Aliases for KSR1 Gene

Aliases for KSR1 Gene

  • Kinase Suppressor Of Ras 1 2 3 3 4 5
  • KSR 3 4
  • Kinase Suppressor Of Ras 2
  • EC 2.7.11.1 4
  • RSU2 3

External Ids for KSR1 Gene

Previous HGNC Symbols for KSR1 Gene

  • KSR

Previous GeneCards Identifiers for KSR1 Gene

  • GC17P022899
  • GC17P025799
  • GC17P022092
  • GC17P025783

Summaries for KSR1 Gene

GeneCards Summary for KSR1 Gene

KSR1 (Kinase Suppressor Of Ras 1) is a Protein Coding gene. Among its related pathways are RET signaling and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is KSR2.

UniProtKB/Swiss-Prot Summary for KSR1 Gene

  • Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity).

Gene Wiki entry for KSR1 Gene

Additional gene information for KSR1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KSR1 Gene

Genomics for KSR1 Gene

GeneHancer (GH) Regulatory Elements for KSR1 Gene

Promoters and enhancers for KSR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J027455 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas 514.5 +1.7 1744 5.7 EP300 FOXK2 ZNF217 CTCF ZSCAN5C NRF1 POLR2G SP1 NCOR1 PHF8 KSR1 WSB1 LGALS9 ENSG00000265801
GH17J027538 Enhancer 1.4 Ensembl ENCODE dbSUPER 36.1 +86.9 86937 10.8 ZSCAN5C TCF12 SP1 NCOR1 FOS EP300 ZIC2 AFF1 REST RELA KSR1 TMEM199 LGALS9 NOS2 piR-41306-110 piR-56902
GH17J027528 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 24 +76.3 76280 9.3 ZNF217 ZSCAN5C TCF12 POLR2G NCOR1 TEAD4 FOS ZIC2 ZNF423 AFF1 KSR1 LGALS9 WSB1 piR-56902 LOC100420848
GH17J027526 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 22.6 +70.3 70323 1.2 ZBTB40 ZIC2 TOE1 MYC CTBP1 ZNF341 SIN3A CREB3L1 ZNF263 NKRF ENSG00000263368 LOC100420848 lnc-NOS2-10 KSR1 piR-49404
GH17J027493 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 17.2 +39.8 39808 5.9 EP300 CTCF TCF12 POLR2G USF1 NCOR1 ZIC2 REST TGIF2 CTBP1 KSR1 piR-49404 piR-31284
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KSR1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KSR1

Top Transcription factor binding sites by QIAGEN in the KSR1 gene promoter:
  • HSF2
  • LyF-1
  • MyoD
  • NF-kappaB
  • NF-kappaB1
  • RORalpha1
  • SEF-1 (1)
  • Tal-1
  • USF-1
  • USF1

Genomic Locations for KSR1 Gene

Genomic Locations for KSR1 Gene
chr17:27,456,464-27,626,441
(GRCh38/hg38)
Size:
169,978 bases
Orientation:
Plus strand
chr17:25,783,670-25,953,461
(GRCh37/hg19)
Size:
169,792 bases
Orientation:
Plus strand

Genomic View for KSR1 Gene

Genes around KSR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KSR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KSR1 Gene

Proteins for KSR1 Gene

  • Protein details for KSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVT5-KSR1_HUMAN
    Recommended name:
    Kinase suppressor of Ras 1
    Protein Accession:
    Q8IVT5
    Secondary Accessions:
    • F8WEA9
    • H7BYU0
    • Q13476

    Protein attributes for KSR1 Gene

    Size:
    923 amino acids
    Molecular mass:
    102160 Da
    Quaternary structure:
    • Homodimer (PubMed:29433126). Heterodimerizes (via N-terminus) with BRAF (via N-terminus) in a MAP2K1/MEK1 or MAP2K2/MEK2-dependent manner (PubMed:29433126). Interacts with MAP2K1/MEK1 and MAP2K2/MEK2 (PubMed:10409742, PubMed:29433126). Binding to MAP2K1/MEK1 releases the intramolecular inhibitory interaction between KSR1 N-terminus and kinase domains which is required for the subsequent RSK1 dimerization with BRAF (PubMed:29433126). Identified in a complex with AKAP13, MAP2K1 and BRAF (By similarity). Interacts with AKAP13 and BRAF (PubMed:21102438). Interacts with RAF and MAPK/ERK, in a Ras-dependent manner (By similarity). Interacts with 14-3-3 proteins including YWHAB (By similarity). Interacts with HSP90AA1/HSP90, YWHAE/14-3-3 and CDC37 (PubMed:10409742, PubMed:29433126). The binding of 14-3-3 proteins to phosphorylated KSR1 prevents the membrane localization (By similarity). Interacts with MARK3 (By similarity). Interacts with PPP2R1A and PPP2CA (By similarity). Interacts with isoform 1 of VRK2 (PubMed:20679487).

    Three dimensional structures from OCA and Proteopedia for KSR1 Gene

    Alternative splice isoforms for KSR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KSR1 Gene

Post-translational modifications for KSR1 Gene

  • Phosphorylated on Ser-311 and, to a higher extent, on Ser-406 by MARK3. Dephosphorylated on Ser-406 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane-associated. Phosphorylated by PKA at Ser-888. Phosphorylation at Ser-888 is required for cAMP-dependent activation of MAPK1 and/or MAPK3 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KSR1 Gene

Domains & Families for KSR1 Gene

Gene Families for KSR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KSR1 Gene

GenScript: Design optimal peptide antigens:
  • Kinase suppressor of Ras 1 (KSR1_HUMAN)
  • cDNA FLJ27209 fis, clone SYN03476 (Q6ZNT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IVT5

UniProtKB/Swiss-Prot:

KSR1_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive. The domain is sufficient for KSR1 and KSR1-mediated MAP2K1 and MAP2K2 membrane localization. The domain is required but not sufficient for MAP kinase-mediated inhibition of ELK1 phosphorylation (PubMed:10409742).
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive. The domain is sufficient for KSR1 and KSR1-mediated MAP2K1 and MAP2K2 membrane localization. The domain is required but not sufficient for MAP kinase-mediated inhibition of ELK1 phosphorylation (PubMed:10409742).
  • The N-terminal region mediates interaction with BRAF (PubMed:29433126). Also mediates membrane localization (By similarity).
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with KSR1: view

Function for KSR1 Gene

Molecular function for KSR1 Gene

UniProtKB/Swiss-Prot Function:
Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.

Enzyme Numbers (IUBMB) for KSR1 Gene

Phenotypes From GWAS Catalog for KSR1 Gene

Gene Ontology (GO) - Molecular Function for KSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005078 MAP-kinase scaffold activity ISS --
GO:0005515 protein binding IPI 11909642
GO:0005524 ATP binding IDA 29433126
GO:0008022 protein C-terminus binding IDA 22572157
genes like me logo Genes that share ontologies with KSR1: view
genes like me logo Genes that share phenotypes with KSR1: view

Animal Models for KSR1 Gene

MGI Knock Outs for KSR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KSR1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KSR1 Gene

Localization for KSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KSR1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cell projection, ruffle membrane. Endoplasmic reticulum membrane. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery. {ECO:0000305 PubMed:12007434}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KSR1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
plasma membrane 4
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endosome 2
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA 22572157
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with KSR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KSR1 Gene

Pathways & Interactions for KSR1 Gene

PathCards logo

SuperPathways for KSR1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Paradoxical activation of RAF signaling by kinase inactive BRAF
3 C-type lectin receptor signaling pathway
4 Developmental Biology
5 Cytokine Signaling in Immune system
genes like me logo Genes that share pathways with KSR1: view

SIGNOR curated interactions for KSR1 Gene

Activates:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for KSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000185 activation of MAPKKK activity IDA 29433126
GO:0006468 protein phosphorylation IEA --
GO:0007265 Ras protein signal transduction IBA,NAS 8521512
GO:0019933 cAMP-mediated signaling ISS --
genes like me logo Genes that share ontologies with KSR1: view

Drugs & Compounds for KSR1 Gene

(4) Additional Compounds for KSR1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1-arachidonyl-3-behenoyl-sn-glycerol
  • DAG(42:0)
  • Diacylglycerol(20:0/0:0/22:0)
  • DG(42:0)
  • Diglyceride
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-Stearoyl-2-palmitoyl-sn-glycerol
  • DAG(18:0/16:0)
  • DAG(34:0)
  • DG(18:0/16:0)
  • DG(34:0)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
genes like me logo Genes that share compounds with KSR1: view

Transcripts for KSR1 Gene

mRNA/cDNA for KSR1 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KSR1

Alternative Splicing Database (ASD) splice patterns (SP) for KSR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6:
SP7: - -

ExUns: 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KSR1 Gene

GeneLoc Exon Structure for
KSR1

Expression for KSR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KSR1 Gene

mRNA differential expression in normal tissues according to GTEx for KSR1 Gene

This gene is overexpressed in Pancreas (x6.5).

Protein differential expression in normal tissues from HIPED for KSR1 Gene

This gene is overexpressed in Heart (25.0), Plasma (15.5), and Peripheral blood mononuclear cells (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KSR1 Gene



Protein tissue co-expression partners for KSR1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KSR1

SOURCE GeneReport for Unigene cluster for KSR1 Gene:

Hs.133534

Evidence on tissue expression from TISSUES for KSR1 Gene

  • Nervous system(4.4)
  • Blood(4.1)
  • Kidney(2.3)
  • Intestine(2.1)
  • Liver(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with KSR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KSR1 Gene

Orthologs for KSR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KSR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KSR1 30
  • 97.68 (n)
cow
(Bos Taurus)
Mammalia KSR1 31 30
  • 90.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KSR1 31 30
  • 90.12 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ksr1 30
  • 88.35 (n)
mouse
(Mus musculus)
Mammalia Ksr1 17 31 30
  • 87 (n)
oppossum
(Monodelphis domestica)
Mammalia KSR1 31
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KSR1 31
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves KSR1 31 30
  • 70.98 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KSR1 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ksr1 30
  • 69.55 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16325 30
zebrafish
(Danio rerio)
Actinopterygii si:dkey-174l22.2 30
  • 67.43 (n)
KSR1 (2 of 2) 31
  • 48 (a)
OneToMany
KSR1 (1 of 2) 31
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ksr 31
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ksr-2 31
  • 27 (a)
ManyToMany
ksr-1 31
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToMany
Cin.11620 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11620 30
Species where no ortholog for KSR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KSR1 Gene

ENSEMBL:
Gene Tree for KSR1 (if available)
TreeFam:
Gene Tree for KSR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KSR1: view image

Paralogs for KSR1 Gene

(12) SIMAP similar genes for KSR1 Gene using alignment to 11 proteins:

  • KSR1_HUMAN
  • A8MY87_HUMAN
  • F5H0K8_HUMAN
  • F8WEA9_HUMAN
  • H7BYU0_HUMAN
  • J3QKR8_HUMAN
  • J3QLI1_HUMAN
  • J3QQK5_HUMAN
  • J3QQL4_HUMAN
  • J3QR75_HUMAN
  • J3QSG8_HUMAN
genes like me logo Genes that share paralogs with KSR1: view

Variants for KSR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KSR1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
VAR_040658 - p.Ser227Pro
VAR_046048 - p.Val359Ala
VAR_046049 - p.Gln663His

Additional dbSNP identifiers (rs#s) for KSR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for KSR1 Gene

Variant ID Type Subtype PubMed ID
esv2422193 CNV duplication 17116639
esv2758683 CNV gain 17122850
esv6766 CNV gain 19470904
nsv474126 CNV novel sequence insertion 20440878
nsv475286 CNV novel sequence insertion 20440878
nsv478552 CNV novel sequence insertion 20440878

Variation tolerance for KSR1 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KSR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KSR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KSR1 Gene

Disorders for KSR1 Gene

Additional Disease Information for KSR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KSR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KSR1 Gene

Publications for KSR1 Gene

  1. KSR, a novel protein kinase required for RAS signal transduction. (PMID: 8521512) Therrien M … Rubin GM (Cell 1995) 2 3 4 54
  2. MEK drives BRAF activation through allosteric control of KSR proteins. (PMID: 29433126) Lavoie H … Therrien M (Nature 2018) 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer. (PMID: 20679487) Fernández IF … Lazo PA (Molecular and cellular biology 2010) 3 4 54
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54

Products for KSR1 Gene