Aliases for KRTCAP2 Gene
External Ids for KRTCAP2 Gene
Previous GeneCards Identifiers for KRTCAP2 Gene
GeneCards Summary for KRTCAP2 Gene
KRTCAP2 (Keratinocyte Associated Protein 2) is a Protein Coding gene. Diseases associated with KRTCAP2 include Congenital Disorder Of Glycosylation, Type Iin and Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type I.
UniProtKB/Swiss-Prot Summary for KRTCAP2 Gene
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:22467853). May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 (PubMed:21768116).