Aliases for LAMA2 Gene
External Ids for LAMA2 Gene
Previous HGNC Symbols for LAMA2 Gene
Previous GeneCards Identifiers for LAMA2 Gene
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for LAMA2 Gene
LAMA2 (Laminin Subunit Alpha 2) is a Protein Coding gene. Diseases associated with LAMA2 include Muscular Dystrophy, Congenital Merosin-Deficient, 1A and Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 23. Among its related pathways are ERK Signaling and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and structural molecule activity. An important paralog of this gene is LAMA1.
UniProtKB/Swiss-Prot Summary for LAMA2 Gene
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.