Aliases for LAMP2 Gene
Aliases for LAMP2 Gene
External Ids for LAMP2 Gene
- HGNC: 6501
- Entrez Gene: 3920
- Ensembl: ENSG00000005893
- OMIM: 309060
- UniProtKB: P13473
Previous GeneCards Identifiers for LAMP2 Gene
- GC0XM114382
- GC0XM116550
- GC0XM117540
- GC0XM118318
- GC0XM119346
- GC0XM119448
- GC0XM119560
- GC0XM109011
Summaries for LAMP2 Gene
-
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for LAMP2 Gene
LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with LAMP2 include Danon Disease and Atrial Standstill 1. Among its related pathways are Phagosome and Innate Immune System. Gene Ontology (GO) annotations related to this gene include enzyme binding and protein domain specific binding. An important paralog of this gene is LAMP1.
UniProtKB/Swiss-Prot for LAMP2 Gene
-
Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
-
Isoform LAMP-2C: Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII.
Additional gene information for LAMP2 Gene
- Monarch Initiative
- Search for LAMP2 at DataMed
- Search for LAMP2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMP2 Gene
Genomics for LAMP2 Gene
GeneHancer (GH) Regulatory Elements for LAMP2 Gene
Promoters and enhancers for LAMP2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XJ120466 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 662.6 | +1.2 | 1224 | 3.6 | PKNOX1 SMAD1 ATF1 ARID4B SIN3A DMAP1 YY1 POLR2B ATF7 RUNX3 | LAMP2 CUL4B NKAPP1 NKAP EEF1A1P30 ATP1B4 | |
| GH0XJ120628 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 650.1 | -160.6 | -160636 | 2.3 | PKNOX1 SIN3A ZNF2 YY1 POLR2B ZNF207 ZNF143 SP3 NFYC REST | C1GALT1C1 LAMP2 CUL4B EEF1A1P30 NKAPP1 NKAP UPF3B MCTS1 | |
| GH0XJ120456 | Enhancer | 1 | Ensembl ENCODE | 13 | +11.1 | 11136 | 2.8 | PKNOX1 ATF1 INSM2 MZF1 FEZF1 ZNF366 ZSCAN5C SCRT2 ATF7 RUNX3 | TMEM255A LAMP2 ATP1B4 | |
| GH0XJ120497 | Enhancer | 0.9 | Ensembl ENCODE | 13.3 | -28.8 | -28835 | 0.8 | CTCF MZF1 RAD21 YY1 ZNF335 CC2D1A ZBTB48 ARID2 SCRT2 ZNF143 | LAMP2 GC0XM120505 | |
| GH0XJ120485 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE | 5.3 | -16.7 | -16744 | 2 | PKNOX1 CLOCK FOXA2 SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 CBX5 | LAMP2 ZBTB33 GC0XM120505 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around LAMP2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LAMP2 gene promoter:
-
- NCX
- TFIID
- TBP
- AP-2alpha isoform 3
- RFX1
- AP-2alpha
- AP-2alpha isoform 2
- AP-2alpha isoform 4
- AP-2alphaA
- Nkx2-2
Regulatory Element Products
Genomic Locations for LAMP2 Gene
Genomic Locations for LAMP2 Gene
- chrX:120,426,148-120,469,365
- (GRCh38/hg38)
- Size:
- 43,218 bases
- Orientation:
- Minus strand
- chrX:119,560,003-119,603,220
- (GRCh37/hg19)
- Size:
- 43,218 bases
- Orientation:
- Minus strand
Genomic View for LAMP2 Gene
Genes around LAMP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq24 by Entrez Gene
- Xq24 by HGNC
- Xq24 by Ensembl
LAMP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LAMP2 Gene
Proteins for LAMP2 Gene
-
Protein details for LAMP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13473-LAMP2_HUMAN
- Recommended name:
- Lysosome-associated membrane glycoprotein 2
- Protein Accession:
- P13473
- A8K4X5
- D3DTF0
- Q16641
- Q6Q3G8
- Q96J30
- Q99534
- Q9UD93
Protein attributes for LAMP2 Gene
- Size:
- 410 amino acids
- Molecular mass:
- 44961 Da
- Quaternary structure:
-
- Monomer (PubMed:18644871, PubMed:25342746). Homodimer (PubMed:25342746). Homotrimer (PubMed:25342746). Forms large homooligomers (PubMed:18644871). Interacts (via its cytoplasmic region) with HSPA8 (PubMed:25342746). Interacts with HSP90 in the lysosome lumen; this enhances LAMP2 stability (By similarity). Interacts with MLLT11 (PubMed:24880125).
Protein Expression for LAMP2 Gene
Post-translational modifications for LAMP2 Gene
- O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
- Glycosylation at isoforms=2, 3356, isoforms=2, 3317, Asn307, Asn300, Asn275, isoforms=2, 3257, isoforms=2, 3242, isoforms=2, 3229, isoforms=2, 3213, Thr211, isoforms=2, 3210, isoforms=2, 3209, isoforms=2, 3207, Thr204, isoforms=2, 3203, isoforms=2, 3200, Thr196, isoforms=2, 3195, Asn179, Asn123, isoforms=2, 3101, isoforms=2, 375, isoforms=2, 358, Asn49, isoforms=2, 338, and isoforms=2, 332
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- LAMP2_HUMAN (356)
Other Protein References for LAMP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for LAMP2 (LAMP-2/CD107b)
- Novus Biologicals Antibodies for LAMP2
- Invitrogen Antibodies for LAMP2
- antibodies-online: Search results for 429 available LAMP2 Antibodies ranked by validation data
- Compare Top LAMP2 Antibodies
-
Recommended
- 97 WB Antibodies (anti-mouse)
- 44 IP Antibodies (anti-mouse)
- 20 FACS Antibodies (anti-mouse)
- 18 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 210 WB Antibodies (anti-human)
- 41 FACS Antibodies (anti-human)
- 15 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 ICS Antibody (anti-human)
- 30 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
- GeneTex LAMP2 Antibody for LAMP2
-
Custom Antibody ServicesProSci Antibodies for LAMP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for LAMP2
- Sino Biological Antibodies for LAMP2
Protein Products
- R&D Systems Proteins and Enzymes for LAMP2 (LAMP-2/CD107b)
-
OriGene Purified Proteins for LAMP2
- Search Origene for MassSpec and Protein Over-expression Lysates for LAMP2
- Origene Custom Protein Services for LAMP2
- Sino Biological Recombinant Proteins for LAMP2
- Sino Biological Cell Lysates for LAMP2
- ProSpec Recombinant Proteins for LAMP2
- Search GeneTex for Proteins for LAMP2
-
ProSci Proteins for LAMP2
Assay Products
No data available for DME Specific Peptides for LAMP2 Gene
Domains & Families for LAMP2 Gene
Gene Families for LAMP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Disease related genes
- Plasma proteins
- Potential drug targets
- Predicted membrane proteins
- Transporters
Protein Domains for LAMP2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for LAMP2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58780, highly similar to Homo sapiens lysosomal-associated membrane protein 2 (LAMP2), transcript variant LAMP2B, mRNA (B4E2S7_HUMAN)
- cDNA FLJ52540, highly similar to Lysosome-associated membrane glycoprotein 2 (B7Z2R9_HUMAN)
- CD107 antigen-like family member B (LAMP2_HUMAN)
- Lamp-2 protein (Q6LDB5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P13473- Family:
-
- Belongs to the LAMP family.
Function for LAMP2 Gene
Molecular function for LAMP2 Gene
- UniProtKB/Swiss-Prot Function:
- Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
- UniProtKB/Swiss-Prot Function:
- Isoform LAMP-2C: Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII.
- UniProtKB/Swiss-Prot Induction:
- In peripheral blood B cells isoform LAMP-2A, LAMP-2B and LAMP-2C are up-regulated in response to treatments that stimulate immune responses via the Toll-like receptors TLR7 or TLR9.
- GENATLAS Biochemistry:
- lysosomal associated membrane protein 2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 26212789 |
| GO:0019899 | enzyme binding | IPI | 22641697 |
| GO:0019904 | protein domain specific binding | IEA | -- |
Phenotypes for LAMP2 Gene
- MGI mutant phenotypes for LAMP2:
-
inferred from 2 alleles
- cardiovascular system phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for LAMP2:
Animal Models for LAMP2 Gene
- MGI Knock Outs for LAMP2:
-
- Lamp2 Lamp2<tm1Psa>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for LAMP2
-
CRISPR Products
-
OriGene CRISPR knockouts for LAMP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LAMP2
- genomics-online: gRNA clones - Search results for 178 available LAMP2 gene related products
- Overview of 178 available LAMP2 gene related products
- Applied Biological Materials CRISPR for LAMP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LAMP2
- GenScript: Design CRISPR guide RNA sequences for LAMP2
miRNA for LAMP2 Gene
- miRTarBase miRNAs that target LAMP2
-
- hsa-mir-124-3p (MIRT022427)
- hsa-mir-103a-3p (MIRT027054)
- hsa-mir-21-5p (MIRT030821)
- hsa-mir-16-5p (MIRT031571)
- hsa-mir-7151-3p (MIRT509161)
- hsa-mir-5095 (MIRT509162)
- hsa-mir-4537 (MIRT509163)
- hsa-mir-6849-3p (MIRT509164)
- hsa-mir-6746-3p (MIRT509165)
- hsa-mir-4438 (MIRT509166)
- hsa-mir-4279 (MIRT522771)
- hsa-mir-3152-3p (MIRT522772)
- hsa-mir-6838-5p (MIRT522773)
- hsa-mir-497-5p (MIRT522774)
- hsa-mir-424-5p (MIRT522775)
- hsa-mir-195-5p (MIRT522776)
- hsa-mir-15b-5p (MIRT522777)
- hsa-mir-15a-5p (MIRT522778)
- hsa-mir-451b (MIRT522779)
- hsa-mir-606 (MIRT522780)
- hsa-mir-377-3p (MIRT625868)
- hsa-mir-8485 (MIRT625869)
- hsa-mir-548c-3p (MIRT633570)
- hsa-mir-1276 (MIRT636470)
- hsa-mir-32-5p (MIRT727322)
- hsa-mir-92b-3p (MIRT727323)
- hsa-mir-92a-3p (MIRT727324)
- hsa-mir-27a-3p (MIRT731462)
- hsa-mir-140-3p (MIRT762629)
- hsa-mir-3914 (MIRT767635)
- hsa-mir-873-5p (MIRT782490)
- hsa-mir-548aj-5p (MIRT787432)
- hsa-mir-548f-5p (MIRT787525)
- hsa-mir-548g-5p (MIRT787532)
- hsa-mir-548p (MIRT787568)
- hsa-mir-548x-5p (MIRT787593)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LAMP2
- Browse OriGene Inhibitory RNA Products For LAMP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LAMP2
- genomics-online: shRNA clones - Search results for 178 available LAMP2 gene related products
- Overview of 178 available LAMP2 gene related products
Clone Products
-
OriGene ORF clones in human for LAMP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LAMP2
- VectorBuilder custom plasmid, inducible vectors for LAMP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LAMP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LAMP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LAMP2
- Applied Biological Materials Clones for LAMP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for LAMP2 (LAMP-2/CD107b)
Cell Line Products
-
Horizon Cell Lines for LAMP2
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for LAMP2 Gene
Localization for LAMP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LAMP2 Gene
- Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, autophagosome membrane. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| lysosome | 5 |
| endosome | 5 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 25645918 |
| GO:0005764 | lysosome | IDA | 12536145 |
| GO:0005765 | lysosomal membrane | IDA | 15297306 |
| GO:0005768 | endosome | IEA | -- |
| GO:0005770 | late endosome | IDA | 15229288 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for LAMP2 Gene
Pathways & Interactions for LAMP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 2 | Innate Immune System |
.61
|
|
| 3 | Autophagy - animal | ||
| 4 | Lysosome |
-
|
|
| 5 | Phagosome | ||
Pathways by source for LAMP2 Gene
1 BioSystems pathway for LAMP2 Gene
7 Reactome pathways for LAMP2 Gene
4 KEGG pathways for LAMP2 Gene
1 R&D Systems pathway for LAMP2 Gene
Interacting Proteins for LAMP2 Gene
Selected Interacting proteins:
P13473-LAMP2_HUMAN
ENSP00000408411
for LAMP2 Gene via
IID
MINT
STRING
GPS-Prot Interaction Network for LAMP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0006605 | protein targeting | ISS | -- |
| GO:0006914 | autophagy | IEA | -- |
| GO:0009267 | cellular response to starvation | ISS | -- |
| GO:0017038 | protein import | TAS | 20176123 |
No data available for SIGNOR curated interactions for LAMP2 Gene
Transcripts for LAMP2 Gene
mRNA/cDNA for LAMP2 Gene
- (3) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (809) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000200639 1867 bps (uc004est.5)
- ENST00000371335 4030 bps (uc010nqp.2)
- ENST00000434600 2089 bps (uc004ess.5)
- ENST00000486593 1069 bps (uc065axq.1)
Unigene Clusters for LAMP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for LAMP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LAMP2
- genomics-online: gRNA clones - Search results for 178 available LAMP2 gene related products
- Overview of 178 available LAMP2 gene related products
- Applied Biological Materials CRISPR for LAMP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LAMP2
- GenScript: Design CRISPR guide RNA sequences for LAMP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LAMP2
- Browse OriGene Inhibitory RNA Products For LAMP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LAMP2
- genomics-online: shRNA clones - Search results for 178 available LAMP2 gene related products
- Overview of 178 available LAMP2 gene related products
Clone Products
-
OriGene ORF clones in human for LAMP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LAMP2
- VectorBuilder custom plasmid, inducible vectors for LAMP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LAMP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LAMP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LAMP2
- Applied Biological Materials Clones for LAMP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for LAMP2 (LAMP-2/CD107b)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||
| SP2: | - | - | - | - | - | ||||||||
| SP3: | |||||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: | - | - | |||||||||||
| SP13: |
Expression for LAMP2 Gene
This gene is overexpressed in Neutrophil (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LAMP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of LAMP2 Gene:
LAMP2SOURCE GeneReport for Unigene cluster for LAMP2 Gene:
Hs.496684mRNA Expression by UniProt/SwissProt for LAMP2 Gene:
P13473-LAMP2_HUMAN
Tissue specificity:
Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle (PubMed:7488019, PubMed:26856698). Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver (PubMed:7488019, PubMed:26856698). Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta (PubMed:26856698).
Evidence on tissue expression from TISSUES for LAMP2 Gene
- Nervous system(5)
- Liver(4.6)
- Bone marrow(4.3)
- Kidney(4)
- Lung(3.6)
- Skin(3.5)
- Pancreas(3.3)
- Blood(2.8)
- Muscle(2.8)
- Heart(2.7)
- Spleen(2.5)
- Intestine(2.4)
- Lymph node(2.3)
- Gall bladder(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for LAMP2 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cranial nerve
- ear
- eye
- head
Thorax:
- heart
- heart valve
Limb:
- foot
- lower limb
- upper limb
General:
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs and template standards for LAMP2
-
OriGene qPCR primer pairs for LAMP2
- genomics-online: primer clones - Search results for 178 available LAMP2 gene related products
- Overview of 178 available LAMP2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for LAMP2 Gene
Orthologs for LAMP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LAMP2 33 |
|
||
| dog (Canis familiaris) |
Mammalia | LAMP2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | LAMP2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Lamp2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Lamp2 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | LAMP2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | LAMP2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LAMP2 34 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | lamp2 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.30895 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | lamp2 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Lamp1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for LAMP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for LAMP2 Gene
- ENSEMBL:
- Gene Tree for LAMP2 (if available)
- TreeFam:
- Gene Tree for LAMP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LAMP2: view image
Paralogs for LAMP2 Gene
Variants for LAMP2 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1004327482 | uncertain-significance, Hypertrophic cardiomyopathy, Danon disease | 120,430,132(-) | T/A | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
| rs10127182 | likely-benign, Hypertrophic cardiomyopathy, Danon disease | 120,428,863(-) | T/C/G | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
| rs10127185 | likely-benign, Hypertrophic cardiomyopathy, Danon disease | 120,428,928(-) | T/C | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1024440041 | uncertain-significance, Danon disease, Hypertrophic cardiomyopathy | 120,429,651(-) | G/A | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1029569080 | uncertain-significance, Danon disease | 120,431,416(-) | C/T | coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv528786 | CNV | gain | 19592680 |
| esv3559258 | CNV | deletion | 23714750 |
| esv2758889 | CNV | loss | 17122850 |
| esv2740433 | CNV | deletion | 23290073 |
| esv2659227 | CNV | deletion | 23128226 |
Residual Variation Intolerance Score:
37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.95;
19.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LAMP2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMP2 Gene
Disorders for LAMP2 Gene
(12) MalaCards diseases for LAMP2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| danon disease |
|
|
| atrial standstill 1 |
|
|
| glycogen storage disease ii |
|
|
| phosphatase, acid, of tissues |
|
|
| myopathy, x-linked, with excessive autophagy |
|
|
Search LAMP2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LAMP2_HUMAN- Danon disease (DAND) [MIM:300257]: DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. {ECO:0000269 PubMed:15673802, ECO:0000269 PubMed:15907287}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for LAMP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for LAMP2 Gene
Publications for LAMP2 Gene
- Glycogen storage diseases presenting as hypertrophic cardiomyopathy. (PMID: 15673802) Arad M … Seidman JG (The New England journal of medicine 2005) 3 4 22 58
- Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene. (PMID: 15907287) Musumeci O … Toscano A (Neuromuscular disorders : NMD 2005) 3 4 22 58
- Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2. (PMID: 16190986) Eskelinen EL … Saftig P (Traffic (Copenhagen, Denmark) 2005) 3 4 22 58
- The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones. (PMID: 2243102) Carlsson SR … Fukuda M (The Journal of biological chemistry 1990) 3 4 22 58
- LAMP-2C Inhibits MHC Class II Presentation of Cytoplasmic Antigens by Disrupting Chaperone-Mediated Autophagy. (PMID: 26856698) Pérez L … Blum JS (Journal of immunology (Baltimore, Md. : 1950) 2016) 3 4 58
Products for LAMP2 Gene
- R&D Systems Antibodies for LAMP2 (LAMP-2/CD107b)
- R&D Systems Proteins and Enzymes for LAMP2 (LAMP-2/CD107b)
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for LAMP2 (LAMP-2/CD107b)
- Browse Human Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for LAMP2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for LAMP2
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- Browse OriGene Inhibitory RNA Products For LAMP2
- OriGene qPCR primer pairs and template standards for LAMP2
- OriGene qPCR primer pairs for LAMP2
- OriGene CRISPR knockouts for LAMP2
- OriGene ORF clones in human for LAMP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LAMP2
- GenScript: Next-day shipping of latest version cDNA ORF clones for LAMP2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for LAMP2
- GenScript Custom Assay Services for LAMP2
- GenScript Custom overexpressing Cell Line Services for LAMP2
- GenScript: Design CRISPR guide RNA sequences for LAMP2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for LAMP2
- Sino Biological Human cDNA Clone for LAMP2
- Sino Biological Recombinant Proteins for LAMP2
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- Sino Biological Antibodies for LAMP2
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for LAMP2
- Novus Biologicals lysates and proteins for LAMP2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for LAMP2
- VectorBuilder custom plasmid, inducible vectors for LAMP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LAMP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LAMP2
- antibodies-online: Search results for 429 available LAMP2 Antibodies ranked by validation data
- Compare Top LAMP2 Antibodies
- Recommended
- 97 WB Antibodies (anti-mouse)
- 44 IP Antibodies (anti-mouse)
- 20 FACS Antibodies (anti-mouse)
- 18 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 210 WB Antibodies (anti-human)
- 41 FACS Antibodies (anti-human)
- 15 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 ICS Antibody (anti-human)
- 30 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
- antibodies-online: Search results for 18 available LAMP2 Elisa Kits ranked by validation data
- Compare Top LAMP2 Elisa Kits
- antibodies-online: Search results for 27 available LAMP2 Proteins ranked by validation data
- Compare Top LAMP2 Proteins
- GeneTex LAMP2 Antibody for LAMP2
- Search GeneTex for Proteins for LAMP2
- Santa Cruz Biotechnology (SCBT) Antibodies for LAMP2
- Search Santa Cruz Biotechnology (SCBT) for LAMP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LAMP2
- Custom Antibody ServicesProSci Antibodies for LAMP2
- ProSci Proteins for LAMP2
- Horizon Cell Lines for LAMP2
- genomics-online: cdna clones - Search results for 178 available LAMP2 gene related products
- Overview of 178 available LAMP2 gene related products
- orf clones - Search results for 178 available LAMP2 gene related products
- Overview of 178 available LAMP2 gene related products
- genomics-online: gRNA clones - Search results for 178 available LAMP2 gene related products
- Overview of 178 available LAMP2 gene related products
- genomics-online: primer clones - Search results for 178 available LAMP2 gene related products
- Overview of 178 available LAMP2 gene related products
- genomics-online: shRNA clones - Search results for 178 available LAMP2 gene related products
- Overview of 178 available LAMP2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LAMP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LAMP2
- GeneCopoeia miRNA 3'UTR Target clone products for LAMP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LAMP2
Sources for LAMP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt