Aliases for KTN1 Gene
Aliases for KTN1 Gene
External Ids for KTN1 Gene
- HGNC: 6467
- Entrez Gene: 3895
- Ensembl: ENSG00000126777
- OMIM: 600381
- UniProtKB: Q86UP2
Previous GeneCards Identifiers for KTN1 Gene
- GC14P053370
- GC14P049842
- GC14P054037
- GC14P055116
- GC14P056046
- GC14P036232
Summaries for KTN1 Gene
-
This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]
GeneCards Summary for KTN1 Gene
KTN1 (Kinectin 1) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include kinesin binding. An important paralog of this gene is RRBP1.
UniProtKB/Swiss-Prot for KTN1 Gene
-
Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KTN1 Gene
Genomics for KTN1 Gene
GeneHancer (GH) Regulatory Elements for KTN1 Gene
Promoters and enhancers for KTN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around KTN1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KTN1 gene promoter:
-
- Roaz
- Max1
- c-Myc
- Pax-4a
- AML1a
- SRF (504 AA)
- SRF
- CUTL1
- MEF-2A
- aMEF-2
Regulatory Element Products
Genomic Locations for KTN1 Gene
Genomic Locations for KTN1 Gene
- chr14:55,559,072-55,701,526
- (GRCh38/hg38)
- Size:
- 142,455 bases
- Orientation:
- Plus strand
- chr14:56,025,790-56,168,244
- (GRCh37/hg19)
- Size:
- 142,455 bases
- Orientation:
- Plus strand
Genomic View for KTN1 Gene
Genes around KTN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q22.3 by Entrez Gene
- 14q22.1 by HGNC
- 14q22.3 by Ensembl
KTN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KTN1 Gene
Proteins for KTN1 Gene
-
Protein details for KTN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86UP2-KTN1_HUMAN
- Recommended name:
- Kinectin
- Protein Accession:
- Q86UP2
- B4DZ88
- Q13999
- Q14707
- Q15387
- Q17RZ5
- Q5GGW3
- Q86W57
Protein attributes for KTN1 Gene
- Size:
- 1357 amino acids
- Molecular mass:
- 156275 Da
- Quaternary structure:
-
- Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms.
- SequenceCaution:
-
- Sequence=AAH50555.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA02794.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for KTN1 Gene
Post-translational modifications for KTN1 Gene
Other Protein References for KTN1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001072989.1
- XP_024305347.1
- XP_006720202.1
- XP_016876772.1
- XP_016876771.1
- XP_016876774.1
- XP_006720204.1
- XP_011535054.1
- XP_011535053.1
- XP_016876773.1
- XP_016876775.1
- XP_016876768.1
- NP_004977.2
- XP_006720201.1
- NP_001072990.1
- XP_011535055.1
- XP_016876770.1
- XP_016876767.1
- XP_006720203.1
- XP_016876769.1
- NP_001257943.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for KTN1
- Novus Biologicals Antibodies for KTN1
- Invitrogen Antibodies for KTN1 (AFLGC-KTN1)
- GeneTex KTN1 Antibody for KTN1
-
Boster Bio Antibodies for KTN1
-
Santa Cruz Biotechnology (SCBT) Antibodies for KTN1
Protein Products
-
OriGene Purified Proteins for KTN1
- Search Origene for MassSpec and Protein Over-expression Lysates for KTN1
- Origene Custom Protein Services for KTN1
- Novus Biologicals proteins for KTN1
- antibodies-online: Search results for 6 available KTN1 Proteins ranked by validation data
- Compare Top KTN1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for KTN1
Assay Products
- antibodies-online: Search results for 2 available KTN1 Elisa Kits ranked by validation data
- Compare Top KTN1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for KTN1 Gene
Domains & Families for KTN1 Gene
Gene Families for KTN1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for KTN1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KTN1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86UP2- Family:
-
- Belongs to the kinectin family.
Function for KTN1 Gene
Molecular function for KTN1 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
- GENATLAS Biochemistry:
- kinectin 1,156kDa,vesicle membrane protein of the endoplasmic reticulum,binding vesicles to kinesin and promoting vesicle motility,expressed in diverse tissues
Phenotypes From GWAS Catalog for KTN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0019894 | kinesin binding | IBA | -- |
| GO:0045296 | cadherin binding | IDA | 25468996 |
Phenotypes for KTN1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for KTN1
-
CRISPR Products
-
OriGene CRISPR knockouts for KTN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KTN1
- genomics-online: gRNA clones - Search results for available KTN1 gene related products
- Applied Biological Materials CRISPR for KTN1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KTN1
- GenScript: Design CRISPR guide RNA sequences for KTN1
miRNA for KTN1 Gene
- miRTarBase miRNAs that target KTN1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KTN1
- Browse OriGene Inhibitory RNA Products For KTN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KTN1
- genomics-online: shRNA clones - Search results for available KTN1 gene related products
Clone Products
-
OriGene ORF clones in human for KTN1
- RC212715
- RC212715L1
- RC212715L2
- RC212715L3
- RC212715L4
- RC214711
- RC214711L1
- RC214711L2
- RC214711L3
- RC214711L4
- RC219832
- RC219832L1
- RC219832L2
- RC219832L3
- RC219832L4
- RC220557
- RC220557L1
- RC220557L2
- RC220557L3
- RC220557L4
- RC235267
- RG212715
- RG214711
- RG219832
- RG220557
- RG235267
- RC212715L1V
- RC212715L2V
- RC212715L3V
- RC212715L4V
- RC214711L1V
- RC214711L2V
- RC214711L3V
- RC214711L4V
- RC219832L1V
- RC219832L2V
- RC219832L3V
- RC219832L4V
- RC220557L1V
- RC220557L2V
- RC220557L3V
- RC220557L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KTN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KTN1
- genomics-online: cdna clones - Search results for available KTN1 gene related products
- orf clones - Search results for available KTN1 gene related products
- Applied Biological Materials Clones for KTN1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KTN1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KTN1 Gene
Localization for KTN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KTN1 Gene
- Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Vesicle membrane protein anchored to the endoplasmic reticulum.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| plasma membrane | 4 |
| cytoskeleton | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Endoplasmic reticulum (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA,IDA | -- |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 7787243 |
| GO:0016020 | membrane | TAS,HDA | 19946888 |
Pathways & Interactions for KTN1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by Rho GTPases | ||
| 2 | Cytoskeletal Signaling | ||
| 3 | Actin Nucleation by ARP-WASP Complex |
.35
|
|
| 4 | RHO GTPases activate KTN1 | ||
| 5 | Signaling by GPCR | ||
Pathways by source for KTN1 Gene
4 Reactome pathways for KTN1 Gene
1 Qiagen pathway for KTN1 Gene
1 Cell Signaling Technology pathway for KTN1 Gene
Interacting Proteins for KTN1 Gene
Selected Interacting proteins:
Q86UP2-KTN1_HUMAN
ENSP00000378720
for KTN1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for KTN1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007018 | microtubule-based movement | IEA,NAS | -- |
| GO:0015031 | protein transport | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
| GO:0044267 | cellular protein metabolic process | TAS | -- |
Drugs & Compounds for KTN1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Kanamycin | Approved, Investigational, Vet_approved | Pharma | Enzyme | 11 |
Drug Products
Transcripts for KTN1 Gene
mRNA/cDNA for KTN1 Gene
- (22) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (582) Selected AceView cDNA sequences:
- (25) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000438792 4449 bps (uc001xce.4)
- ENST00000395314 4618 bps (uc001xcc.4)
- ENST00000459737 4793 bps (uc001xcb.4)
- ENST00000395308 4134 bps (uc059bto.1)
- ENST00000395311 4516 bps (uc059btp.1)
Unigene Clusters for KTN1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KTN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KTN1
- genomics-online: gRNA clones - Search results for available KTN1 gene related products
- Applied Biological Materials CRISPR for KTN1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KTN1
- GenScript: Design CRISPR guide RNA sequences for KTN1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KTN1
- Browse OriGene Inhibitory RNA Products For KTN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KTN1
- genomics-online: shRNA clones - Search results for available KTN1 gene related products
Clone Products
-
OriGene ORF clones in human for KTN1
- RC212715
- RC212715L1
- RC212715L2
- RC212715L3
- RC212715L4
- RC214711
- RC214711L1
- RC214711L2
- RC214711L3
- RC214711L4
- RC219832
- RC219832L1
- RC219832L2
- RC219832L3
- RC219832L4
- RC220557
- RC220557L1
- RC220557L2
- RC220557L3
- RC220557L4
- RC235267
- RG212715
- RG214711
- RG219832
- RG220557
- RG235267
- RC212715L1V
- RC212715L2V
- RC212715L3V
- RC212715L4V
- RC214711L1V
- RC214711L2V
- RC214711L3V
- RC214711L4V
- RC219832L1V
- RC219832L2V
- RC219832L3V
- RC219832L4V
- RC220557L1V
- RC220557L2V
- RC220557L3V
- RC220557L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KTN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KTN1
- genomics-online: cdna clones - Search results for available KTN1 gene related products
- orf clones - Search results for available KTN1 gene related products
- Applied Biological Materials Clones for KTN1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35a | · | 35b | · | 35c | ^ | 36a | · | 36b | ^ | 37 | ^ | 38 | ^ | 39a | · | 39b | ^ | 40 | ^ | 41 | ^ | 42 | ^ | 43a | · | 43b | ^ | 44a | · | 44b | ^ | 45a | · | 45b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 46 | ^ | 47 |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: |
Expression for KTN1 Gene
mRNA differential expression in normal tissues according to GTEx for KTN1 Gene
This gene is overexpressed in Muscle - Skeletal (x4.4).
This gene is overexpressed in Lymph node (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KTN1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of KTN1 Gene:
KTN1SOURCE GeneReport for Unigene cluster for KTN1 Gene:
Hs.509414mRNA Expression by UniProt/SwissProt for KTN1 Gene:
Q86UP2-KTN1_HUMAN
Tissue specificity:
High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.
Evidence on tissue expression from TISSUES for KTN1 Gene
- Nervous system(4.9)
- Liver(4.8)
- Lung(4.7)
- Blood(4.4)
- Bone marrow(4.3)
- Heart(4.2)
- Adrenal gland(4)
- Kidney(3.8)
- Intestine(3.1)
- Skin(2.8)
- Muscle(2.6)
- Spleen(2.6)
- Eye(2.3)
Primer Products
-
OriGene qPCR primer pairs for KTN1
- genomics-online: primer clones - Search results for available KTN1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KTN1 Gene
Orthologs for KTN1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KTN1 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KTN1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | KTN1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ktn1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | KTN1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | KTN1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KTN1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.11429 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2481 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ktn1 34 33 33 |
|
OneToOne |
- Species where no ortholog for KTN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for KTN1 Gene
- ENSEMBL:
- Gene Tree for KTN1 (if available)
- TreeFam:
- Gene Tree for KTN1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KTN1: view image
Paralogs for KTN1 Gene
(1) SIMAP similar genes for KTN1 Gene using alignment to 16 proteins:
- KTN1_HUMAN
- B4DZ88_HUMAN
- B7Z6P3_HUMAN
- G3V475_HUMAN
- G3V4L8_HUMAN
- G3V4Y7_HUMAN
- G3V5G2_HUMAN
- G3V5P0_HUMAN
- G3V5Q0_HUMAN
- H0YJB7_HUMAN
- H0YJP2_HUMAN
- H0YJV5_HUMAN
- H0YJZ8_HUMAN
- Q3SWV9_HUMAN
- Q6NZ46_HUMAN
- Q6PDF7_HUMAN
Variants for KTN1 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035931 | A breast cancer sample | p.Pro226Arg | |||
| VAR_035932 | A breast cancer sample | p.Thr1316Pro | |||
| rs1000006335 | -- | 55,641,367(+) | A/C | intron_variant | |
| rs1000053918 | -- | 55,607,843(+) | T/C | intron_variant | |
| rs1000063988 | -- | 55,618,770(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1069796 | CNV | deletion | 25765185 |
| nsv1143750 | CNV | deletion | 24896259 |
| nsv1283 | CNV | deletion | 18451855 |
| nsv832804 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.12;
61.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KTN1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KTN1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KTN1 Gene
Disorders for KTN1 Gene
Additional Disease Information for KTN1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for KTN1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KTN1 Gene
Publications for KTN1 Gene
- Candidate-gene testing for orphan limb-girdle muscular dystrophies. (PMID: 19472918) Aurino S … Nigro V (Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 2008) 3 22 44 58
- Integrin clustering induces kinectin accumulation. (PMID: 11973345) Tran H … Yamada KM (Journal of cell science 2002) 3 4 22 58
- Assignment of the human kinectin gene (KTN1), encoding a kinesin-binding protein, to chromosome 14 band q22.1 by in situ hybridization. (PMID: 9605849) Rao PN … Sheetz MP (Cytogenetics and cell genetics 1997) 2 3 22 58
- The CG-1 gene, a member of the kinectin and ES/130 family, maps to human chromosome band 14q22. (PMID: 8575822) Print CG … Krissansen GW (Immunogenetics 1996) 3 4 22 58
- Molecular cloning and characterization of human kinectin. (PMID: 7787243) Fütterer A … Krönke M (Molecular biology of the cell 1995) 3 4 22 58
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Sources for KTN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (14) ProtoNet
- (15) Blocks
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
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- (86) RefSeq
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- (91) Illumina
- (92) COMPARTMENTS
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- (97) antibodies-online
- (98) CYP
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- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
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- (105) Taconic Biosciences
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