Aliases for LANCL3 Gene

Aliases for LANCL3 Gene

  • LanC Like 3 2 3 5
  • LanC-Like Protein 3 3 4
  • LanC Lantibiotic Synthetase Component C-Like 3 (Bacterial) 2
  • LanC Lantibiotic Synthetase Component C-Like 3 3

External Ids for LANCL3 Gene

Previous GeneCards Identifiers for LANCL3 Gene

  • GC0XP037188
  • GC0XP037315
  • GC0XP037431
  • GC0XP035177

Summaries for LANCL3 Gene

GeneCards Summary for LANCL3 Gene

LANCL3 (LanC Like 3) is a Protein Coding gene. An important paralog of this gene is LANCL1.

Additional gene information for LANCL3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LANCL3 Gene

Genomics for LANCL3 Gene

GeneHancer (GH) Regulatory Elements for LANCL3 Gene

Promoters and enhancers for LANCL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ037684 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.1 +114.2 114225 3.5 NRF1 ZNF10 POLR2A ZBTB11 ZBTB26 TOE1 MYC CTBP1 SREBF2 KDM5B XK LANCL3 ENSG00000285944 ENSG00000250349
GH0XJ037572 Promoter 1.2 EPDnew Ensembl 500.7 +0.8 832 2.4 CTCF ZBTB26 REST HINFP NFIC ZNF777 ZNF335 ZNF654 ZFP91 NRF1 LANCL3 piR-57176-685 ENSG00000250349
GH0XJ037652 Enhancer 1 Ensembl ENCODE 0.2 +81.5 81532 2.6 PHB2 HES1 MYC NFRKB ATF2 HDAC3 NCOR1 MBD2 NEUROD1 TRIM25 XK piR-38352-594 LANCL3 ENSG00000250349
GH0XJ037627 Enhancer 0.6 ENCODE 0.2 +56.3 56294 0.2 FOXA2 NR2F2 ZBTB33 JUND NR2F1 HDAC2 RAD21 RXRA MAX NR2F6 piR-33605-509 lnc-XK-1 LANCL3 ENSG00000250349
GH0XJ037643 Enhancer 0.7 Ensembl ENCODE 0.2 +73.2 73206 1.7 FOS CEBPB JUN JUND CEBPG ATF4 ZEB2 ATF3 ZNF692 XK piR-38352-594 piR-46002-613 LANCL3 ENSG00000250349
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LANCL3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LANCL3

Top Transcription factor binding sites by QIAGEN in the LANCL3 gene promoter:
  • AML1a
  • ATF6
  • Ik-3
  • LCR-F1
  • Pax-3
  • Pax-4a
  • Pax-5
  • POU6F1 (c2)
  • XBP-1

Genomic Locations for LANCL3 Gene

Genomic Locations for LANCL3 Gene
chrX:37,571,569-37,684,463
(GRCh38/hg38)
Size:
112,895 bases
Orientation:
Plus strand
chrX:37,430,822-37,543,716
(GRCh37/hg19)
Size:
112,895 bases
Orientation:
Plus strand

Genomic View for LANCL3 Gene

Genes around LANCL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LANCL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LANCL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LANCL3 Gene

Proteins for LANCL3 Gene

  • Protein details for LANCL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZV70-LANC3_HUMAN
    Recommended name:
    LanC-like protein 3
    Protein Accession:
    Q6ZV70
    Secondary Accessions:
    • A6NHE3

    Protein attributes for LANCL3 Gene

    Size:
    420 amino acids
    Molecular mass:
    46319 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LANCL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LANCL3 Gene

Post-translational modifications for LANCL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LANCL3 Gene

No data available for DME Specific Peptides for LANCL3 Gene

Domains & Families for LANCL3 Gene

Gene Families for LANCL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LANCL3 Gene

Suggested Antigen Peptide Sequences for LANCL3 Gene

GenScript: Design optimal peptide antigens:
  • LanC-like protein 3 (LANC3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZV70

UniProtKB/Swiss-Prot:

LANC3_HUMAN :
  • Belongs to the LanC-like protein family.
Family:
  • Belongs to the LanC-like protein family.
genes like me logo Genes that share domains with LANCL3: view

Function for LANCL3 Gene

Gene Ontology (GO) - Molecular Function for LANCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with LANCL3: view

Phenotypes for LANCL3 Gene

genes like me logo Genes that share phenotypes with LANCL3: view

Animal Model Products

CRISPR Products

miRNA for LANCL3 Gene

miRTarBase miRNAs that target LANCL3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LANCL3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LANCL3 Gene

Localization for LANCL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LANCL3 gene
Compartment Confidence
plasma membrane 3
cytosol 2
extracellular 1
nucleus 1
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LANCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with LANCL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LANCL3 Gene

Pathways & Interactions for LANCL3 Gene

PathCards logo

SuperPathways for LANCL3 Gene

No Data Available

Interacting Proteins for LANCL3 Gene

;

Gene Ontology (GO) - Biological Process for LANCL3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LANCL3 Gene

Drugs & Compounds for LANCL3 Gene

No Compound Related Data Available

Transcripts for LANCL3 Gene

mRNA/cDNA for LANCL3 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LANCL3

Alternative Splicing Database (ASD) splice patterns (SP) for LANCL3 Gene

No ASD Table

Relevant External Links for LANCL3 Gene

GeneLoc Exon Structure for
LANCL3

Expression for LANCL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LANCL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LANCL3 Gene

This gene is overexpressed in Spinal cord (31.6), Peripheral blood mononuclear cells (13.3), Platelet (7.1), and Colon (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LANCL3 Gene



Protein tissue co-expression partners for LANCL3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LANCL3

SOURCE GeneReport for Unigene cluster for LANCL3 Gene:

Hs.521932

Evidence on tissue expression from TISSUES for LANCL3 Gene

  • Heart(4.2)
  • Nervous system(4.1)
  • Lung(4)
genes like me logo Genes that share expression patterns with LANCL3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LANCL3 Gene

Orthologs for LANCL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LANCL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LANCL3 31 30
  • 99.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LANCL3 31 30
  • 92.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LANCL3 31 30
  • 91.9 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LANCL3 31
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lancl3 30
  • 88.97 (n)
mouse
(Mus musculus)
Mammalia Lancl3 17 31 30
  • 88.81 (n)
chicken
(Gallus gallus)
Aves LANCL3 31 30
  • 80.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LANCL3 31
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lancl3 30
  • 71.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNNB2 30
  • 53.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2061 31 30
  • 51.75 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 59 (a)
OneToOne
Species where no ortholog for LANCL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LANCL3 Gene

ENSEMBL:
Gene Tree for LANCL3 (if available)
TreeFam:
Gene Tree for LANCL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LANCL3: view image

Paralogs for LANCL3 Gene

Paralogs for LANCL3 Gene

(2) SIMAP similar genes for LANCL3 Gene using alignment to 1 proteins:

  • LANC3_HUMAN

Pseudogenes.org Pseudogenes for LANCL3 Gene

genes like me logo Genes that share paralogs with LANCL3: view

Variants for LANCL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LANCL3 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
781640 Benign: not provided 37,659,631(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for LANCL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for LANCL3 Gene

Variant ID Type Subtype PubMed ID
esv3576845 CNV gain 25503493
nsv1076705 CNV duplication 25765185
nsv1115859 CNV duplication 24896259
nsv1149128 CNV duplication 26484159
nsv479040 CNV novel sequence insertion 20440878

Variation tolerance for LANCL3 Gene

Gene Damage Index Score: 1.23; 24.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LANCL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LANCL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LANCL3 Gene

Disorders for LANCL3 Gene

Additional Disease Information for LANCL3

No disorders were found for LANCL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LANCL3 Gene

Publications for LANCL3 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for LANCL3 Gene

Sources for LANCL3 Gene