HUMAN
  • F8VZ60_HUMAN
  • F8W1I4_HUMAN
  • F8W1Z5_HUMAN
  • Q6P4E2_HUMAN
  • Q8TBL5_HUMAN
  • Q8WVX5_HUMAN
  • Q96J85_HUMAN

Pseudogenes.org Pseudogenes for LARP4 Gene

genes like me logo Genes that share paralogs with LARP4: view

Variants for LARP4 Gene

Sequence variations from dbSNP and Humsavar for LARP4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000003071 -- 50,416,217(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000018827 -- 50,469,459(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000048544 -- 50,469,754(+) G/T genic_downstream_transcript_variant, intron_variant
rs1000051031 -- 50,439,508(+) T/C intron_variant
rs1000074919 -- 50,423,332(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LARP4 Gene

Variant ID Type Subtype PubMed ID
nsv973064 CNV duplication 23825009
nsv973063 CNV duplication 23825009
nsv558841 CNV loss 21841781
nsv470291 CNV gain 18288195
nsv469376 CNV loss 19166990
nsv1144624 CNV deletion 24896259
nsv1134229 CNV deletion 24896259
nsv1122732 CNV deletion 24896259
esv3629481 CNV loss 21293372
esv2761738 CNV gain 21179565
esv2745871 CNV deletion 23290073
dgv1499n100 CNV gain 25217958
dgv1498n100 CNV gain 25217958

Variation tolerance for LARP4 Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LARP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LARP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARP4 Gene

Disorders for LARP4 Gene

Additional Disease Information for LARP4

No disorders were found for LARP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LARP4 Gene

Publications for LARP4 Gene

  1. The RNA-binding protein LARP4 regulates cancer cell migration and invasion. (PMID: 27615744) Seetharaman S … Ridley AJ (Cytoskeleton (Hoboken, N.J.) 2016) 3 4 58
  2. La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability. (PMID: 21098120) Yang R … Maraia RJ (Molecular and cellular biology 2011) 3 4 58
  3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. (PMID: 21834987) Bai SW … Ridley AJ (BMC biology 2011) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58

Products for LARP4 Gene

Sources for LARP4 Gene

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