Aliases for KSR2 Gene

Aliases for KSR2 Gene

  • Kinase Suppressor Of Ras 2 2 3 3 4 5
  • EC 2.7.11.1 4
  • FLJ25965 2
  • HKSR2 4
  • KSR2 5

External Ids for KSR2 Gene

Previous GeneCards Identifiers for KSR2 Gene

  • GC12M117738
  • GC12M116367
  • GC12M116316
  • GC12M116370
  • GC12M117890
  • GC12M114899

Summaries for KSR2 Gene

GeneCards Summary for KSR2 Gene

KSR2 (Kinase Suppressor Of Ras 2) is a Protein Coding gene. Among its related pathways are RET signaling and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is KSR1.

UniProtKB/Swiss-Prot Summary for KSR2 Gene

  • Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KSR2 Gene

Genomics for KSR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KSR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J117968 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 250.7 -0.1 -110 2.2 ZNF600 ZNF580 ZNF10 ZIC2 POLR2A ZBTB10 CHD2 FEZF1 ZNF639 ZNF341 KSR2 piR-38351-117 RFC5 SUDS3 VSIG10 lnc-WSB2-3
GH12J118187 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas 8 -220.3 -220308 3.8 POLR2A TAL1 JUND ZFP91 PRDM10 SPI1 ZNF384 ZBTB33 RFX1 ATF2 HSALNG0094417 KSR2 PEBP1 VSIG10 lnc-VSIG10-1 TAOK3
GH12J117911 Enhancer 0.4 FANTOM5 11.2 +57.5 57486 0.3 RAD51 TRIM28 RBAK USF1 RFC5 KSR2 VSIG10 piR-43107-075 ENSG00000256071 lnc-WSB2-3 NOS1
GH12J117912 Enhancer 0.2 Ensembl 11.2 +56.0 55989 0.8 KSR2 piR-43107-075 ENSG00000256071 lnc-WSB2-3 NOS1
GH12J117985 Enhancer 0.6 Ensembl ENCODE 0.4 -17.5 -17510 3 NFIC JUND NFIB PRDM10 HSALNG0094401 HSALNG0094402 KSR2 RFC5 lnc-WSB2-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KSR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KSR2

Top Transcription factor binding sites by QIAGEN in the KSR2 gene promoter:
  • ATF6
  • Cart-1
  • CREB
  • deltaCREB
  • IRF-1
  • Lmo2
  • MAZR
  • Meis-1
  • Meis-1a
  • Meis-1b

Genomic Locations for KSR2 Gene

Latest Assembly
chr12:117,453,012-117,968,990
(GRCh38/hg38)
Size:
515,979 bases
Orientation:
Minus strand

Previous Assembly
chr12:117,890,817-118,406,795
(GRCh37/hg19 by Entrez Gene)
Size:
515,979 bases
Orientation:
Minus strand

chr12:117,890,817-118,406,788
(GRCh37/hg19 by Ensembl)
Size:
515,972 bases
Orientation:
Minus strand

Genomic View for KSR2 Gene

Genes around KSR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KSR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KSR2 Gene

Proteins for KSR2 Gene

  • Protein details for KSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6VAB6-KSR2_HUMAN
    Recommended name:
    Kinase suppressor of Ras 2
    Protein Accession:
    Q6VAB6
    Secondary Accessions:
    • A0PJT2
    • Q3B828
    • Q8N775

    Protein attributes for KSR2 Gene

    Size:
    950 amino acids
    Molecular mass:
    107632 Da
    Quaternary structure:
    • Heterodimerizes (via N-terminus) with BRAF (via N-terminus) in a MAP2K1/MEK1-dependent manner (PubMed:29433126). Interacts with BRAF; this increases the low intrinsic protein kinase activity of KSR2 (PubMed:21441910). Interacts with MAP2K1, forming a heterodimer that can dimerize to form a heterotetramer (PubMed:29433126, PubMed:21441910, PubMed:12975377). Interacts with MAP3K8, MAPK, RAS and RAF (PubMed:12975377).

    Three dimensional structures from OCA and Proteopedia for KSR2 Gene

    Alternative splice isoforms for KSR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KSR2 Gene

Post-translational modifications for KSR2 Gene

Antibodies for research

  • Abcam antibodies for KSR2
  • Santa Cruz Biotechnology (SCBT) Antibodies for KSR2

No data available for DME Specific Peptides for KSR2 Gene

Domains & Families for KSR2 Gene

Gene Families for KSR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KSR2 Gene

GenScript: Design optimal peptide antigens:
  • Kinase suppressor of Ras 2 (KSR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6VAB6

UniProtKB/Swiss-Prot:

KSR2_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive and seems to have very low intrinsic kinase activity. This low kinase activity can be increased by interaction with BRAF.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive and seems to have very low intrinsic kinase activity. This low kinase activity can be increased by interaction with BRAF.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with KSR2: view

Function for KSR2 Gene

Molecular function for KSR2 Gene

UniProtKB/Swiss-Prot Function:
Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:21441910};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:21441910};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Kinase activity is inhibited by ASC24.

Enzyme Numbers (IUBMB) for KSR2 Gene

Phenotypes From GWAS Catalog for KSR2 Gene

Gene Ontology (GO) - Molecular Function for KSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,IBA 21873635
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 25036637
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KSR2: view
genes like me logo Genes that share phenotypes with KSR2: view

Animal Models for KSR2 Gene

MGI Knock Outs for KSR2:

Animal Models for research

  • Taconic Biosciences Mouse Models for KSR2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KSR2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KSR2 Gene

Localization for KSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KSR2 Gene

Cytoplasm. Membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KSR2 gene
Compartment Confidence
plasma membrane 4
cytosol 4
nucleus 3
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IBA 21873635
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KSR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KSR2 Gene

Pathways & Interactions for KSR2 Gene

PathCards logo

SuperPathways for KSR2 Gene

SuperPathway Contained pathways
1 RET signaling
2 Paradoxical activation of RAF signaling by kinase inactive BRAF
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with KSR2: view

Pathways by source for KSR2 Gene

1 KEGG pathway for KSR2 Gene

SIGNOR curated interactions for KSR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IBA 21873635
GO:0007265 Ras protein signal transduction IBA 21873635
GO:0016310 phosphorylation IEA --
GO:0019722 calcium-mediated signaling IBA 21873635
genes like me logo Genes that share ontologies with KSR2: view

Drugs & Compounds for KSR2 Gene

(5) Additional Compounds for KSR2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
genes like me logo Genes that share compounds with KSR2: view

Transcripts for KSR2 Gene

mRNA/cDNA for KSR2 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KSR2

Alternative Splicing Database (ASD) splice patterns (SP) for KSR2 Gene

No ASD Table

Relevant External Links for KSR2 Gene

GeneLoc Exon Structure for
KSR2

Expression for KSR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KSR2 Gene

mRNA differential expression in normal tissues according to GTEx for KSR2 Gene

This gene is overexpressed in Pituitary (x9.2), Brain - Cerebellum (x5.5), Brain - Cerebellar Hemisphere (x5.0), and Brain - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for KSR2 Gene

This gene is overexpressed in Plasma (47.3), Pancreatic juice (12.6), and Skin (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KSR2 Gene



Protein tissue co-expression partners for KSR2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KSR2

SOURCE GeneReport for Unigene cluster for KSR2 Gene:

Hs.375836

mRNA Expression by UniProt/SwissProt for KSR2 Gene:

Q6VAB6-KSR2_HUMAN
Tissue specificity: Mainly expressed in brain and kidney.

Evidence on tissue expression from TISSUES for KSR2 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with KSR2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KSR2 Gene

Orthologs for KSR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KSR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KSR2 29 30
  • 99.71 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KSR2 30
  • 94 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 94 (a)
OneToMany
-- 30
  • 92 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia KSR2 29 30
  • 93.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KSR2 29 30
  • 92.93 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ksr2 29 16 30
  • 88.78 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ksr2 29
  • 88.53 (n)
Chicken
(Gallus gallus)
Aves KSR2 30
  • 59 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KSR2 30
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ksr2 29
  • 78.87 (n)
Zebrafish
(Danio rerio)
Actinopterygii ksr2 29 30
  • 76.12 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta ksr 30
  • 32 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ksr-2 30
  • 27 (a)
ManyToMany
ksr-1 30
  • 26 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 43 (a)
OneToMany
Species where no ortholog for KSR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KSR2 Gene

ENSEMBL:
Gene Tree for KSR2 (if available)
TreeFam:
Gene Tree for KSR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KSR2: view image
Alliance of Genome Resources:
Additional Orthologs for KSR2

Paralogs for KSR2 Gene

(1) SIMAP similar genes for KSR2 Gene using alignment to 3 proteins:

  • KSR2_HUMAN
  • E9PB13_HUMAN
  • H7BXM9_HUMAN
genes like me logo Genes that share paralogs with KSR2: view

Variants for KSR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KSR2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs1414100133 Likely Benign: not specified 117,582,364(-) A/G
NM_173598.6(KSR2):c.1172-5T>C
INTRON
rs143431986 Benign: not provided 117,582,313(-) A/G
NM_173598.6(KSR2):c.1218T>C (p.Asp406=)
SYNONYMOUS
rs147858305 Benign: not provided 117,525,228(-) G/A
NM_173598.6(KSR2):c.1852-9C>T
rs182412626 Benign: not provided 117,582,369(-) G/A
NM_173598.6(KSR2):c.1172-10C>T
rs373653489 Benign: not provided 117,485,664(-) G/A
NM_173598.6(KSR2):c.2247C>T (p.Ser749=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KSR2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KSR2 Gene

Variant ID Type Subtype PubMed ID
dgv879n106 CNV duplication 24896259
dgv89e215 CNV deletion 23714750
dgv923e59 CNV duplication 20981092
esv1001837 CNV insertion 20482838
esv1951791 CNV deletion 18987734
esv2661492 CNV deletion 23128226
esv2667163 CNV deletion 23128226
esv2674921 CNV deletion 23128226
esv2746440 CNV deletion 23290073
esv2746442 CNV deletion 23290073
esv2746443 CNV deletion 23290073
esv2746444 CNV deletion 23290073
esv2746445 CNV deletion 23290073
esv2746446 CNV deletion 23290073
esv2746447 CNV deletion 23290073
esv2746448 CNV deletion 23290073
esv2746449 CNV deletion 23290073
esv2746450 CNV deletion 23290073
esv3303451 CNV mobile element insertion 20981092
esv3372967 CNV insertion 20981092
esv3423992 CNV insertion 20981092
esv3580493 CNV loss 25503493
esv3580495 CNV loss 25503493
esv3580496 CNV loss 25503493
esv3581916 CNV gain 25503493
esv3630872 CNV loss 21293372
esv3630873 CNV gain 21293372
esv3630874 CNV loss 21293372
esv3630875 CNV loss 21293372
esv3630877 CNV loss 21293372
esv988370 CNV deletion 20482838
nsv1045538 CNV loss 25217958
nsv1075849 CNV duplication 25765185
nsv1122771 CNV deletion 24896259
nsv1127296 CNV deletion 24896259
nsv1127297 CNV deletion 24896259
nsv1138173 CNV deletion 24896259
nsv1138174 CNV deletion 24896259
nsv1145629 CNV deletion 24896259
nsv1150302 CNV deletion 26484159
nsv1160064 CNV deletion 26073780
nsv442289 CNV loss 18776908
nsv509481 CNV insertion 20534489
nsv517825 CNV loss 19592680
nsv519555 CNV gain+loss 19592680
nsv528755 CNV loss 19592680
nsv53849 CNV deletion 16902084
nsv560386 CNV gain 21841781
nsv560387 CNV loss 21841781
nsv560388 CNV loss 21841781
nsv832527 CNV gain 17160897

Variation tolerance for KSR2 Gene

Residual Variation Intolerance Score: 4.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KSR2 Gene

Human Gene Mutation Database (HGMD)
KSR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KSR2
Leiden Open Variation Database (LOVD)
KSR2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KSR2 Gene

Disorders for KSR2 Gene

Additional Disease Information for KSR2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for KSR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KSR2 Gene

Publications for KSR2 Gene

  1. hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation. (PMID: 16039990) Channavajhala PL … Zhang YG (Biochemical and biophysical research communications 2005) 3 4 22
  2. Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. (PMID: 12975377) Channavajhala PL … Zhang Y (The Journal of biological chemistry 2003) 3 4 22
  3. MEK drives BRAF activation through allosteric control of KSR proteins. (PMID: 29433126) Lavoie H … Therrien M (Nature 2018) 3 4
  4. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. (PMID: 21441910) Brennan DF … Barford D (Nature 2011) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40

Products for KSR2 Gene

Sources for KSR2 Gene