Aliases for LAMTOR5 Gene
External Ids for LAMTOR5 Gene
Previous HGNC Symbols for LAMTOR5 Gene
Previous GeneCards Identifiers for LAMTOR5 Gene
This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]
GeneCards Summary for LAMTOR5 Gene
LAMTOR5 (Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5) is a Protein Coding gene. Diseases associated with LAMTOR5 include Hepatitis B and Hepatitis. Among its related pathways are Cellular Senescence (REACTOME) and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and protein-containing complex scaffold activity.
UniProtKB/Swiss-Prot Summary for LAMTOR5 Gene
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.