Aliases for LAMA3 Gene
- Laminin Subunit Alpha 3 2 3 5
- Laminin, Alpha 3 (Nicein (150kD), Kalinin (165kD), BM600 (150kD), Epilegrin) 2 3
- Laminin Subunit Alpha-3 3 4
- Laminin-5 Subunit Alpha 3 4
- Laminin-6 Subunit Alpha 3 4
- Laminin-7 Subunit Alpha 3 4
- Kalinin Subunit Alpha 3 4
- Nicein Subunit Alpha 3 4
- LAMNA 3 4
- E170 3 4
- Laminin 5, Alpha-3 Subunit 3
- Epiligrin 170 Kda Subunit 3
- Epiligrin Alpha 3 Subunit 3
- Epiligrin 170 KDa Subunit 4
External Ids for LAMA3 Gene
Previous HGNC Symbols for LAMA3 Gene
Previous GeneCards Identifiers for LAMA3 Gene
The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for LAMA3 Gene
LAMA3 (Laminin Subunit Alpha 3) is a Protein Coding gene. Diseases associated with LAMA3 include Laryngoonychocutaneous Syndrome and Epidermolysis Bullosa, Junctional, Herlitz Type. Among its related pathways are Integrin Pathway and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and obsolete signal transducer activity. An important paralog of this gene is LAMA5.
UniProtKB/Swiss-Prot Summary for LAMA3 Gene
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.