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Aliases for LAMB4 Gene

Aliases for LAMB4 Gene

  • Laminin Subunit Beta 4 2 3 5
  • Laminin Beta-1-Related Protein 4
  • Laminin, Beta 4 2

External Ids for LAMB4 Gene

Previous GeneCards Identifiers for LAMB4 Gene

  • GC07M106148
  • GC07M107210
  • GC07M107224
  • GC07M107257
  • GC07M107451
  • GC07M107663
  • GC07M102026

Summaries for LAMB4 Gene

GeneCards Summary for LAMB4 Gene

LAMB4 (Laminin Subunit Beta 4) is a Protein Coding gene. Diseases associated with LAMB4 include Diverticulitis. Among its related pathways are Integrin Pathway and ERK Signaling. An important paralog of this gene is LAMB1.

UniProtKB/Swiss-Prot for LAMB4 Gene

  • Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Additional gene information for LAMB4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMB4 Gene

Genomics for LAMB4 Gene

GeneHancer (GH) Regulatory Elements for LAMB4 Gene

Promoters and enhancers for LAMB4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I108130 Promoter 0.5 EPDnew 550.8 0.0 -25 0.1 LAMB4 LOC102724363
GH07I107993 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 +130.8 130849 12.1 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 YY1 KLF13 SP3 REST KAT8 LAMB1 ENSG00000238297 GC07M108000 LAMB4 GC07M107805
GH07I107945 Enhancer 1.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.4 +180.5 180497 9.5 PKNOX1 FOXA2 NEUROD1 SIN3A YY1 FOS PPARG NFIL3 MAFF RCOR2 GC07M107948 LAMB4 ENSG00000273055 DLD CBLL1 SLC26A3 GC07M107805 LAMB1
GH07I108014 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.5 +114.6 114643 3.4 FOXA2 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ETS1 GTF3C2 ZNF121 ZNF213 LAMB4 CBLL1 GC07P108024 LAMB1
GH07I108077 Enhancer 1.2 Ensembl ENCODE 10.6 +50.5 50501 3.9 HDGF PKNOX1 ARNT ARID4B DMAP1 ZNF48 ZNF280A TCF12 GATA2 FOS LAMB4 LOC105375446 GC07P108054
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LAMB4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LAMB4 gene promoter:

Genomic Locations for LAMB4 Gene

Genomic Locations for LAMB4 Gene
126,371 bases
Minus strand

Genomic View for LAMB4 Gene

Genes around LAMB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAMB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAMB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMB4 Gene

Proteins for LAMB4 Gene

  • Protein details for LAMB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Laminin subunit beta-4
    Protein Accession:
    Secondary Accessions:
    • A5PKU6
    • B2RTT3
    • B5MEB9
    • Q86TP7
    • Q86XN2
    • Q8NBX5

    Protein attributes for LAMB4 Gene

    1761 amino acids
    Molecular mass:
    193540 Da
    Quaternary structure:
    • Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.

    Alternative splice isoforms for LAMB4 Gene


neXtProt entry for LAMB4 Gene

Post-translational modifications for LAMB4 Gene

  • Glycosylation at posLast=169169, isoforms=2, 3229, isoforms=2, 3246, isoforms=31016, posLast=10551055, posLast=12231223, posLast=13011301, isoforms=31326, posLast=13331333, isoforms=31354, posLast=14691469, posLast=15171517, posLast=15871587, posLast=15961596, posLast=16091609, and posLast=17251725
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LAMB4 Gene

Domains & Families for LAMB4 Gene

Gene Families for LAMB4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for LAMB4 Gene

Suggested Antigen Peptide Sequences for LAMB4 Gene

Graphical View of Domain Structure for InterPro Entry



  • The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
  • The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
  • Domains VI and IV are globular.
genes like me logo Genes that share domains with LAMB4: view

Function for LAMB4 Gene

Molecular function for LAMB4 Gene

GENATLAS Biochemistry:
laminin,beta 4,with two alternatively spliced
UniProtKB/Swiss-Prot Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Phenotypes From GWAS Catalog for LAMB4 Gene

Phenotypes for LAMB4 Gene

genes like me logo Genes that share phenotypes with LAMB4: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LAMB4 Gene

Localization for LAMB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMB4 Gene

Secreted, extracellular space, extracellular matrix, basement membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAMB4 gene
Compartment Confidence
extracellular 5
plasma membrane 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LAMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005604 basement membrane IEA --
genes like me logo Genes that share ontologies with LAMB4: view

Pathways & Interactions for LAMB4 Gene

genes like me logo Genes that share pathways with LAMB4: view

Pathways by source for LAMB4 Gene

Gene Ontology (GO) - Biological Process for LAMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with LAMB4: view

No data available for SIGNOR curated interactions for LAMB4 Gene

Drugs & Compounds for LAMB4 Gene

No Compound Related Data Available

Transcripts for LAMB4 Gene

Unigene Clusters for LAMB4 Gene

Laminin, beta 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAMB4 Gene

No ASD Table

Relevant External Links for LAMB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LAMB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LAMB4 Gene

mRNA differential expression in normal tissues according to GTEx for LAMB4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x24.1) and Skin - Sun Exposed (Lower leg) (x22.7).

Protein differential expression in normal tissues from HIPED for LAMB4 Gene

This gene is overexpressed in Bone (22.4), Neutrophil (12.2), Tlymphocyte (12.0), Monocytes (11.7), and Blymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LAMB4 Gene

Protein tissue co-expression partners for LAMB4 Gene

NURSA nuclear receptor signaling pathways regulating expression of LAMB4 Gene:


SOURCE GeneReport for Unigene cluster for LAMB4 Gene:


Evidence on tissue expression from TISSUES for LAMB4 Gene

  • Heart(3.8)
  • Adrenal gland(2.7)
  • Intestine(2.4)
  • Gall bladder(2.3)
  • Eye(2)
genes like me logo Genes that share expression patterns with LAMB4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LAMB4 Gene

Orthologs for LAMB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LAMB4 33 34
  • 99.32 (n)
(Canis familiaris)
Mammalia LAMB4 33 34
  • 83.36 (n)
(Bos Taurus)
Mammalia LAMB4 34
  • 73 (a)
(Monodelphis domestica)
Mammalia LAMB4 34
  • 66 (a)
(Gallus gallus)
Aves LAMB4 33 34
  • 65.61 (n)
(Anolis carolinensis)
Reptilia LAMB4 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lamb4 33
  • 59.07 (n)
(Danio rerio)
Actinopterygii lamb4 34
  • 42 (a)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta LanB1 34
  • 35 (a)
(Caenorhabditis elegans)
Secernentea lam-1 34
  • 35 (a)
Species where no ortholog for LAMB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LAMB4 Gene

Gene Tree for LAMB4 (if available)
Gene Tree for LAMB4 (if available)

Paralogs for LAMB4 Gene

Variants for LAMB4 Gene

Sequence variations from dbSNP and Humsavar for LAMB4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000024306 -- 108,049,120(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000024748 -- 108,027,886(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000030559 -- 108,099,768(-) C/A intron_variant
rs1000063762 -- 108,113,442(-) A/C intron_variant
rs1000084442 -- 108,058,054(-) T/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LAMB4 Gene

Variant ID Type Subtype PubMed ID
esv2037177 CNV deletion 18987734
esv2595279 CNV deletion 19546169
esv2734998 CNV deletion 23290073
esv2734999 CNV deletion 23290073
esv2735000 CNV deletion 23290073
esv3089 CNV loss 18987735
esv3329103 CNV insertion 20981092
esv3542249 CNV deletion 23714750
esv3614469 CNV loss 21293372
esv3614470 CNV loss 21293372
nsv1017114 CNV gain 25217958
nsv1152516 CNV deletion 26484159
nsv365697 CNV deletion 16902084
nsv476393 CNV novel sequence insertion 20440878
nsv831088 CNV loss 17160897
nsv831089 CNV loss 17160897

Variation tolerance for LAMB4 Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.27; 92.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LAMB4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMB4 Gene

Disorders for LAMB4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LAMB4 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search LAMB4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LAMB4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LAMB4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LAMB4 Gene

Publications for LAMB4 Gene

  1. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. (PMID: 21876539) Amin N … van Duijn CM (Molecular psychiatry 2012) 3 44 58
  2. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E … IMGSAC (Molecular psychiatry 2010) 3 44 58
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  4. Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas. (PMID: 25787250) Cromer MK … Lifton RP (Proceedings of the National Academy of Sciences of the United States of America 2015) 4 58
  5. Laminin gene LAMB4 is somatically mutated and expressionally altered in gastric and colorectal cancers. (PMID: 25257191) Choi MR … Lee SH (APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2015) 3 58

Products for LAMB4 Gene

Sources for LAMB4 Gene

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