Aliases for KYAT3 Gene
External Ids for KYAT3 Gene
Previous HGNC Symbols for KYAT3 Gene
Previous GeneCards Identifiers for KYAT3 Gene
This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid, which is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Mar 2017]
GeneCards Summary for KYAT3 Gene
KYAT3 (Kynurenine Aminotransferase 3) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism. An important paralog of this gene is ENSG00000286112.
UniProtKB/Swiss-Prot Summary for KYAT3 Gene
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro).