Aliases for L3MBTL4 Gene

Aliases for L3MBTL4 Gene

  • L3MBTL Histone Methyl-Lysine Binding Protein 4 2 3 5
  • L3MBTL4, Histone Methyl-Lysine Binding Protein 2 3
  • Lethal(3)Malignant Brain Tumor-Like Protein 4 3 4
  • H-L(3)Mbt-Like Protein 4 3 4
  • L(3)Mbt-Like 4 (Drosophila) 2
  • L(3)Mbt-Like Protein 4 4
  • L3mbt-Like 4 4
  • HsT1031 3

External Ids for L3MBTL4 Gene

Previous GeneCards Identifiers for L3MBTL4 Gene

  • GC18M005945
  • GC18M005946

Summaries for L3MBTL4 Gene

GeneCards Summary for L3MBTL4 Gene

L3MBTL4 (L3MBTL Histone Methyl-Lysine Binding Protein 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is L3MBTL3.

UniProtKB/Swiss-Prot Summary for L3MBTL4 Gene

  • Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity).

Additional gene information for L3MBTL4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for L3MBTL4 Gene

Genomics for L3MBTL4 Gene

GeneHancer (GH) Regulatory Elements for L3MBTL4 Gene

Promoters and enhancers for L3MBTL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J006413 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 757.2 +0.8 760 2.2 RBPJ RELA RAD21 MNT NKRF POLR2A SP7 ZNF687 IKZF1 GLIS2 L3MBTL4 lnc-TMEM200C-2
GH18J006416 Enhancer 0.2 FANTOM5 754.4 -1.8 -1783 0.2 L3MBTL4 piR-48209-309
GH18J006371 Enhancer 1.1 Ensembl ENCODE 17.5 +44.2 44237 1.2 LCORL MLX NR2F6 CREB1 MIXL1 ZNF701 RAD21 NFIB BCL6B ELF3 L3MBTL4 MIR4317 lnc-TMEM200C-1 lnc-TMEM200C-2
GH18J006406 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 13.5 +8.9 8936 2.2 NR2F6 CREB1 MIXL1 HLF ELF3 SP1 CEBPG ZNF24 PPARG HNF1A L3MBTL4 ENSG00000279885 lnc-TMEM200C-2
GH18J006366 Enhancer 0.7 Ensembl ENCODE 16.4 +48.5 48536 3 ZIC2 OSR2 PRDM4 ZNF423 ZNF18 ZNF335 FEZF1 PRDM6 GLIS1 lnc-TMEM200C-1 L3MBTL4 lnc-TMEM200C-2 lnc-ARHGAP28-11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around L3MBTL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the L3MBTL4 gene promoter:
  • AREB6
  • CUTL1
  • FOXF2
  • FOXO4
  • IRF-7A
  • MyoD
  • POU2F1
  • POU2F1a
  • S8

Genomic Locations for L3MBTL4 Gene

Genomic Locations for L3MBTL4 Gene
460,535 bases
Minus strand
460,532 bases
Minus strand

Genomic View for L3MBTL4 Gene

Genes around L3MBTL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
L3MBTL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for L3MBTL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for L3MBTL4 Gene

Proteins for L3MBTL4 Gene

  • Protein details for L3MBTL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lethal(3)malignant brain tumor-like protein 4
    Protein Accession:
    Secondary Accessions:
    • A8MTL8
    • Q8IXS3

    Protein attributes for L3MBTL4 Gene

    623 amino acids
    Molecular mass:
    71122 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for L3MBTL4 Gene


neXtProt entry for L3MBTL4 Gene

Post-translational modifications for L3MBTL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for L3MBTL4 Gene

Domains & Families for L3MBTL4 Gene

Protein Domains for L3MBTL4 Gene

Suggested Antigen Peptide Sequences for L3MBTL4 Gene

GenScript: Design optimal peptide antigens:
  • Lethal(3)malignant brain tumor-like protein 4 (LMBL4_HUMAN)
genes like me logo Genes that share domains with L3MBTL4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for L3MBTL4 Gene

Function for L3MBTL4 Gene

Molecular function for L3MBTL4 Gene

UniProtKB/Swiss-Prot Function:
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity).

Phenotypes From GWAS Catalog for L3MBTL4 Gene

Gene Ontology (GO) - Molecular Function for L3MBTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0140110 transcription regulator activity IEA --
genes like me logo Genes that share ontologies with L3MBTL4: view
genes like me logo Genes that share phenotypes with L3MBTL4: view

Animal Model Products

CRISPR Products

miRNA for L3MBTL4 Gene

miRTarBase miRNAs that target L3MBTL4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for L3MBTL4 Gene

Localization for L3MBTL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for L3MBTL4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for L3MBTL4 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for L3MBTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with L3MBTL4: view

Pathways & Interactions for L3MBTL4 Gene

PathCards logo

SuperPathways for L3MBTL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for L3MBTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with L3MBTL4: view

No data available for Pathways by source and SIGNOR curated interactions for L3MBTL4 Gene

Drugs & Compounds for L3MBTL4 Gene

No Compound Related Data Available

Transcripts for L3MBTL4 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for L3MBTL4 Gene

No ASD Table

Relevant External Links for L3MBTL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for L3MBTL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for L3MBTL4 Gene

NURSA nuclear receptor signaling pathways regulating expression of L3MBTL4 Gene:


SOURCE GeneReport for Unigene cluster for L3MBTL4 Gene:

genes like me logo Genes that share expression patterns with L3MBTL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for L3MBTL4 Gene

Orthologs for L3MBTL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for L3MBTL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia L3MBTL4 33 32
  • 99.41 (n)
(Canis familiaris)
Mammalia L3MBTL4 33 32
  • 89.78 (n)
(Mus musculus)
Mammalia L3mbtl4 17 33 32
  • 83.44 (n)
(Monodelphis domestica)
Mammalia L3MBTL4 33
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia L3MBTL4 33
  • 76 (a)
(Gallus gallus)
Aves -- 33
  • 34 (a)
(Danio rerio)
Actinopterygii L3MBTL4 33
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006811 32
  • 49.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(3)mbt 33
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 45 (a)
Species where no ortholog for L3MBTL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for L3MBTL4 Gene

Gene Tree for L3MBTL4 (if available)
Gene Tree for L3MBTL4 (if available)
Evolutionary constrained regions (ECRs) for L3MBTL4: view image

Paralogs for L3MBTL4 Gene

(7) SIMAP similar genes for L3MBTL4 Gene using alignment to 6 proteins:

  • F5H508_HUMAN
  • F8W9S8_HUMAN
  • J3KS41_HUMAN
genes like me logo Genes that share paralogs with L3MBTL4: view

Variants for L3MBTL4 Gene

Sequence variations from dbSNP and Humsavar for L3MBTL4 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000005756 -- 6,365,292(-) GG/G genic_upstream_transcript_variant, intron_variant
rs1000006381 -- 5,965,902(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000012856 -- 6,149,557(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000013928 -- 6,400,583(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000021048 -- 6,068,997(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for L3MBTL4 Gene

Variant ID Type Subtype PubMed ID
dgv3318n100 CNV gain 25217958
esv1675053 CNV deletion 17803354
esv2585361 CNV deletion 19546169
esv2658589 CNV deletion 23128226
esv2673610 CNV deletion 23128226
esv2674522 CNV deletion 23128226
esv2678059 CNV deletion 23128226
esv27049 CNV loss 19812545
esv2716721 CNV deletion 23290073
esv2716722 CNV deletion 23290073
esv2716723 CNV deletion 23290073
esv2716724 CNV deletion 23290073
esv2716725 CNV deletion 23290073
esv2716726 CNV deletion 23290073
esv2716727 CNV deletion 23290073
esv2716728 CNV deletion 23290073
esv2716730 CNV deletion 23290073
esv2716731 CNV deletion 23290073
esv2716732 CNV deletion 23290073
esv2716733 CNV deletion 23290073
esv29099 CNV gain+loss 19812545
esv3353825 CNV insertion 20981092
esv3433465 CNV insertion 20981092
esv3573909 CNV gain 25503493
esv3641663 CNV loss 21293372
esv3641664 CNV loss 21293372
esv3641665 CNV loss 21293372
nsv1059678 CNV gain 25217958
nsv1121947 CNV deletion 24896259
nsv131635 CNV insertion 16902084
nsv131663 CNV insertion 16902084
nsv131965 CNV deletion 16902084
nsv512514 CNV loss 21212237
nsv518347 CNV loss 19592680
nsv521173 CNV gain 19592680
nsv521604 CNV loss 19592680
nsv525681 CNV loss 19592680
nsv576394 CNV loss 21841781
nsv576395 CNV loss 21841781
nsv817781 CNV loss 17921354
nsv819367 CNV gain 19587683
nsv821505 CNV deletion 20802225
nsv828169 CNV loss 20364138

Variation tolerance for L3MBTL4 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.84; 73.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for L3MBTL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for L3MBTL4 Gene

Disorders for L3MBTL4 Gene

Additional Disease Information for L3MBTL4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for L3MBTL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for L3MBTL4 Gene

Publications for L3MBTL4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 56
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  4. Genome Wide Association Study Identifies L3MBTL4 as a Novel Susceptibility Gene for Hypertension. (PMID: 27480026) Liu X … Cai J (Scientific reports 2016) 3 56
  5. A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S … Beisel C (Cell reports 2016) 3 56

Products for L3MBTL4 Gene

  • Biorbyt antibodies for L3MBTL4

Sources for L3MBTL4 Gene