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Aliases for LANCL1 Gene

Aliases for LANCL1 Gene

  • LanC Like 1 2 3 5
  • LanC (Bacterial Lantibiotic Synthetase Component C)-Like 1 2 3
  • 40 KDa Erythrocyte Membrane Protein 3 4
  • GPR69A 3 4
  • P40 3 4
  • LanC Lantibiotic Synthetase Component C-Like 1 (Bacterial) 2
  • LanC (Bacterial Lantibiotic Synthetase Component) 3
  • LanC Lantibiotic Synthetase Component C-Like 1 3
  • G Protein-Coupled Receptor 69A 3
  • LanC-Like Protein 1 3

External Ids for LANCL1 Gene

Previous HGNC Symbols for LANCL1 Gene

  • GPR69A

Previous GeneCards Identifiers for LANCL1 Gene

  • GC02M209571
  • GC02M210020
  • GC02M211259
  • GC02M211498
  • GC02M211121
  • GC02M211004
  • GC02M203142

Summaries for LANCL1 Gene

Entrez Gene Summary for LANCL1 Gene

  • This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

GeneCards Summary for LANCL1 Gene

LANCL1 (LanC Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and low-density lipoprotein particle receptor binding. An important paralog of this gene is LANCL2.

UniProtKB/Swiss-Prot for LANCL1 Gene

  • May play a role in EPS8 signaling. Binds glutathione.

Additional gene information for LANCL1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LANCL1 Gene

Genomics for LANCL1 Gene

GeneHancer (GH) Regulatory Elements for LANCL1 Gene

Promoters and enhancers for LANCL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J210475 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.8 790 2.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 ZNF121 CPS1 LANCL1 GC02M210241
GH02J210452 Enhancer 0.4 dbSUPER 11.7 +21.6 21642 6.1 ZNF585B HLF RCOR1 CPS1 LANCL1 ENSG00000272807 LANCL1-AS1 GC02M210241
GH02J210503 Enhancer 0.9 Ensembl ENCODE 4.9 -26.3 -26303 1.5 CTCF USF1 MAX RAD21 RFX5 TEAD3 SMC3 ZNF143 ZNF444 MAFK CPS1 LANCL1 GC02M210562
GH02J210453 Enhancer 0.3 dbSUPER 11.7 +25.2 25191 0.9 RCOR1 LANCL1 CPS1 GC02M210241 LANCL1-AS1
GH02J210439 Enhancer 0.3 dbSUPER 11.6 +37.2 37215 1.9 HNF4A CPS1 LANCL1 GC02M210241 LANCL1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LANCL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LANCL1 gene promoter:
  • Pax-3
  • CBF-B
  • CBF-C
  • CP1A

Genomic Locations for LANCL1 Gene

Genomic Locations for LANCL1 Gene
46,404 bases
Minus strand
46,404 bases
Minus strand

Genomic View for LANCL1 Gene

Genes around LANCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LANCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LANCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LANCL1 Gene

Proteins for LANCL1 Gene

  • Protein details for LANCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LanC-like protein 1
    Protein Accession:

    Protein attributes for LANCL1 Gene

    399 amino acids
    Molecular mass:
    45283 Da
    Quaternary structure:
    • Interacts with the C-terminal of STOM. Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding. Interacts with P.falciparum SBP1.

    Three dimensional structures from OCA and Proteopedia for LANCL1 Gene

neXtProt entry for LANCL1 Gene

Post-translational modifications for LANCL1 Gene

  • Ubiquitination at Lys128
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LANCL1 Gene

Domains & Families for LANCL1 Gene

Gene Families for LANCL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LANCL1 Gene

Suggested Antigen Peptide Sequences for LANCL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LanC-like protein family.
  • Belongs to the LanC-like protein family.
genes like me logo Genes that share domains with LANCL1: view

Function for LANCL1 Gene

Molecular function for LANCL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in EPS8 signaling. Binds glutathione.

Gene Ontology (GO) - Molecular Function for LANCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 9512664
GO:0005515 protein binding IPI 19528316
GO:0008270 zinc ion binding IDA 19528316
GO:0017124 SH3 domain binding IPI 19528316
genes like me logo Genes that share ontologies with LANCL1: view
genes like me logo Genes that share phenotypes with LANCL1: view

Animal Models for LANCL1 Gene

MGI Knock Outs for LANCL1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LANCL1 Gene

Localization for LANCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LANCL1 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LANCL1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 3
cytosol 3
peroxisome 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LANCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IBA --
GO:0005887 NOT integral component of plasma membrane TAS,IDA 10944443
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with LANCL1: view

Pathways & Interactions for LANCL1 Gene

SuperPathways for LANCL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LANCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 NOT G-protein coupled receptor signaling pathway IDA,TAS 10944443
genes like me logo Genes that share ontologies with LANCL1: view

No data available for Pathways by source and SIGNOR curated interactions for LANCL1 Gene

Drugs & Compounds for LANCL1 Gene

(1) Additional Compounds for LANCL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LANCL1: view

Transcripts for LANCL1 Gene

mRNA/cDNA for LANCL1 Gene

Unigene Clusters for LANCL1 Gene

LanC lantibiotic synthetase component C-like 1 (bacterial):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LANCL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10

Relevant External Links for LANCL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LANCL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LANCL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LANCL1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.4).

Protein differential expression in normal tissues from HIPED for LANCL1 Gene

This gene is overexpressed in Frontal cortex (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LANCL1 Gene

Protein tissue co-expression partners for LANCL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LANCL1 Gene:


SOURCE GeneReport for Unigene cluster for LANCL1 Gene:


mRNA Expression by UniProt/SwissProt for LANCL1 Gene:

Tissue specificity: Detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta and spleen (at protein level). Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and testis.

Evidence on tissue expression from TISSUES for LANCL1 Gene

  • Nervous system(5)
  • Blood(4.2)
  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with LANCL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LANCL1 Gene

Orthologs for LANCL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LANCL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LANCL1 34 33
  • 99.42 (n)
(Bos Taurus)
Mammalia LANCL1 34 33
  • 89.06 (n)
(Canis familiaris)
Mammalia LANCL1 34 33
  • 88.89 (n)
(Mus musculus)
Mammalia Lancl1 16 34 33
  • 87.39 (n)
(Rattus norvegicus)
Mammalia Lancl1 33
  • 86.63 (n)
(Monodelphis domestica)
Mammalia LANCL1 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia LANCL1 34
  • 71 (a)
(Gallus gallus)
Aves LANCL1 34 33
  • 75.05 (n)
(Anolis carolinensis)
Reptilia LANCL1 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lancl1 33
  • 66.83 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC52973 33
(Danio rerio)
Actinopterygii lancl1 34 33
  • 64.74 (n)
Dr.1004 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8239 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003148 33
  • 46.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD28247 35
  • 35 (a)
CG2061 34
  • 31 (a)
Species where no ortholog for LANCL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LANCL1 Gene

Gene Tree for LANCL1 (if available)
Gene Tree for LANCL1 (if available)
Evolutionary constrained regions (ECRs) for LANCL1: view image

Paralogs for LANCL1 Gene

Paralogs for LANCL1 Gene

(2) SIMAP similar genes for LANCL1 Gene using alignment to 6 proteins:

  • H7C2E3_HUMAN
  • Q53TN2_HUMAN
genes like me logo Genes that share paralogs with LANCL1: view

Variants for LANCL1 Gene

Sequence variations from dbSNP and Humsavar for LANCL1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs111491997 benign, not specified 210,477,748(-) G/A upstream_transcript_variant
rs17552879 benign, not specified 210,477,778(-) G/A upstream_transcript_variant
rs1000098809 -- 210,465,277(-) A/G intron_variant
rs1000114454 -- 210,437,042(-) T/C intron_variant
rs1000180677 -- 210,476,736(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LANCL1 Gene

Variant ID Type Subtype PubMed ID
nsv1012567 CNV gain 25217958
nsv3147 CNV deletion 18451855

Variation tolerance for LANCL1 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LANCL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LANCL1 Gene

Disorders for LANCL1 Gene

Additional Disease Information for LANCL1

No disorders were found for LANCL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LANCL1 Gene

Publications for LANCL1 Gene

  1. Isolation, molecular characterization, and tissue-specific expression of a novel putative G protein-coupled receptor. (PMID: 9512664) Mayer H … Prohaska R (Biochimica et biophysica acta 1998) 2 3 4 22 58
  2. Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione. (PMID: 19528316) Zhang W … Zhang XC (Genes & development 2009) 3 4 22 58
  3. Organization and chromosomal localization of the human and mouse genes coding for LanC-like protein 1 (LANCL1). (PMID: 11474189) Mayer H … Prohaska R (Cytogenetics and cell genetics 2001) 3 4 22 58
  4. Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense. (PMID: 22891245) Zhong WX … Luo JH (The Journal of biological chemistry 2012) 2 3 58
  5. LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development. (PMID: 15811525) Blisnick T … Braun Breton C (Molecular and biochemical parasitology 2005) 4 22 58

Products for LANCL1 Gene

Sources for LANCL1 Gene

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