Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KYAT3 Gene

Aliases for KYAT3 Gene

  • Kynurenine Aminotransferase 3 2 3 4 5
  • Kynurenine--Oxoglutarate Transaminase III 3 4
  • Kynurenine--Oxoglutarate Transaminase 3 2 3
  • Kynurenine--Glyoxylate Transaminase 3 4
  • Cysteine-S-Conjugate Beta-Lyase 2 3 4
  • Kynurenine Aminotransferase III 3 4
  • KATIII 3 4
  • CCBL2 3 4
  • KAT3 3 4
  • Cysteine Conjugate Beta Lyase 2 2
  • EC 4.4.1.13 4
  • EC 2.6.1.63 4
  • EC 2.6.1.7 4

External Ids for KYAT3 Gene

Previous HGNC Symbols for KYAT3 Gene

  • CCBL2

Summaries for KYAT3 Gene

Entrez Gene Summary for KYAT3 Gene

  • This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid, which is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Mar 2017]

GeneCards Summary for KYAT3 Gene

KYAT3 (Kynurenine Aminotransferase 3) is a Protein Coding gene. Among its related pathways are superpathway of tryptophan utilization and Viral mRNA Translation. An important paralog of this gene is KYAT1.

UniProtKB/Swiss-Prot for KYAT3 Gene

  • Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).

Additional gene information for KYAT3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KYAT3 Gene

Genomics for KYAT3 Gene

GeneHancer (GH) Regulatory Elements for KYAT3 Gene

Promoters and enhancers for KYAT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I088990 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +0.4 403 4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 KYAT3 RBMXL1 GBP3 GBP5 GBP6 GBP7 PTGES3P1 GC01M088952
GH01I088889 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 65.8 +101.4 101374 4 FEZF1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 GTF2B KYAT3 PKN2 ELOCP19 LOC100130455 PTGES3P1 RBMXL1 GC01M088841
GH01I088682 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 54.1 +308.4 308398 4.5 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC PKN2 PKN2-AS1 KYAT3 ELOCP19 LOC100130455 RBMXL1 PTGES3P1
GH01I088867 Enhancer 0.6 ENCODE 32.4 +125.0 125012 1.2 ZNF140 JUNB BATF ATF2 NFATC1 IKZF1 ATF7 RUNX3 KYAT3 LOC100130455 PKN2 GTF2B GC01M088841
GH01I088661 Enhancer 0.4 ENCODE 28.9 +330.7 330662 1.6 PKNOX1 ATF7 KYAT3 GC01M088677 PKN2-AS1 LOC105378838
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KYAT3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KYAT3 Gene

Genomic Locations for KYAT3 Gene
chr1:88,935,773-88,992,960
(GRCh38/hg38)
Size:
57,188 bases
Orientation:
Minus strand
chr1:89,401,456-89,458,643
(GRCh37/hg19)

Genomic View for KYAT3 Gene

Genes around KYAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KYAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KYAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KYAT3 Gene

Proteins for KYAT3 Gene

  • Protein details for KYAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6YP21-KAT3_HUMAN
    Recommended name:
    Kynurenine--oxoglutarate transaminase 3
    Protein Accession:
    Q6YP21
    Secondary Accessions:
    • B3KQ13
    • O95335
    • Q5JS27
    • Q5T9T7
    • Q5T9T8
    • Q6AI27
    • Q6ICW1
    • Q9BVY5

    Protein attributes for KYAT3 Gene

    Size:
    454 amino acids
    Molecular mass:
    51400 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAC72959.1; Type=Frameshift; Positions=336; Evidence={ECO:0000305}; Sequence=AAH00819.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAG29278.1; Type=Frameshift; Positions=336; Evidence={ECO:0000305}; Sequence=CAI21695.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21696.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41340.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KYAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KYAT3 Gene

Post-translational modifications for KYAT3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for KYAT3 Gene

Domains & Families for KYAT3 Gene

Gene Families for KYAT3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q6YP21

UniProtKB/Swiss-Prot:

KAT3_HUMAN :
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with KYAT3: view

Function for KYAT3 Gene

Molecular function for KYAT3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
UniProtKB/Swiss-Prot CatalyticActivity:
An L-cysteine-S-conjugate + H(2)O = RSH + NH(3) + pyruvate.
UniProtKB/Swiss-Prot CatalyticActivity:
L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.
UniProtKB/Swiss-Prot Function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).

Enzyme Numbers (IUBMB) for KYAT3 Gene

Gene Ontology (GO) - Molecular Function for KYAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003824 catalytic activity IEA --
GO:0008483 transaminase activity IEA --
GO:0016212 kynurenine-oxoglutarate transaminase activity ISS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with KYAT3: view
genes like me logo Genes that share phenotypes with KYAT3: view

Animal Model Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KYAT3 Gene

Localization for KYAT3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KYAT3 gene
Compartment Confidence
mitochondrion 4
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KYAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with KYAT3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KYAT3 Gene

Pathways & Interactions for KYAT3 Gene

genes like me logo Genes that share pathways with KYAT3: view

Gene Ontology (GO) - Biological Process for KYAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006103 2-oxoglutarate metabolic process IEA --
GO:0006520 cellular amino acid metabolic process ISS,IEA --
GO:0009058 biosynthetic process IEA --
GO:0070189 kynurenine metabolic process ISS,IEA --
GO:0097052 L-kynurenine metabolic process IEA --
genes like me logo Genes that share ontologies with KYAT3: view

No data available for SIGNOR curated interactions for KYAT3 Gene

Drugs & Compounds for KYAT3 Gene

(10) Drugs for KYAT3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic Acid Approved Nutra Full agonist, Agonist, Target 251
Pyridoxal Phosphate Approved, Investigational Nutra Target, cofactor 17
Ammonia Approved Pharma 0
Water Approved Pharma 0
Glycine Approved, Vet_approved Nutra Full agonist, Agonist 254

(7) Additional Compounds for KYAT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Oxo-4-methylthiobutanoic acid
  • 2-Keto-4-methylthiobutyrate
  • 2-Keto-4-methylthiobutyric acid
  • 2-Ketomethiobutyrate
  • 2-Oxo-4-methylthiobutanoate
  • 2-Oxo-4-methylthiobutanoic acid
583-92-6
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
  • 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
  • 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoate
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoic acid
  • 4-(2-Aminophenyl)-2,4-dioxobutanoate
  • 4-(2-Aminophenyl)-2,4-dioxobutanoic acid
L-3-Hydroxykynurenine
  • 3-(2-Amino-3-hydroxybenzoyl)-L-alanine
  • 3-(3-Hydroxyanthraniloyl)-L-alanine
  • 3-Hydroxy-L-kynurenine
  • L-3-HK
606-14-4
L-Methionine
  • (2S)-2-amino-4-(methylsulfanyl)butanoate
  • (2S)-2-amino-4-(methylsulfanyl)butanoic acid
  • (L)-methionine
  • (S)-(+)-methionine
  • (S)-2-amino-4-(methylthio)-Butanoate
63-68-3
genes like me logo Genes that share compounds with KYAT3: view

Transcripts for KYAT3 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KYAT3 Gene

No ASD Table

Relevant External Links for KYAT3 Gene

GeneLoc Exon Structure for
KYAT3
ECgene alternative splicing isoforms for
KYAT3

Expression for KYAT3 Gene

NURSA nuclear receptor signaling pathways regulating expression of KYAT3 Gene:

KYAT3

Evidence on tissue expression from TISSUES for KYAT3 Gene

  • Stomach(4.2)
  • Nervous system(3.7)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KYAT3 Gene

Orthologs for KYAT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KYAT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCBL2 33 34
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia CCBL2 33 34
  • 91.69 (n)
cow
(Bos Taurus)
Mammalia CCBL2 33 34
  • 91.56 (n)
mouse
(Mus musculus)
Mammalia Ccbl2 33 34
  • 84.21 (n)
Kyat3 16
rat
(Rattus norvegicus)
Mammalia Kat3 33
  • 81.35 (n)
oppossum
(Monodelphis domestica)
Mammalia CCBL2 34
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCBL2 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCBL2 33 34
  • 73.44 (n)
lizard
(Anolis carolinensis)
Reptilia CCBL2 34
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch73-97h19.2 33
  • 66.75 (n)
CCBL2 (3 of 4) 34
  • 63 (a)
OneToMany
ccbl2 34 34
  • 62 (a)
OneToMany
CCBL2 (4 of 4) 34
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6950 33 34
  • 53.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011158 33
  • 52.61 (n)
worm
(Caenorhabditis elegans)
Secernentea nkat-1 33 34
  • 53.08 (n)
nkat-3 34
  • 41 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNA3 33 34
  • 48.94 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F01617g 33
  • 47.57 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G77670 33
  • 50.62 (n)
rice
(Oryza sativa)
Liliopsida Os09g0453800 33
  • 51.6 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 62 (a)
ManyToMany
CSA.3659 34
  • 48 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC6B12.04c 33
  • 46.9 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03347 33
  • 44.88 (n)
Species where no ortholog for KYAT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KYAT3 Gene

ENSEMBL:
Gene Tree for KYAT3 (if available)
TreeFam:
Gene Tree for KYAT3 (if available)

Paralogs for KYAT3 Gene

Paralogs for KYAT3 Gene

genes like me logo Genes that share paralogs with KYAT3: view

Variants for KYAT3 Gene

Sequence variations from dbSNP and Humsavar for KYAT3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000016600 -- 88,954,933(-) T/A intron_variant
rs1000087935 -- 88,956,547(-) C/T intron_variant
rs1000128092 -- 88,953,351(-) C/G intron_variant
rs1000179640 -- 88,935,819(-) A/G 3_prime_UTR_variant
rs1000180404 -- 88,939,077(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KYAT3 Gene

Variant ID Type Subtype PubMed ID
dgv207n100 CNV loss 25217958
esv2758948 CNV gain 17122850
esv7403 CNV gain 19470904
nsv1002798 CNV gain 25217958
nsv462472 CNV loss 19166990
nsv546784 CNV loss 21841781
nsv830525 CNV loss 17160897
nsv830537 CNV gain 17160897
nsv946054 CNV duplication 23825009

Variation tolerance for KYAT3 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KYAT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KYAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KYAT3 Gene

Disorders for KYAT3 Gene

No disorders were found for KYAT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KYAT3 Gene

Publications for KYAT3 Gene

  1. Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family. (PMID: 16376499) Yu P … Cai T (Gene 2006) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S … Dorf ME (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 58

Products for KYAT3 Gene

Sources for KYAT3 Gene

Content
Loading form....