The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [p... See more...

Aliases for LAMP2 Gene

Aliases for LAMP2 Gene

  • Lysosomal Associated Membrane Protein 2 2 3 5
  • Lysosome-Associated Membrane Glycoprotein 2 3 4
  • CD107 Antigen-Like Family Member B 3 4
  • LAMP-2 3 4
  • LGP-96 3 4
  • Lysosomal-Associated Membrane Protein 2 2
  • Lysosome-Associated Membrane Protein 2 4
  • CD107b Antigen 4
  • CD107b 3
  • LGP110 3
  • LAMPB 3
  • DND 3

External Ids for LAMP2 Gene

Previous GeneCards Identifiers for LAMP2 Gene

  • GC0XM114382
  • GC0XM116550
  • GC0XM117540
  • GC0XM118318
  • GC0XM119346
  • GC0XM119448
  • GC0XM119560
  • GC0XM109011

Summaries for LAMP2 Gene

Entrez Gene Summary for LAMP2 Gene

  • The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for LAMP2 Gene

LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with LAMP2 include Danon Disease and Rare Cardiomyopathy. Among its related pathways are Innate Immune System and Autophagy - animal. Gene Ontology (GO) annotations related to this gene include enzyme binding and protein domain specific binding. An important paralog of this gene is LAMP1.

UniProtKB/Swiss-Prot Summary for LAMP2 Gene

  • Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
  • [Isoform LAMP-2C]: Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII.

Gene Wiki entry for LAMP2 Gene

Additional gene information for LAMP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LAMP2 Gene

Genomics for LAMP2 Gene

GeneHancer (GH) Regulatory Elements for LAMP2 Gene

Promoters and enhancers for LAMP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ120466 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 512.5 +1.2 1202 3.7 POLR2G SP1 PHF8 ZFX POLR2A ZBTB10 CLOCK ZBTB11 ZBTB26 ZBTB25 LAMP2 RF00017-8663 piR-35674-565
GH0XJ120628 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.1 -160.4 -160436 2.8 ZBTB40 ZNF217 NRF1 POLR2G SP1 ZNF639 ZIC2 POLR2A ZBTB10 CLOCK C1GALT1C1 lnc-C1GALT1C1-1 lnc-MCTS1-3 piR-35674-567 LAMP2 NKAPP1 UPF3B piR-35674-566
GH0XJ120456 Promoter/Enhancer 1.1 Ensembl ENCODE 13 +11.1 11136 2.8 ZNF217 ZSCAN5C ZNF639 POLR2A RUNX1 OSR2 CBFB FOS PBX2 STAT3 TMEM255A LAMP2 piR-35674-565 HSALNG0139847
GH0XJ120497 Enhancer 0.7 ENCODE 13.4 -28.8 -28846 0.2 CTCF REST RAD21 TRIM22 SMC3 ELF1 ZNF335 ZBTB48 IKZF1 ZNF654 LAMP2 RF00066-202
GH0XJ120446 Enhancer 0.4 Ensembl 23.9 +22.5 22539 0.7 JUND FOS CTCF TMEM255A LAMP2 ATP1B4 HSALNG0139847 piR-35674-565
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LAMP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LAMP2

Top Transcription factor binding sites by QIAGEN in the LAMP2 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • NCX
  • Nkx2-2
  • RFX1
  • TBP
  • TFIID

Genomic Locations for LAMP2 Gene

Genomic Locations for LAMP2 Gene
chrX:120,426,148-120,469,365
(GRCh38/hg38)
Size:
43,218 bases
Orientation:
Minus strand
chrX:119,560,003-119,603,220
(GRCh37/hg19)
Size:
43,218 bases
Orientation:
Minus strand

Genomic View for LAMP2 Gene

Genes around LAMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMP2 Gene

Proteins for LAMP2 Gene

  • Protein details for LAMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13473-LAMP2_HUMAN
    Recommended name:
    Lysosome-associated membrane glycoprotein 2
    Protein Accession:
    P13473
    Secondary Accessions:
    • A8K4X5
    • D3DTF0
    • Q16641
    • Q6Q3G8
    • Q96J30
    • Q99534
    • Q9UD93

    Protein attributes for LAMP2 Gene

    Size:
    410 amino acids
    Molecular mass:
    44961 Da
    Quaternary structure:
    • Monomer (PubMed:18644871, PubMed:25342746). Homodimer (PubMed:25342746). Homotrimer (PubMed:25342746). Forms large homooligomers (PubMed:18644871). Interacts (via its cytoplasmic region) with HSPA8 (PubMed:25342746). Interacts with HSP90 in the lysosome lumen; this enhances LAMP2 stability (By similarity). Interacts with MLLT11 (PubMed:24880125).

    Three dimensional structures from OCA and Proteopedia for LAMP2 Gene

    Alternative splice isoforms for LAMP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAMP2 Gene

Post-translational modifications for LAMP2 Gene

  • O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
  • Glycosylation at Asn32, Asn38, Asn49, Asn58, Asn75, Asn101, Asn123, Asn179, Ser195, Thr196, Thr200, Thr203, Thr204, Ser207, Thr209, Thr210, Thr211, Thr213, Asn229, Asn242, Asn257, Asn275, Asn300, Asn307, Asn317, and Asn356
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • LAMP2_HUMAN (356)

Other Protein References for LAMP2 Gene

Antibody Products

No data available for DME Specific Peptides for LAMP2 Gene

Domains & Families for LAMP2 Gene

Gene Families for LAMP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Plasma proteins
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for LAMP2 Gene

Blocks:
  • Lysosome-associated membrane glycoprotein (Lamp)/CD68
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LAMP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58780, highly similar to Homo sapiens lysosomal-associated membrane protein 2 (LAMP2), transcript variant LAMP2B, mRNA (B4E2S7_HUMAN)
  • cDNA FLJ52540, highly similar to Lysosome-associated membrane glycoprotein 2 (B7Z2R9_HUMAN)
  • CD107 antigen-like family member B (LAMP2_HUMAN)
  • Lamp-2 protein (Q6LDB5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P13473

UniProtKB/Swiss-Prot:

LAMP2_HUMAN :
  • Belongs to the LAMP family.
Family:
  • Belongs to the LAMP family.
genes like me logo Genes that share domains with LAMP2: view

Function for LAMP2 Gene

Molecular function for LAMP2 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
UniProtKB/Swiss-Prot Function:
[Isoform LAMP-2C]: Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII.
UniProtKB/Swiss-Prot Induction:
In peripheral blood B cells isoform LAMP-2A, LAMP-2B and LAMP-2C are up-regulated in response to treatments that stimulate immune responses via the Toll-like receptors TLR7 or TLR9.
GENATLAS Biochemistry:
lysosomal associated membrane protein 2

Phenotypes From GWAS Catalog for LAMP2 Gene

Gene Ontology (GO) - Molecular Function for LAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26212789
GO:0019899 enzyme binding IPI 22641697
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with LAMP2: view
genes like me logo Genes that share phenotypes with LAMP2: view

Human Phenotype Ontology for LAMP2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LAMP2 Gene

MGI Knock Outs for LAMP2:

Clone Products

  • Addgene plasmids for LAMP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LAMP2 Gene

Localization for LAMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMP2 Gene

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, autophagosome membrane. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAMP2 gene
Compartment Confidence
extracellular 5
endosome 5
lysosome 5
plasma membrane 4
golgi apparatus 4
cytoskeleton 3
endoplasmic reticulum 3
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25645918
GO:0005623 cell IEA --
GO:0005764 lysosome IEA,IDA 12536145
GO:0005765 lysosomal membrane IDA 15297306
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with LAMP2: view

Pathways & Interactions for LAMP2 Gene

genes like me logo Genes that share pathways with LAMP2: view

Pathways by source for LAMP2 Gene

Interacting Proteins for LAMP2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: P13473-LAMP2_HUMAN ENSP00000408411 for LAMP2 Gene via MINT STRING IID