Aliases for LANCL2 Gene

Aliases for LANCL2 Gene

  • LanC Like 2 2 3 5
  • Testis-Specific Adriamycin Sensitivity Protein 2 3 4
  • LanC (Bacterial Lantibiotic Synthetase Component C)-Like 2 2 3
  • G Protein-Coupled Receptor 69B 2 3
  • LanC-Like Protein 2 3 4
  • GPR69B 3 4
  • TASP 3 4
  • LanC Lantibiotic Synthetase Component C-Like 2 (Bacterial) 2
  • LanC Lantibiotic Synthetase Component C-Like 2 3

External Ids for LANCL2 Gene

Previous HGNC Symbols for LANCL2 Gene

  • GPR69B

Previous GeneCards Identifiers for LANCL2 Gene

  • GC07P054897
  • GC07P055140
  • GC07P055175
  • GC07P055174
  • GC07P055207
  • GC07P055400
  • GC07P055433

Summaries for LANCL2 Gene

GeneCards Summary for LANCL2 Gene

LANCL2 (LanC Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and phosphatidylinositol-4-phosphate binding. An important paralog of this gene is LANCL1.

UniProtKB/Swiss-Prot Summary for LANCL2 Gene

  • Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.

Gene Wiki entry for LANCL2 Gene

Additional gene information for LANCL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LANCL2 Gene

Genomics for LANCL2 Gene

GeneHancer (GH) Regulatory Elements for LANCL2 Gene

Promoters and enhancers for LANCL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J055364 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.8 807 3.9 FOXK2 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G BCLAF1 LANCL2 lnc-VOPP1-7 SUMF2 LOC100129276
GH07J055312 Enhancer 0.3 Ensembl 12.4 -52.9 -52947 1 SPI1 piR-43583-504 piR-41399-435 piR-45504-502 piR-36393-482 piR-53562-364 piR-55655-520 LOC100129276 LANCL2 EGFR-AS1 EGFR
GH07J055713 Enhancer 0.6 Ensembl dbSUPER 4.9 +351.8 351753 7.6 CEBPG CEBPB ZNF766 piR-41195-056 piR-57133-548 PSPHP1 ZNF713 VOPP1 LANCL2 FKBP9P1 RF00017-6173 lnc-SEPT14-5
GH07J055336 Enhancer 0.2 Ensembl 12.7 -28.8 -28847 0.8 LOC100129276 LANCL2 lnc-LANCL2-5 piR-45504-502
GH07J055405 Enhancer 0.2 ENCODE 11.6 +40.6 40615 0.2 LANCL2 ENSG00000234707 SEC61G piR-36393-483 HSALNG0058183
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LANCL2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LANCL2

Top Transcription factor binding sites by QIAGEN in the LANCL2 gene promoter:
  • AREB6
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • POU2F1
  • POU2F1a
  • RP58
  • SRY

Genomic Locations for LANCL2 Gene

Genomic Locations for LANCL2 Gene
chr7:55,365,448-55,433,742
(GRCh38/hg38)
Size:
68,295 bases
Orientation:
Plus strand
chr7:55,433,141-55,501,435
(GRCh37/hg19)
Size:
68,295 bases
Orientation:
Plus strand

Genomic View for LANCL2 Gene

Genes around LANCL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LANCL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LANCL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LANCL2 Gene

Proteins for LANCL2 Gene

  • Protein details for LANCL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS86-LANC2_HUMAN
    Recommended name:
    LanC-like protein 2
    Protein Accession:
    Q9NS86
    Secondary Accessions:
    • B2R8D4
    • Q6NSL4
    • Q8TCQ3
    • Q9BSR1

    Protein attributes for LANCL2 Gene

    Size:
    450 amino acids
    Molecular mass:
    50854 Da
    Quaternary structure:
    • Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association.
    Miscellaneous:
    • Its exogenous expression in a sarcoma cell line decreases the expression of ABCB1 (P-glycoprotein 1) and increases cellular sensitivity to an anticancer drug (adriamycin).

neXtProt entry for LANCL2 Gene

Post-translational modifications for LANCL2 Gene

  • Myristoylated. Essential for membrane association.
  • Ubiquitination at Lys164
  • Modification sites at PhosphoSitePlus

Other Protein References for LANCL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LANCL2 Gene

Domains & Families for LANCL2 Gene

Gene Families for LANCL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LANCL2 Gene

Suggested Antigen Peptide Sequences for LANCL2 Gene

GenScript: Design optimal peptide antigens:
  • Testis-specific adriamycin sensitivity protein (LANC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NS86

UniProtKB/Swiss-Prot:

LANC2_HUMAN :
  • Belongs to the LanC-like protein family.
Family:
  • Belongs to the LanC-like protein family.
genes like me logo Genes that share domains with LANCL2: view

Function for LANCL2 Gene

Molecular function for LANCL2 Gene

UniProtKB/Swiss-Prot Function:
Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.

Phenotypes From GWAS Catalog for LANCL2 Gene

Gene Ontology (GO) - Molecular Function for LANCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 21044950
GO:0005524 ATP binding NAS 11762191
GO:0005525 GTP binding NAS 11762191
GO:0010314 phosphatidylinositol-5-phosphate binding IDA 16979580
genes like me logo Genes that share ontologies with LANCL2: view
genes like me logo Genes that share phenotypes with LANCL2: view

Animal Models for LANCL2 Gene

MGI Knock Outs for LANCL2:
  • Lancl2 Lancl2<tm2b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for LANCL2 Gene

miRTarBase miRNAs that target LANCL2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LANCL2 Gene

Localization for LANCL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LANCL2 Gene

Nucleus. Cytoplasm. Cell membrane. Note=Localizes to the juxta-nuclear vesicles (PubMed:16979580). Associates with the cortical actin cytoskeleton (PubMed:16979580). Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580). Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580). {ECO:0000269 PubMed:16979580}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LANCL2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LANCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 12566319
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 12566319
GO:0005886 plasma membrane IDA,IBA 12566319
genes like me logo Genes that share ontologies with LANCL2: view

Pathways & Interactions for LANCL2 Gene

PathCards logo

SuperPathways for LANCL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LANCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009789 positive regulation of abscisic acid-activated signaling pathway IDA 19667068
GO:0045892 negative regulation of transcription, DNA-templated IDA 12566319
genes like me logo Genes that share ontologies with LANCL2: view

No data available for Pathways by source and SIGNOR curated interactions for LANCL2 Gene

Drugs & Compounds for LANCL2 Gene

(3) Additional Compounds for LANCL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LANCL2: view

Transcripts for LANCL2 Gene

mRNA/cDNA for LANCL2 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LANCL2 Gene

No ASD Table

Relevant External Links for LANCL2 Gene

GeneLoc Exon Structure for
LANCL2

Expression for LANCL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LANCL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LANCL2 Gene

This gene is overexpressed in Frontal cortex (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LANCL2 Gene



Protein tissue co-expression partners for LANCL2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LANCL2

SOURCE GeneReport for Unigene cluster for LANCL2 Gene:

Hs.706612

mRNA Expression by UniProt/SwissProt for LANCL2 Gene:

Q9NS86-LANC2_HUMAN
Tissue specificity: Expressed in brain and testis.

Evidence on tissue expression from TISSUES for LANCL2 Gene

  • Liver(4.2)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with LANCL2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LANCL2 Gene

Orthologs for LANCL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LANCL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LANCL2 31 30
  • 99.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LANCL2 31 30
  • 88.32 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LANCL2 31 30
  • 88.06 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lancl2 17 31 30
  • 84.78 (n)
rat
(Rattus norvegicus)
Mammalia Lancl2 30
  • 84.56 (n)
oppossum
(Monodelphis domestica)
Mammalia LANCL2 31
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LANCL2 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves LANCL2 31 30
  • 76.49 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LANCL2 31
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lancl2 30
  • 72.17 (n)
zebrafish
(Danio rerio)
Actinopterygii lancl2 31 30
  • 69.12 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10119 30
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD28247 32
  • 35 (a)
CG2061 31
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GPCR 30
  • 48.13 (n)
rice
(Oryza sativa)
Liliopsida Os10g0497900 30
  • 53.28 (n)
Os.46469 30
wheat
(Triticum aestivum)
Liliopsida Ta.7258 30
barley
(Hordeum vulgare)
Liliopsida Hv.12135 30
bread mold
(Neurospora crassa)
Ascomycetes NCU08190 30
  • 43.49 (n)
Species where no ortholog for LANCL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for LANCL2 Gene

ENSEMBL:
Gene Tree for LANCL2 (if available)
TreeFam:
Gene Tree for LANCL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LANCL2: view image

Paralogs for LANCL2 Gene

Paralogs for LANCL2 Gene

(2) SIMAP similar genes for LANCL2 Gene using alignment to 2 proteins:

  • LANC2_HUMAN
  • H7BZ40_HUMAN
genes like me logo Genes that share paralogs with LANCL2: view

Variants for LANCL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LANCL2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
781899 Benign: not provided 55,412,005(+) A/G SYNONYMOUS_VARIANT
rs2272263 - p.Thr56Pro
rs6961412 - p.Ile74Val

Additional dbSNP identifiers (rs#s) for LANCL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for LANCL2 Gene

Variant ID Type Subtype PubMed ID
esv23398 CNV gain 19812545
esv2734425 CNV deletion 23290073
esv3613237 CNV gain 21293372
nsv818506 CNV gain 17921354

Variation tolerance for LANCL2 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LANCL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LANCL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LANCL2 Gene

Disorders for LANCL2 Gene

Additional Disease Information for LANCL2

No disorders were found for LANCL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LANCL2 Gene

Publications for LANCL2 Gene

  1. LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells. (PMID: 19667068) Sturla L … Zocchi E (The Journal of biological chemistry 2009) 2 3 4 54
  2. Myristoylation of human LanC-like protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin. (PMID: 16979580) Landlinger C … Prohaska R (Biochimica et biophysica acta 2006) 3 4 23 54
  3. Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism. (PMID: 12566319) Park S … James CD (Cancer research 2003) 3 4 23 54
  4. Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family. (PMID: 11762191) Mayer H … Prohaska R (DNA sequence : the journal of DNA sequencing and mapping 2001) 2 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for LANCL2 Gene

Sources for LANCL2 Gene