Aliases for KYAT3 Gene
External Ids for KYAT3 Gene
Previous HGNC Symbols for KYAT3 Gene
This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid, which is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Mar 2017]
GeneCards Summary for KYAT3 Gene
KYAT3 (Kynurenine Aminotransferase 3) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Glutathione metabolism. An important paralog of this gene is ENSG00000286112.
UniProtKB/Swiss-Prot Summary for KYAT3 Gene
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).