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Aliases for KRTAP5-11 Gene
Aliases for KRTAP5-11 Gene
External Ids for KRTAP5-11 Gene
- HGNC: 23606
- Entrez Gene: 440051
- Ensembl: ENSG00000204571
- UniProtKB: Q6L8G4
Previous GeneCards Identifiers for KRTAP5-11 Gene
- GC00U913948
- GC11U900627
- GC11M070971
- GC11M071291
- GC11M067586
- GC11M071297
Summaries for KRTAP5-11 Gene
GeneCards Summary for KRTAP5-11 Gene
KRTAP5-11 (Keratin Associated Protein 5-11) is a Protein Coding gene. Among its related pathways are Developmental Biology and Keratinization.
UniProtKB/Swiss-Prot Summary for KRTAP5-11 Gene
-
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Additional gene information for KRTAP5-11 Gene
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRTAP5-11 Gene
Genomics for KRTAP5-11 Gene
GeneHancer (GH) Regulatory Elements for KRTAP5-11 Gene
Promoters and enhancers for KRTAP5-11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KRTAP5-11 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KRTAP5-11 gene promoter:
-
- c-Myb
- Elk-1
- FOXO3b
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- TBP
- TFIID
Genomic Locations for KRTAP5-11 Gene
Genomic Locations for KRTAP5-11 Gene
- chr11:71,579,714-71,603,353
- (GRCh38/hg38)
- Size:
- 23,640 bases
- Orientation:
- Minus strand
- chr11:71,292,901-71,314,399
- (GRCh37/hg19)
- Size:
- 21,499 bases
- Orientation:
- Minus strand
Genomic View for KRTAP5-11 Gene
Genes around KRTAP5-11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.4 by HGNC
- 11q13.4 by Entrez Gene
- 11q13.4 by Ensembl
KRTAP5-11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KRTAP5-11 Gene
Proteins for KRTAP5-11 Gene
-
Protein details for KRTAP5-11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6L8G4-KR511_HUMAN
- Recommended name:
- Keratin-associated protein 5-11
- Protein Accession:
- Q6L8G4
Protein attributes for KRTAP5-11 Gene
- Size:
- 156 amino acids
- Molecular mass:
- 14610 Da
- Quaternary structure:
-
- Interacts with hair keratins.
Post-translational modifications for KRTAP5-11 Gene
Other Protein References for KRTAP5-11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KRTAP5-11
- Origene Custom Protein Services for KRTAP5-11
- antibodies-online: Show 3 available KRTAP5-11 Proteins ranked by validation data
- Compare Top KRTAP5-11 Proteins
-
Quality Products:
No data available for DME Specific Peptides for KRTAP5-11 Gene
Domains & Families for KRTAP5-11 Gene
Gene Families for KRTAP5-11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for KRTAP5-11 Gene
- GenScript: Design optimal peptide antigens:
-
- Ultrahigh sulfur keratin-associated protein 5.11 (KR511_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6L8G4- Family:
-
- Belongs to the KRTAP type 5 family.
Function for KRTAP5-11 Gene
Molecular function for KRTAP5-11 Gene
- UniProtKB/Swiss-Prot Function:
- In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Phenotypes From GWAS Catalog for KRTAP5-11 Gene
Phenotypes for KRTAP5-11 Gene
- GenomeRNAi human phenotypes for KRTAP5-11:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Browse CRISPR knockouts for KRTAP5-11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRTAP5-11
- genomics-online: gRNA clones - Search for available KRTAP5-11 gRNA products
- Overview of 42 available KRTAP5-11 gene related products
- Applied Biological Materials (abm): CRISPR Clones for KRTAP5-11 - Select products 50% OFF >
- * KRTAP5-11 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * KRTAP5-11 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRTAP5-11
miRNA Products
Inhibitory RNA Products
- Origene sirna and shrna products in human, mouse, rat for KRTAP5-11
- Browse OriGene Inhibitory RNA Products For KRTAP5-11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRTAP5-11
- genomics-online: shRNA clones - Search for available KRTAP5-11 shRNA products
- Overview of 42 available KRTAP5-11 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KRTAP5-11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRTAP5-11
- Applied Biological Materials (abm): Clones for KRTAP5-11 - Select products 50% OFF >
- * KRTAP5-11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * KRTAP5-11 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for KRTAP5-11
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP5-11 Gene
Localization for KRTAP5-11 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| cytoskeleton | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0005882 | intermediate filament | IEA | -- |
| GO:0045095 | keratin filament | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRTAP5-11 Gene
Pathways & Interactions for KRTAP5-11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Developmental Biology | ||
| 2 | Keratinization |
.33
|
|
Pathways by source for KRTAP5-11 Gene
2 Reactome pathways for KRTAP5-11 Gene
Interacting Proteins for KRTAP5-11 Gene
Selected Interacting proteins:
Q6L8G4-KR511_HUMAN
ENSP00000381541
for KRTAP5-11 Gene via
UniProtKB
STRING
GPS-Prot Interaction Network for KRTAP5-11
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0031424 | keratinization | TAS | -- |
No data available for SIGNOR curated interactions for KRTAP5-11 Gene
Transcripts for KRTAP5-11 Gene
mRNA/cDNA for KRTAP5-11 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (8) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000398530 1021 bps (ENST00000398530.1)
- ENST00000526239 628 bps (ENST00000526239.1)
- ENST00000617152 558 bps (ENST00000617152.1)
CRISPR Products
- Browse CRISPR knockouts for KRTAP5-11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRTAP5-11
- genomics-online: gRNA clones - Search for available KRTAP5-11 gRNA products
- Overview of 42 available KRTAP5-11 gene related products
- Applied Biological Materials (abm): CRISPR Clones for KRTAP5-11 - Select products 50% OFF >
- * KRTAP5-11 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * KRTAP5-11 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRTAP5-11
miRNA Products
Inhibitory RNA Products
- Origene sirna and shrna products in human, mouse, rat for KRTAP5-11
- Browse OriGene Inhibitory RNA Products For KRTAP5-11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRTAP5-11
- genomics-online: shRNA clones - Search for available KRTAP5-11 shRNA products
- Overview of 42 available KRTAP5-11 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KRTAP5-11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRTAP5-11
- Applied Biological Materials (abm): Clones for KRTAP5-11 - Select products 50% OFF >
- * KRTAP5-11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * KRTAP5-11 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for KRTAP5-11 Gene
mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRTAP5-11 Gene
SOURCE GeneReport for Unigene cluster for KRTAP5-11 Gene:
Hs.679617mRNA Expression by UniProt/SwissProt for KRTAP5-11 Gene:
Q6L8G4-KR511_HUMAN
Tissue specificity:
Restricted to hair root, not detected in any other tissues.
Evidence on tissue expression from TISSUES for KRTAP5-11 Gene
- Skin(4)
Primer Products
-
OriGene qPCR primer pairs for KRTAP5-11
- genomics-online: primer clones - Search for available KRTAP5-11 Primer products
- Overview of 42 available KRTAP5-11 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP5-11 Gene
Orthologs for KRTAP5-11 Gene
Evolution for KRTAP5-11 Gene
- ENSEMBL:
- Gene Tree for KRTAP5-11 (if available)
- TreeFam:
- Gene Tree for KRTAP5-11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KRTAP5-11: view image
No data available for Orthologs for KRTAP5-11 Gene
Paralogs for KRTAP5-11 Gene
No data available for Paralogs for KRTAP5-11 Gene
Variants for KRTAP5-11 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000959594 | -- | 71,584,619(-) | G/A/T | upstream_transcript_variant | |
| rs1002154553 | -- | 71,583,731(-) | T/G | upstream_transcript_variant | |
| rs1002826040 | -- | 71,581,652(-) | C/T | downstream_transcript_variant | |
| rs1004155997 | -- | 71,584,265(-) | C/G | upstream_transcript_variant | |
| rs1005229488 | -- | 71,583,559(-) | C/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1222n100 | CNV | gain | 25217958 |
| esv3892025 | CNV | gain | 25118596 |
| nsv1043207 | CNV | gain | 25217958 |
| nsv825988 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.52;
29.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KRTAP5-11 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KRTAP5-11
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP5-11 Gene
Disorders for KRTAP5-11 Gene
Additional Disease Information for KRTAP5-11
No disorders were found for KRTAP5-11 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP5-11 Gene
Publications for KRTAP5-11 Gene
- Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11. (PMID: 15144888) Yahagi S … Shimizu N (Biochemical and biophysical research communications 2004) 2 3 4 56
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56
Products for KRTAP5-11 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KRTAP5-11
- Origene Custom Protein Services for KRTAP5-11
- Origene sirna and shrna products in human, mouse, rat for KRTAP5-11
- Browse OriGene Inhibitory RNA Products For KRTAP5-11
- OriGene qPCR primer pairs for KRTAP5-11
- Browse CRISPR knockouts for KRTAP5-11
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For KRTAP5-11
- Sino Biological Human cDNA Clone for KRTAP5-11
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- antibodies-online: Search results for available KRTAP5-11 related products ranked by validation data
- antibodies-online: Search results for available KRTAP5-11 related products ranked by validation data
- antibodies-online: Show 3 available KRTAP5-11 Proteins ranked by validation data
- Compare Top KRTAP5-11 Proteins
- Quality Products:
- Horizon Cell Lines for KRTAP5-11
- genomics-online: cdna clones - Search for available KRTAP5-11 CDNA products
- Overview of 42 available KRTAP5-11 gene related products
- orf clones - Search for available KRTAP5-11 ORF products
- Overview of 42 available KRTAP5-11 gene related products
- genomics-online: gRNA clones - Search for available KRTAP5-11 gRNA products
- Overview of 42 available KRTAP5-11 gene related products
- genomics-online: primer clones - Search for available KRTAP5-11 Primer products
- Overview of 42 available KRTAP5-11 gene related products
- genomics-online: shRNA clones - Search for available KRTAP5-11 shRNA products
- Overview of 42 available KRTAP5-11 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRTAP5-11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRTAP5-11
- Search GeneCopoeia for miRNA 3'UTR Target clone products for KRTAP5-11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRTAP5-11
Sources for KRTAP5-11 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource