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Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]
LAMB1 (Laminin Subunit Beta 1) is a Protein Coding gene. Diseases associated with LAMB1 include Lissencephaly 5 and Pierson Syndrome. Among its related pathways are Integrin Pathway and Cell adhesion_Plasmin signaling. Gene Ontology (GO) annotations related to this gene include enzyme binding and integrin binding. An important paralog of this gene is LAMB2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005178 | integrin binding | IBA | 21873635 |
GO:0005198 | structural molecule activity | NAS | 10842354 |
GO:0005201 | extracellular matrix structural constituent | IDA,RCA | 25037231 |
GO:0005515 | protein binding | IPI | 26438063 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005604 | basement membrane | TAS | 3493487 |
GO:0005606 | laminin-1 complex | TAS | 14557481 |
GO:0005607 | laminin-2 complex | TAS | 15894315 |
GO:0005615 | extracellular space | IDA | 10964500 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
|
UPA-UPAR Pathway
.56
Inhibition of Angiogenesis by TSP1
.50
Transendothelial Migration of Leukocytes
.38
|
2 | MET promotes cell motility |
.45
|
|
3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
4 | Focal Adhesion |
.61
|
.61
|
5 | PI3K-Akt signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | TAS | 14557481 |
GO:0009887 | animal organ morphogenesis | IBA | 21873635 |
GO:0009888 | tissue development | IBA | 21873635 |
GO:0016477 | cell migration | IBA | 21873635 |
GO:0021812 | neuronal-glial interaction involved in cerebral cortex radial glia guided migration | IMP | 23472759 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Laminin (925-933) | Extracellular matrix glycoprotein | 110590-60-8 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP16: |
ExUns: | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | · | 22c | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b | ^ | 28a | · | 28b | · | 28c | ^ | 29a | · | 29b | ^ | 30a | · | 30b | · | 30c | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP16: |
ExUns: | 31 | ^ | 32 | ^ | 33a | · | 33b | ^ | 34 | ^ | 35a | · | 35b | ^ | 36 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||
SP2: | |||||||||||||||
SP3: | |||||||||||||||
SP4: | |||||||||||||||
SP5: | |||||||||||||||
SP6: | |||||||||||||||
SP7: | |||||||||||||||
SP8: | |||||||||||||||
SP9: | |||||||||||||||
SP10: | |||||||||||||||
SP11: | |||||||||||||||
SP12: | |||||||||||||||
SP13: | |||||||||||||||
SP14: | |||||||||||||||
SP15: | |||||||||||||||
SP16: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LAMB1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LAMB1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LAMB1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LAMB1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lamb1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lamb1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | LAMB1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LAMB1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lamb1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | lamb1a 30 31 |
|
OneToOne | |
-- 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11110 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | LanB1 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | lam-1 31 32 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
668354 | Likely Benign: not provided | 107,973,015(-) | G/A | SYNONYMOUS_VARIANT | |
668619 | Likely Benign: not provided | 107,940,108(-) | C/A | SYNONYMOUS_VARIANT | |
677579 | Benign: not provided | 107,964,867(-) | G/A | INTRON_VARIANT | |
681222 | Benign: not provided | 107,964,967(-) | C/T | INTRON_VARIANT | |
681223 | Benign: not provided | 107,960,113(-) | C/T | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3641n106 | CNV | deletion | 24896259 |
esv2734996 | CNV | deletion | 23290073 |
esv2734997 | CNV | deletion | 23290073 |
nsv1135985 | CNV | deletion | 24896259 |
nsv1150103 | CNV | deletion | 26484159 |
nsv831088 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
lissencephaly 5 |
|
|
pierson syndrome |
|
|
cutis laxa |
|
|
band heterotopia |
|
|
lissencephaly |
|
|