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Aliases for LAP3 Gene

Aliases for LAP3 Gene

  • Leucine Aminopeptidase 3 2 3 4 5
  • Peptidase S 2 3 4
  • Proline Aminopeptidase 3 4
  • Leucyl Aminopeptidase 3 4
  • Prolyl Aminopeptidase 3 4
  • EC 4 56
  • LAP-3 3 4
  • LAPEP 3 4
  • PEPS 3 4
  • Epididymis Secretory Protein Li 106 3
  • Cytosol Aminopeptidase 3
  • EC 4
  • HEL-S-106 3
  • EC 3.4.11 56
  • LAP 3

External Ids for LAP3 Gene

Previous HGNC Symbols for LAP3 Gene

  • PEPS

Previous GeneCards Identifiers for LAP3 Gene

  • GC04P017393
  • GC04P017520
  • GC04P017267
  • GC04P017329
  • GC04P017255
  • GC04P016933

Summaries for LAP3 Gene

GeneCards Summary for LAP3 Gene

LAP3 (Leucine Aminopeptidase 3) is a Protein Coding gene. Diseases associated with LAP3 include Bacterial Vaginosis and Granulocytopenia. Among its related pathways are Arginine and proline metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include peptidase activity and aminopeptidase activity. An important paralog of this gene is NPEPL1.

UniProtKB/Swiss-Prot for LAP3 Gene

  • Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Additional gene information for LAP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAP3 Gene

Genomics for LAP3 Gene

GeneHancer (GH) Regulatory Elements for LAP3 Gene

Promoters and enhancers for LAP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I017575 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 603.9 +1.4 1438 5.3 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 IRF4 YY1 LAP3 MED28 ENSG00000249502 DCAF16 NCAPG QDPR LCORL GC04M017599
GH04I017613 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 34 +37.4 37409 2.4 CLOCK FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B MED28 ENSG00000249502 LAP3 DCAF16 QDPR
GH04I017616 Enhancer 0.4 ENCODE 34 +41.5 41505 4.6 FOXA2 POLR2A HLF PIR38754 LAP3 MED28 NCAPG DCAF16
GH04I017636 Enhancer 0.7 ENCODE 16.4 +59.6 59582 0.8 CTCF RB1 MZF1 ZNF384 ZIC2 ZNF48 RAD21 CTBP1 POLR2A ARID2 LAP3 FAM184B PIR38754 GC04P017652
GH04I017623 Enhancer 0.2 ENCODE 30.3 +46.4 46421 0.2 LAP3 DCAF16 NCAPG FAM184B PIR38754 MED28 GC04P017652
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LAP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LAP3 gene promoter:

Genomic Locations for LAP3 Gene

Genomic Locations for LAP3 Gene
30,781 bases
Plus strand

Genomic View for LAP3 Gene

Genes around LAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAP3 Gene

Proteins for LAP3 Gene

  • Protein details for LAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytosol aminopeptidase
    Protein Accession:
    Secondary Accessions:
    • B3KMQ3
    • Q6IAM6
    • Q6P0L6
    • Q9UQE3

    Protein attributes for LAP3 Gene

    519 amino acids
    Molecular mass:
    56166 Da
    Quaternary structure:
    • Homohexamer.

    Alternative splice isoforms for LAP3 Gene


neXtProt entry for LAP3 Gene

Selected DME Specific Peptides for LAP3 Gene


Post-translational modifications for LAP3 Gene

  • Ubiquitination at posLast=118118, isoforms=2188, and isoforms=2476

Other Protein References for LAP3 Gene

Antibody Products

  • Abcam antibodies for LAP3

Domains & Families for LAP3 Gene

Gene Families for LAP3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for LAP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M17 family.
  • Belongs to the peptidase M17 family.
genes like me logo Genes that share domains with LAP3: view

Function for LAP3 Gene

Molecular function for LAP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal amino acid, Xaa- -Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
UniProtKB/Swiss-Prot CatalyticActivity:
Release of N-terminal proline from a peptide.
UniProtKB/Swiss-Prot Function:
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Enzyme Numbers (IUBMB) for LAP3 Gene

Gene Ontology (GO) - Molecular Function for LAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity NAS 1908238
GO:0008233 peptidase activity IEA --
GO:0008235 metalloexopeptidase activity NAS 1908238
GO:0016787 hydrolase activity IEA --
GO:0030145 manganese ion binding IEA --
genes like me logo Genes that share ontologies with LAP3: view
genes like me logo Genes that share phenotypes with LAP3: view

Animal Models for LAP3 Gene

MGI Knock Outs for LAP3:

Animal Model Products

CRISPR Products

miRNA for LAP3 Gene

miRTarBase miRNAs that target LAP3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LAP3

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LAP3 Gene

Localization for LAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAP3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAP3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 4
lysosome 2
golgi apparatus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Midbody (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,HDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with LAP3: view

Pathways & Interactions for LAP3 Gene

genes like me logo Genes that share pathways with LAP3: view

Pathways by source for LAP3 Gene

Gene Ontology (GO) - Biological Process for LAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 1908238
GO:0019538 protein metabolic process IEA --
genes like me logo Genes that share ontologies with LAP3: view

No data available for SIGNOR curated interactions for LAP3 Gene

Drugs & Compounds for LAP3 Gene

(32) Drugs for LAP3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2430
Water Approved Pharma 0
Glycine Approved, Vet_approved Nutra Full agonist, Agonist 254
L-Cysteine Approved Nutra 0
L-Proline Approved Nutra 0

(20) Additional Compounds for LAP3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Cys-Gly
  • L-Cysteinylglycine
  • N-Cysteinyl Glycine
  • N-Cysteinyl-Glycine
  • N-L-Cysteinyl-Glycine
genes like me logo Genes that share compounds with LAP3: view

Transcripts for LAP3 Gene

Unigene Clusters for LAP3 Gene

Leucine aminopeptidase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LAP3

Alternative Splicing Database (ASD) splice patterns (SP) for LAP3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a ·
SP1: - - - - - - - -
SP2: -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: -
SP7: - - - -
SP10: - -

ExUns: 16b

Relevant External Links for LAP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LAP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LAP3 Gene

This gene is overexpressed in Liver, secretome (14.3) and Lymph node (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LAP3 Gene

Protein tissue co-expression partners for LAP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of LAP3 Gene:


SOURCE GeneReport for Unigene cluster for LAP3 Gene:


Evidence on tissue expression from TISSUES for LAP3 Gene

  • Nervous system(4.7)
  • Liver(4.6)
  • Lung(4.5)
  • Eye(4.3)
  • Kidney(3.3)
  • Intestine(2.7)
  • Skin(2.6)
  • Heart(2.4)
  • Muscle(2.4)
  • Blood(2.3)
  • Lymph node(2.1)
  • Spleen(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with LAP3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LAP3 Gene

Orthologs for LAP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LAP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LAP3 33 34
  • 99.23 (n)
(Canis familiaris)
Mammalia LAP3 33 34
  • 88.63 (n)
(Bos Taurus)
Mammalia LAP3 33 34
  • 88.44 (n)
(Mus musculus)
Mammalia Lap3 33 16 34
  • 86.77 (n)
(Rattus norvegicus)
Mammalia Lap3 33
  • 86.58 (n)
(Monodelphis domestica)
Mammalia LAP3 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia LAP3 34
  • 79 (a)
(Gallus gallus)
Aves LAP3 33 34
  • 71.26 (n)
(Anolis carolinensis)
Reptilia LAP3 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lap3 33
  • 70.92 (n)
(Danio rerio)
Actinopterygii lap3 33 34
  • 67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003869 33
  • 56.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6372 35
  • 43 (a)
CG13340 35
  • 40 (a)
CG18369 35
  • 40 (a)
CG4439 35
  • 40 (a)
S-Lap1 34
  • 40 (a)
S-Lap4 34
  • 40 (a)
CG4750 35
  • 39 (a)
S-Lap2 34
  • 39 (a)
loopin-1 34
  • 38 (a)
S-Lap3 34
  • 38 (a)
S-Lap7 34
  • 37 (a)
S-Lap8 34
  • 37 (a)
S-Lap5 34
  • 36 (a)
Dip-B 34
  • 16 (a)
(Caenorhabditis elegans)
Secernentea lap-2 34
  • 17 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G30920 33
  • 47.11 (n)
(Glycine max)
eudicotyledons Gma.18061 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2753 33
(Oryza sativa)
Liliopsida Os12g0434400 33
  • 47.27 (n)
Os.5433 33
(Hordeum vulgare)
Liliopsida Hv.429 33
(Triticum aestivum)
Liliopsida Ta.2854 33
(Zea mays)
Liliopsida Zm.4204 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC13A11.05 33
  • 50.9 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
-- 34
  • 14 (a)
Species where no ortholog for LAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for LAP3 Gene

Gene Tree for LAP3 (if available)
Gene Tree for LAP3 (if available)

Paralogs for LAP3 Gene

Paralogs for LAP3 Gene Pseudogenes for LAP3 Gene

genes like me logo Genes that share paralogs with LAP3: view

Variants for LAP3 Gene

Sequence variations from dbSNP and Humsavar for LAP3 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000091363 -- 17,576,921(+) AAAAAAA/AAAAAAAA upstream_transcript_variant
rs1000134747 -- 17,600,025(+) C/T intron_variant
rs1000145733 -- 17,589,058(+) G/A intron_variant
rs1000177339 -- 17,588,761(+) T/C intron_variant
rs10002358 -- 17,604,019(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LAP3 Gene

Variant ID Type Subtype PubMed ID
nsv593781 CNV gain 21841781
nsv289804 CNV deletion 16902084
esv3599780 CNV loss 21293372
esv2759228 CNV loss 17122850
esv2666830 CNV deletion 23128226

Variation tolerance for LAP3 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LAP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAP3 Gene

Disorders for LAP3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for LAP3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bacterial vaginosis
  • vaginosis, bacterial
  • agranulocytosis
vaginal disease
  • vaginal diseases
- elite association - COSMIC cancer census association via MalaCards
Search LAP3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LAP3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LAP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LAP3 Gene

Publications for LAP3 Gene

  1. Structural and immunological evidence for the identity of prolyl aminopeptidase with leucyl aminopeptidase. (PMID: 1908238) Matsushima M … Takahashi K (Biochemical and biophysical research communications 1991) 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for LAP3 Gene

  • Addgene plasmids for LAP3

Sources for LAP3 Gene

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