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Aliases for LARP1B Gene

Aliases for LARP1B Gene

  • La Ribonucleoprotein Domain Family Member 1B 2 3 4 5
  • La Ribonucleoprotein Domain Family, Member 2 2 3
  • La-Related Protein 2 3 4
  • LARP2 3 4
  • La Ribonucleoprotein Domain Family, Member 1B 2
  • La Ribonucleoprotein Domain Family Member 2 4
  • La-Related Protein 1B 3

External Ids for LARP1B Gene

Previous HGNC Symbols for LARP1B Gene

  • LARP2

Previous GeneCards Identifiers for LARP1B Gene

  • GC04P129202
  • GC04P128983
  • GC04P124714

Summaries for LARP1B Gene

Entrez Gene Summary for LARP1B Gene

  • This gene encodes a protein containing domains found in the La related protein of Drosophila melanogaster. La motif-containing proteins are thought to be RNA-binding proteins, where the La motif and adjacent amino acids fold into an RNA recognition motif. The La motif is also found in proteins unrelated to the La protein. Alternative splicing has been observed at this locus and multiple variants, encoding distinct isoforms, are described. Additional splice variation has been identified but the full-length nature of these transcripts has not been determined. [provided by RefSeq, Jun 2013]

GeneCards Summary for LARP1B Gene

LARP1B (La Ribonucleoprotein Domain Family Member 1B) is a Protein Coding gene. An important paralog of this gene is LARP1.

Additional gene information for LARP1B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LARP1B Gene

Genomics for LARP1B Gene

GeneHancer (GH) Regulatory Elements for LARP1B Gene

Promoters and enhancers for LARP1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I128059 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.3 287 3.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 GC04M128059 LARP1B HSPA4L INTU ABHD18 RPL15P8
GH04I128159 Enhancer 1 Ensembl ENCODE 0.1 +100.7 100718 5.8 ELF3 CTCF FOXA2 SAP130 JUN RAD21 RARA SMARCC2 FOSL2 NR2F6 HSPA4L INTU PGRMC2 FOSL1P1 LARP1B
GH04I128191 Enhancer 0.9 Ensembl ENCODE 0.1 +130.3 130335 0.8 HDGF CTCF PKNOX1 RB1 MZF1 EBF1 ZNF2 IRF4 RAD21 CC2D1A HSPA4L FOSL1P1 PGRMC2 LARP1B
GH04I128069 Enhancer 0.2 FANTOM5 0.4 +8.4 8401 0 RPL15P8 LARP1B FOSL1P1
GH04I128220 Enhancer 0.8 Ensembl ENCODE 0.1 +159.7 159659 1.7 CTCF PKNOX1 ZNF654 JUN RAD21 JUND FOXK2 HMBOX1 SMC3 NFE2 ABHD18 INTU PGRMC2 FOSL1P1 LARP1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LARP1B on UCSC Golden Path with GeneCards custom track

Genomic Locations for LARP1B Gene

Genomic Locations for LARP1B Gene
chr4:128,061,266-128,222,931
(GRCh38/hg38)
Size:
161,666 bases
Orientation:
Plus strand
chr4:128,982,423-129,144,086
(GRCh37/hg19)

Genomic View for LARP1B Gene

Genes around LARP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LARP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LARP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LARP1B Gene

Proteins for LARP1B Gene

  • Protein details for LARP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q659C4-LAR1B_HUMAN
    Recommended name:
    La-related protein 1B
    Protein Accession:
    Q659C4
    Secondary Accessions:
    • Q2YDB6
    • Q4W599
    • Q4W5B2
    • Q659A0
    • Q6P5X2
    • Q7Z3F7
    • Q86VK7
    • Q8N6F4
    • Q8N7H4
    • Q8NAF2
    • Q9H5E7
    • Q9NW12

    Protein attributes for LARP1B Gene

    Size:
    914 amino acids
    Molecular mass:
    105322 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH50654.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH50654.1; Type=Frameshift; Positions=753; Evidence={ECO:0000305}; Sequence=BAB15679.1; Type=Frameshift; Positions=721; Evidence={ECO:0000305}; Sequence=CAH56379.1; Type=Frameshift; Positions=113; Evidence={ECO:0000305};

    Alternative splice isoforms for LARP1B Gene

neXtProt entry for LARP1B Gene

Post-translational modifications for LARP1B Gene

No Post-translational modifications

No data available for DME Specific Peptides for LARP1B Gene

Domains & Families for LARP1B Gene

Gene Families for LARP1B Gene

Protein Domains for LARP1B Gene

Suggested Antigen Peptide Sequences for LARP1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q659C4

UniProtKB/Swiss-Prot:

LAR1B_HUMAN :
  • Belongs to the LARP family.
Family:
  • Belongs to the LARP family.
genes like me logo Genes that share domains with LARP1B: view

Function for LARP1B Gene

Gene Ontology (GO) - Molecular Function for LARP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LARP1B: view
genes like me logo Genes that share phenotypes with LARP1B: view

Animal Model Products

miRNA for LARP1B Gene

miRTarBase miRNAs that target LARP1B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LARP1B Gene

Localization for LARP1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LARP1B gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LARP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA,IDA 21630459
GO:0019013 viral nucleocapsid IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with LARP1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LARP1B Gene

Pathways & Interactions for LARP1B Gene

SuperPathways for LARP1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for LARP1B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LARP1B Gene

Drugs & Compounds for LARP1B Gene

No Compound Related Data Available

Transcripts for LARP1B Gene

Unigene Clusters for LARP1B Gene

La ribonucleoprotein domain family, member 1B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LARP1B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2:
SP3:
SP4: -
SP5: -
SP6: -

Relevant External Links for LARP1B Gene

GeneLoc Exon Structure for
LARP1B
ECgene alternative splicing isoforms for
LARP1B

Expression for LARP1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LARP1B Gene

Protein differential expression in normal tissues from HIPED for LARP1B Gene

This gene is overexpressed in Testis (32.5), Plasma (12.2), Tlymphocyte (7.9), and Heart (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LARP1B Gene



Protein tissue co-expression partners for LARP1B Gene

NURSA nuclear receptor signaling pathways regulating expression of LARP1B Gene:

LARP1B

SOURCE GeneReport for Unigene cluster for LARP1B Gene:

Hs.657067

Evidence on tissue expression from TISSUES for LARP1B Gene

  • Liver(4.4)
  • Nervous system(4.4)
  • Intestine(4.2)
  • Lung(4.2)
  • Thyroid gland(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with LARP1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LARP1B Gene

Orthologs for LARP1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LARP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LARP1B 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia LARP1B 33 34
  • 92.78 (n)
cow
(Bos Taurus)
Mammalia LOC515517 33
  • 91.89 (n)
LARP1B 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Larp1b 34 34
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LARP1B 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LARP1B 33 34
  • 75.83 (n)
lizard
(Anolis carolinensis)
Reptilia LARP1B 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia larp1b 33
  • 67.49 (n)
Str.20349 33
zebrafish
(Danio rerio)
Actinopterygii larp1b 33 34
  • 62.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta larp 34
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea larp-1 34
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRO9 36
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7357 33
barley
(Hordeum vulgare)
Liliopsida Hv.7702 33
wheat
(Triticum aestivum)
Liliopsida Ta.23156 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
Species where no ortholog for LARP1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for LARP1B Gene

ENSEMBL:
Gene Tree for LARP1B (if available)
TreeFam:
Gene Tree for LARP1B (if available)

Paralogs for LARP1B Gene

Paralogs for LARP1B Gene

(4) SIMAP similar genes for LARP1B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with LARP1B: view

Variants for LARP1B Gene

Sequence variations from dbSNP and Humsavar for LARP1B Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs193920764 uncertain-significance, Malignant tumor of prostate 128,121,988(+) G/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000011941 -- 128,095,754(+) C/G intron_variant
rs1000022508 -- 128,082,029(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000048762 -- 128,124,152(+) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000068431 -- 128,136,603(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LARP1B Gene

Variant ID Type Subtype PubMed ID
nsv967794 CNV duplication 23825009
nsv966318 CNV duplication 23825009
nsv966317 CNV duplication 23825009
nsv955820 CNV deletion 24416366
nsv595396 CNV loss 21841781
nsv595391 CNV gain 21841781
nsv595388 CNV gain 21841781
nsv473285 CNV novel sequence insertion 20440878
nsv1078542 CNV duplication 25765185
esv3602159 CNV loss 21293372
esv2728292 CNV deletion 23290073
esv24873 CNV loss 19812545
dgv9260n54 CNV loss 21841781
dgv9259n54 CNV gain 21841781
dgv9258n54 CNV loss 21841781
dgv5385n100 CNV gain 25217958

Variation tolerance for LARP1B Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LARP1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LARP1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARP1B Gene

Disorders for LARP1B Gene

Additional Disease Information for LARP1B

No disorders were found for LARP1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LARP1B Gene

Publications for LARP1B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The La protein. (PMID: 12045101) Wolin SL … Cedervall T (Annual review of biochemistry 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for LARP1B Gene

Sources for LARP1B Gene

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