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Aliases for KRTDAP Gene

Aliases for KRTDAP Gene

  • Keratinocyte Differentiation Associated Protein 2 3 5
  • KDAP 3 4
  • Keratinocyte Differentiation-Associated Protein 3
  • KIPV467 3
  • UNQ467 3

External Ids for KRTDAP Gene

Previous GeneCards Identifiers for KRTDAP Gene

  • GC19U990285
  • GC19M040654
  • GC19M040671
  • GC19M035978
  • GC19M032483
  • GC19M035764
  • GC19M035921
  • GC19M035947
  • GC19M036816
  • GC19M037436
  • GC19M037775
  • GC19M038075
  • GC19M038360

Summaries for KRTDAP Gene

Entrez Gene Summary for KRTDAP Gene

  • This gene encodes a protein which may function in the regulation of keratinocyte differentiation and maintenance of stratified epithelia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for KRTDAP Gene

KRTDAP (Keratinocyte Differentiation Associated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTDAP Gene

  • May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.

Gene Wiki entry for KRTDAP Gene

Additional gene information for KRTDAP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTDAP Gene

Genomics for KRTDAP Gene

GeneHancer (GH) Regulatory Elements for KRTDAP Gene

Promoters and enhancers for KRTDAP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J035495 Enhancer 1.1 Ensembl ENCODE 650.7 +0.1 61 0.7 PKNOX1 ARID4B SIN3A ZNF2 IRF4 ZNF48 YY1 GLIS2 ZNF143 RXRA KRTDAP ZFP82 CLIP3 ZNF566 LINC00665 ZNF302 ZNF30 ENSG00000233214 FFAR2 SBSN
GH19J035490 Promoter 0.6 EPDnew 650.4 +5.1 5074 0.1 ZNF263 KRTDAP HAUS5 KMT2B TMEM147-AS1 U2AF1L4 PROSER3 RBM42 LIN37 ENSG00000267049 SDHAF1
GH19J035328 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 +164.5 164523 5.1 HDGF PKNOX1 SMAD1 RB1 STAT5A BMI1 KLF5 IRF4 TCF12 ZNF207 CD22 ENSG00000269553 TMEM147-AS1 MAG RBM42 KMT2B PROSER3 KRTDAP DMKN HAMP
GH19J035304 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 10.5 +187.6 187595 6.2 HDGF PKNOX1 FOXA2 ARNT ARID4B NEUROD1 ZNF766 ZNF143 FOS REST CD22 MAG LSR HAMP DMKN FAM187B KRTDAP ENSG00000233214 ENSG00000232680 ATP4A
GH19J035435 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +58.8 58825 2.7 HDAC1 STAT5A BATF IRF4 YY1 ATF7 FOS ETV6 IKZF2 RUNX3 ZNF599 TMEM147-AS1 HAUS5 NFKBID ENSG00000267049 PROSER3 U2AF1L4 KMT2B FFAR2 LIN37
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRTDAP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRTDAP gene promoter:
  • Brachyury
  • POU3F1
  • PPAR-gamma2
  • PPAR-gamma1
  • C/EBPbeta
  • MZF-1
  • Olf-1
  • SRF (504 AA)
  • SRF

Genomic Locations for KRTDAP Gene

Genomic Locations for KRTDAP Gene
chr19:35,487,324-35,495,558
(GRCh38/hg38)
Size:
8,235 bases
Orientation:
Minus strand
chr19:35,978,226-35,986,460
(GRCh37/hg19)
Size:
8,235 bases
Orientation:
Minus strand

Genomic View for KRTDAP Gene

Genes around KRTDAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTDAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTDAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTDAP Gene

Proteins for KRTDAP Gene

  • Protein details for KRTDAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60985-KTDAP_HUMAN
    Recommended name:
    Keratinocyte differentiation-associated protein
    Protein Accession:
    P60985
    Secondary Accessions:
    • A1L4D7

    Protein attributes for KRTDAP Gene

    Size:
    99 amino acids
    Molecular mass:
    11050 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRTDAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRTDAP Gene

Post-translational modifications for KRTDAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTDAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTDAP Gene

Domains & Families for KRTDAP Gene

Gene Families for KRTDAP Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for KRTDAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTDAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRTDAP: view

No data available for UniProtKB/Swiss-Prot for KRTDAP Gene

Function for KRTDAP Gene

Molecular function for KRTDAP Gene

UniProtKB/Swiss-Prot Function:
May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated in situ in psoriatic skin (at protein level).

Phenotypes From GWAS Catalog for KRTDAP Gene

Gene Ontology (GO) - Molecular Function for KRTDAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with KRTDAP: view
genes like me logo Genes that share phenotypes with KRTDAP: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTDAP Gene

Localization for KRTDAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRTDAP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRTDAP gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KRTDAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 15140226
GO:0042599 lamellar body IDA 15140226
genes like me logo Genes that share ontologies with KRTDAP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KRTDAP Gene

Pathways & Interactions for KRTDAP Gene

SuperPathways for KRTDAP Gene

No Data Available

Interacting Proteins for KRTDAP Gene

Gene Ontology (GO) - Biological Process for KRTDAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008544 epidermis development IBA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with KRTDAP: view

No data available for Pathways by source and SIGNOR curated interactions for KRTDAP Gene

Drugs & Compounds for KRTDAP Gene

No Compound Related Data Available

Transcripts for KRTDAP Gene

mRNA/cDNA for KRTDAP Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTDAP Gene

Keratinocyte differentiation-associated protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTDAP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for KRTDAP Gene

GeneLoc Exon Structure for
KRTDAP
ECgene alternative splicing isoforms for
KRTDAP

Expression for KRTDAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRTDAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRTDAP Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x21.5), Skin - Sun Exposed (Lower leg) (x20.1), and Vagina (x6.8).

Protein differential expression in normal tissues from HIPED for KRTDAP Gene

This gene is overexpressed in Oral epithelium (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRTDAP Gene



NURSA nuclear receptor signaling pathways regulating expression of KRTDAP Gene:

KRTDAP

SOURCE GeneReport for Unigene cluster for KRTDAP Gene:

Hs.112457

mRNA Expression by UniProt/SwissProt for KRTDAP Gene:

P60985-KTDAP_HUMAN
Tissue specificity: Highly expressed in skin and detected at lower levels in thymus. In skin, found exclusively in lamellar granules of granular keratinocytes and in the intracellular space of the stratum corneum. Also highly expressed in oral mucosa, tongue, esophagus, and stomach, and at much lower levels in bladder and uterus. Not detected in gastrointestinal mucosa.

Evidence on tissue expression from TISSUES for KRTDAP Gene

  • Skin(3.6)
genes like me logo Genes that share expression patterns with KRTDAP: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTDAP Gene

Orthologs for KRTDAP Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTDAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTDAP 34 33
  • 98.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KRTDAP 34 33
  • 86.2 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KRTDAP 34 33
  • 85.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Krtdap 16 34 33
  • 69.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KRTDAP 34
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KRTDAP 34
  • 56 (a)
OneToOne
Species where no ortholog for KRTDAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTDAP Gene

ENSEMBL:
Gene Tree for KRTDAP (if available)
TreeFam:
Gene Tree for KRTDAP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRTDAP: view image

Paralogs for KRTDAP Gene

No data available for Paralogs for KRTDAP Gene

Variants for KRTDAP Gene

Sequence variations from dbSNP and Humsavar for KRTDAP Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000184906 -- 35,488,540(-) T/C intron_variant
rs1000258648 -- 35,488,376(-) G/A intron_variant
rs1000519343 -- 35,489,729(-) G/T intron_variant
rs1000592746 -- 35,489,501(-) C/T intron_variant
rs1001481896 -- 35,490,500(-) A/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for KRTDAP Gene

Variant ID Type Subtype PubMed ID
nsv833811 CNV gain 17160897

Variation tolerance for KRTDAP Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRTDAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTDAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTDAP Gene

Disorders for KRTDAP Gene

Additional Disease Information for KRTDAP

No disorders were found for KRTDAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTDAP Gene

Publications for KRTDAP Gene

  1. Characterization of Kdap, a protein secreted by keratinocytes. (PMID: 15140226) Tsuchida S … Ariizumi K (The Journal of investigative dermatology 2004) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Kdap, a novel gene associated with the stratification of the epithelium. (PMID: 11054531) Oomizu S … Yoshizato K (Gene 2000) 2 3 58
  4. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A … Wiemann S (Nucleic acids research 2006) 3 58
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S … Poustka A (Genome research 2004) 3 58

Products for KRTDAP Gene

Sources for KRTDAP Gene

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