The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and ves... See more...

Aliases for LAIR2 Gene

Aliases for LAIR2 Gene

  • Leukocyte Associated Immunoglobulin Like Receptor 2 2 3 5
  • Leukocyte-Associated Immunoglobulin-Like Receptor 2 2 3 4
  • CD306 2 3 4
  • LAIR-2 3 4
  • Leukocyte-Associated Ig-Like Receptor 2 2
  • Leukocyte-Associated Ig-Like Receptor-2 3
  • CD306 Antigen 4
  • LAIR2 5

External Ids for LAIR2 Gene

Previous GeneCards Identifiers for LAIR2 Gene

  • GC19P055877
  • GC19P055438
  • GC19P059689
  • GC19P059705
  • GC19P055009
  • GC19P051337
  • GC19P054512
  • GC19P054515
  • GC19P054528
  • GC19P054576

Summaries for LAIR2 Gene

Entrez Gene Summary for LAIR2 Gene

  • The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for LAIR2 Gene

LAIR2 (Leukocyte Associated Immunoglobulin Like Receptor 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is LILRA6.

Gene Wiki entry for LAIR2 Gene

Additional gene information for LAIR2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LAIR2 Gene

Genomics for LAIR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LAIR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054497 Promoter/Enhancer 1 EPDnew Ensembl dbSUPER 606.3 +0.2 222 1.4 IKZF1 EZH2 LAIR2 lnc-CDC42EP5-1 LILRA2
GH19J054502 Promoter/Enhancer 0.8 EPDnew Ensembl dbSUPER 621.3 +5.5 5522 1.2 LAIR2 lnc-CDC42EP5-1 LILRA2
GH19J054506 Enhancer 0.3 dbSUPER 16.6 +9.4 9449 1.7 TCF7 LAIR2 lnc-CDC42EP5-1 LILRA2
GH19J054481 Enhancer 0.8 Ensembl ENCODE 5.2 -16.3 -16278 4 CTCF ZNF143 PKNOX1 REST RAD21 IKZF2 TRIM22 EED ARID3A RUNX3 LAIR2 CDC42EP5 hsa-miR-5095-283
GH19J054373 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.6 -123.0 -122962 2.7 BACH1 ZNF143 RELA IKZF2 TRIM22 YY1 PKNOX1 EED RELB RUNX3 MN297615 FCAR LAIR1 LILRB2 OSCAR LILRA5 VSTM1 LILRB3 LILRB4 LILRB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LAIR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LAIR2

Top Transcription factor binding sites by QIAGEN in the LAIR2 gene promoter:
  • Bach1
  • NRSF form 1
  • NRSF form 2

Genomic Locations for LAIR2 Gene

Genomic Locations for LAIR2 Gene
chr19:54,497,879-54,510,693
(GRCh38/hg38)
Size:
12,815 bases
Orientation:
Plus strand
chr19:55,009,100-55,021,900
(GRCh37/hg19)
Size:
12,801 bases
Orientation:
Plus strand

Genomic View for LAIR2 Gene

Genes around LAIR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAIR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAIR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAIR2 Gene

Proteins for LAIR2 Gene

  • Protein details for LAIR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ISS4-LAIR2_HUMAN
    Recommended name:
    Leukocyte-associated immunoglobulin-like receptor 2
    Protein Accession:
    Q6ISS4
    Secondary Accessions:
    • Q6PEZ4

    Protein attributes for LAIR2 Gene

    Size:
    152 amino acids
    Molecular mass:
    16280 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LAIR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAIR2 Gene

Post-translational modifications for LAIR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LAIR2 Gene

No data available for DME Specific Peptides for LAIR2 Gene

Domains & Families for LAIR2 Gene

Gene Families for LAIR2 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for LAIR2 Gene

InterPro:
Blocks:
  • Immunoglobulin subtype
ProtoNet:

Suggested Antigen Peptide Sequences for LAIR2 Gene

GenScript: Design optimal peptide antigens:
  • Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2_HUMAN)
genes like me logo Genes that share domains with LAIR2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LAIR2 Gene

Function for LAIR2 Gene

Molecular function for LAIR2 Gene

GENATLAS Biochemistry:
leukocyte-associated immunoglobulin-like receptor,32kDa,expressed in monocytes

Phenotypes From GWAS Catalog for LAIR2 Gene

Gene Ontology (GO) - Molecular Function for LAIR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LAIR2: view
genes like me logo Genes that share phenotypes with LAIR2: view

Animal Model Products

CRISPR Products

miRNA for LAIR2 Gene

miRTarBase miRNAs that target LAIR2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LAIR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LAIR2 Gene

Localization for LAIR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAIR2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAIR2 gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for LAIR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with LAIR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LAIR2 Gene

Pathways & Interactions for LAIR2 Gene

genes like me logo Genes that share pathways with LAIR2: view

Pathways by source for LAIR2 Gene

Gene Ontology (GO) - Biological Process for LAIR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with LAIR2: view

No data available for SIGNOR curated interactions for LAIR2 Gene

Drugs & Compounds for LAIR2 Gene

No Compound Related Data Available

Transcripts for LAIR2 Gene

mRNA/cDNA for LAIR2 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LAIR2

Alternative Splicing Database (ASD) splice patterns (SP) for LAIR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for LAIR2 Gene

GeneLoc Exon Structure for
LAIR2

Expression for LAIR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LAIR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LAIR2 Gene

This gene is overexpressed in Whole Blood (x22.7) and Pituitary (x6.1).

Protein differential expression in normal tissues from HIPED for LAIR2 Gene

This gene is overexpressed in Urine (61.2) and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LAIR2 Gene



Protein tissue co-expression partners for LAIR2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LAIR2

SOURCE GeneReport for Unigene cluster for LAIR2 Gene:

Hs.43803

Evidence on tissue expression from TISSUES for LAIR2 Gene

  • Blood(2.6)
genes like me logo Genes that share expression patterns with LAIR2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LAIR2 Gene

Orthologs for LAIR2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LAIR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LAIR2 30 31
  • 98.9 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 24 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 23 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Lair1 31
  • 18 (a)
OneToMany
Species where no ortholog for LAIR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LAIR2 Gene

ENSEMBL:
Gene Tree for LAIR2 (if available)
TreeFam:
Gene Tree for LAIR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LAIR2: view image

Paralogs for LAIR2 Gene

(20) SIMAP similar genes for LAIR2 Gene using alignment to 2 proteins:

  • LAIR2_HUMAN
  • C9JFQ0_HUMAN
genes like me logo Genes that share paralogs with LAIR2: view

Variants for LAIR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LAIR2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs34423078 - p.His87Arg
rs34429135 - p.Phe115Tyr
rs36121405 - p.Gly78Ser

Additional dbSNP identifiers (rs#s) for LAIR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for LAIR2 Gene

Variant ID Type Subtype PubMed ID
dgv3663n100 CNV gain 25217958
esv2667609 CNV deletion 23128226
esv2718872 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv3644810 CNV loss 21293372
nsv1148744 OTHER inversion 26484159
nsv580237 CNV loss 21841781
nsv833878 CNV loss 17160897

Variation tolerance for LAIR2 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LAIR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LAIR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAIR2 Gene

Disorders for LAIR2 Gene

Additional Disease Information for LAIR2

No disorders were found for LAIR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LAIR2 Gene

Publications for LAIR2 Gene

  1. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. (PMID: 9285412) Meyaard L … Phillips JH (Immunity 1997) 2 3 4
  2. Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III. (PMID: 19345263) Lebbink RJ … Meyaard L (Matrix biology : journal of the International Society for Matrix Biology 2009) 3 23
  3. The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction. (PMID: 18209062) Lebbink RJ … Meyaard L (Journal of immunology (Baltimore, Md. : 1950) 2008) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. (PMID: 10229813) Meyaard L … Phillips JH (Journal of immunology (Baltimore, Md. : 1950) 1999) 3 4

Products for LAIR2 Gene

Sources for LAIR2 Gene