Aliases for L3MBTL3 Gene
External Ids for L3MBTL3 Gene
Previous GeneCards Identifiers for L3MBTL3 Gene
This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma. [provided by RefSeq, Oct 2016]
GeneCards Summary for L3MBTL3 Gene
L3MBTL3 (L3MBTL Histone Methyl-Lysine Binding Protein 3) is a Protein Coding gene. Diseases associated with L3MBTL3 include Lipodystrophy, Familial Partial, Type 1 and Gastric Dilatation. An important paralog of this gene is L3MBTL4.
UniProtKB/Swiss-Prot Summary for L3MBTL3 Gene
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).