Aliases for LACC1 Gene
External Ids for LACC1 Gene
Previous HGNC Symbols for LACC1 Gene
Previous GeneCards Identifiers for LACC1 Gene
This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages. The encoded protein forms a complex with fatty acid synthase on peroxisomes and is thought to be modulated by peroxisome proliferator-activated receptor signaling events. Naturally occurring mutations in this gene are associated with inflammatory bowel disease, Behcet's disease, leprosy, ulcerative colitis, early-onset Crohn's disease, and systemic juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017]
GeneCards Summary for LACC1 Gene
LACC1 (Laccase Domain Containing 1) is a Protein Coding gene. Diseases associated with LACC1 include Rheumatoid Arthritis, Systemic Juvenile and Arthritis. An important paralog of this gene is ENSG00000281883.
UniProtKB/Swiss-Prot Summary for LACC1 Gene
Central regulator of the metabolic function and bioenergetic state of macrophages. In macrophages, promotes flux through de novo lipogenesis to concomitantly drive high levels of both fatty-acid oxidation and glycolysis.