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L1TD1 (LINE1 Type Transposase Domain Containing 1) is a Protein Coding gene. Diseases associated with L1TD1 include Testis Seminoma. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and obsolete signal transducer activity.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J062194 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE dbSUPER | 287.3 | +2.2 | 2216 | 5.9 | CEBPA ETS1 KDM6A THAP11 CEBPB ZNF623 SIN3A ZNF511 SMAD4 SAP130 | L1TD1 PATJ ENSG00000237227 lnc-KANK4-2 KANK4 | |
GH01J062192 | Enhancer | 0.3 | Ensembl | 277.6 | -1.8 | -1848 | 0.4 | EGR2 | L1TD1 lnc-L1TD1-1 PATJ | |
GH01J062179 | Enhancer | 0.9 | ENCODE CraniofacialAtlas dbSUPER | 23.8 | -12.8 | -12794 | 4.3 | ETS1 ZNF217 CUX1 CTBP1 YY1 SMARCE1 DPF2 NFIB POU5F1 ZHX2 | HSALNG0004053 piR-61846-001 L1TD1 KANK4 PATJ | |
GH01J062176 | Enhancer | 0.7 | Ensembl ENCODE dbSUPER | 22.7 | -17.5 | -17455 | 2 | SCRT1 SP1 NANOG | piR-39323-001 piR-31433-001 piR-40646-001 L1TD1 PATJ HSALNG0004053 lnc-L1TD1-7 | |
GH01J062234 | Enhancer | 1.2 | Ensembl ENCODE CraniofacialAtlas | 6.3 | +41.6 | 41552 | 4 | CEBPA HOMEZ KDM6A THAP11 CEBPB FOXA2 MAFF SMAD4 SAP130 EP300 | hsa-miR-5095-022 L1TD1 lnc-L1TD1-3 KANK4 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003727 | single-stranded RNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 25702638 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
GO:1990904 | ribonucleoprotein complex | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0032197 | transposition, RNA-mediated | IBA | 21873635 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | L1TD1 30 31 |
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OneToOne | |
Mouse (Mus musculus) |
Mammalia | L1td1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
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OneToMany | |
-- 31 |
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany | |||
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OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs202029696 | Benign: not provided | 62,210,575(+) |
GAACT/G NM_019079.5(L1TD1):c.1805_1808del (p.Leu602fs) |
FRAMESHIFT | |
rs11207933 | - |
p.Pro549Thr |
|||
rs11207934 | - |
p.Leu860Val |
|||
rs2457828 | - |
p.Lys329Asn |
|||
rs2886644 | - |
p.Thr613Ile |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3577899 | CNV | loss | 25503493 |
esv3893601 | CNV | loss | 25118596 |
esv3893612 | CNV | loss | 25118596 |
Disorder | Aliases | PubMed IDs |
---|---|---|
testis seminoma |
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