This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid, which is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences... See more...

Aliases for KYAT3 Gene

Aliases for KYAT3 Gene

  • Kynurenine Aminotransferase 3 2 3 4 5
  • Kynurenine--Oxoglutarate Transaminase 3 2 3 4
  • Kynurenine--Oxoglutarate Transaminase III 3 4
  • Kynurenine--Glyoxylate Transaminase 3 4
  • Cysteine-S-Conjugate Beta-Lyase 2 3 4
  • Kynurenine Aminotransferase III 3 4
  • KATIII 3 4
  • CCBL2 3 4
  • KAT3 3 4
  • Cysteine Conjugate Beta Lyase 2 2
  • EC 4.4.1.13 4
  • EC 2.6.1.63 4
  • EC 2.6.1.7 4

External Ids for KYAT3 Gene

Previous HGNC Symbols for KYAT3 Gene

  • CCBL2

Summaries for KYAT3 Gene

Entrez Gene Summary for KYAT3 Gene

  • This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid, which is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Mar 2017]

GeneCards Summary for KYAT3 Gene

KYAT3 (Kynurenine Aminotransferase 3) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Glutathione metabolism. An important paralog of this gene is ENSG00000286112.

UniProtKB/Swiss-Prot Summary for KYAT3 Gene

  • Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).

Additional gene information for KYAT3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KYAT3 Gene

Genomics for KYAT3 Gene

GeneHancer (GH) Regulatory Elements for KYAT3 Gene

Promoters and enhancers for KYAT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J088990 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 510.3 +0.4 403 4 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 NRF1 POLR2G SP1 NCOR1 GTF2E2 KYAT3 HSALNG0005043 RBMXL1 GBP3 PKN2 ELOCP19 GTF2B GBP5 GBP6 ENSG00000235308
GH01J088889 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 41.7 +101.3 101275 4.2 FOXK2 ZNF217 EP300 ZSCAN5C SIN3A NRF1 TCF12 POLR2G USF1 SP1 GTF2B HSALNG0005035 lnc-GTF2B-2 KYAT3 ENSG00000235308 PKN2 RBMXL1 piR-43107-014
GH01J088682 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 39 +308.1 308100 5.1 EP300 CTCF SIN3A ZNF300 POLR2G USF1 SP1 RBAK PHF8 SIX5 PKN2 PKN2-AS1 KYAT3 GTF2B ENSG00000235308 ELOCP19 RBMXL1 lnc-GTF2B-6
GH01J088980 Promoter/Enhancer 0.9 EPDnew Ensembl 67.7 +12.1 12059 3.4 ZNF843 SCRT1 PRDM6 FEZF1 HLF MTA2 HMBOX1 RUNX3 SCRT2 RBMXL1 KYAT3 GBP6 GBP5 GBP2 lnc-PKN2-4
GH01J088971 Enhancer 0.7 Ensembl 74.9 +20.3 20259 4.2 CTCF REST RAD21 TRIM22 SMC3 GATA3 SRF CHAMP1 ZNF654 ZNF384 KYAT3 GBP5 RBMXL1 lnc-PKN2-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KYAT3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KYAT3

Genomic Locations for KYAT3 Gene

Genomic Locations for KYAT3 Gene
chr1:88,935,773-88,992,960
(GRCh38/hg38)
Size:
57,188 bases
Orientation:
Minus strand
chr1:89,401,456-89,458,643
(GRCh37/hg19)
Size:
57,188 bases
Orientation:
Minus strand

Genomic View for KYAT3 Gene

Genes around KYAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KYAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KYAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KYAT3 Gene

Proteins for KYAT3 Gene

  • Protein details for KYAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6YP21-KAT3_HUMAN
    Recommended name:
    Kynurenine--oxoglutarate transaminase 3
    Protein Accession:
    Q6YP21
    Secondary Accessions:
    • B3KQ13
    • O95335
    • Q5JS27
    • Q5T9T7
    • Q5T9T8
    • Q6AI27
    • Q6ICW1
    • Q9BVY5

    Protein attributes for KYAT3 Gene

    Size:
    454 amino acids
    Molecular mass:
    51400 Da
    Cofactor:
    Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAC72959.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH00819.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAG29278.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for KYAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KYAT3 Gene

Post-translational modifications for KYAT3 Gene

  • Ubiquitination at Lys108 and Lys447
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KYAT3 Gene

Domains & Families for KYAT3 Gene

Gene Families for KYAT3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for KYAT3 Gene

Blocks:
  • Aminotransferase, class I and II
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KYAT3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ32614 fis, clone STOMA2000121, highly similar to Homo sapiens kynurenine aminotransferase III (KAT3), transcript variant 2, mRNA (B3KQ13_HUMAN)
  • Kynurenine--oxoglutarate transaminase III (KAT3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6YP21

UniProtKB/Swiss-Prot:

KAT3_HUMAN :
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with KYAT3: view

Function for KYAT3 Gene

Molecular function for KYAT3 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-oxoglutarate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate; Xref=Rhea:RHEA:20964, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57959, ChEBI:CHEBI:58147; EC=2.6.1.7;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an S-substituted L-cysteine + H2O = a thiol + NH4(+) + pyruvate; Xref=Rhea:RHEA:18121, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29256, ChEBI:CHEBI:58717; EC=4.4.1.13;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glyoxylate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine; Xref=Rhea:RHEA:19249, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:57959, ChEBI:CHEBI:58147; EC=2.6.1.63;.

Enzyme Numbers (IUBMB) for KYAT3 Gene

Phenotypes From GWAS Catalog for KYAT3 Gene

Gene Ontology (GO) - Molecular Function for KYAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003824 catalytic activity IEA --
GO:0008483 transaminase activity IEA --
GO:0016212 kynurenine-oxoglutarate transaminase activity IBA,ISS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with KYAT3: view
genes like me logo Genes that share phenotypes with KYAT3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KYAT3

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KYAT3 Gene

Localization for KYAT3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KYAT3 gene
Compartment Confidence
mitochondrion 4
cytosol 3
nucleus 2
extracellular 1
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KYAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IBA 21873635
genes like me logo Genes that share ontologies with KYAT3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KYAT3 Gene

Pathways & Interactions for KYAT3 Gene

genes like me logo Genes that share pathways with KYAT3: view

Gene Ontology (GO) - Biological Process for KYAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006103 2-oxoglutarate metabolic process IEA --
GO:0006520 cellular amino acid metabolic process IEA,ISS --
GO:0009058 biosynthetic process IEA --
GO:0070189 kynurenine metabolic process IEA,ISS --
GO:0097052 L-kynurenine metabolic process IEA --
genes like me logo Genes that share ontologies with KYAT3: view

No data available for SIGNOR curated interactions for KYAT3 Gene

Drugs & Compounds for KYAT3 Gene

(12) Drugs for KYAT3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic acid Approved Nutra Full agonist, Agonist, Target 289
Pyridoxal Phosphate Approved, Investigational Nutra Target, cofactor 20
Ammonia Approved Pharma 0
Water Approved Pharma 0
Glycine Approved, Vet_approved Nutra Full agonist, Agonist 369

(5) Additional Compounds for KYAT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Oxo-4-methylthiobutanoic acid
  • 2-keto-4-Methylthiobutyric acid
  • 2-oxo-4-Methylthiobutanoate
  • 2-Oxomethionine
  • 4-(METHYLsulfanyl)-2-oxobutanoIC ACID
  • 4-methylthio-2-Oxobutanoate
583-92-6
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
  • 4-(2-amino-3-Hydroxyphenyl)-2,4-dioxobutanoate
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
  • 4-(2-Aminophenyl)-2,4-dioxobutanoate
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoate
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoic acid
L-3-Hydroxykynurenine
  • (2S)-2-amino-4-(2-amino-3-Hydroxyphenyl)-4-oxobutanoic acid
  • 3-(3-Hydroxyanthraniloyl)-L-alanine
  • (2S)-2-amino-4-(2-amino-3-Hydroxyphenyl)-4-oxobutanoate
  • 3-(2-amino-3-Hydroxybenzoyl)-L-alanine
  • 3-Hydroxy-L-kynurenine
606-14-4
Methylselenopyruvate
  • beta-Methylselenopyruvate
  • b-Methylselenopyruvate
  • b-Methylselenopyruvic acid
  • beta-Methylselenopyruvic acid
  • β-methylselenopyruvate
genes like me logo Genes that share compounds with KYAT3: view

Transcripts for KYAT3 Gene

mRNA/cDNA for KYAT3 Gene

6 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KYAT3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KYAT3 Gene

No ASD Table

Relevant External Links for KYAT3 Gene

GeneLoc Exon Structure for
KYAT3

Expression for KYAT3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KYAT3

Evidence on tissue expression from TISSUES for KYAT3 Gene

  • Stomach(4.2)
  • Nervous system(3.7)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KYAT3 Gene

Orthologs for KYAT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KYAT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCBL2 31 30
  • 99.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCBL2 31 30
  • 91.69 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCBL2 31 30
  • 91.56 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccbl2 31 30
  • 84.21 (n)
OneToOne
Kyat3 17
rat
(Rattus norvegicus)
Mammalia Kat3 30
  • 81.35 (n)
oppossum
(Monodelphis domestica)
Mammalia CCBL2 31
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCBL2 31
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCBL2 31 30
  • 73.44 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCBL2 31
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch73-97h19.2 30
  • 66.75 (n)
CCBL2 (3 of 4) 31
  • 63 (a)
OneToMany
ccbl2 31 31
  • 62 (a)
OneToMany
CCBL2 (4 of 4) 31
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6950 31 30
  • 53.53 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011158 30
  • 52.61 (n)
worm
(Caenorhabditis elegans)
Secernentea nkat-1 31 30
  • 53.08 (n)
ManyToMany
nkat-3 31
  • 41 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNA3 31 30
  • 48.94 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F01617g 30
  • 47.57 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G77670 30
  • 50.62 (n)
rice
(Oryza sativa)
Liliopsida Os09g0453800 30
  • 51.6 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 62 (a)
ManyToMany
CSA.3659 31
  • 48 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC6B12.04c 30
  • 46.9 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03347 30
  • 44.88 (n)
Species where no ortholog for KYAT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KYAT3 Gene

ENSEMBL:
Gene Tree for KYAT3 (if available)
TreeFam:
Gene Tree for KYAT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KYAT3: view image

Paralogs for KYAT3 Gene

Paralogs for KYAT3 Gene

genes like me logo Genes that share paralogs with KYAT3: view

Variants for KYAT3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KYAT3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1059370 - p.Ser206Pro

Additional dbSNP identifiers (rs#s) for KYAT3 Gene

Structural Variations from Database of Genomic Variants (DGV) for KYAT3 Gene

Variant ID Type Subtype PubMed ID
dgv207n100 CNV loss 25217958
esv2758948 CNV gain 17122850
esv7403 CNV gain 19470904
nsv1002798 CNV gain 25217958
nsv462472 CNV loss 19166990
nsv546784 CNV loss 21841781
nsv830525 CNV loss 17160897
nsv830537 CNV gain 17160897
nsv946054 CNV duplication 23825009

Variation tolerance for KYAT3 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KYAT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KYAT3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KYAT3 Gene

Disorders for KYAT3 Gene

Additional Disease Information for KYAT3

No disorders were found for KYAT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KYAT3 Gene

Publications for KYAT3 Gene

  1. Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family. (PMID: 16376499) Yu P … Cai T (Gene 2006) 2 3 4 23 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. (PMID: 30652415) Liu Y … Chen L (Cancer medicine 2019) 3 54
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 54
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54

Products for KYAT3 Gene

Sources for KYAT3 Gene