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Aliases for LACTB Gene

Aliases for LACTB Gene

  • Lactamase Beta 2 3 5
  • MRPL56 3 4
  • Serine Beta-Lactamase-Like Protein LACTB, Mitochondrial 3
  • Mitochondrial 39S Ribosomal Protein L56 3
  • Mitochondrial Ribosomal Protein L56 2
  • EC 3.4.-.- 4
  • G24 3

External Ids for LACTB Gene

Previous HGNC Symbols for LACTB Gene

  • MRPL56

Previous GeneCards Identifiers for LACTB Gene

  • GC15P059200
  • GC15P056461
  • GC15P060992
  • GC15P061129
  • GC15P061201
  • GC15P063413
  • GC15P040237
  • GC15P063465
  • GC15P063776
  • GC15P064277
  • GC15P066326
  • GC15P066880
  • GC15P067409
  • GC15P067935

Summaries for LACTB Gene

Entrez Gene Summary for LACTB Gene

  • This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013]

GeneCards Summary for LACTB Gene

LACTB (Lactamase Beta) is a Protein Coding gene. Diseases associated with LACTB include Lung Abscess and Otitis Media. Gene Ontology (GO) annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for LACTB Gene

  • Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758).

Gene Wiki entry for LACTB Gene

Additional gene information for LACTB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LACTB Gene

Genomics for LACTB Gene

GeneHancer (GH) Regulatory Elements for LACTB Gene

Promoters and enhancers for LACTB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I063121 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 563.7 +0.4 430 2.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 YBX1 ZNF2 ZBTB7B LACTB SNX1 RPS27L USP3 APH1B CA12 TPM1
GH15I063495 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.9 +379.4 379449 12.4 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 USP3 ENSG00000276651 LACTB TRIP4 ZNF609 RAB8B FBXL22 USP3-AS1 LINC02568 HERC1
GH15I063489 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 36.8 +369.9 369895 3.8 KLF17 MZF1 FEZF1 ZNF335 ZNF121 ZSCAN5C ATF7 ETV6 FOS IKZF2 GC15P069449 LACTB USP3 RAB8B APH1B HERC1 ENSG00000276651
GH15I063486 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 31 +365.9 365927 2.6 HDGF ARID4B SIN3A IRF4 ZNF48 YY1 ARID2 ZNF143 FOS ATF7 GC15P069438 LACTB USP3 USP3-AS1 CA12 RAB8B LINC02568 SNX1 ENSG00000259268
GH15I063478 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22 +358.2 358239 4 PKNOX1 ATF1 FOXA2 SMAD1 FEZF1 ZNF766 ZNF207 ZNF143 FOS ATF7 USP3 LACTB HERC1 FBXL22 ENSG00000259268 CA12 SNX1 RAB8B TPM1 GC15P069438
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LACTB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LACTB gene promoter:

Genomic Locations for LACTB Gene

Genomic Locations for LACTB Gene
chr15:63,121,800-63,142,065
(GRCh38/hg38)
Size:
20,266 bases
Orientation:
Plus strand
chr15:63,413,999-63,434,260
(GRCh37/hg19)

Genomic View for LACTB Gene

Genes around LACTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LACTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LACTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LACTB Gene

Proteins for LACTB Gene

  • Protein details for LACTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P83111-LACTB_HUMAN
    Recommended name:
    Serine beta-lactamase-like protein LACTB, mitochondrial
    Protein Accession:
    P83111
    Secondary Accessions:
    • P83096

    Protein attributes for LACTB Gene

    Size:
    547 amino acids
    Molecular mass:
    60694 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LACTB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LACTB Gene

Post-translational modifications for LACTB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LACTB Gene

No data available for DME Specific Peptides for LACTB Gene

Domains & Families for LACTB Gene

Gene Families for LACTB Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for LACTB Gene

Suggested Antigen Peptide Sequences for LACTB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P83111

UniProtKB/Swiss-Prot:

LACTB_HUMAN :
  • Belongs to the peptidase S12 family.
Family:
  • Belongs to the peptidase S12 family.
genes like me logo Genes that share domains with LACTB: view

Function for LACTB Gene

Molecular function for LACTB Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758).
UniProtKB/Swiss-Prot Induction:
Down-regulated in a number of cancer cells.

Enzyme Numbers (IUBMB) for LACTB Gene

Phenotypes From GWAS Catalog for LACTB Gene

Gene Ontology (GO) - Molecular Function for LACTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IDA,IEA 28329758
GO:0016787 hydrolase activity IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with LACTB: view
genes like me logo Genes that share phenotypes with LACTB: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LACTB Gene

Localization for LACTB Gene

Subcellular locations from UniProtKB/Swiss-Prot for LACTB Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LACTB gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LACTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 28329758
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with LACTB: view

Pathways & Interactions for LACTB Gene

SuperPathways for LACTB Gene

No Data Available

Gene Ontology (GO) - Biological Process for LACTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IDA 28329758
GO:0006629 lipid metabolic process IEA --
GO:0019216 regulation of lipid metabolic process IDA 28329758
genes like me logo Genes that share ontologies with LACTB: view

No data available for Pathways by source and SIGNOR curated interactions for LACTB Gene

Drugs & Compounds for LACTB Gene

(91) Drugs for LACTB Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sulbactam Approved Pharma 35
Tigecycline Approved Pharma Glycylcycline antibiotic 58
Avibactam Approved Pharma Beta-lactamase inhibitor 28
Sulbactam sodium Pharma 0
Nafcillin Sodium Pharma 0

(27) Additional Compounds for LACTB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) ApexBio Compounds for LACTB Gene

Compound Action Cas Number
Avibactam Beta-lactamase inhibitor 1192500-31-4
Nafcillin Sodium 7177-50-6
Sulbactam 68373-14-8
Sulbactam sodium 69388-84-7
Tigecycline Glycylcycline antibiotic 220620-09-7
genes like me logo Genes that share compounds with LACTB: view

Drug Products

Transcripts for LACTB Gene

Unigene Clusters for LACTB Gene

Lactamase, beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LACTB Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for LACTB Gene

GeneLoc Exon Structure for
LACTB
ECgene alternative splicing isoforms for
LACTB

Expression for LACTB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LACTB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LACTB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1), Lymph node (7.0), and Liver (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LACTB Gene



Protein tissue co-expression partners for LACTB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LACTB Gene:

LACTB

SOURCE GeneReport for Unigene cluster for LACTB Gene:

Hs.410388

mRNA Expression by UniProt/SwissProt for LACTB Gene:

P83111-LACTB_HUMAN
Tissue specificity: Expressed predominantly in skeletal muscle.

Evidence on tissue expression from TISSUES for LACTB Gene

  • Liver(4.4)
  • Nervous system(4.3)
  • Kidney(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with LACTB: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LACTB Gene

Orthologs for LACTB Gene

This gene was present in the common ancestor of animals.

Orthologs for LACTB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LACTB 33 34
  • 99.76 (n)
cow
(Bos Taurus)
Mammalia LACTB 33 34
  • 90.98 (n)
dog
(Canis familiaris)
Mammalia LACTB 33 34
  • 90.77 (n)
mouse
(Mus musculus)
Mammalia Lactb 33 16 34
  • 85.26 (n)
rat
(Rattus norvegicus)
Mammalia Lactb 33
  • 84.46 (n)
oppossum
(Monodelphis domestica)
Mammalia LACTB 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LACTB 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves LACTB 33 34
  • 72.42 (n)
lizard
(Anolis carolinensis)
Reptilia LACTB 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lactb 33
  • 66.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19482 33
zebrafish
(Danio rerio)
Actinopterygii lactb 33 34
  • 62.34 (n)
wufj21e07 33
worm
(Caenorhabditis elegans)
Secernentea lact-9 33 34
  • 51.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToOne
Species where no ortholog for LACTB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LACTB Gene

ENSEMBL:
Gene Tree for LACTB (if available)
TreeFam:
Gene Tree for LACTB (if available)

Paralogs for LACTB Gene

No data available for Paralogs for LACTB Gene

Variants for LACTB Gene

Sequence variations from dbSNP and Humsavar for LACTB Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs34925488 benign, Abnormality of neuronal migration 63,121,917(+) G/A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000103223 -- 63,133,503(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000137379 -- 63,133,873(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000271771 -- 63,123,702(+) C/G intron_variant
rs1000495823 -- 63,141,169(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LACTB Gene

Variant ID Type Subtype PubMed ID
esv27033 CNV gain+loss 19812545
esv3636712 CNV gain 21293372
nsv1035441 CNV gain 25217958
nsv428305 CNV gain 18775914

Variation tolerance for LACTB Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LACTB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LACTB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LACTB Gene

Disorders for LACTB Gene

MalaCards: The human disease database

(10) MalaCards diseases for LACTB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung abscess
otitis media
  • otitis media, susceptibility to
mycobacterium fortuitum
  • m. fortuitum
gastroenteritis
  • cholera morbus
meningitis
- elite association - COSMIC cancer census association via MalaCards
Search LACTB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LACTB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LACTB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LACTB Gene

Publications for LACTB Gene

  1. Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain. (PMID: 11707067) Smith TS … Debouck C (Genomics 2001) 2 3 4 22 58
  2. LACTB is a tumour suppressor that modulates lipid metabolism and cell state. (PMID: 28329758) Keckesova Z … Weinberg RA (Nature 2017) 3 4 58
  3. Human metabolic individuality in biomedical and pharmaceutical research. (PMID: 21886157) Suhre K … Gieger C (Nature 2011) 3 44 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. LACTB is a filament-forming protein localized in mitochondria. (PMID: 19858488) Polianskyte Z … Eriksson O (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 58

Products for LACTB Gene

Sources for LACTB Gene

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