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Aliases for LALBA Gene

Aliases for LALBA Gene

  • Lactalbumin Alpha 2 3 5
  • Lactose Synthase B Protein 3 4
  • Lysozyme-Like Protein 7 3 4
  • Lactalbumin, Alpha- 2
  • Alpha-Lactalbumin 3
  • Lysozyme G 3
  • LYZL7 4
  • LYZG 3

External Ids for LALBA Gene

Previous GeneCards Identifiers for LALBA Gene

  • GC12M048927
  • GC12M048678
  • GC12M047247
  • GC12M045995

Summaries for LALBA Gene

Entrez Gene Summary for LALBA Gene

  • This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for LALBA Gene

LALBA (Lactalbumin Alpha) is a Protein Coding gene. Diseases associated with LALBA include Milk Allergy and Goat Milk Allergy. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and lactose synthase activity. An important paralog of this gene is LYZ.

UniProtKB/Swiss-Prot for LALBA Gene

  • Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Gene Wiki entry for LALBA Gene

Additional gene information for LALBA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LALBA Gene

Genomics for LALBA Gene

GeneHancer (GH) Regulatory Elements for LALBA Gene

Promoters and enhancers for LALBA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I048600 Enhancer 0.9 Ensembl ENCODE 550.8 -1.1 -1090 1.2 PKNOX1 JUN BACH1 EBF1 BATF RELA FOSL1 CTBP1 ZNF766 ZNF316 LALBA SNORA2C CCDC184 ASB8 TUBA1C OR11M1P GC12M048339
GH12I048804 Enhancer 0.2 FANTOM5 1.9 -204.6 -204627 0 LALBA LOC390314 GC12P048810
GH12I048618 Enhancer 0.7 ENCODE 0.4 -18.5 -18522 0.2 CTCF RB1 BMI1 IRF4 RAD21 RELA CC2D1A ARID2 SMC3 ZNF143 SNORA2C ASB8 CCDC184 RNU6-1203P OR11M1P LALBA GC12M048339
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LALBA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LALBA gene promoter:

Genomic Locations for LALBA Gene

Genomic Locations for LALBA Gene
32,428 bases
Minus strand

Genomic View for LALBA Gene

Genes around LALBA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LALBA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LALBA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LALBA Gene

Proteins for LALBA Gene

  • Protein details for LALBA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6FGX0
    • Q9UDK4

    Protein attributes for LALBA Gene

    142 amino acids
    Molecular mass:
    16225 Da
    Quaternary structure:
    • Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).

    Three dimensional structures from OCA and Proteopedia for LALBA Gene

neXtProt entry for LALBA Gene

Post-translational modifications for LALBA Gene

No Post-translational modifications

Other Protein References for LALBA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LALBA Gene

Domains & Families for LALBA Gene

Gene Families for LALBA Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for LALBA Gene

Suggested Antigen Peptide Sequences for LALBA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 22 family.
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LALBA: view

Function for LALBA Gene

Molecular function for LALBA Gene

GENATLAS Biochemistry:
lactalbumin,alpha,expressed in mammary gland,homolog to lypozyne,non catalytic regulatory protein,B chain of lactose synthase
UniProtKB/Swiss-Prot Function:
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Phenotypes From GWAS Catalog for LALBA Gene

Gene Ontology (GO) - Molecular Function for LALBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IBA --
GO:0004461 lactose synthase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LALBA: view
genes like me logo Genes that share phenotypes with LALBA: view

Animal Models for LALBA Gene

MGI Knock Outs for LALBA:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LALBA Gene

Localization for LALBA Gene

Subcellular locations from UniProtKB/Swiss-Prot for LALBA Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LALBA gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LALBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 7644538
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with LALBA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LALBA Gene

Pathways & Interactions for LALBA Gene

genes like me logo Genes that share pathways with LALBA: view

Pathways by source for LALBA Gene

3 Reactome pathways for LALBA Gene
2 KEGG pathways for LALBA Gene
1 GeneGo (Thomson Reuters) pathway for LALBA Gene

Gene Ontology (GO) - Biological Process for LALBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005989 lactose biosynthetic process IEA,TAS --
GO:0006915 apoptotic process TAS 7644538
GO:0007165 signal transduction TAS 7644538
GO:0007267 cell-cell signaling TAS 7644538
GO:0016998 cell wall macromolecule catabolic process IBA --
genes like me logo Genes that share ontologies with LALBA: view

No data available for SIGNOR curated interactions for LALBA Gene

Drugs & Compounds for LALBA Gene

(43) Drugs for LALBA Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lactose Approved, Investigational Pharma 0
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist, Target 23
D-glucose Approved Pharma 0
Uridine diphosphategalactose Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0

(44) Additional Compounds for LALBA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • beta-D-Galactopyranosyl-(1->4)-beta-D-glucopyranose
  • beta-D-Galactopyranosyl-(1->4)-beta-D-glucose
  • beta-Lactose
genes like me logo Genes that share compounds with LALBA: view

Transcripts for LALBA Gene

mRNA/cDNA for LALBA Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LALBA Gene

Lactalbumin, alpha-:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LALBA Gene

No ASD Table

Relevant External Links for LALBA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LALBA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LALBA Gene

mRNA differential expression in normal tissues according to GTEx for LALBA Gene

This gene is overexpressed in Breast - Mammary Tissue (x51.8).

Protein differential expression in normal tissues from HIPED for LALBA Gene

This gene is overexpressed in Milk (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LALBA Gene

Protein tissue co-expression partners for LALBA Gene

NURSA nuclear receptor signaling pathways regulating expression of LALBA Gene:


SOURCE GeneReport for Unigene cluster for LALBA Gene:


mRNA Expression by UniProt/SwissProt for LALBA Gene:

Tissue specificity: Mammary gland specific. Secreted in milk.

Evidence on tissue expression from TISSUES for LALBA Gene

  • Nervous system(4.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with LALBA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LALBA Gene

Orthologs for LALBA Gene

This gene was present in the common ancestor of animals.

Orthologs for LALBA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LALBA 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia LALBA 33 34
  • 87.79 (n)
(Bos Taurus)
Mammalia LALBA 33 34
  • 84.51 (n)
(Rattus norvegicus)
Mammalia Lalba 33
  • 78.01 (n)
(Mus musculus)
Mammalia Lalba 33 16 34
  • 75.89 (n)
(Monodelphis domestica)
Mammalia LALBA 34
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 35 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
-- 34
  • 31 (a)
-- 34
  • 29 (a)
-- 34
  • 27 (a)
-- 34
  • 24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16756 34
  • 28 (a)
LysP 34
  • 28 (a)
CG11159 34
  • 27 (a)
LysE 34
  • 27 (a)
LysS 34
  • 27 (a)
LysX 34
  • 27 (a)
CG7798 34
  • 26 (a)
LysB 34
  • 26 (a)
LysC 34
  • 26 (a)
LysD 34
  • 26 (a)
CG30062 34
  • 23 (a)
CG16799 34
  • 22 (a)
CG8492 34
  • 3 (a)
Species where no ortholog for LALBA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LALBA Gene

Gene Tree for LALBA (if available)
Gene Tree for LALBA (if available)

Paralogs for LALBA Gene

Paralogs for LALBA Gene

(7) SIMAP similar genes for LALBA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LALBA: view

Variants for LALBA Gene

Sequence variations from dbSNP and Humsavar for LALBA Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000205309 -- 48,571,621(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000724046 -- 48,571,851(-) G/A upstream_transcript_variant
rs1001001577 -- 48,567,614(-) A/T downstream_transcript_variant
rs1001324354 -- 48,573,032(-) G/T upstream_transcript_variant
rs1001608635 -- 48,572,823(-) A/G upstream_transcript_variant

Variation tolerance for LALBA Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LALBA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LALBA Gene

Disorders for LALBA Gene

MalaCards: The human disease database

(11) MalaCards diseases for LALBA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
milk allergy
  • milk allergic reaction
goat milk allergy
  • capra hircus milk allergy
  • breast inflammation
allergic hypersensitivity disease
  • allergic disease
cutaneous adenocystic carcinoma
  • adenoid cystic carcinoma of the skin
- elite association - COSMIC cancer census association via MalaCards
Search LALBA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LALBA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LALBA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LALBA Gene

Publications for LALBA Gene

  1. Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin. (PMID: 9537992) Chandra N … Acharya KR (Biochemistry 1998) 3 4 22 58
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  3. The oleic acid complexes of proteolytic fragments of alpha-lactalbumin display apoptotic activity. (PMID: 19968717) Tolin S … Fontana A (The FEBS journal 2010) 3 22 58
  4. Detection of a single nucleotide polymorphism in the human alpha-lactalbumin gene: implications for human milk proteins. (PMID: 15866226) Chowanadisai W … Lönnerdal B (The Journal of nutritional biochemistry 2005) 4 22 58
  5. Effects of the stabilization of the molten globule state on the folding mechanism of alpha-lactalbumin: a study of a chimera of bovine and human alpha-lactalbumin. (PMID: 16121399) Mizuguchi M … Kawano K (Proteins 2005) 3 22 58

Products for LALBA Gene

Sources for LALBA Gene

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