Aliases for LAMTOR1 Gene
- Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1 2 3 5
- Protein Associated With DRMs And Endosomes 2 3 4
- Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 1 3 4
- P27kip1 Releasing Factor From RhoA 2 3
- P27Kip1-Releasing Factor From RhoA 3 4
- Lipid Raft Adaptor Protein P18 3 4
- P27RF-Rho 3 4
- C11orf59 3 4
External Ids for LAMTOR1 Gene
Previous HGNC Symbols for LAMTOR1 Gene
Previous GeneCards Identifiers for LAMTOR1 Gene
GeneCards Summary for LAMTOR1 Gene
LAMTOR1 (Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Translational Control. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and protein-containing complex scaffold activity.
UniProtKB/Swiss-Prot for LAMTOR1 Gene
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.