Aliases for LAPTM4B Gene
External Ids for LAPTM4B Gene
Previous GeneCards Identifiers for LAPTM4B Gene
GeneCards Summary for LAPTM4B Gene
LAPTM4B (Lysosomal Protein Transmembrane 4 Beta) is a Protein Coding gene. Diseases associated with LAPTM4B include Hepatocellular Carcinoma. Among its related pathways are Lysosome. An important paralog of this gene is LAPTM4A.
UniProtKB/Swiss-Prot for LAPTM4B Gene
Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).