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Aliases for LACTB2 Gene

Aliases for LACTB2 Gene

  • Lactamase Beta 2 2 3 5
  • Beta-Lactamase-Like Protein 2 3 4
  • Testicular Secretory Protein Li 23 3
  • Endoribonuclease LACTB2 3
  • EC 3.1.27.- 4
  • CGI-83 3

External Ids for LACTB2 Gene

Previous GeneCards Identifiers for LACTB2 Gene

  • GC08M071599
  • GC08M071712
  • GC08M071549
  • GC08M067042

Summaries for LACTB2 Gene

GeneCards Summary for LACTB2 Gene

LACTB2 (Lactamase Beta 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for LACTB2 Gene

  • Endoribonuclease; cleaves preferentially 3 to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3 -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

Additional gene information for LACTB2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LACTB2 Gene

Genomics for LACTB2 Gene

GeneHancer (GH) Regulatory Elements for LACTB2 Gene

Promoters and enhancers for LACTB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J070665 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 657.9 +1.2 1178 5.2 CLOCK SMAD1 FOXA2 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 XKR9 LACTB2 LACTB2-AS1 TRAM1 RN7SL19P
GH08J070606 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 16.6 +60.4 60447 5.5 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B XKR9 TRAM1 LACTB2-AS1 LACTB2 RN7SL19P GC08P070527
GH08J070556 Enhancer 0.9 Ensembl ENCODE 16.3 +111.6 111579 1.4 PKNOX1 FOXA2 NEUROD1 CTBP1 GATA3 FOS FOSL2 MAFK TCF7L2 SMARCE1 XKR9 LACTB2 LOC105375890 GC08P070527 TRAM1
GH08J070147 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.2 +520.8 520762 1.7 PKNOX1 ATF1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ARID2 ZNF143 XKR9 LACTB2 LACTB2-AS1 TRAM1 H2AFZP2 BTF3P12 NCOA2
GH08J070533 Enhancer 1 Ensembl ENCODE 11.3 +135.3 135288 1.8 ELF3 ARID4B BATF ZNF2 IRF4 ZNF48 RAD21 RFX5 ZNF366 ZNF143 XKR9 LACTB2 LOC105375890 GC08P070527
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LACTB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LACTB2 gene promoter:
  • AREB6
  • FAC1
  • MEF-2A
  • aMEF-2
  • SRF
  • SRF (504 AA)
  • POU2F1a
  • POU2F1

Genomic Locations for LACTB2 Gene

Genomic Locations for LACTB2 Gene
chr8:70,635,318-70,669,212
(GRCh38/hg38)
Size:
33,895 bases
Orientation:
Minus strand
chr8:71,547,553-71,581,447
(GRCh37/hg19)
Size:
33,895 bases
Orientation:
Minus strand

Genomic View for LACTB2 Gene

Genes around LACTB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LACTB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LACTB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LACTB2 Gene

Proteins for LACTB2 Gene

  • Protein details for LACTB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53H82-LACB2_HUMAN
    Recommended name:
    Endoribonuclease LACTB2
    Protein Accession:
    Q53H82
    Secondary Accessions:
    • A8K2D6
    • Q9Y392

    Protein attributes for LACTB2 Gene

    Size:
    288 amino acids
    Molecular mass:
    32806 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • RNAi-mediated down-regulation results in rapid cell death. The reason for this is not clear; there are only minor changes in mitochondrial mRNA levels.

    Three dimensional structures from OCA and Proteopedia for LACTB2 Gene

neXtProt entry for LACTB2 Gene

Post-translational modifications for LACTB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LACTB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LACTB2 Gene

Domains & Families for LACTB2 Gene

Gene Families for LACTB2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LACTB2 Gene

Suggested Antigen Peptide Sequences for LACTB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53H82

UniProtKB/Swiss-Prot:

LACB2_HUMAN :
  • Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Family:
  • Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
genes like me logo Genes that share domains with LACTB2: view

Function for LACTB2 Gene

Molecular function for LACTB2 Gene

UniProtKB/Swiss-Prot Function:
Endoribonuclease; cleaves preferentially 3 to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3 -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

Enzyme Numbers (IUBMB) for LACTB2 Gene

Phenotypes From GWAS Catalog for LACTB2 Gene

Gene Ontology (GO) - Molecular Function for LACTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003727 single-stranded RNA binding IDA 26826708
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004521 endoribonuclease activity IDA 26826708
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LACTB2: view
genes like me logo Genes that share phenotypes with LACTB2: view

Animal Model Products

CRISPR Products

miRNA for LACTB2 Gene

miRTarBase miRNAs that target LACTB2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LACTB2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LACTB2 Gene

Localization for LACTB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LACTB2 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LACTB2 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LACTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix IDA,IEA 26826708
genes like me logo Genes that share ontologies with LACTB2: view

Pathways & Interactions for LACTB2 Gene

SuperPathways for LACTB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LACTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IDA 26826708
genes like me logo Genes that share ontologies with LACTB2: view

No data available for Pathways by source and SIGNOR curated interactions for LACTB2 Gene

Drugs & Compounds for LACTB2 Gene

(2) Drugs for LACTB2 Gene - From:

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nafcillin Sodium Pharma 0
Sulbactam sodium Pharma 0
genes like me logo Genes that share compounds with LACTB2: view

Transcripts for LACTB2 Gene

mRNA/cDNA for LACTB2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LACTB2 Gene

Lactamase, beta 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LACTB2

Alternative Splicing Database (ASD) splice patterns (SP) for LACTB2 Gene

No ASD Table

Relevant External Links for LACTB2 Gene

GeneLoc Exon Structure for
LACTB2
ECgene alternative splicing isoforms for
LACTB2

Expression for LACTB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LACTB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LACTB2 Gene

This gene is overexpressed in Liver (x4.9).

Protein differential expression in normal tissues from HIPED for LACTB2 Gene

This gene is overexpressed in Kidney (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LACTB2 Gene



Protein tissue co-expression partners for LACTB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LACTB2 Gene:

LACTB2

SOURCE GeneReport for Unigene cluster for LACTB2 Gene:

Hs.118554

Evidence on tissue expression from TISSUES for LACTB2 Gene

  • Liver(4.4)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with LACTB2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LACTB2 Gene

Orthologs for LACTB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LACTB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LACTB2 34 33
  • 90.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LACTB2 34 33
  • 89.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LACTB2 34 33
  • 89.7 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lactb2 33
  • 84.37 (n)
mouse
(Mus musculus)
Mammalia Lactb2 16 34 33
  • 84.26 (n)
oppossum
(Monodelphis domestica)
Mammalia LACTB2 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LACTB2 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves LACTB2 34 33
  • 74.07 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LACTB2 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lactb2 33
  • 69.93 (n)
Str.10744 33
zebrafish
(Danio rerio)
Actinopterygii lactb2 34 33
  • 62.85 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4741 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004236 33
  • 53.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12375 34 33
  • 52.59 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y53F4B.39 33
  • 55.6 (n)
Y53F4B.39 34
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU02376 33
  • 50.42 (n)
Species where no ortholog for LACTB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LACTB2 Gene

ENSEMBL:
Gene Tree for LACTB2 (if available)
TreeFam:
Gene Tree for LACTB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LACTB2: view image

Paralogs for LACTB2 Gene

No data available for Paralogs for LACTB2 Gene

Variants for LACTB2 Gene

Sequence variations from dbSNP and Humsavar for LACTB2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000058707 -- 70,656,779(-) C/A intron_variant
rs1000176961 -- 70,645,457(-) C/T intron_variant
rs1000177649 -- 70,671,072(-) C/T upstream_transcript_variant
rs1000335099 -- 70,666,840(-) G/A intron_variant
rs1000414536 -- 70,639,916(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LACTB2 Gene

Variant ID Type Subtype PubMed ID
esv3308414 CNV mobile element insertion 20981092
esv3444036 CNV insertion 20981092
esv3576585 CNV gain 25503493
nsv1068714 OTHER inversion 25765185

Variation tolerance for LACTB2 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LACTB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LACTB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LACTB2 Gene

Disorders for LACTB2 Gene

Additional Disease Information for LACTB2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LACTB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LACTB2 Gene

Publications for LACTB2 Gene

  1. Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease. (PMID: 26826708) Levy S … Schuster G (Nucleic acids research 2016) 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Disruption of NCOA2 by recurrent fusion with LACTB2 in colorectal cancer. (PMID: 25823027) Yu J … Sung JJ (Oncogene 2016) 3 58

Products for LACTB2 Gene

Sources for LACTB2 Gene

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