Aliases for LARP1 Gene

Aliases for LARP1 Gene

  • La Ribonucleoprotein 1, Translational Regulator 2 3 5
  • La Ribonucleoprotein Domain Family Member 1 2 3 4
  • LARP 2 3 4
  • La-Related Protein 1 3 4
  • KIAA0731 2 4
  • Lar1 2 3
  • Lhp1 2 3
  • La Ribonucleoprotein Domain Family, Member 1 2
  • MGC19556 2
  • LARP1 5

External Ids for LARP1 Gene

Previous GeneCards Identifiers for LARP1 Gene

  • GC05P154073
  • GC05P154092
  • GC05P149234

Summaries for LARP1 Gene

GeneCards Summary for LARP1 Gene

LARP1 (La Ribonucleoprotein 1, Translational Regulator) is a Protein Coding gene. Diseases associated with LARP1 include Dengue Virus and Hepatocellular Carcinoma. Among its related pathways are Translational Control. Gene Ontology (GO) annotations related to this gene include translation initiation factor binding. An important paralog of this gene is LARP1B.

UniProtKB/Swiss-Prot Summary for LARP1 Gene

  • RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543).
  • (Microbial infection) Positively regulates the replication of dengue virus (DENV).

Gene Wiki entry for LARP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LARP1 Gene

Genomics for LARP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LARP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LARP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LARP1

Top Transcription factor binding sites by QIAGEN in the LARP1 gene promoter:
  • AML1a
  • AP-2gamma
  • Arnt
  • C/EBPalpha
  • Evi-1
  • HNF-3beta
  • Max1
  • MyoD
  • NF-1

Genomic Locations for LARP1 Gene

Latest Assembly
chr5:154,682,979-154,817,605
(GRCh38/hg38)
Size:
134,627 bases
Orientation:
Plus strand

Previous Assembly
chr5:154,062,539-154,197,165
(GRCh37/hg19 by Entrez Gene)
Size:
134,627 bases
Orientation:
Plus strand

chr5:154,092,462-154,197,167
(GRCh37/hg19 by Ensembl)
Size:
104,706 bases
Orientation:
Plus strand

Genomic View for LARP1 Gene

Genes around LARP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LARP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LARP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LARP1 Gene

Proteins for LARP1 Gene

  • Protein details for LARP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PKG0-LARP1_HUMAN
    Recommended name:
    La-related protein 1
    Protein Accession:
    Q6PKG0
    Secondary Accessions:
    • O94836
    • Q8N4M2
    • Q8NB73
    • Q9UFD7

    Protein attributes for LARP1 Gene

    Size:
    1096 amino acids
    Molecular mass:
    123510 Da
    Quaternary structure:
    • Interacts with PABPC1/PABP (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:23711370, PubMed:28650797). Interacts with EIF4A1 (PubMed:24532714). Interacts with RPTOR (PubMed:24532714, PubMed:25940091, PubMed:28650797). Recruited to the active mTORC1 complex via interaction with RPTOR (PubMed:25940091, PubMed:28650797). Inhibition of mTORC1 activity strongly reduces interaction with RPTOR and the mTORC1 complex (PubMed:25940091, PubMed:28650797). Identified in a complex with mRNA, PABPC1, EIF4E and EIF4G1 (PubMed:20430826, PubMed:28650797). Found in a complex with PABPC1 and SHFL (PubMed:26735137).
    SequenceCaution:
    • Sequence=AAH33856.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA34451.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LARP1 Gene

    Alternative splice isoforms for LARP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LARP1 Gene

Post-translational modifications for LARP1 Gene

  • Phosphorylated on multiple Ser and Thr residues in response to active mTORC1. Phosphorylation is important for interaction with RPTOR and the mTORC1 complex. Phosphorylation promotes dissociation from the 5'UTR of mRNA molecules with a 5'TOP motif.
  • Ubiquitination at Lys539, Lys753, Lys792, Lys805, Lys881, Lys944, Lys972, and Lys1017
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LARP1 Gene

Domains & Families for LARP1 Gene

Gene Families for LARP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LARP1 Gene

InterPro:
Blocks:
  • Cytochrome b5

Suggested Antigen Peptide Sequences for LARP1 Gene

GenScript: Design optimal peptide antigens:
  • La ribonucleoprotein domain family member 1 (LARP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6PKG0

UniProtKB/Swiss-Prot:

LARP1_HUMAN :
  • The C-terminal region mediates interaction with the mRNA and polysomes (PubMed:24532714, PubMed:26206669, PubMed:28379136). It is required for translational repression of mRNAs with a 5'TOP motif (PubMed:29244122).
  • Belongs to the LARP family.
Domain:
  • The C-terminal region mediates interaction with the mRNA and polysomes (PubMed:24532714, PubMed:26206669, PubMed:28379136). It is required for translational repression of mRNAs with a 5'TOP motif (PubMed:29244122).
  • The N-terminal region mediates interaction with PABPC1.
Family:
  • Belongs to the LARP family.
genes like me logo Genes that share domains with LARP1: view

Function for LARP1 Gene

Molecular function for LARP1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Positively regulates the replication of dengue virus (DENV).
UniProtKB/Swiss-Prot Induction:
Up-regulated in a number of hepatocellular carcinoma cell lines and liver cancer lesions, as well as in patients with hepatocellular carcinoma with a lower survival rate (at protein level).

Phenotypes From GWAS Catalog for LARP1 Gene

Gene Ontology (GO) - Molecular Function for LARP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding IDA 24532714
GO:0000340 RNA 7-methylguanosine cap binding IDA 28379136
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003730 mRNA 3'-UTR binding IDA 23711370
GO:0005515 protein binding IPI 20430826
genes like me logo Genes that share ontologies with LARP1: view
genes like me logo Genes that share phenotypes with LARP1: view

miRNA for LARP1 Gene

miRTarBase miRNAs that target LARP1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LARP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LARP1 Gene

Localization for LARP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LARP1 Gene

Cytoplasm. Cytoplasmic granule. Note=Colocalizes with RPTOR and PABPC1 in cytoplasmic granules that resemble stress granules. {ECO:0000269 PubMed:24532714, ECO:0000269 PubMed:25940091}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LARP1 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LARP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 20430826
GO:0005844 colocalizes_with polysome IDA 25940091
GO:0010494 cytoplasmic stress granule IDA 25940091
GO:0016020 membrane HDA 19946888
GO:0031931 colocalizes_with TORC1 complex IDA 24532714
genes like me logo Genes that share ontologies with LARP1: view

Pathways & Interactions for LARP1 Gene

PathCards logo

SuperPathways for LARP1 Gene

SuperPathway Contained pathways
1 Translational Control
genes like me logo Genes that share pathways with LARP1: view

Pathways by source for LARP1 Gene

1 Cell Signaling Technology pathway for LARP1 Gene

SIGNOR curated interactions for LARP1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for LARP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IMP 20430826
GO:0006417 regulation of translation IEA --
GO:0008283 cell proliferation IMP 24532714
GO:0010608 posttranscriptional regulation of gene expression IDA 26001795
genes like me logo Genes that share ontologies with LARP1: view

Drugs & Compounds for LARP1 Gene

No Compound Related Data Available

Transcripts for LARP1 Gene

mRNA/cDNA for LARP1 Gene

9 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LARP1

Alternative Splicing Database (ASD) splice patterns (SP) for LARP1 Gene

No ASD Table

Relevant External Links for LARP1 Gene

GeneLoc Exon Structure for
LARP1

Expression for LARP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LARP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LARP1 Gene

This gene is overexpressed in Lung (31.0) and Pancreas (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LARP1 Gene



Protein tissue co-expression partners for LARP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LARP1

SOURCE GeneReport for Unigene cluster for LARP1 Gene:

Hs.292078

Evidence on tissue expression from TISSUES for LARP1 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Skin(3.7)
  • Lung(3.5)
  • Intestine(3.1)
  • Eye(2.8)
  • Kidney(2.6)
  • Muscle(2.5)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with LARP1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LARP1 Gene

Orthologs for LARP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LARP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LARP1 29 30
  • 99.61 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LARP1 29 30
  • 93.73 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LARP1 29 30
  • 91.15 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Larp1 29 16 30
  • 90.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Larp1 29
  • 89.68 (n)
Oppossum
(Monodelphis domestica)
Mammalia LARP1 30
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LARP1 30
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LARP1 29 30
  • 78.15 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LARP1 30
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia larp1 29
  • 72.91 (n)
Zebrafish
(Danio rerio)
Actinopterygii larp1 29 30
  • 69.46 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta larp 30
  • 17 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea larp-1 30
  • 20 (a)
OneToMany
Corn
(Zea mays)
Liliopsida Zm.4402 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 52 (a)
ManyToMany
-- 30
  • 24 (a)
ManyToMany
Species where no ortholog for LARP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LARP1 Gene

ENSEMBL:
Gene Tree for LARP1 (if available)
TreeFam:
Gene Tree for LARP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LARP1: view image
Alliance of Genome Resources:
Additional Orthologs for LARP1

Paralogs for LARP1 Gene

Paralogs for LARP1 Gene

(4) SIMAP similar genes for LARP1 Gene using alignment to 11 proteins:

  • LARP1_HUMAN
  • E5RH50_HUMAN
  • E5RHK4_HUMAN
  • H0YAN4_HUMAN
  • H0YAX9_HUMAN
  • H0YBJ5_HUMAN
  • H0YBM7_HUMAN
  • H0YBR8_HUMAN
  • H0YBW1_HUMAN
  • H0YC33_HUMAN
  • H0YC73_HUMAN

Pseudogenes.org Pseudogenes for LARP1 Gene

genes like me logo Genes that share paralogs with LARP1: view

Variants for LARP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LARP1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs766635412 Likely Benign: not provided 154,793,826(+) G/A
NM_033551.3(LARP1):c.895G>A (p.Val299Met)
MISSENSE_VARIANT,INTRON
rs80111507 Benign: not provided 154,811,250(+) T/C
NM_033551.3(LARP1):c.2847T>C (p.Tyr949=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LARP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LARP1 Gene

Variant ID Type Subtype PubMed ID
dgv3198n106 CNV deletion 24896259
esv2730937 CNV deletion 23290073
esv3566846 CNV deletion 23714750
nsv1021153 CNV gain 25217958
nsv1074339 CNV deletion 25765185
nsv1123999 CNV deletion 24896259
nsv1140583 CNV deletion 24896259
nsv830521 CNV gain 17160897
nsv964965 CNV duplication 23825009

Variation tolerance for LARP1 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LARP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LARP1
Leiden Open Variation Database (LOVD)
LARP1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LARP1 Gene

Disorders for LARP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LARP1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
dengue virus
  • dengue virus, susceptibility to
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search LARP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LARP1

genes like me logo Genes that share disorders with LARP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LARP1 Gene

Publications for LARP1 Gene

  1. La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region. (PMID: 29244122) Philippe L … Thoreen CC (Nucleic acids research 2018) 2 3 4
  2. Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation. (PMID: 24532714) Tcherkezian J … Roux PP (Genes & development 2014) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  4. Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes. (PMID: 28673543) Gentilella A … Thomas G (Molecular cell 2017) 3 4
  5. La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs. (PMID: 28379136) Lahr RM … Berman AJ (eLife 2017) 3 4

Products for LARP1 Gene

Sources for LARP1 Gene