Free for academic non-profit institutions. Other users need a Commercial license

Aliases for L1TD1 Gene

Aliases for L1TD1 Gene

  • LINE1 Type Transposase Domain Containing 1 2 3 5
  • ES Cell-Associated Protein 11 3 4
  • ECAT11 3 4
  • LINE-1 Type Transposase Domain-Containing Protein 1 3
  • LINE-1 Type Transposase Domain Containing 1 3

External Ids for L1TD1 Gene

Previous GeneCards Identifiers for L1TD1 Gene

  • GC01P062434
  • GC01P062660
  • GC01P060773

Summaries for L1TD1 Gene

GeneCards Summary for L1TD1 Gene

L1TD1 (LINE1 Type Transposase Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and signal transducer activity.

Additional gene information for L1TD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for L1TD1 Gene

Genomics for L1TD1 Gene

GeneHancer (GH) Regulatory Elements for L1TD1 Gene

Promoters and enhancers for L1TD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I062194 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 587.4 +2.2 2225 5.8 ELF3 ARID4B SIN3A ZSCAN9 RARA ETS1 ATF7 THAP11 MIXL1 PAF1 L1TD1 GC01P062196 PATJ GC01P062201
GH01I062179 Enhancer 0.8 ENCODE dbSUPER 23.8 -12.7 -12747 4.3 SMARCE1 NFIB NEUROD1 DPF2 ETS1 ZNF217 CTBP1 NFIC POLR2A POU5F1 L1TD1 KANK4 PATJ PIGPP2 GC01P062128
GH01I062176 Enhancer 0.6 ENCODE dbSUPER 22.7 -17.5 -17540 1.7 SP1 SCRT2 L1TD1 PATJ PIGPP2 GC01P062128
GH01I062228 Enhancer 1 Ensembl ENCODE 6.9 +35.3 35253 3.6 NFIB SIN3A RAD21 BRCA1 RFX5 ZNF335 FOS RCOR1 DEK EGR2 L1TD1 GC01M062237 GC01P062219
GH01I062285 Enhancer 1 Ensembl ENCODE 6.2 +91.8 91796 1.3 ELF3 FOXA2 ARID4B RAD21 RARA MXD4 ELF1 KAT8 TGIF2 SSRP1 KANK4 L1TD1 GC01M062299 GC01M062237
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around L1TD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the L1TD1 gene promoter:

Genomic Locations for L1TD1 Gene

Genomic Locations for L1TD1 Gene
chr1:62,194,802-62,212,328
(GRCh38/hg38)
Size:
17,527 bases
Orientation:
Plus strand
chr1:62,660,474-62,678,000
(GRCh37/hg19)

Genomic View for L1TD1 Gene

Genes around L1TD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
L1TD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for L1TD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for L1TD1 Gene

Proteins for L1TD1 Gene

  • Protein details for L1TD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7N2-LITD1_HUMAN
    Recommended name:
    LINE-1 type transposase domain-containing protein 1
    Protein Accession:
    Q5T7N2
    Secondary Accessions:
    • Q8NDA1
    • Q9NUV8
    • Q9NV78

    Protein attributes for L1TD1 Gene

    Size:
    865 amino acids
    Molecular mass:
    98850 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91878.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91878.1; Type=Erroneous termination; Positions=555; Note=Translated as Leu.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for L1TD1 Gene

neXtProt entry for L1TD1 Gene

Post-translational modifications for L1TD1 Gene

No Post-translational modifications

Other Protein References for L1TD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for L1TD1 Gene

Domains & Families for L1TD1 Gene

Gene Families for L1TD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for L1TD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for L1TD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T7N2

UniProtKB/Swiss-Prot:

LITD1_HUMAN :
  • Belongs to the transposase 22 family.
Family:
  • Belongs to the transposase 22 family.
genes like me logo Genes that share domains with L1TD1: view

Function for L1TD1 Gene

Phenotypes From GWAS Catalog for L1TD1 Gene

Gene Ontology (GO) - Molecular Function for L1TD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003727 single-stranded RNA binding IBA --
genes like me logo Genes that share ontologies with L1TD1: view
genes like me logo Genes that share phenotypes with L1TD1: view

miRNA for L1TD1 Gene

miRTarBase miRNAs that target L1TD1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for L1TD1 Gene

Localization for L1TD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for L1TD1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for L1TD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030529 intracellular ribonucleoprotein complex IBA --
genes like me logo Genes that share ontologies with L1TD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for L1TD1 Gene

Pathways & Interactions for L1TD1 Gene

SuperPathways for L1TD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for L1TD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032197 transposition, RNA-mediated IBA --
genes like me logo Genes that share ontologies with L1TD1: view

No data available for Pathways by source and SIGNOR curated interactions for L1TD1 Gene

Drugs & Compounds for L1TD1 Gene

No Compound Related Data Available

Transcripts for L1TD1 Gene

mRNA/cDNA for L1TD1 Gene

Unigene Clusters for L1TD1 Gene

LINE-1 type transposase domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for L1TD1 Gene

No ASD Table

Relevant External Links for L1TD1 Gene

GeneLoc Exon Structure for
L1TD1
ECgene alternative splicing isoforms for
L1TD1

Expression for L1TD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for L1TD1 Gene

mRNA differential expression in normal tissues according to GTEx for L1TD1 Gene

This gene is overexpressed in Testis (x12.1), Colon - Transverse (x10.7), and Nerve - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for L1TD1 Gene

This gene is overexpressed in Cervix (27.4), Prostate (12.3), Testis (10.5), and Plasma (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for L1TD1 Gene



Protein tissue co-expression partners for L1TD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of L1TD1 Gene:

L1TD1

SOURCE GeneReport for Unigene cluster for L1TD1 Gene:

Hs.685462

Evidence on tissue expression from TISSUES for L1TD1 Gene

  • Lung(4.2)
  • Bone(3.6)
genes like me logo Genes that share expression patterns with L1TD1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for L1TD1 Gene

Orthologs for L1TD1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for L1TD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia L1TD1 33 34
  • 99.03 (n)
mouse
(Mus musculus)
Mammalia L1td1 34
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 30 (a)
OneToMany
-- 34
  • 30 (a)
OneToMany
-- 34
  • 29 (a)
OneToMany
-- 34
  • 29 (a)
OneToMany
-- 34
  • 29 (a)
OneToMany
-- 34
  • 29 (a)
OneToMany
-- 34
  • 29 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
-- 34
  • 27 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
-- 34
  • 22 (a)
OneToMany
-- 34
  • 21 (a)
OneToMany
-- 34
  • 17 (a)
OneToMany
-- 34
  • 15 (a)
OneToMany
Species where no ortholog for L1TD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for L1TD1 Gene

ENSEMBL:
Gene Tree for L1TD1 (if available)
TreeFam:
Gene Tree for L1TD1 (if available)

Paralogs for L1TD1 Gene

(1) SIMAP similar genes for L1TD1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for L1TD1 Gene

genes like me logo Genes that share paralogs with L1TD1: view

No data available for Paralogs for L1TD1 Gene

Variants for L1TD1 Gene

Sequence variations from dbSNP and Humsavar for L1TD1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000066997 -- 62,207,186(+) AAATCGCAA/ coding_sequence_variant, inframe_deletion
rs1000224873 -- 62,193,782(+) C/A upstream_transcript_variant
rs1000523340 -- 62,198,359(+) G/A intron_variant
rs1000672510 -- 62,205,889(+) G/A intron_variant
rs1000695546 -- 62,207,745(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for L1TD1 Gene

Variant ID Type Subtype PubMed ID
esv3893612 CNV loss 25118596
esv3893601 CNV loss 25118596
esv3577899 CNV loss 25503493

Variation tolerance for L1TD1 Gene

Gene Damage Index Score: 6.21; 76.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for L1TD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
L1TD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for L1TD1 Gene

Disorders for L1TD1 Gene

Additional Disease Information for L1TD1

No disorders were found for L1TD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for L1TD1 Gene

Publications for L1TD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. SPAG6 and L1TD1 are transcriptionally regulated by DNA methylation in non-small cell lung cancers. (PMID: 28093071) Altenberger C … Zöchbauer-Müller S (Molecular cancer 2017) 3 58
  4. The L1TD1 protein interactome reveals the importance of post-transcriptional regulation in human pluripotency. (PMID: 25702638) Emani MR … Lahesmaa R (Stem cell reports 2015) 3 58
  5. Embryonic Stem Cell-Related Protein L1TD1 Is Required for Cell Viability, Neurosphere Formation, and Chemoresistance in Medulloblastoma. (PMID: 26159230) Santos MC … Okamoto OK (Stem cells and development 2015) 3 58

Products for L1TD1 Gene

Sources for L1TD1 Gene

Content
Loading form....