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Aliases for KRTAP9-9 Gene

Aliases for KRTAP9-9 Gene

  • Keratin Associated Protein 9-9 2 3 5
  • Ultrahigh Sulfur Keratin-Associated Protein 9.9 3 4
  • Keratin-Associated Protein 9-5 3 4
  • Keratin-Associated Protein 9.5 3 4
  • KRTAP9-5 3 4
  • KRTAP9.9 3 4
  • KAP9.5 3 4
  • KAP9.9 3 4
  • Keratin Associated Protein 9-5 2
  • Keratin-Associated Protein 9-9 3
  • Keratin-Associated Protein 9.9 4
  • KRTAP9.5 4

External Ids for KRTAP9-9 Gene

Previous HGNC Symbols for KRTAP9-9 Gene

  • KRTAP9-5

Previous GeneCards Identifiers for KRTAP9-9 Gene

  • GC17P038967
  • GC17P041499
  • GC17P039294
  • GC17P039767
  • GC17P039721
  • GC17P036659
  • GC17U900598
  • GC17P036637
  • GC17P039382
  • GC17P035175
  • GC17P039406
  • GC17P041226

Summaries for KRTAP9-9 Gene

Entrez Gene Summary for KRTAP9-9 Gene

  • This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. Alternative haplotypes of this gene are represented in the GRCh38 reference genome assembly. [provided by RefSeq, Dec 2015]

GeneCards Summary for KRTAP9-9 Gene

KRTAP9-9 (Keratin Associated Protein 9-9) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. An important paralog of this gene is KRTAP9-2.

UniProtKB/Swiss-Prot for KRTAP9-9 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Additional gene information for KRTAP9-9 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP9-9 Gene

Genomics for KRTAP9-9 Gene

GeneHancer (GH) Regulatory Elements for KRTAP9-9 Gene

Promoters and enhancers for KRTAP9-9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I041255 Promoter 0.7 EPDnew 550.8 +0.1 74 0.1 SCRT1 SCRT2 ZIC2 KRTAP9-9 KRTAP9-6 GC17M041245
GH17I041499 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +244.9 244889 1.3 HDGF HDAC1 PKNOX1 SMAD1 TCF12 POLR2B ZNF766 EGR1 FOS ATF7 ENSG00000229732 KRTAP2-1 KRTAP9-2 KRT38 KRTAP2-2 KRTAP9-1 KRTAP9-9 KRT34 KRT37 KRTAP2-4
GH17I041352 Enhancer 0.7 FANTOM5 dbSUPER 8.3 +97.8 97775 0.3 ZNF629 TSHZ1 REST KRTAP2-1 KRTAP9-1 KRTAP2-2 KRTAP9-2 KRTAP9-9 KRT37 KRT40 KRTAP2-4 KRT35 KRT38
GH17I041534 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 4.2 +281.9 281859 5.4 PKNOX1 CLOCK FOXA2 NFIB NEUROD1 SIN3A NFXL1 BMI1 ZBTB7B ZNF121 ENSG00000267758 SMARCE1 KRT36 STAT5A KRT35 GHDC NAGLU KRT31 LOC100505782 KRT19
GH17I041518 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.8 +269.9 269870 13.6 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B KRT19 KRT15 ENSG00000267758 SMARCE1 ACLY DHX58 KRT36 ENSG00000259623 KRT14 STAT5A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRTAP9-9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRTAP9-9 gene promoter:

Genomic Locations for KRTAP9-9 Gene

Genomic Locations for KRTAP9-9 Gene
981 bases
Plus strand

Genomic View for KRTAP9-9 Gene

Genes around KRTAP9-9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP9-9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP9-9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP9-9 Gene

Proteins for KRTAP9-9 Gene

  • Protein details for KRTAP9-9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin-associated protein 9-9
    Protein Accession:
    Secondary Accessions:
    • B5MDD6
    • Q9BYQ1

    Protein attributes for KRTAP9-9 Gene

    154 amino acids
    Molecular mass:
    16266 Da
    Quaternary structure:
    • Interacts with hair keratins.

    Alternative splice isoforms for KRTAP9-9 Gene


neXtProt entry for KRTAP9-9 Gene

Post-translational modifications for KRTAP9-9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP9-9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP9-9 Gene

Domains & Families for KRTAP9-9 Gene

Gene Families for KRTAP9-9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRTAP9-9 Gene


Suggested Antigen Peptide Sequences for KRTAP9-9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the KRTAP type 9 family.
  • Belongs to the KRTAP type 9 family.
genes like me logo Genes that share domains with KRTAP9-9: view

Function for KRTAP9-9 Gene

Molecular function for KRTAP9-9 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP9-9 Gene

Localization for KRTAP9-9 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRTAP9-9 gene
Compartment Confidence
cytosol 5
extracellular 2
cytoskeleton 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP9-9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP9-9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRTAP9-9 Gene

Pathways & Interactions for KRTAP9-9 Gene

SuperPathways for KRTAP9-9 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRTAP9-9: view

Pathways by source for KRTAP9-9 Gene

2 Reactome pathways for KRTAP9-9 Gene

Interacting Proteins for KRTAP9-9 Gene

Gene Ontology (GO) - Biological Process for KRTAP9-9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
genes like me logo Genes that share ontologies with KRTAP9-9: view

No data available for SIGNOR curated interactions for KRTAP9-9 Gene

Drugs & Compounds for KRTAP9-9 Gene

No Compound Related Data Available

Transcripts for KRTAP9-9 Gene

mRNA/cDNA for KRTAP9-9 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP9-9 Gene

No ASD Table

Relevant External Links for KRTAP9-9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRTAP9-9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRTAP9-9 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP9-9 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x49.6).

SOURCE GeneReport for Unigene cluster for KRTAP9-9 Gene:


Evidence on tissue expression from TISSUES for KRTAP9-9 Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with KRTAP9-9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP9-9 Gene

Orthologs for KRTAP9-9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP9-9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRTAP9-9 34
  • 96 (a)
KRTAP9-2 33
  • 94.14 (n)
(Mus musculus)
Mammalia Krtap9-1 34
  • 53 (a)
Gm11559 34
  • 51 (a)
Gm11567 34
  • 49 (a)
Gm11568 34
  • 46 (a)
(Bos Taurus)
Mammalia -- 34
  • 46 (a)
KRTAP9-1 34
  • 41 (a)
Species where no ortholog for KRTAP9-9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP9-9 Gene

Gene Tree for KRTAP9-9 (if available)
Gene Tree for KRTAP9-9 (if available)

Paralogs for KRTAP9-9 Gene

Paralogs for KRTAP9-9 Gene

(9) SIMAP similar genes for KRTAP9-9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KRTAP9-9: view

Variants for KRTAP9-9 Gene

Sequence variations from dbSNP and Humsavar for KRTAP9-9 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000590823 -- 41,253,647(+) A/C upstream_transcript_variant
rs1000692699 -- 41,254,123(+) A/C upstream_transcript_variant
rs1000809764 -- 41,254,341(+) C/T upstream_transcript_variant
rs1001618346 -- 41,256,079(+) TCTCT/TCT 3_prime_UTR_variant
rs1002364956 -- 41,255,221(+) A/C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KRTAP9-9 Gene

Variant ID Type Subtype PubMed ID
dgv3159n100 CNV gain 25217958
dgv3160n100 CNV gain+loss 25217958
dgv3161n100 CNV loss 25217958
dgv413e201 CNV deletion 23290073
esv2758690 CNV gain+loss 17122850
esv3584937 CNV gain 24956385
nsv1059597 CNV loss 25217958
nsv1146669 OTHER inversion 26484159
nsv1160474 CNV deletion 26073780
nsv510710 CNV deletion 20534489
nsv575028 CNV gain 21841781
nsv9551 CNV loss 18304495
nsv960487 CNV duplication 23825009

Variation tolerance for KRTAP9-9 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.75; 97.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRTAP9-9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP9-9 Gene

Disorders for KRTAP9-9 Gene

Additional Disease Information for KRTAP9-9

No disorders were found for KRTAP9-9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP9-9 Gene

Publications for KRTAP9-9 Gene

  1. Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers MA … Schweizer J (The Journal of biological chemistry 2001) 2 3 4 58
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58

Products for KRTAP9-9 Gene

Sources for KRTAP9-9 Gene

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