Aliases for LACTBL1 Gene

Aliases for LACTBL1 Gene

  • Lactamase Beta Like 1 2 3 5
  • Putative Beta-Lactamase-Like 1 3 4

External Ids for LACTBL1 Gene

Previous GeneCards Identifiers for LACTBL1 Gene

  • GC01M023279
  • GC01M021523

Summaries for LACTBL1 Gene

GeneCards Summary for LACTBL1 Gene

LACTBL1 (Lactamase Beta Like 1) is a Protein Coding gene. An important paralog of this gene is LACTB.

Additional gene information for LACTBL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LACTBL1 Gene

Genomics for LACTBL1 Gene

GeneHancer (GH) Regulatory Elements for LACTBL1 Gene

Promoters and enhancers for LACTBL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J022971 Enhancer 0.6 Ensembl 750.6 +0.4 416 1.4 CREB1 SOX6 SCRT2 SKIL ZNF623 ZNF366 ATF1 ZNF513 ATF2 JUN LACTBL1 LUZP1 lnc-EPHB2-1
GH01J023018 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 15.1 -48.0 -47985 3.8 ZNF785 SIN3A ZNF24 SP1 ZBTB40 MLX SMARCE1 RBPJ POLR2A CREB1 KDM1A HNRNPR ZNF436-AS1 SRSF10 LINC01355 PITHD1 LACTBL1 ZBTB40 ELOA ZNF436
GH01J023187 Enhancer 1.3 Ensembl ENCODE dbSUPER 17.1 -216.6 -216627 3.2 LCORL MLX RBPJ NR2F1 NR2F6 CREB1 MIXL1 NFYC NFIB SP1 LACTBL1 LUZP1 RNU6-135P RNU6-514P HTR1D piR-42491-003
GH01J023166 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.7 -196.0 -195984 4.6 ZNF785 ZBTB40 SP1 ZBTB6 SMARCE1 POLR2A USF2 ATF1 CREB1 ZNF362 LUZP1 SRSF10 ZBTB40 PNRC2 RPL11 LINC01355 HNRNPR ELOA E2F2 ZNF436-AS1
GH01J023637 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 14.6 -665.4 -665430 0.8 CTCF ZBTB6 LCORL RBPJ MIXL1 ZNF362 MYC CC2D1A HLF L3MBTL2 ENSG00000229239 ENSG00000230228 ENSG00000215381 ENSG00000240553 LACTBL1 MDS2 ID3 piR-50437-019 lnc-ID3-5 lnc-ID3-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LACTBL1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LACTBL1 Gene

Genomic Locations for LACTBL1 Gene
chr1:22,953,043-22,972,316
(GRCh38/hg38)
Size:
19,274 bases
Orientation:
Minus strand
chr1:23,279,536-23,291,831
(GRCh37/hg19)
Size:
12,296 bases
Orientation:
Minus strand

Genomic View for LACTBL1 Gene

Genes around LACTBL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LACTBL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LACTBL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LACTBL1 Gene

Proteins for LACTBL1 Gene

  • Protein details for LACTBL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MY62-BLML_HUMAN
    Recommended name:
    Putative beta-lactamase-like 1
    Protein Accession:
    A8MY62

    Protein attributes for LACTBL1 Gene

    Size:
    500 amino acids
    Molecular mass:
    54653 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LACTBL1 Gene

Post-translational modifications for LACTBL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LACTBL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LACTBL1 Gene

Domains & Families for LACTBL1 Gene

Gene Families for LACTBL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LACTBL1 Gene

Suggested Antigen Peptide Sequences for LACTBL1 Gene

GenScript: Design optimal peptide antigens:
  • Putative beta-lactamase-like 1 (BLML_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A8MY62

UniProtKB/Swiss-Prot:

BLML_HUMAN :
  • Belongs to the beta-lactamase family.
Family:
  • Belongs to the beta-lactamase family.
genes like me logo Genes that share domains with LACTBL1: view

Function for LACTBL1 Gene

Phenotypes From GWAS Catalog for LACTBL1 Gene

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LACTBL1 Gene

Localization for LACTBL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LACTBL1 gene
Compartment Confidence
nucleus 2
peroxisome 1
cytosol 1
extracellular 0
mitochondrion 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LACTBL1 Gene

Pathways & Interactions for LACTBL1 Gene

PathCards logo

SuperPathways for LACTBL1 Gene

No Data Available

Interacting Proteins for LACTBL1 Gene

Gene Ontology (GO) - Biological Process for LACTBL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LACTBL1 Gene

Drugs & Compounds for LACTBL1 Gene

No Compound Related Data Available

Transcripts for LACTBL1 Gene

mRNA/cDNA for LACTBL1 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LACTBL1 Gene

No ASD Table

Relevant External Links for LACTBL1 Gene

GeneLoc Exon Structure for
LACTBL1
ECgene alternative splicing isoforms for
LACTBL1

Expression for LACTBL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LACTBL1 Gene

mRNA differential expression in normal tissues according to GTEx for LACTBL1 Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for LACTBL1 Gene

This gene is overexpressed in Gallbladder (35.7), Heart (26.7), and Retina (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LACTBL1 Gene



Protein tissue co-expression partners for LACTBL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of LACTBL1 Gene:

LACTBL1
genes like me logo Genes that share expression patterns with LACTBL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LACTBL1 Gene

Orthologs for LACTBL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LACTBL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LACTBL1 32
  • 92.44 (n)
dog
(Canis familiaris)
Mammalia LACTBL1 33 32
  • 90.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LACTBL1 33 32
  • 88.6 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lactbl1 17 33 32
  • 79.16 (n)
oppossum
(Monodelphis domestica)
Mammalia LACTBL1 33
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LACTBL1 33
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves LACTBL1 33 32
  • 67.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LACTBL1 33
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lactbl1b 33 32
  • 59.94 (n)
OneToMany
lactbl1a 33
  • 57 (a)
OneToMany
Species where no ortholog for LACTBL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LACTBL1 Gene

ENSEMBL:
Gene Tree for LACTBL1 (if available)
TreeFam:
Gene Tree for LACTBL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LACTBL1: view image

Paralogs for LACTBL1 Gene

Paralogs for LACTBL1 Gene

genes like me logo Genes that share paralogs with LACTBL1: view

Variants for LACTBL1 Gene

Sequence variations from dbSNP and Humsavar for LACTBL1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000174599 -- 22,971,744(-) C/T intron_variant
rs1000222357 -- 22,972,455(-) A/C intron_variant
rs1000253273 -- 22,957,290(-) T/C intron_variant
rs1000271883 -- 22,962,365(-) C/A intron_variant
rs1000464006 -- 22,968,687(-) T/C intron_variant

Variation tolerance for LACTBL1 Gene

Gene Damage Index Score: 10.93; 91.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LACTBL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LACTBL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LACTBL1 Gene

Disorders for LACTBL1 Gene

Additional Disease Information for LACTBL1

No disorders were found for LACTBL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LACTBL1 Gene

Publications for LACTBL1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56

Products for LACTBL1 Gene

Sources for LACTBL1 Gene