This gene encodes a protein containing domains found in the La related protein of Drosophila melanogaster. La motif-containing proteins are thought to be RNA-binding proteins, where the La motif and adjacent amino acids fold into an RNA recognition motif. The La motif is also found in proteins unrelated to the La protein. Alternative splicing has been observed at this locus and... See more...

Aliases for LARP1B Gene

Aliases for LARP1B Gene

  • La Ribonucleoprotein 1B 2 3
  • La Ribonucleoprotein Domain Family Member 1B 2 3 4 5
  • La Ribonucleoprotein Domain Family, Member 2 2 3
  • La-Related Protein 1B 3 4
  • La-Related Protein 2 3 4
  • LARP2 3 4
  • La Ribonucleoprotein Domain Family, Member 1B 2
  • La Ribonucleoprotein Domain Family Member 2 4

External Ids for LARP1B Gene

Previous HGNC Symbols for LARP1B Gene

  • LARP2

Previous GeneCards Identifiers for LARP1B Gene

  • GC04P129202
  • GC04P128983
  • GC04P124714

Summaries for LARP1B Gene

Entrez Gene Summary for LARP1B Gene

  • This gene encodes a protein containing domains found in the La related protein of Drosophila melanogaster. La motif-containing proteins are thought to be RNA-binding proteins, where the La motif and adjacent amino acids fold into an RNA recognition motif. The La motif is also found in proteins unrelated to the La protein. Alternative splicing has been observed at this locus and multiple variants, encoding distinct isoforms, are described. Additional splice variation has been identified but the full-length nature of these transcripts has not been determined. [provided by RefSeq, Jun 2013]

GeneCards Summary for LARP1B Gene

LARP1B (La Ribonucleoprotein 1B) is a Protein Coding gene. An important paralog of this gene is LARP1.

Additional gene information for LARP1B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LARP1B Gene

Genomics for LARP1B Gene

GeneHancer (GH) Regulatory Elements for LARP1B Gene

Promoters and enhancers for LARP1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J128059 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.4 435 3.8 HNRNPK SIN3A NRF1 POLR2G GTF2E2 PHF8 ZFX CTCF ZIC2 REST LARP1B lnc-MFSD8-7 INTU MFSD8 HSPA4L ABHD18 lnc-LARP1B-4 RPL15P8
GH04J128179 Promoter 0.3 EPDnew 500.1 +118.0 118049 0.1 LARP1B RF00994-772 FOSL1P1
GH04J128067 Enhancer 0.6 Ensembl 0.7 +4.9 4934 0.4 TEAD1 SAP130 NR2F6 TEAD3 ARID3A JUND CEBPG ZNF384 ATF7 SOX13 INTU LARP1B RPL15P8
GH04J128159 Enhancer 0.9 Ensembl ENCODE 0.1 +100.6 100569 6.1 TCF12 JUND FOS TCF7 FOXA1 CUX1 EP300 SMARCC2 TEAD1 CTCF HSPA4L INTU PGRMC2 FOSL1P1 RF00994-772 LARP1B
GH04J128191 Enhancer 0.9 Ensembl ENCODE 0.1 +130.3 130335 0.8 CTCF TCF12 REST RAD21 TRIM22 SMC3 ZNF263 KLF13 NBN IRF4 HSPA4L RF00994-772 MG828668-088 LARP1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LARP1B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LARP1B

Genomic Locations for LARP1B Gene

Genomic Locations for LARP1B Gene
chr4:128,061,266-128,222,931
(GRCh38/hg38)
Size:
161,666 bases
Orientation:
Plus strand
chr4:128,982,423-129,144,086
(GRCh37/hg19)
Size:
161,664 bases
Orientation:
Plus strand

Genomic View for LARP1B Gene

Genes around LARP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LARP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LARP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LARP1B Gene

Proteins for LARP1B Gene

  • Protein details for LARP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q659C4-LAR1B_HUMAN
    Recommended name:
    La-related protein 1B
    Protein Accession:
    Q659C4
    Secondary Accessions:
    • Q2YDB6
    • Q4W599
    • Q4W5B2
    • Q659A0
    • Q6P5X2
    • Q7Z3F7
    • Q86VK7
    • Q8N6F4
    • Q8N7H4
    • Q8NAF2
    • Q9H5E7
    • Q9NW12

    Protein attributes for LARP1B Gene

    Size:
    914 amino acids
    Molecular mass:
    105322 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH50654.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH50654.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB15679.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAH56379.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for LARP1B Gene

neXtProt entry for LARP1B Gene

Post-translational modifications for LARP1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LARP1B Gene

Domains & Families for LARP1B Gene

Gene Families for LARP1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LARP1B Gene

Suggested Antigen Peptide Sequences for LARP1B Gene

GenScript: Design optimal peptide antigens:
  • La-related protein 2 (LAR1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q659C4

UniProtKB/Swiss-Prot:

LAR1B_HUMAN :
  • Belongs to the LARP family.
Family:
  • Belongs to the LARP family.
genes like me logo Genes that share domains with LARP1B: view

Function for LARP1B Gene

Gene Ontology (GO) - Molecular Function for LARP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LARP1B: view
genes like me logo Genes that share phenotypes with LARP1B: view

Animal Model Products

CRISPR Products

miRNA for LARP1B Gene

miRTarBase miRNAs that target LARP1B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LARP1B Gene

Localization for LARP1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LARP1B gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LARP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with LARP1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LARP1B Gene

Pathways & Interactions for LARP1B Gene

PathCards logo

SuperPathways for LARP1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for LARP1B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LARP1B Gene

Drugs & Compounds for LARP1B Gene

No Compound Related Data Available

Transcripts for LARP1B Gene

mRNA/cDNA for LARP1B Gene

5 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LARP1B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2:
SP3:
SP4: -
SP5: -
SP6: -

Relevant External Links for LARP1B Gene

GeneLoc Exon Structure for
LARP1B

Expression for LARP1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LARP1B Gene

Protein differential expression in normal tissues from HIPED for LARP1B Gene

This gene is overexpressed in Testis (32.5), Plasma (12.2), Tlymphocyte (7.9), and Heart (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LARP1B Gene



Protein tissue co-expression partners for LARP1B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LARP1B

SOURCE GeneReport for Unigene cluster for LARP1B Gene:

Hs.657067

Evidence on tissue expression from TISSUES for LARP1B Gene

  • Liver(4.4)
  • Nervous system(4.4)
  • Intestine(4.2)
  • Lung(4.2)
  • Thyroid gland(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with LARP1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LARP1B Gene

Orthologs for LARP1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LARP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LARP1B 31 30
  • 99.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LARP1B 31 30
  • 92.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC515517 30
  • 91.89 (n)
LARP1B 31
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Larp1b 31 31
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LARP1B 31
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LARP1B 31 30
  • 75.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LARP1B 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia larp1b 30
  • 67.49 (n)
Str.20349 30
zebrafish
(Danio rerio)
Actinopterygii larp1b 31 30
  • 62.92 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta larp 31
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea larp-1 31
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRO9 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7357 30
barley
(Hordeum vulgare)
Liliopsida Hv.7702 30
wheat
(Triticum aestivum)
Liliopsida Ta.23156 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
Species where no ortholog for LARP1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for LARP1B Gene

ENSEMBL:
Gene Tree for LARP1B (if available)
TreeFam:
Gene Tree for LARP1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LARP1B: view image

Paralogs for LARP1B Gene

Paralogs for LARP1B Gene

(4) SIMAP similar genes for LARP1B Gene using alignment to 7 proteins:

  • LAR1B_HUMAN
  • D6R9W6_HUMAN
  • D6RJB0_HUMAN
  • G3V0E9_HUMAN
  • G3XAJ5_HUMAN
  • H0Y9B4_HUMAN
  • H0Y9K3_HUMAN
genes like me logo Genes that share paralogs with LARP1B: view

Variants for LARP1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LARP1B Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs193920764 Uncertain Significance: Malignant tumor of prostate 128,121,988(+) G/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs12508837 - p.Pro462Arg
rs12645577 - p.Arg660His

Additional dbSNP identifiers (rs#s) for LARP1B Gene

Structural Variations from Database of Genomic Variants (DGV) for LARP1B Gene

Variant ID Type Subtype PubMed ID
dgv5385n100 CNV gain 25217958
dgv9258n54 CNV loss 21841781
dgv9259n54 CNV gain 21841781
dgv9260n54 CNV loss 21841781
esv24873 CNV loss 19812545
esv2728292 CNV deletion 23290073
esv3602159 CNV loss 21293372
nsv1078542 CNV duplication 25765185
nsv473285 CNV novel sequence insertion 20440878
nsv595388 CNV gain 21841781
nsv595391 CNV gain 21841781
nsv595396 CNV loss 21841781
nsv955820 CNV deletion 24416366
nsv966317 CNV duplication 23825009
nsv966318 CNV duplication 23825009
nsv967794 CNV duplication 23825009

Variation tolerance for LARP1B Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LARP1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LARP1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARP1B Gene

Disorders for LARP1B Gene

Additional Disease Information for LARP1B

No disorders were found for LARP1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LARP1B Gene

Publications for LARP1B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. The La protein. (PMID: 12045101) Wolin SL … Cedervall T (Annual review of biochemistry 2002) 2 3 54
  3. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 54
  4. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54
  5. PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation. (PMID: 30209976) Choi J … Busino L (Cell cycle (Georgetown, Tex.) 2018) 3 54

Products for LARP1B Gene

Sources for LARP1B Gene