Aliases for LAMA1 Gene
External Ids for LAMA1 Gene
Previous HGNC Symbols for LAMA1 Gene
Previous GeneCards Identifiers for LAMA1 Gene
This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]
GeneCards Summary for LAMA1 Gene
LAMA1 (Laminin Subunit Alpha 1) is a Protein Coding gene. Diseases associated with LAMA1 include Poretti-Boltshauser Syndrome and Myopia. Among its related pathways are ERK Signaling and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and glycosphingolipid binding. An important paralog of this gene is LAMA2.
UniProtKB/Swiss-Prot for LAMA1 Gene
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.