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The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. [provided by RefSeq, Jul 2008]
LAD1 (Ladinin 1) is a Protein Coding gene. Diseases associated with LAD1 include Linear Iga Disease and Cicatricial Pemphigoid. Gene Ontology (GO) annotations related to this gene include structural molecule activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005198 | structural molecule activity | IEA | -- |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005604 | basement membrane | IEA | -- |
GO:0015629 | actin cytoskeleton | IDA | -- |
GO:0070062 | extracellular exosome | HDA | 18570454 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP7: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | LAD1 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | LAD1 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Lad1 32 |
|
||
mouse (Mus musculus) |
Mammalia | Lad1 17 33 32 |
|
||
cow (Bos Taurus) |
Mammalia | LAD1 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | LAD1 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | LAD1 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | LAD1 33 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | LAD1 33 |
|
OneToOne |
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000133133 | -- | 201,400,081(-) | T/G | upstream_transcript_variant | |
rs1000227609 | -- | 201,393,573(-) | C/T | intron_variant | |
rs1000264306 | -- | 201,387,388(-) | C/T | intron_variant | |
rs1000285350 | -- | 201,386,092(-) | G/C | intron_variant | |
rs1000337205 | -- | 201,385,876(-) | T/G | intron_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
linear iga disease |
|
|
cicatricial pemphigoid |
|
|
bullous pemphigoid |
|
|
epidermolysis bullosa, junctional, non-herlitz type |
|
|
pyloric atresia |
|
|