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Aliases for LACRT Gene

Aliases for LACRT Gene

  • Lacritin 2 3 5
  • Extracellular Glycoprotein Lacritin 3

External Ids for LACRT Gene

Previous GeneCards Identifiers for LACRT Gene

  • GC12P049944
  • GC12M055138
  • GC12M054741
  • GC12M053310
  • GC12M055024
  • GC12M052063

Summaries for LACRT Gene

Entrez Gene Summary for LACRT Gene

  • The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]

GeneCards Summary for LACRT Gene

LACRT (Lacritin) is a Protein Coding gene. Diseases associated with LACRT include Blepharitis and Dry Eye Syndrome. Gene Ontology (GO) annotations related to this gene include growth factor activity and collagen binding.

UniProtKB/Swiss-Prot for LACRT Gene

  • Modulates secretion by lacrimal acinar cells.

Gene Wiki entry for LACRT Gene

Additional gene information for LACRT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LACRT Gene

Genomics for LACRT Gene

GeneHancer (GH) Regulatory Elements for LACRT Gene

Promoters and enhancers for LACRT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J054634 Promoter 0.5 EPDnew 650.7 0.0 -20 0.1 LACRT DCD
GH12J054648 Promoter 0.6 EPDnew 0.4 -13.5 -13487 0.1 FOXA2 DCD GC12P054648 LACRT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LACRT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LACRT gene promoter:
  • HNF-3beta
  • Evi-1
  • HFH-3
  • FOXI1
  • POU2F1a
  • POU2F1
  • LCR-F1
  • Meis-1a
  • Meis-1
  • HOXA9B

Genomic Locations for LACRT Gene

Genomic Locations for LACRT Gene
chr12:54,630,811-54,634,895
(GRCh38/hg38)
Size:
4,085 bases
Orientation:
Minus strand
chr12:55,024,595-55,028,679
(GRCh37/hg19)
Size:
4,085 bases
Orientation:
Minus strand

Genomic View for LACRT Gene

Genes around LACRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LACRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LACRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LACRT Gene

Proteins for LACRT Gene

  • Protein details for LACRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZZ8-LACRT_HUMAN
    Recommended name:
    Extracellular glycoprotein lacritin
    Protein Accession:
    Q9GZZ8

    Protein attributes for LACRT Gene

    Size:
    138 amino acids
    Molecular mass:
    14246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LACRT Gene

Post-translational modifications for LACRT Gene

  • Glycosylation at Asn119 and Ser76
  • Modification sites at PhosphoSitePlus

Other Protein References for LACRT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LACRT Gene

Domains & Families for LACRT Gene

Gene Families for LACRT Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for LACRT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LACRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LACRT: view

No data available for UniProtKB/Swiss-Prot for LACRT Gene

Function for LACRT Gene

Molecular function for LACRT Gene

UniProtKB/Swiss-Prot Function:
Modulates secretion by lacrimal acinar cells.

Gene Ontology (GO) - Molecular Function for LACRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IDA 11419941
GO:0005515 protein binding IDA 11419941
GO:0005518 collagen binding IDA 11419941
GO:0008083 growth factor activity IDA 16982797
GO:0043237 laminin-1 binding IDA 11419941
genes like me logo Genes that share ontologies with LACRT: view
genes like me logo Genes that share phenotypes with LACRT: view

Animal Model Products

CRISPR Products

miRNA for LACRT Gene

miRTarBase miRNAs that target LACRT

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LACRT

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LACRT Gene

Localization for LACRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for LACRT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LACRT gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for LACRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 17850790
GO:0005615 extracellular space HDA 22664934
GO:0030141 secretory granule IDA 11419941
genes like me logo Genes that share ontologies with LACRT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LACRT Gene

Pathways & Interactions for LACRT Gene

SuperPathways for LACRT Gene

No Data Available

Gene Ontology (GO) - Biological Process for LACRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006473 protein acetylation IMP 23640897
GO:0008284 positive regulation of cell proliferation IDA 11419941
GO:0010469 regulation of signaling receptor activity IEA --
GO:0010669 epithelial structure maintenance IDA 25034600
GO:0016239 positive regulation of macroautophagy IDA 23640897
genes like me logo Genes that share ontologies with LACRT: view

No data available for Pathways by source and SIGNOR curated interactions for LACRT Gene

Drugs & Compounds for LACRT Gene

(1) Drugs for LACRT Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with LACRT: view

Transcripts for LACRT Gene

mRNA/cDNA for LACRT Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(89) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LACRT Gene

Lacritin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LACRT

Alternative Splicing Database (ASD) splice patterns (SP) for LACRT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1: - -
SP2: - - -
SP3:
SP4: - -

Relevant External Links for LACRT Gene

GeneLoc Exon Structure for
LACRT
ECgene alternative splicing isoforms for
LACRT

Expression for LACRT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LACRT Gene

mRNA differential expression in normal tissues according to GTEx for LACRT Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x30.8), Skin - Not Sun Exposed (Suprapubic) (x12.0), and Minor Salivary Gland (x5.6).

Protein differential expression in normal tissues from HIPED for LACRT Gene

This gene is overexpressed in Platelet (38.0) and Heart (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LACRT Gene



Protein tissue co-expression partners for LACRT Gene

NURSA nuclear receptor signaling pathways regulating expression of LACRT Gene:

LACRT

SOURCE GeneReport for Unigene cluster for LACRT Gene:

Hs.307096

mRNA Expression by UniProt/SwissProt for LACRT Gene:

Q9GZZ8-LACRT_HUMAN
Tissue specificity: Expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinar cells of salivary glands.

Evidence on tissue expression from TISSUES for LACRT Gene

  • Eye(4.9)
  • Saliva(4.2)
  • Thyroid gland(4)
genes like me logo Genes that share expression patterns with LACRT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for LACRT Gene

Orthologs for LACRT Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for LACRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LACRT 34 33
  • 99.27 (n)
OneToOne
Species where no ortholog for LACRT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LACRT Gene

ENSEMBL:
Gene Tree for LACRT (if available)
TreeFam:
Gene Tree for LACRT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LACRT: view image

Paralogs for LACRT Gene

No data available for Paralogs for LACRT Gene

Variants for LACRT Gene

Sequence variations from dbSNP and Humsavar for LACRT Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000594022 -- 54,633,766(-) G/A intron_variant
rs1000951181 -- 54,632,674(-) A/G intron_variant
rs1001132320 -- 54,633,987(-) A/T intron_variant
rs1001278679 -- 54,636,514(-) T/C upstream_transcript_variant
rs1001429595 -- 54,630,774(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LACRT Gene

Variant ID Type Subtype PubMed ID
nsv832421 CNV gain 17160897

Variation tolerance for LACRT Gene

Residual Variation Intolerance Score: 44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LACRT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LACRT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LACRT Gene

Disorders for LACRT Gene

MalaCards: The human disease database

(3) MalaCards diseases for LACRT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
blepharitis
dry eye syndrome
  • xerophthalmia
lacrimal apparatus disease
  • lacrimal apparatus diseases
- elite association - COSMIC cancer census association via MalaCards
Search LACRT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LACRT

genes like me logo Genes that share disorders with LACRT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LACRT Gene

Publications for LACRT Gene

  1. cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. (PMID: 11419941) Sanghi S … Laurie GW (Journal of molecular biology 2001) 2 3 4 22 58
  2. Lacritin and other new proteins of the lacrimal functional unit. (PMID: 18840430) McKown RL … Laurie GW (Experimental eye research 2009) 3 22 58
  3. Quantitative analysis of N-linked glycoproteins in tear fluid of climatic droplet keratopathy by glycopeptide capture and iTRAQ. (PMID: 19714880) Lei Z … Serra HM (Journal of proteome research 2009) 3 22 58
  4. Mass spectrometry-based proteomic analyses in contact lens-related dry eye. (PMID: 19770725) Nichols JJ … Green-Church KB (Cornea 2009) 3 22 58
  5. Mass spectrometry-based proteomic analyses of contact lens deposition. (PMID: 18334948) Green-Church KB … Nichols JJ (Molecular vision 2008) 3 22 58

Products for LACRT Gene

Sources for LACRT Gene

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