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The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [p... See more...
Aliases for LAMP2 Gene
Aliases for LAMP2 Gene
External Ids for LAMP2 Gene
- HGNC: 6501
- Entrez Gene: 3920
- Ensembl: ENSG00000005893
- OMIM: 309060
- UniProtKB: P13473
Previous GeneCards Identifiers for LAMP2 Gene
- GC0XM114382
- GC0XM116550
- GC0XM117540
- GC0XM118318
- GC0XM119346
- GC0XM119448
- GC0XM119560
- GC0XM109011
Summaries for LAMP2 Gene
-
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for LAMP2 Gene
LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with LAMP2 include Danon Disease and Rare Cardiomyopathy. Among its related pathways are Lysosome and Tuberculosis. Gene Ontology (GO) annotations related to this gene include enzyme binding and protein domain specific binding. An important paralog of this gene is LAMP1.
UniProtKB/Swiss-Prot Summary for LAMP2 Gene
-
Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
-
[Isoform LAMP-2C]: Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII.
Additional gene information for LAMP2 Gene
- HGNC(6501)
- Entrez Gene(3920)
- Ensembl(ENSG00000005893)
- OMIM(309060)
- UniProtKB(P13473)
- Open Targets Platform(ENSG00000005893)
- Monarch Initiative
- Search for LAMP2 at DataMed
- Search for LAMP2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LAMP2 Gene
Genomics for LAMP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LAMP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LAMP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LAMP2
- Top Transcription factor binding sites by QIAGEN in the LAMP2 gene promoter:
-
- AP-2alpha
- AP-2alpha isoform 2
- AP-2alpha isoform 3
- AP-2alpha isoform 4
- AP-2alphaA
- NCX
- Nkx2-2
- RFX1
- TBP
- TFIID
Genomic Locations for LAMP2 Gene
Genomic Locations for LAMP2 Gene
- chrX:120,426,148-120,469,365
- (GRCh38/hg38)
- Size:
- 43,218 bases
- Orientation:
- Minus strand
- chrX:119,560,003-119,603,220
- (GRCh37/hg19)
- Size:
- 43,218 bases
- Orientation:
- Minus strand
Genomic View for LAMP2 Gene
Genes around LAMP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq24 by HGNC
- Xq24 by Entrez Gene
- Xq24 by Ensembl
LAMP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LAMP2 Gene
Proteins for LAMP2 Gene
-
Protein details for LAMP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13473-LAMP2_HUMAN
- Recommended name:
- Lysosome-associated membrane glycoprotein 2
- Protein Accession:
- P13473
- A8K4X5
- D3DTF0
- Q16641
- Q6Q3G8
- Q96J30
- Q99534
- Q9UD93
Protein attributes for LAMP2 Gene
- Size:
- 410 amino acids
- Molecular mass:
- 44961 Da
- Quaternary structure:
-
- Monomer (PubMed:18644871, PubMed:25342746). Homodimer (PubMed:25342746). Homotrimer (PubMed:25342746). Forms large homooligomers (PubMed:18644871). Interacts (via its cytoplasmic region) with HSPA8 (PubMed:25342746). Interacts with HSP90 in the lysosome lumen; this enhances LAMP2 stability (By similarity). Interacts with MLLT11 (PubMed:24880125).
Protein Expression for LAMP2 Gene
Post-translational modifications for LAMP2 Gene
- O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
-
Glycosylation at Asn32, Asn38, Asn49, Asn58, Asn75, Asn101, Asn123, Asn179, Ser195, Thr196, Thr200, Thr203, Thr204, Ser207, Thr209, Thr210, Thr211, Thr213, Asn229, Asn242, Asn257, Asn275, Asn300, Asn307, Asn317, and Asn356
- NX_P13473 (NX_P13473-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- LAMP2_HUMAN (356)
Other Protein References for LAMP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ LAMP2 Antibody
-
SouthernBiotech
- Mouse Anti-Human CD107b-SPRD
- Mouse Anti-Human CD107b-UNLB
- Mouse Anti-Human CD107b-AF647
- Mouse Anti-Human CD107b-BIOT
- Mouse Anti-Human CD107b-PE (9840-09)
- Mouse Anti-Human CD107b-FITC (9840-02)
- Mouse Anti-Human CD107b-AF488
- Mouse Anti-Human CD107b-FITC (9840-02S)
- Mouse Anti-Human CD107b-PACBLU
- Mouse Anti-Human CD107b-PE (9840-09S)
- Mouse Anti-Human CD107b-AF700
- GeneTex Anti-LAMP2A antibody and Anti-LAMP2 antibody
- NSJ Bioreagents LAMP2 Antibody (Mouse Monoclonal)
-
BioLegend
- CD107b (LAMP-2) Antibody (354303)
- CD107b (LAMP-2) Antibody (354305)
- CD107b (LAMP-2) Antibody (354304)
- CD107b (LAMP-2) Antibody (354306)
- CD107b (LAMP-2) Antibody (354301)
- CD107b (LAMP-2) Antibody (354302)
- CD107b (LAMP-2) Antibody (354310)
- CD107b (LAMP-2) Antibody (354309)
- CD107b (LAMP-2) Antibody (354312)
- CD107b (LAMP-2) Antibody (354311)
- CD107b (LAMP-2) Antibody (354308)
- CD107b (LAMP-2) Antibody (354307)
-
Custom Antibody ServicesOriGene Antibodies for LAMP2
- Novus Biologicals Antibodies for LAMP2
- Invitrogen Antibodies for LAMP2 (AFLGC-LAMP2)
- antibodies-online: Show 176 available LAMP2 Antibodies ranked by validation data
- Compare Top LAMP2 Antibodies
-
Recommended
- 250 WB Antibodies (anti-human)
- 28 FACS Antibodies (anti-human)
- 15 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC (fro) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 ICS Antibody (anti-human)
- 124 WB Antibodies (anti-mouse)
- 42 IP Antibodies (anti-mouse)
- 28 FACS Antibodies (anti-mouse)
- 13 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 2 IHC (fro) Antibodies (anti-mouse)
- 35 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for LAMP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for LAMP2
- Sino Biological Antibodies for LAMP2
Protein Products
- G Biosciences Human LAMP2/CD107b, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for LAMP2
- Origene Custom Protein Services for LAMP2
- Sino Biological Recombinant Proteins for LAMP2
- Sino Biological Cell Lysates for LAMP2
- ProSpec Recombinant Proteins for LAMP2
-
ProSci Proteins for LAMP2
No data available for DME Specific Peptides for LAMP2 Gene
Domains & Families for LAMP2 Gene
Gene Families for LAMP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Disease related genes
- Plasma proteins
- Potential drug targets
- Predicted membrane proteins
- Transporters
Protein Domains for LAMP2 Gene
- InterPro:
- Blocks:
-
- Lysosome-associated membrane glycoprotein (Lamp)/CD68
- ProtoNet:
Suggested Antigen Peptide Sequences for LAMP2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58780, highly similar to Homo sapiens lysosomal-associated membrane protein 2 (LAMP2), transcript variant LAMP2B, mRNA (B4E2S7_HUMAN)
- cDNA FLJ52540, highly similar to Lysosome-associated membrane glycoprotein 2 (B7Z2R9_HUMAN)
- CD107 antigen-like family member B (LAMP2_HUMAN)
- Lamp-2 protein (Q6LDB5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P13473- Family:
-
- Belongs to the LAMP family.
Function for LAMP2 Gene
Molecular function for LAMP2 Gene
- UniProtKB/Swiss-Prot Function:
- Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
- UniProtKB/Swiss-Prot Function:
- [Isoform LAMP-2C]: Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII.
- UniProtKB/Swiss-Prot Induction:
- In peripheral blood B cells isoform LAMP-2A, LAMP-2B and LAMP-2C are up-regulated in response to treatments that stimulate immune responses via the Toll-like receptors TLR7 or TLR9.
- GENATLAS Biochemistry:
- lysosomal associated membrane protein 2
Phenotypes From GWAS Catalog for LAMP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 26212789 |
| GO:0019899 | enzyme binding | IPI | 22641697 |
| GO:0019904 | protein domain specific binding | IEA | -- |
Phenotypes for LAMP2 Gene
- MGI mutant phenotypes for LAMP2:
-
inferred from 2 alleles
- nervous system phenotype
- immune system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for LAMP2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- shRNA abundance <= 50%
- Increased gamma-H2AX phosphorylation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased shRNA abundance (Z-score > 2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
Animal Models for LAMP2 Gene
- MGI Knock Outs for LAMP2:
-
- Lamp2 Lamp2<tm1Psa>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LAMP2 - Select products 50% OFF >
- * LAMP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LAMP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for LAMP2
miRNA for LAMP2 Gene
- miRTarBase miRNAs that target LAMP2
-
- hsa-miR-124-3p (MIRT022427)
- hsa-miR-103a-3p (MIRT027054)
- hsa-miR-21-5p (MIRT030821)
- hsa-miR-16-5p (MIRT031571)
- hsa-miR-7151-3p (MIRT509161)
- hsa-miR-5095 (MIRT509162)
- hsa-miR-4537 (MIRT509163)
- hsa-miR-6849-3p (MIRT509164)
- hsa-miR-6746-3p (MIRT509165)
- hsa-miR-4438 (MIRT509166)
- hsa-miR-4279 (MIRT522771)
- hsa-miR-3152-3p (MIRT522772)
- hsa-miR-6838-5p (MIRT522773)
- hsa-miR-497-5p (MIRT522774)
- hsa-miR-424-5p (MIRT522775)
- hsa-miR-195-5p (MIRT522776)
- hsa-miR-15b-5p (MIRT522777)
- hsa-miR-15a-5p (MIRT522778)
- hsa-miR-451b (MIRT522779)
- hsa-miR-606 (MIRT522780)
- mmu-miR-145a-5p (MIRT582723)
- mmu-miR-448-5p (MIRT582724)
- hsa-miR-377-3p (MIRT625868)
- hsa-miR-8485 (MIRT625869)
- hsa-miR-548c-3p (MIRT633570)
- hsa-miR-1276 (MIRT636470)
- hsa-miR-32-5p (MIRT727322)
- hsa-miR-92b-3p (MIRT727323)
- hsa-miR-92a-3p (MIRT727324)
- hsa-miR-27a-3p (MIRT731462)
- hsa-miR-140-3p (MIRT762629)
- hsa-miR-3914 (MIRT767635)
- hsa-miR-873-5p (MIRT782490)
- hsa-miR-548aj-5p (MIRT787432)
- hsa-miR-548f-5p (MIRT787525)
- hsa-miR-548g-5p (MIRT787532)
- hsa-miR-548p (MIRT787568)
- hsa-miR-548x-5p (MIRT787593)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LAMP2
- Browse OriGene Inhibitory RNA Products For LAMP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LAMP2
Clone Products
- Applied Biological Materials (abm): Clones for LAMP2 - Select products 50% OFF >
- * LAMP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG222875
- MG222878
- MR222875
- MR222875L3
- MR222875L4
- MR222878
- MR222878L1
- MR222878L2
- MR222878L3
- MR222878L4
- MR229796
- RC200456
- RC200456L1
- RC200456L2
- RC200456L3
- RC200456L4
- RC221216
- RC221216L1
- RC221216L2
- RC221216L3
- RC221216L4
- RC225644
- RC225644L3
- RC225644L4
- RG200456
- RG221216
- RG225644
- RR206761
- RR206761L3
- RR206761L4
- MR222875L3V
- MR222875L4V
- MR222878L1V
- MR222878L2V
- MR222878L3V
- MR222878L4V
- RC200456L1V
- RC200456L2V
- RC200456L3V
- RC200456L4V
- RC221216L1V
- RC221216L2V
- RC221216L3V
- RC221216L4V
- RC225644L3V
- RC225644L4V
- RR206761L3V
- RR206761L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LAMP2
- Addgene plasmids for LAMP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LAMP2
Cell Line Products
-
Horizon Cell Lines for LAMP2
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LAMP2 Gene
Localization for LAMP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LAMP2 Gene
- Cell membrane. Single-pass type I membrane protein. Endosome membrane. Single-pass type I membrane protein. Lysosome membrane. Single-pass type I membrane protein. Cytoplasmic vesicle, autophagosome membrane. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endosome | 5 |
| lysosome | 5 |
| plasma membrane | 4 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| endoplasmic reticulum | 3 |
| mitochondrion | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| cytosol | 2 |
- Plasma membrane (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000421 | autophagosome membrane | IEA | -- |
| GO:0005615 | extracellular space | IDA | 25645918 |
| GO:0005623 | cell | IEA | -- |
| GO:0005764 | lysosome | IEA,IDA | 12536145 |
| GO:0005765 | lysosomal membrane | IDA | 15297306 |
Pathways & Interactions for LAMP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 2 | Innate Immune System |
.61
|
|
| 3 | Autophagy - animal | ||
| 4 | Lysosome |
-
|
|
| 5 | Phagosome | ||
Pathways by source for LAMP2 Gene
1 BioSystems pathway for LAMP2 Gene
7 Reactome pathways for LAMP2 Gene
4 KEGG pathways for LAMP2 Gene
1 R&D Systems pathway for LAMP2 Gene
Interacting Proteins for LAMP2 Gene
Selected Interacting proteins:
P13473-LAMP2_HUMAN
ENSP00000408411
for LAMP2 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for LAMP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0006605 | protein targeting | ISS | -- |
| GO:0006914 | autophagy | IEA | -- |
| GO:0009267 | cellular response to starvation | IBA,ISS | -- |
| GO:0017038 | protein import | TAS | 20176123 |
No data available for SIGNOR curated interactions for LAMP2 Gene
Drugs & Compounds for LAMP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- G Biosciences Human LAMP2/CD107b, Lyophilized
Transcripts for LAMP2 Gene
mRNA/cDNA for LAMP2 Gene
- 3 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000200639 6535 nts (view in UCSC)
- ENST00000371335 4030 nts (view in UCSC)
- ENST00000434600 2089 nts (view in UCSC)
- ENST00000486593 1069 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LAMP2 - Select products 50% OFF >
- * LAMP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LAMP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for LAMP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LAMP2
- Browse OriGene Inhibitory RNA Products For LAMP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LAMP2
Clone Products
- Applied Biological Materials (abm): Clones for LAMP2 - Select products 50% OFF >
- * LAMP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG222875
- MG222878
- MR222875
- MR222875L3
- MR222875L4
- MR222878
- MR222878L1
- MR222878L2
- MR222878L3
- MR222878L4
- MR229796
- RC200456
- RC200456L1
- RC200456L2
- RC200456L3
- RC200456L4
- RC221216
- RC221216L1
- RC221216L2
- RC221216L3
- RC221216L4
- RC225644
- RC225644L3
- RC225644L4
- RG200456
- RG221216
- RG225644
- RR206761
- RR206761L3
- RR206761L4
- MR222875L3V
- MR222875L4V
- MR222878L1V
- MR222878L2V
- MR222878L3V
- MR222878L4V
- RC200456L1V
- RC200456L2V
- RC200456L3V
- RC200456L4V
- RC221216L1V
- RC221216L2V
- RC221216L3V
- RC221216L4V
- RC225644L3V
- RC225644L4V
- RR206761L3V
- RR206761L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LAMP2
- Addgene plasmids for LAMP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LAMP2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||
| SP2: | - | - | - | - | - | ||||||||
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Relevant External Links for LAMP2 Gene
- GeneLoc Exon Structure for
- LAMP2
Expression for LAMP2 Gene
This gene is overexpressed in Neutrophil (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LAMP2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LAMP2
SOURCE GeneReport for Unigene cluster for LAMP2 Gene:
Hs.496684mRNA Expression by UniProt/SwissProt for LAMP2 Gene:
P13473-LAMP2_HUMAN
Tissue specificity:
Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle (PubMed:7488019, PubMed:26856698). Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver (PubMed:7488019, PubMed:26856698). Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta (PubMed:26856698).
Evidence on tissue expression from TISSUES for LAMP2 Gene
- Nervous system(5)
- Liver(4.7)
- Bone marrow(4.6)
- Kidney(4.2)
- Skin(4)
- Lung(3.9)
- Pancreas(3.7)
- Blood(3.4)
- Muscle(3.1)
- Heart(3.1)
- Intestine(3.1)
- Spleen(3)
- Lymph node(2.9)
- Stomach(2.6)
- Thyroid gland(2.6)
- Adrenal gland(2.5)
- Eye(2.2)
- Gall bladder(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for LAMP2 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cranial nerve
- ear
- eye
- head
Thorax:
- heart
- heart valve
Limb:
- foot
- lower limb
- upper limb
General:
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs for LAMP2
-
OriGene qPCR primer pairs and template standards for LAMP2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for LAMP2 Gene
Orthologs for LAMP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LAMP2 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | LAMP2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LAMP2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Lamp2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Lamp2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | LAMP2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | LAMP2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LAMP2 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lamp2 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.30895 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | lamp2 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Lamp1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for LAMP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for LAMP2 Gene
- ENSEMBL:
- Gene Tree for LAMP2 (if available)
- TreeFam:
- Gene Tree for LAMP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LAMP2: view image
Paralogs for LAMP2 Gene
Variants for LAMP2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LAMP2 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 180873 | Uncertain Significance: Danon disease | 120,447,845(-) | T/C | MISSENSE_VARIANT | |
| 636417 | Likely Pathogenic: not provided | 120,447,913(-) | A/C | NONSENSE | |
| 636442 | Likely Pathogenic: not provided | 120,446,334(-) | TG/T | FRAMESHIFT_VARIANT | |
| 636563 | Uncertain Significance: not provided | 120,448,957(-) | A/T | INTRON_VARIANT | |
| 641626 | Uncertain Significance: Danon disease | 120,455,566(-) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2659227 | CNV | deletion | 23128226 |
| esv2740433 | CNV | deletion | 23290073 |
| esv2758889 | CNV | loss | 17122850 |
| esv3559258 | CNV | deletion | 23714750 |
| nsv528786 | CNV | gain | 19592680 |
Residual Variation Intolerance Score:
37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.95;
19.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LAMP2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMP2 Gene
Disorders for LAMP2 Gene
(27) MalaCards diseases for LAMP2 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| danon disease |
|
|
| rare cardiomyopathy |
|
|
| atrial standstill 1 |
|
|
| hypertrophic cardiomyopathy |
|
|
| dilated cardiomyopathy |
|
Search LAMP2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LAMP2_HUMAN- Danon disease (DAND) [MIM:300257]: DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. {ECO:0000269 PubMed:15673802, ECO:0000269 PubMed:15907287}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for LAMP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for LAMP2 Gene
Publications for LAMP2 Gene
- Shared genetic causes of cardiac hypertrophy in children and adults. (PMID: 18403758) Morita H … Seidman CE (The New England journal of medicine 2008) 3 23 41
- Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene. (PMID: 15907287) Musumeci O … Toscano A (Neuromuscular disorders : NMD 2005) 3 4 23
- Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2. (PMID: 16190986) Eskelinen EL … Saftig P (Traffic (Copenhagen, Denmark) 2005) 3 4 23
- Glycogen storage diseases presenting as hypertrophic cardiomyopathy. (PMID: 15673802) Arad M … Seidman JG (The New England journal of medicine 2005) 3 4 23
- The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones. (PMID: 2243102) Carlsson SR … Fukuda M (The Journal of biological chemistry 1990) 3 4 23
ExternalLinks
Products for LAMP2 Gene
- View all 13 R&D Systems LAMP2 (LAMP-2/CD107b) Products
- View all R&D Systems LAMP2 (LAMP-2/CD107b) Proteins and Enzymes
- View all 10 R&D Systems LAMP2 (LAMP-2/CD107b) Primary Antibodies
- View all 2 R&D Systems LAMP2 (LAMP-2/CD107b) cDNA Clones
- Learn more about R&D Systems custom LAMP2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for LAMP2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for LAMP2
- Origene Custom Protein Services for LAMP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LAMP2
- Browse OriGene Inhibitory RNA Products For LAMP2
- OriGene qPCR primer pairs for LAMP2
- OriGene qPCR primer pairs and template standards for LAMP2
- MG222875
- MG222878
- MR222875
- MR222875L3
- MR222875L4
- MR222878
- MR222878L1
- MR222878L2
- MR222878L3
- MR222878L4
- MR229796
- RC200456
- RC200456L1
- RC200456L2
- RC200456L3
- RC200456L4
- RC221216
- RC221216L1
- RC221216L2
- RC221216L3
- RC221216L4
- RC225644
- RC225644L3
- RC225644L4
- RG200456
- RG221216
- RG225644
- RR206761
- RR206761L3
- RR206761L4
- MR222875L3V
- MR222875L4V
- MR222878L1V
- MR222878L2V
- MR222878L3V
- MR222878L4V
- RC200456L1V
- RC200456L2V
- RC200456L3V
- RC200456L4V
- RC221216L1V
- RC221216L2V
- RC221216L3V
- RC221216L4V
- RC225644L3V
- RC225644L4V
- RR206761L3V
- RR206761L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LAMP2
- Sino Biological Human cDNA Clone for LAMP2
- Sino Biological Recombinant Proteins for LAMP2
- Sino Biological Cell Lysates for LAMP2
- Sino Biological Antibodies for LAMP2
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for LAMP2
- Novus Biologicals proteins and lysates for LAMP2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder Custom and pre-made DNA vectors for LAMP2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for LAMP2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for LAMP2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for LAMP2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for LAMP2
- Addgene plasmids for LAMP2
- antibodies-online: Show 176 available LAMP2 Antibodies ranked by validation data
- Compare Top LAMP2 Antibodies
- Recommended
- 250 WB Antibodies (anti-human)
- 28 FACS Antibodies (anti-human)
- 15 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC (fro) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 ICS Antibody (anti-human)
- 124 WB Antibodies (anti-mouse)
- 42 IP Antibodies (anti-mouse)
- 28 FACS Antibodies (anti-mouse)
- 13 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 2 IHC (fro) Antibodies (anti-mouse)
- 35 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
- antibodies-online: Show 22 available LAMP2 Elisa Kits ranked by validation data
- Compare Top LAMP2 Elisa Kits
- antibodies-online: Show 27 available LAMP2 Proteins ranked by validation data
- Compare Top LAMP2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for LAMP2
- Search Santa Cruz Biotechnology (SCBT) for LAMP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LAMP2
- Custom Antibody ServicesProSci Antibodies for LAMP2
- ProSci Proteins for LAMP2
- Horizon Cell Lines for LAMP2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LAMP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LAMP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for LAMP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LAMP2
Sources for LAMP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB