Aliases for KRTAP5-11 Gene
Aliases for KRTAP5-11 Gene
External Ids for KRTAP5-11 Gene
- HGNC: 23606
- Entrez Gene: 440051
- Ensembl: ENSG00000204571
- UniProtKB: Q6L8G4
Previous GeneCards Identifiers for KRTAP5-11 Gene
- GC00U913948
- GC11U900627
- GC11M070971
- GC11M071291
- GC11M067586
- GC11M071297
Summaries for KRTAP5-11 Gene
GeneCards Summary for KRTAP5-11 Gene
KRTAP5-11 (Keratin Associated Protein 5-11) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology.
UniProtKB/Swiss-Prot for KRTAP5-11 Gene
-
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Additional gene information for KRTAP5-11 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP5-11 Gene
Genomics for KRTAP5-11 Gene
GeneHancer (GH) Regulatory Elements for KRTAP5-11 Gene
Promoters and enhancers for KRTAP5-11 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11I071582 | Promoter | 0.5 | EPDnew | 550.3 | +20.4 | 20436 | 0.1 | KRTAP5-11 KRTAP5-14P OR7E87P | ||
| GH11I071693 | Enhancer | 0.5 | FANTOM5 | 2.1 | -89.9 | -89860 | 0.1 | MITF CBFA2T2 MLLT1 KDM1A MGA | PIR57181 KRTAP5-11 FOLR1 ENSG00000254972 LOC645544 | |
| GH11I071606 | Enhancer | 0.3 | Ensembl | 0.8 | -4.7 | -4653 | 2.2 | EZH2 | FOLR3 KRTAP5-11 UNC93B6 OR7E4P | |
| GH11I071587 | Enhancer | 0.6 | ENCODE | 0.4 | +14.8 | 14819 | 1.3 | CTCF SOX13 PKNOX1 RB1 HLF TRIM22 ZEB2 ATF2 CTBP1 ZNF143 | KRTAP5-10 OR7E87P KRTAP5-14P KRTAP5-11 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around KRTAP5-11 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for KRTAP5-11 Gene
Genomic Locations for KRTAP5-11 Gene
- chr11:71,579,714-71,603,353
- (GRCh38/hg38)
- Size:
- 23,640 bases
- Orientation:
- Minus strand
- chr11:71,292,901-71,314,399
- (GRCh37/hg19)
Genomic View for KRTAP5-11 Gene
Genes around KRTAP5-11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.4 by Ensembl
- 11q13.4 by Entrez Gene
- 11q13.4 by HGNC
KRTAP5-11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KRTAP5-11 Gene
Proteins for KRTAP5-11 Gene
-
Protein details for KRTAP5-11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6L8G4-KR511_HUMAN
- Recommended name:
- Keratin-associated protein 5-11
- Protein Accession:
- Q6L8G4
Protein attributes for KRTAP5-11 Gene
- Size:
- 156 amino acids
- Molecular mass:
- 14610 Da
- Quaternary structure:
-
- Interacts with hair keratins.
Post-translational modifications for KRTAP5-11 Gene
No Post-translational modifications
Other Protein References for KRTAP5-11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KRTAP5-11
- Origene Custom Protein Services for KRTAP5-11
- antibodies-online: Search results for 3 available KRTAP5-11 Proteins ranked by validation data
- Compare Top KRTAP5-11 Proteins
-
Quality Products:
- Search GeneTex for Proteins for KRTAP5-11
Assay Products
No data available for DME Specific Peptides for KRTAP5-11 Gene
Domains & Families for KRTAP5-11 Gene
Gene Families for KRTAP5-11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for KRTAP5-11 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6L8G4- Family:
-
- Belongs to the KRTAP type 5 family.
Function for KRTAP5-11 Gene
Molecular function for KRTAP5-11 Gene
- UniProtKB/Swiss-Prot Function:
- In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Phenotypes for KRTAP5-11 Gene
Animal Model Products
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-
-
ViGene Biosciences ready-to-package AAV shRNAs for KRTAP5-11 gene
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CRISPR Products
- Browse CRISPR knockouts for KRTAP5-11
- genomics-online: gRNA clones - Search results for 38 available KRTAP5-11 gene related products
- Overview of 38 available KRTAP5-11 gene related products
- Applied Biological Materials CRISPR for KRTAP5-11
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRTAP5-11
- GenScript: Design CRISPR guide RNA sequences for KRTAP5-11
miRNA Products
- Search ViGene Biosciences for KRTAP5-11
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for 38 available KRTAP5-11 gene related products
- Overview of 38 available KRTAP5-11 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KRTAP5-11 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KRTAP5-11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KRTAP5-11
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for KRTAP5-11
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KRTAP5-11
-
ViGene Biosciences adenoviral particle packaged cDNA for KRTAP5-11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KRTAP5-11 gene
- Search ViGene Biosciences for KRTAP5-11
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP5-11 Gene
Localization for KRTAP5-11 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 3 |
| cytoskeleton | 2 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0005882 | intermediate filament | IEA | -- |
| GO:0045095 | keratin filament | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRTAP5-11 Gene
Pathways & Interactions for KRTAP5-11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Developmental Biology | ||
| 2 | Keratinization |
.33
|
|
Pathways by source for KRTAP5-11 Gene
2 Reactome pathways for KRTAP5-11 Gene
Interacting Proteins for KRTAP5-11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0031424 | keratinization | TAS | -- |
No data available for SIGNOR curated interactions for KRTAP5-11 Gene
Transcripts for KRTAP5-11 Gene
mRNA/cDNA for KRTAP5-11 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (8) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KRTAP5-11 Gene
- Keratin associated protein 5-11:
- Representative Sequences:
CRISPR Products
- Browse CRISPR knockouts for KRTAP5-11
- genomics-online: gRNA clones - Search results for 38 available KRTAP5-11 gene related products
- Overview of 38 available KRTAP5-11 gene related products
- Applied Biological Materials CRISPR for KRTAP5-11
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRTAP5-11
- GenScript: Design CRISPR guide RNA sequences for KRTAP5-11
miRNA Products
- Search ViGene Biosciences for KRTAP5-11
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for 38 available KRTAP5-11 gene related products
- Overview of 38 available KRTAP5-11 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KRTAP5-11 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KRTAP5-11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KRTAP5-11
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for KRTAP5-11
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for KRTAP5-11 Gene
mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRTAP5-11 Gene
SOURCE GeneReport for Unigene cluster for KRTAP5-11 Gene:
Hs.679617mRNA Expression by UniProt/SwissProt for KRTAP5-11 Gene:
Q6L8G4-KR511_HUMAN
Tissue specificity:
Restricted to hair root, not detected in any other tissues.
Evidence on tissue expression from TISSUES for KRTAP5-11 Gene
- Skin(4)
Primer Products
- genomics-online: primer clones - Search results for 38 available KRTAP5-11 gene related products
- Overview of 38 available KRTAP5-11 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP5-11 Gene
Orthologs for KRTAP5-11 Gene
No data available for Orthologs for KRTAP5-11 Gene
Paralogs for KRTAP5-11 Gene
No data available for Paralogs for KRTAP5-11 Gene
Variants for KRTAP5-11 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000959594 | -- | 71,584,619(-) | G/A/T | upstream_transcript_variant | |
| rs1002154553 | -- | 71,583,731(-) | T/G | upstream_transcript_variant | |
| rs1002826040 | -- | 71,581,652(-) | C/T | downstream_transcript_variant | |
| rs1004155997 | -- | 71,584,265(-) | C/G | upstream_transcript_variant | |
| rs1005229488 | -- | 71,583,559(-) | C/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv825988 | CNV | loss | 20364138 |
| nsv1043207 | CNV | gain | 25217958 |
| esv3892025 | CNV | gain | 25118596 |
| dgv1222n100 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.52;
29.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KRTAP5-11 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KRTAP5-11
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP5-11 Gene
Disorders for KRTAP5-11 Gene
Additional Disease Information for KRTAP5-11
No disorders were found for KRTAP5-11 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP5-11 Gene
Publications for KRTAP5-11 Gene
- Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11. (PMID: 15144888) Yahagi S … Shimizu N (Biochemical and biophysical research communications 2004) 2 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
Products for KRTAP5-11 Gene
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- Cloud-Clone Corp. primary cells service
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for KRTAP5-11
- VectorBuilder custom plasmid, inducible vectors for KRTAP5-11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KRTAP5-11
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available KRTAP5-11 related products ranked by validation data
- antibodies-online: Search results for available KRTAP5-11 related products ranked by validation data
- antibodies-online: Search results for 3 available KRTAP5-11 Proteins ranked by validation data
- Compare Top KRTAP5-11 Proteins
- Quality Products:
- Search GeneTex for Antibodies for KRTAP5-11
- Search GeneTex for Proteins for KRTAP5-11
- ViGene Biosciences adenoviral particle packaged cDNA for KRTAP5-11 gene
- ViGene Biosciences ready-to-package AAV shRNAs for KRTAP5-11 gene
- Search ViGene Biosciences for KRTAP5-11
- Horizon Cell Lines for KRTAP5-11
- genomics-online: cdna clones - Search results for 38 available KRTAP5-11 gene related products
- Overview of 38 available KRTAP5-11 gene related products
- orf clones - Search results for 38 available KRTAP5-11 gene related products
- Overview of 38 available KRTAP5-11 gene related products
- genomics-online: gRNA clones - Search results for 38 available KRTAP5-11 gene related products
- Overview of 38 available KRTAP5-11 gene related products
- genomics-online: primer clones - Search results for 38 available KRTAP5-11 gene related products
- Overview of 38 available KRTAP5-11 gene related products
- genomics-online: shRNA clones - Search results for 38 available KRTAP5-11 gene related products
- Overview of 38 available KRTAP5-11 gene related products
Sources for KRTAP5-11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (122) MedlinePlus
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- (125) NCBI Bookshelf
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- (128) ViGene Biosciences
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew